LOCUS       NM_001360711            2638 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus dipeptidylpeptidase 3 (Dpp3), transcript variant 2,
            mRNA.
ACCESSION   NM_001360711 XM_006531854
VERSION     NM_001360711.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2638)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2638)
  AUTHORS   Liu,J.K., Abudula,A., Yang,H.T., Xu,L.X., Nuerrula,Y., Bai,G.,
            Tulahong,A. and Eli,M.
  TITLE     DPP3 expression promotes cell proliferation and migration in vitro
            and tumour growth in vivo, which is associated with poor prognosis
            of oesophageal carcinoma
  JOURNAL   Oncol Rep 49 (1) (2023)
   PUBMED   36382663
  REMARK    GeneRIF: DPP3 expression promotes cell proliferation and migration
            in vitro and tumour growth in vivo, which is associated with poor
            prognosis of oesophageal carcinoma.
REFERENCE   3  (bases 1 to 2638)
  AUTHORS   Ren,X., Yu,J., Guo,L. and Ma,H.
  TITLE     Dipeptidyl-peptidase 3 protects oxygen-glucose
            deprivation/reoxygenation-injured hippocampal neurons by
            suppressing apoptosis, oxidative stress and inflammation via
            modulation of Keap1/Nrf2 signaling
  JOURNAL   Int Immunopharmacol 96, 107595 (2021)
   PUBMED   33812256
  REMARK    GeneRIF: Dipeptidyl-peptidase 3 protects oxygen-glucose
            deprivation/reoxygenation-injured hippocampal neurons by
            suppressing apoptosis, oxidative stress and inflammation via
            modulation of Keap1/Nrf2 signaling.
REFERENCE   4  (bases 1 to 2638)
  AUTHORS   Jha,S., Taschler,U., Domenig,O., Poglitsch,M., Bourgeois,B.,
            Pollheimer,M., Pusch,L.M., Malovan,G., Frank,S., Madl,T.,
            Gruber,K., Zimmermann,R. and Macheroux,P.
  TITLE     Dipeptidyl peptidase 3 modulates the renin-angiotensin system in
            mice
  JOURNAL   J Biol Chem 295 (40), 13711-13723 (2020)
   PUBMED   32546481
  REMARK    GeneRIF: Dipeptidyl peptidase 3 modulates the renin-angiotensin
            system in mice.
REFERENCE   5  (bases 1 to 2638)
  AUTHORS   Menale,C., Robinson,L.J., Palagano,E., Rigoni,R., Erreni,M.,
            Almarza,A.J., Strina,D., Mantero,S., Lizier,M., Forlino,A.,
            Besio,R., Monari,M., Vezzoni,P., Cassani,B., Blair,H.C., Villa,A.
            and Sobacchi,C.
  TITLE     Absence of Dipeptidyl Peptidase 3 Increases Oxidative Stress and
            Causes Bone Loss
  JOURNAL   J Bone Miner Res 34 (11), 2133-2148 (2019)
   PUBMED   31295380
  REMARK    GeneRIF: Absence of Dipeptidyl Peptidase 3 Increases Oxidative
            Stress and Causes Bone Loss.
REFERENCE   6  (bases 1 to 2638)
  AUTHORS   Gamrekelashvili,J., Kapanadze,T., Han,M., Wissing,J., Ma,C.,
            Jaensch,L., Manns,M.P., Armstrong,T., Jaffee,E., White,A.O.,
            Citrin,D.E., Korangy,F. and Greten,T.F.
  TITLE     Peptidases released by necrotic cells control CD8+ T cell
            cross-priming
  JOURNAL   J Clin Invest 123 (11), 4755-4768 (2013)
   PUBMED   24216478
  REMARK    GeneRIF: the cellular peptidases dipeptidyl peptidase 3 (DPP-3) and
            thimet oligopeptidase 1 (TOP-1), both of which are present in
            nonimmunogenic necrotic cells, eliminated proteasomal degradation
            products and blocked Ag cross-presentation
REFERENCE   7  (bases 1 to 2638)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124502.4 and AC141437.4.
            
            On Feb 10, 2018 this sequence version replaced XM_006531854.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.298259.1,
                                           SRR1660813.19224.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                AC124502.4         195618-195640
            24-298              AC124502.4         196529-196803
            299-388             AC124502.4         199815-199904
            389-526             AC124502.4         200384-200521
            527-601             AC124502.4         201192-201266
            602-695             AC124502.4         202354-202447
            696-826             AC124502.4         205213-205343
            827-957             AC124502.4         205438-205568
            958-1016            AC124502.4         205658-205716
            1017-1211           AC124502.4         206502-206696
            1212-1324           AC124502.4         206778-206890
            1325-1417           AC124502.4         207217-207309
            1418-1480           AC124502.4         208507-208569
            1481-1605           AC124502.4         208654-208778
            1606-1726           AC124502.4         208888-209008
            1727-1906           AC124502.4         209636-209815
            1907-2069           AC141437.4         722-884
            2070-2638           AC141437.4         2933-3501
FEATURES             Location/Qualifiers
     source          1..2638
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 4.15 cM"
     gene            1..2638
                     /gene="Dpp3"
                     /gene_synonym="4930533O14Rik; DPP III"
                     /note="dipeptidylpeptidase 3"
                     /db_xref="GeneID:75221"
                     /db_xref="MGI:MGI:1922471"
     exon            1..23
                     /gene="Dpp3"
                     /gene_synonym="4930533O14Rik; DPP III"
                     /inference="alignment:Splign:2.1.0"
     exon            24..298
                     /gene="Dpp3"
                     /gene_synonym="4930533O14Rik; DPP III"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..2245
                     /gene="Dpp3"
                     /gene_synonym="4930533O14Rik; DPP III"
                     /EC_number="3.4.14.4"
                     /note="dipeptidyl-peptidase 3; dipeptidyl aminopeptidase
                     III; dipeptidyl arylamidase III; dipeptidylpeptidase III;
                     dipeptidyl peptidase III; enkephalinase B"
                     /codon_start=1
                     /product="dipeptidyl peptidase 3"
                     /protein_id="NP_001347640.1"
                     /db_xref="CCDS:CCDS29443.1"
                     /db_xref="GeneID:75221"
                     /db_xref="MGI:MGI:1922471"
                     /translation="MADTQYILPNDIGVSSLDCREAFRLLSPTERLYAHHLSRAAWYG
                     GLAVLLQTSPEAPYIYALLSRLFRAQDPDQLRQHALAEGLTEEEYQAFLVYAAGVYSN
                     MGNYKSFGDTKFVPNLPKDKLGRVILGSKAAQQRPEEVRDLWQTCGDLMFSLEPRLRH
                     LGLGKEGVTTYFSGDCTMEDAKLAQDFLDSQNLSAYNTRLFKVVGQEGKSHYEVRLAS
                     VLNTDPALDSELTSKLKRYEFQGNHFQVTRGDYAPILQKVVEHLEKAKAYAANSHQEQ
                     MLAQYVESFTQGSIEAHKRGSRFWIQDKGPIVESYIGFIESYRDPFGSRGEFEGFVAM
                     VNKAMSAKFERLVASAEQLLKELPWPLAFEKDKFLTPDFTSLDVLTFAGSGIPAGINI
                     PNYDDLRQTEGFKNVSLGNVLAVAYAAKREKLTFLEEEDKDLYIRWKGPSFDVQVGLH
                     ELLGHGSGKLFVQDEKGAFNFDKETVINPETGEQIQSWYRSGETWDSKFSTIASSYEE
                     CRAESVGLYLCLNPQVLEIFGFEGADAEDVIYVNWLNMVRAGLLALEFYTPEAANWRQ
                     AHMQARFVILRVLLEAGEGLVTVTPTTGSDGRPDARVRLDRSKIRSVGRPALERFLRR
                     LQVLKSTGDVVAGRALYEGYAAVTDAPPECFLTLRDTVLLRKESRKLIVQPNTRLEGS
                     EVQLVEYEASAAGLIRSFCERFPEDGPELEEVLIQLAAADARFWRNQAQEAPPGQA"
     exon            299..388
                     /gene="Dpp3"
                     /gene_synonym="4930533O14Rik; DPP III"
                     /inference="alignment:Splign:2.1.0"
     exon            389..526
                     /gene="Dpp3"
                     /gene_synonym="4930533O14Rik; DPP III"
                     /inference="alignment:Splign:2.1.0"
     exon            527..601
                     /gene="Dpp3"
                     /gene_synonym="4930533O14Rik; DPP III"
                     /inference="alignment:Splign:2.1.0"
     exon            602..695
                     /gene="Dpp3"
                     /gene_synonym="4930533O14Rik; DPP III"
                     /inference="alignment:Splign:2.1.0"
     exon            696..826
                     /gene="Dpp3"
                     /gene_synonym="4930533O14Rik; DPP III"
                     /inference="alignment:Splign:2.1.0"
     exon            827..957
                     /gene="Dpp3"
                     /gene_synonym="4930533O14Rik; DPP III"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1016
                     /gene="Dpp3"
                     /gene_synonym="4930533O14Rik; DPP III"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1211
                     /gene="Dpp3"
                     /gene_synonym="4930533O14Rik; DPP III"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1324
                     /gene="Dpp3"
                     /gene_synonym="4930533O14Rik; DPP III"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1417
                     /gene="Dpp3"
                     /gene_synonym="4930533O14Rik; DPP III"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1480
                     /gene="Dpp3"
                     /gene_synonym="4930533O14Rik; DPP III"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..1605
                     /gene="Dpp3"
                     /gene_synonym="4930533O14Rik; DPP III"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..1726
                     /gene="Dpp3"
                     /gene_synonym="4930533O14Rik; DPP III"
                     /inference="alignment:Splign:2.1.0"
     exon            1727..1906
                     /gene="Dpp3"
                     /gene_synonym="4930533O14Rik; DPP III"
                     /inference="alignment:Splign:2.1.0"
     exon            1907..2069
                     /gene="Dpp3"
                     /gene_synonym="4930533O14Rik; DPP III"
                     /inference="alignment:Splign:2.1.0"
     exon            2070..2638
                     /gene="Dpp3"
                     /gene_synonym="4930533O14Rik; DPP III"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2617..2622
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dpp3"
                     /gene_synonym="4930533O14Rik; DPP III"
                     /note="hexamer: AATAAA"
     polyA_site      2636
                     /gene="Dpp3"
                     /gene_synonym="4930533O14Rik; DPP III"
                     /note="major polyA site"
ORIGIN      
        1 aggggcggag cgtggagaat gtgggctcat ggcagatacc cagtacatcc tgcccaatga
       61 cattggtgtg tctagcctgg actgcaggga ggcattccgc ctgctgtcac ccacagagcg
      121 cctctatgcc catcacctgt ctagagctgc ttggtatggg ggcctggcag tgctgctcca
      181 gacatcccct gaagccccct acatctatgc cctgcttagc cgcctcttcc gtgcccagga
      241 ccctgaccag ctgcgccaac atgccctggc tgagggtctt actgaagaag agtaccaggc
      301 attcctggtc tacgctgcag gggtctactc caacatgggc aactacaagt cctttggtga
      361 caccaagttt gttcctaacc tgcccaagga caagctggga cgtgtgatcc tggggagtaa
      421 ggctgcccag cagcggccag aagaagtcag ggacctttgg cagacctgtg gggaccttat
      481 gttctccctg gaaccgaggc ttcgacatct tgggctgggg aaggagggag tcaccaccta
      541 tttctctggg gattgtacca tggaagatgc taagctggcc caggactttc tggactctca
      601 gaacctcagt gcatacaaca ctcggctctt caaggtcgtt ggccaggaag ggaagtccca
      661 ctatgaggtg cggctggctt cagtcctcaa cacagaccct gctctcgact ctgaattgac
      721 ctccaagctg aagagatatg agttccaggg gaaccatttc caggtcaccc ggggggacta
      781 tgcccccatc ctccagaagg tggtagaaca cttggagaaa gctaaggctt atgcagccaa
      841 cagccaccag gagcaaatgc tggctcagta cgtggagagc ttcacccagg gctccattga
      901 ggcccataag aggggctccc gcttctggat tcaggacaaa ggccccattg tagagagtta
      961 cattggcttc attgagagct accgtgaccc ctttggctcc cgaggagagt ttgaaggctt
     1021 cgtggccatg gtaaacaaag ccatgagtgc caagttcgag cggctggtcg cgagtgctga
     1081 gcagctgctg aaggagctgc cctggcctct tgccttcgag aaggacaagt tcctcacccc
     1141 tgacttcacc tccctggacg tcctcacctt tgctggctct ggcattcctg cgggcatcaa
     1201 catccccaac tacgatgacc tgagacagac agaaggcttt aagaatgtat cgctggggaa
     1261 tgtgctggct gtggcctatg ccgcaaagcg ggagaagctc acgttcttgg aggaggaaga
     1321 caaggacctg tatatccgct ggaaggggcc gtcctttgat gtgcaggtgg ggttacacga
     1381 gctgttgggc catggcagcg gcaagctctt tgtacaggat gagaaaggtg ctttcaactt
     1441 tgacaaggag actgtgatca acccagagac tggggaacag atccagagct ggtaccggag
     1501 tggagagacg tgggatagca aattcagcac cattgcctcc agctacgaag agtgccgggc
     1561 cgagagtgtg ggcctctacc tctgtctcaa cccccaagtg ctggagatct ttggctttga
     1621 gggagctgat gcagaagatg taatctacgt gaactggctc aacatggttc gggctggctt
     1681 gttggctttg gagttctaca ccccagaggc agccaactgg cgacaggccc acatgcaggc
     1741 ccggtttgtg atcctgcggg ttttgctgga agctggcgaa ggactcgtta ccgtcactcc
     1801 caccacaggc tctgatgggc gccctgatgc ccgggtccgc ctggaccgca gcaagatccg
     1861 gtcagtgggc agacctgcct tggagcggtt cctgcggaga ctccaggtgc tgaagtccac
     1921 gggggacgtg gtcgcggggc gggccctgta cgagggctat gcagcagtca ctgacgcacc
     1981 tccagagtgc ttccttaccc taagggatac ggtactgctg cgcaaggagt cccggaagct
     2041 tattgttcaa cccaacactc gccttgaagg ctcagaagta caacttgtgg agtatgaggc
     2101 ctcagccgct ggtctcatcc gctccttctg tgagcggttt cccgaggatg ggcccgagtt
     2161 ggaggaggtt cttatccagc tggctgcagc agatgcccga ttctggagga accaggccca
     2221 ggaggcccca cctggccagg cttgagaaga tctgtgtggt ctctcccctc tttgtcaaac
     2281 cagggctgtc agtagctctg agttgtgtgt gattaggagt caggggaggg aggggcagga
     2341 gcttggactt tggtgctacc tcagctgagg gtggtgatgc gaaccccttc catttgtcag
     2401 cactttgcag tttaccgtat gtcctcagtt tctggatctg cactgccatc tatggccgga
     2461 gctcaacagg gtgcctagtc cggttttcca catgggaagg tggcaattct gagaagtgac
     2521 tgttctagac ccggcaggtg gcatgtgaca gagccagggc tcaaagcatt ctcaccaaat
     2581 ccagcgctct tcgtgtatta cttttatagc cagaaaaata aatatgacga ccaccatc
//
