LOCUS       NM_133803               2683 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus dipeptidylpeptidase 3 (Dpp3), transcript variant 1,
            mRNA.
ACCESSION   NM_133803
VERSION     NM_133803.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2683)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2683)
  AUTHORS   Liu,J.K., Abudula,A., Yang,H.T., Xu,L.X., Nuerrula,Y., Bai,G.,
            Tulahong,A. and Eli,M.
  TITLE     DPP3 expression promotes cell proliferation and migration in vitro
            and tumour growth in vivo, which is associated with poor prognosis
            of oesophageal carcinoma
  JOURNAL   Oncol Rep 49 (1) (2023)
   PUBMED   36382663
  REMARK    GeneRIF: DPP3 expression promotes cell proliferation and migration
            in vitro and tumour growth in vivo, which is associated with poor
            prognosis of oesophageal carcinoma.
REFERENCE   3  (bases 1 to 2683)
  AUTHORS   Ren,X., Yu,J., Guo,L. and Ma,H.
  TITLE     Dipeptidyl-peptidase 3 protects oxygen-glucose
            deprivation/reoxygenation-injured hippocampal neurons by
            suppressing apoptosis, oxidative stress and inflammation via
            modulation of Keap1/Nrf2 signaling
  JOURNAL   Int Immunopharmacol 96, 107595 (2021)
   PUBMED   33812256
  REMARK    GeneRIF: Dipeptidyl-peptidase 3 protects oxygen-glucose
            deprivation/reoxygenation-injured hippocampal neurons by
            suppressing apoptosis, oxidative stress and inflammation via
            modulation of Keap1/Nrf2 signaling.
REFERENCE   4  (bases 1 to 2683)
  AUTHORS   Jha,S., Taschler,U., Domenig,O., Poglitsch,M., Bourgeois,B.,
            Pollheimer,M., Pusch,L.M., Malovan,G., Frank,S., Madl,T.,
            Gruber,K., Zimmermann,R. and Macheroux,P.
  TITLE     Dipeptidyl peptidase 3 modulates the renin-angiotensin system in
            mice
  JOURNAL   J Biol Chem 295 (40), 13711-13723 (2020)
   PUBMED   32546481
  REMARK    GeneRIF: Dipeptidyl peptidase 3 modulates the renin-angiotensin
            system in mice.
REFERENCE   5  (bases 1 to 2683)
  AUTHORS   Menale,C., Robinson,L.J., Palagano,E., Rigoni,R., Erreni,M.,
            Almarza,A.J., Strina,D., Mantero,S., Lizier,M., Forlino,A.,
            Besio,R., Monari,M., Vezzoni,P., Cassani,B., Blair,H.C., Villa,A.
            and Sobacchi,C.
  TITLE     Absence of Dipeptidyl Peptidase 3 Increases Oxidative Stress and
            Causes Bone Loss
  JOURNAL   J Bone Miner Res 34 (11), 2133-2148 (2019)
   PUBMED   31295380
  REMARK    GeneRIF: Absence of Dipeptidyl Peptidase 3 Increases Oxidative
            Stress and Causes Bone Loss.
REFERENCE   6  (bases 1 to 2683)
  AUTHORS   Gamrekelashvili,J., Kapanadze,T., Han,M., Wissing,J., Ma,C.,
            Jaensch,L., Manns,M.P., Armstrong,T., Jaffee,E., White,A.O.,
            Citrin,D.E., Korangy,F. and Greten,T.F.
  TITLE     Peptidases released by necrotic cells control CD8+ T cell
            cross-priming
  JOURNAL   J Clin Invest 123 (11), 4755-4768 (2013)
   PUBMED   24216478
  REMARK    GeneRIF: the cellular peptidases dipeptidyl peptidase 3 (DPP-3) and
            thimet oligopeptidase 1 (TOP-1), both of which are present in
            nonimmunogenic necrotic cells, eliminated proteasomal degradation
            products and blocked Ag cross-presentation
REFERENCE   7  (bases 1 to 2683)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY131486.1, AK031020.1 and AK150101.1.
            
            On Jul 2, 2009 this sequence version replaced NM_133803.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK150101.1, AK031020.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                BY131486.1         2-36
            36-2680             AK031020.1         1-2645
            2681-2683           AK150101.1         2641-2643
FEATURES             Location/Qualifiers
     source          1..2683
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 4.15 cM"
     gene            1..2683
                     /gene="Dpp3"
                     /gene_synonym="4930533O14Rik; DPP III"
                     /note="dipeptidylpeptidase 3"
                     /db_xref="GeneID:75221"
                     /db_xref="MGI:MGI:1922471"
     exon            1..68
                     /gene="Dpp3"
                     /gene_synonym="4930533O14Rik; DPP III"
                     /inference="alignment:Splign:2.1.0"
     exon            69..343
                     /gene="Dpp3"
                     /gene_synonym="4930533O14Rik; DPP III"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..2290
                     /gene="Dpp3"
                     /gene_synonym="4930533O14Rik; DPP III"
                     /EC_number="3.4.14.4"
                     /note="dipeptidyl-peptidase 3; dipeptidyl aminopeptidase
                     III; dipeptidyl arylamidase III; dipeptidylpeptidase III;
                     dipeptidyl peptidase III; enkephalinase B"
                     /codon_start=1
                     /product="dipeptidyl peptidase 3"
                     /protein_id="NP_598564.2"
                     /db_xref="CCDS:CCDS29443.1"
                     /db_xref="GeneID:75221"
                     /db_xref="MGI:MGI:1922471"
                     /translation="MADTQYILPNDIGVSSLDCREAFRLLSPTERLYAHHLSRAAWYG
                     GLAVLLQTSPEAPYIYALLSRLFRAQDPDQLRQHALAEGLTEEEYQAFLVYAAGVYSN
                     MGNYKSFGDTKFVPNLPKDKLGRVILGSKAAQQRPEEVRDLWQTCGDLMFSLEPRLRH
                     LGLGKEGVTTYFSGDCTMEDAKLAQDFLDSQNLSAYNTRLFKVVGQEGKSHYEVRLAS
                     VLNTDPALDSELTSKLKRYEFQGNHFQVTRGDYAPILQKVVEHLEKAKAYAANSHQEQ
                     MLAQYVESFTQGSIEAHKRGSRFWIQDKGPIVESYIGFIESYRDPFGSRGEFEGFVAM
                     VNKAMSAKFERLVASAEQLLKELPWPLAFEKDKFLTPDFTSLDVLTFAGSGIPAGINI
                     PNYDDLRQTEGFKNVSLGNVLAVAYAAKREKLTFLEEEDKDLYIRWKGPSFDVQVGLH
                     ELLGHGSGKLFVQDEKGAFNFDKETVINPETGEQIQSWYRSGETWDSKFSTIASSYEE
                     CRAESVGLYLCLNPQVLEIFGFEGADAEDVIYVNWLNMVRAGLLALEFYTPEAANWRQ
                     AHMQARFVILRVLLEAGEGLVTVTPTTGSDGRPDARVRLDRSKIRSVGRPALERFLRR
                     LQVLKSTGDVVAGRALYEGYAAVTDAPPECFLTLRDTVLLRKESRKLIVQPNTRLEGS
                     EVQLVEYEASAAGLIRSFCERFPEDGPELEEVLIQLAAADARFWRNQAQEAPPGQA"
     exon            344..433
                     /gene="Dpp3"
                     /gene_synonym="4930533O14Rik; DPP III"
                     /inference="alignment:Splign:2.1.0"
     exon            434..571
                     /gene="Dpp3"
                     /gene_synonym="4930533O14Rik; DPP III"
                     /inference="alignment:Splign:2.1.0"
     exon            572..646
                     /gene="Dpp3"
                     /gene_synonym="4930533O14Rik; DPP III"
                     /inference="alignment:Splign:2.1.0"
     exon            647..740
                     /gene="Dpp3"
                     /gene_synonym="4930533O14Rik; DPP III"
                     /inference="alignment:Splign:2.1.0"
     exon            741..871
                     /gene="Dpp3"
                     /gene_synonym="4930533O14Rik; DPP III"
                     /inference="alignment:Splign:2.1.0"
     exon            872..1002
                     /gene="Dpp3"
                     /gene_synonym="4930533O14Rik; DPP III"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1061
                     /gene="Dpp3"
                     /gene_synonym="4930533O14Rik; DPP III"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1256
                     /gene="Dpp3"
                     /gene_synonym="4930533O14Rik; DPP III"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1369
                     /gene="Dpp3"
                     /gene_synonym="4930533O14Rik; DPP III"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1462
                     /gene="Dpp3"
                     /gene_synonym="4930533O14Rik; DPP III"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1525
                     /gene="Dpp3"
                     /gene_synonym="4930533O14Rik; DPP III"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1650
                     /gene="Dpp3"
                     /gene_synonym="4930533O14Rik; DPP III"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..1771
                     /gene="Dpp3"
                     /gene_synonym="4930533O14Rik; DPP III"
                     /inference="alignment:Splign:2.1.0"
     exon            1772..1951
                     /gene="Dpp3"
                     /gene_synonym="4930533O14Rik; DPP III"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..2114
                     /gene="Dpp3"
                     /gene_synonym="4930533O14Rik; DPP III"
                     /inference="alignment:Splign:2.1.0"
     exon            2115..2683
                     /gene="Dpp3"
                     /gene_synonym="4930533O14Rik; DPP III"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2662..2667
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dpp3"
                     /gene_synonym="4930533O14Rik; DPP III"
                     /note="hexamer: AATAAA"
     polyA_site      2681
                     /gene="Dpp3"
                     /gene_synonym="4930533O14Rik; DPP III"
                     /note="major polyA site"
ORIGIN      
        1 gtgtcccaat gaatggggcg gggagccgga agcaggaagt gagtttgcga acggagcagc
       61 tgcagcaggg ctcatggcag atacccagta catcctgccc aatgacattg gtgtgtctag
      121 cctggactgc agggaggcat tccgcctgct gtcacccaca gagcgcctct atgcccatca
      181 cctgtctaga gctgcttggt atgggggcct ggcagtgctg ctccagacat cccctgaagc
      241 cccctacatc tatgccctgc ttagccgcct cttccgtgcc caggaccctg accagctgcg
      301 ccaacatgcc ctggctgagg gtcttactga agaagagtac caggcattcc tggtctacgc
      361 tgcaggggtc tactccaaca tgggcaacta caagtccttt ggtgacacca agtttgttcc
      421 taacctgccc aaggacaagc tgggacgtgt gatcctgggg agtaaggctg cccagcagcg
      481 gccagaagaa gtcagggacc tttggcagac ctgtggggac cttatgttct ccctggaacc
      541 gaggcttcga catcttgggc tggggaagga gggagtcacc acctatttct ctggggattg
      601 taccatggaa gatgctaagc tggcccagga ctttctggac tctcagaacc tcagtgcata
      661 caacactcgg ctcttcaagg tcgttggcca ggaagggaag tcccactatg aggtgcggct
      721 ggcttcagtc ctcaacacag accctgctct cgactctgaa ttgacctcca agctgaagag
      781 atatgagttc caggggaacc atttccaggt cacccggggg gactatgccc ccatcctcca
      841 gaaggtggta gaacacttgg agaaagctaa ggcttatgca gccaacagcc accaggagca
      901 aatgctggct cagtacgtgg agagcttcac ccagggctcc attgaggccc ataagagggg
      961 ctcccgcttc tggattcagg acaaaggccc cattgtagag agttacattg gcttcattga
     1021 gagctaccgt gacccctttg gctcccgagg agagtttgaa ggcttcgtgg ccatggtaaa
     1081 caaagccatg agtgccaagt tcgagcggct ggtcgcgagt gctgagcagc tgctgaagga
     1141 gctgccctgg cctcttgcct tcgagaagga caagttcctc acccctgact tcacctccct
     1201 ggacgtcctc acctttgctg gctctggcat tcctgcgggc atcaacatcc ccaactacga
     1261 tgacctgaga cagacagaag gctttaagaa tgtatcgctg gggaatgtgc tggctgtggc
     1321 ctatgccgca aagcgggaga agctcacgtt cttggaggag gaagacaagg acctgtatat
     1381 ccgctggaag gggccgtcct ttgatgtgca ggtggggtta cacgagctgt tgggccatgg
     1441 cagcggcaag ctctttgtac aggatgagaa aggtgctttc aactttgaca aggagactgt
     1501 gatcaaccca gagactgggg aacagatcca gagctggtac cggagtggag agacgtggga
     1561 tagcaaattc agcaccattg cctccagcta cgaagagtgc cgggccgaga gtgtgggcct
     1621 ctacctctgt ctcaaccccc aagtgctgga gatctttggc tttgagggag ctgatgcaga
     1681 agatgtaatc tacgtgaact ggctcaacat ggttcgggct ggcttgttgg ctttggagtt
     1741 ctacacccca gaggcagcca actggcgaca ggcccacatg caggcccggt ttgtgatcct
     1801 gcgggttttg ctggaagctg gcgaaggact cgttaccgtc actcccacca caggctctga
     1861 tgggcgccct gatgcccggg tccgcctgga ccgcagcaag atccggtcag tgggcagacc
     1921 tgccttggag cggttcctgc ggagactcca ggtgctgaag tccacggggg acgtggtcgc
     1981 ggggcgggcc ctgtacgagg gctatgcagc agtcactgac gcacctccag agtgcttcct
     2041 taccctaagg gatacggtac tgctgcgcaa ggagtcccgg aagcttattg ttcaacccaa
     2101 cactcgcctt gaaggctcag aagtacaact tgtggagtat gaggcctcag ccgctggtct
     2161 catccgctcc ttctgtgagc ggtttcccga ggatgggccc gagttggagg aggttcttat
     2221 ccagctggct gcagcagatg cccgattctg gaggaaccag gcccaggagg ccccacctgg
     2281 ccaggcttga gaagatctgt gtggtctctc ccctctttgt caaaccaggg ctgtcagtag
     2341 ctctgagttg tgtgtgatta ggagtcaggg gagggagggg caggagcttg gactttggtg
     2401 ctacctcagc tgagggtggt gatgcgaacc ccttccattt gtcagcactt tgcagtttac
     2461 cgtatgtcct cagtttctgg atctgcactg ccatctatgg ccggagctca acagggtgcc
     2521 tagtccggtt ttccacatgg gaaggtggca attctgagaa gtgactgttc tagacccggc
     2581 aggtggcatg tgacagagcc agggctcaaa gcattctcac caaatccagc gctcttcgtg
     2641 tattactttt atagccagaa aaataaatat gacgaccacc atc
//
