LOCUS       NM_199021               5114 bp    mRNA    linear   ROD 07-DEC-2024
DEFINITION  Mus musculus dipeptidylpeptidase 10 (Dpp10), transcript variant 1,
            mRNA.
ACCESSION   NM_199021 XM_193952
VERSION     NM_199021.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5114)
  AUTHORS   Shigesawa,I., Nakamura,A., Yamauchi,Y., Kawata,S., Miyazaki,A.,
            Nomoto,H., Kameda,H., Terauchi,Y. and Atsumi,T.
  TITLE     Effects of glucokinase haploinsufficiency on the pancreatic
            beta-cell mass and function of long-term high-fat, high-sucrose
            diet-fed mice
  JOURNAL   J Diabetes Investig 15 (12), 1732-1742 (2024)
   PUBMED   39305123
REFERENCE   2  (bases 1 to 5114)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 5114)
  AUTHORS   Sapir,T., Kshirsagar,A., Gorelik,A., Olender,T., Porat,Z.,
            Scheffer,I.E., Goldstein,D.B., Devinsky,O. and Reiner,O.
  TITLE     Heterogeneous nuclear ribonucleoprotein U (HNRNPU) safeguards the
            developing mouse cortex
  JOURNAL   Nat Commun 13 (1), 4209 (2022)
   PUBMED   35864088
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5114)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5114)
  AUTHORS   Zhang,Y., Poobalasingam,T., Yates,L.L., Walker,S.A., Taylor,M.S.,
            Chessum,L., Harrison,J., Tsaprouni,L., Adcock,I.M., Lloyd,C.M.,
            Cookson,W.O., Moffatt,M.F. and Dean,C.H.
  TITLE     Manipulation of dipeptidylpeptidase 10 in mouse and human in vivo
            and in vitro models indicates a protective role in asthma
  JOURNAL   Dis Model Mech 11 (1) (2018)
   PUBMED   29361513
  REMARK    GeneRIF: These results show that a Dpp10 point mutation leads to
            increased airway responsiveness following allergen challenge.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5114)
  AUTHORS   Oeschger,F.M., Wang,W.Z., Lee,S., Garcia-Moreno,F., Goffinet,A.M.,
            Arbones,M.L., Rakic,S. and Molnar,Z.
  TITLE     Gene expression analysis of the embryonic subplate
  JOURNAL   Cereb Cortex 22 (6), 1343-1359 (2012)
   PUBMED   21862448
REFERENCE   7  (bases 1 to 5114)
  AUTHORS   Marionneau,C., LeDuc,R.D., Rohrs,H.W., Link,A.J., Townsend,R.R. and
            Nerbonne,J.M.
  TITLE     Proteomic analyses of native brain K(V)4.2 channel complexes
  JOURNAL   Channels (Austin) 3 (4), 284-294 (2009)
   PUBMED   19713751
REFERENCE   8  (bases 1 to 5114)
  AUTHORS   Zagha,E., Ozaita,A., Chang,S.Y., Nadal,M.S., Lin,U., Saganich,M.J.,
            McCormack,T., Akinsanya,K.O., Qi,S.Y. and Rudy,B.
  TITLE     DPP10 modulates Kv4-mediated A-type potassium channels
  JOURNAL   J Biol Chem 280 (19), 18853-18861 (2005)
   PUBMED   15671030
REFERENCE   9  (bases 1 to 5114)
  AUTHORS   Allen,M., Heinzmann,A., Noguchi,E., Abecasis,G., Broxholme,J.,
            Ponting,C.P., Bhattacharyya,S., Tinsley,J., Zhang,Y., Holt,R.,
            Jones,E.Y., Lench,N., Carey,A., Jones,H., Dickens,N.J., Dimon,C.,
            Nicholls,R., Baker,C., Xue,L., Townsend,E., Kabesch,M.,
            Weiland,S.K., Carr,D., von Mutius,E., Adcock,I.M., Barnes,P.J.,
            Lathrop,G.M., Edwards,M., Moffatt,M.F. and Cookson,W.O.
  TITLE     Positional cloning of a novel gene influencing asthma from
            chromosome 2q14
  JOURNAL   Nat Genet 35 (3), 258-263 (2003)
   PUBMED   14566338
REFERENCE   10 (bases 1 to 5114)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC157770.4, AC103602.12, AC101848.8, AC101887.10, AC157806.4 and
            AC103600.8.
            
            On May 13, 2022 this sequence version replaced NM_199021.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC067026.1, SRR9219380.20518.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-676               AC157770.4         65391-66066         c
            677-791             AC103602.12        24089-24203         c
            792-887             AC101848.8         214322-214417       c
            888-982             AC101848.8         46377-46471         c
            983-1057            AC101887.10        20651-20725
            1058-1110           AC157806.4         67531-67583
            1111-1192           AC157806.4         67681-67762
            1193-1313           AC103600.8         16900-17020
            1314-1468           AC103600.8         29136-29290
            1469-1566           AC103600.8         38511-38608
            1567-1690           AC103600.8         50387-50510
            1691-1729           AC103600.8         59350-59388
            1730-1837           AC103600.8         63593-63700
            1838-1929           AC103600.8         77208-77299
            1930-1977           AC103600.8         77889-77936
            1978-2099           AC103600.8         83973-84094
            2100-2147           AC103600.8         85547-85594
            2148-2246           AC103600.8         94348-94446
            2247-2316           AC103600.8         94554-94623
            2317-2511           AC103600.8         108615-108809
            2512-2566           AC103600.8         109533-109587
            2567-2666           AC103600.8         120505-120604
            2667-2725           AC103600.8         120843-120901
            2726-2798           AC103600.8         121044-121116
            2799-2872           AC103600.8         125324-125397
            2873-5114           AC103600.8         127838-130079
FEATURES             Location/Qualifiers
     source          1..5114
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 53.68 cM"
     gene            1..5114
                     /gene="Dpp10"
                     /gene_synonym="6430601K09Rik; DPP X; Dprp3"
                     /note="dipeptidylpeptidase 10"
                     /db_xref="GeneID:269109"
                     /db_xref="MGI:MGI:2442409"
     exon            1..676
                     /gene="Dpp10"
                     /gene_synonym="6430601K09Rik; DPP X; Dprp3"
                     /inference="alignment:Splign:2.1.0"
     exon            677..791
                     /gene="Dpp10"
                     /gene_synonym="6430601K09Rik; DPP X; Dprp3"
                     /inference="alignment:Splign:2.1.0"
     exon            792..887
                     /gene="Dpp10"
                     /gene_synonym="6430601K09Rik; DPP X; Dprp3"
                     /inference="alignment:Splign:2.1.0"
     exon            888..982
                     /gene="Dpp10"
                     /gene_synonym="6430601K09Rik; DPP X; Dprp3"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1057
                     /gene="Dpp10"
                     /gene_synonym="6430601K09Rik; DPP X; Dprp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1110
                     /gene="Dpp10"
                     /gene_synonym="6430601K09Rik; DPP X; Dprp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1192
                     /gene="Dpp10"
                     /gene_synonym="6430601K09Rik; DPP X; Dprp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1313
                     /gene="Dpp10"
                     /gene_synonym="6430601K09Rik; DPP X; Dprp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1468
                     /gene="Dpp10"
                     /gene_synonym="6430601K09Rik; DPP X; Dprp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1566
                     /gene="Dpp10"
                     /gene_synonym="6430601K09Rik; DPP X; Dprp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1567..1690
                     /gene="Dpp10"
                     /gene_synonym="6430601K09Rik; DPP X; Dprp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..1729
                     /gene="Dpp10"
                     /gene_synonym="6430601K09Rik; DPP X; Dprp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1730..1837
                     /gene="Dpp10"
                     /gene_synonym="6430601K09Rik; DPP X; Dprp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1838..1929
                     /gene="Dpp10"
                     /gene_synonym="6430601K09Rik; DPP X; Dprp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1930..1977
                     /gene="Dpp10"
                     /gene_synonym="6430601K09Rik; DPP X; Dprp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1978..2099
                     /gene="Dpp10"
                     /gene_synonym="6430601K09Rik; DPP X; Dprp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2100..2147
                     /gene="Dpp10"
                     /gene_synonym="6430601K09Rik; DPP X; Dprp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2148..2246
                     /gene="Dpp10"
                     /gene_synonym="6430601K09Rik; DPP X; Dprp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2247..2316
                     /gene="Dpp10"
                     /gene_synonym="6430601K09Rik; DPP X; Dprp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2317..2511
                     /gene="Dpp10"
                     /gene_synonym="6430601K09Rik; DPP X; Dprp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2512..2566
                     /gene="Dpp10"
                     /gene_synonym="6430601K09Rik; DPP X; Dprp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2567..2666
                     /gene="Dpp10"
                     /gene_synonym="6430601K09Rik; DPP X; Dprp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2667..2725
                     /gene="Dpp10"
                     /gene_synonym="6430601K09Rik; DPP X; Dprp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2726..2798
                     /gene="Dpp10"
                     /gene_synonym="6430601K09Rik; DPP X; Dprp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2799..2872
                     /gene="Dpp10"
                     /gene_synonym="6430601K09Rik; DPP X; Dprp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2873..5114
                     /gene="Dpp10"
                     /gene_synonym="6430601K09Rik; DPP X; Dprp3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5094..5099
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dpp10"
                     /gene_synonym="6430601K09Rik; DPP X; Dprp3"
                     /note="hexamer: AATACA"
     polyA_site      5114
                     /gene="Dpp10"
                     /gene_synonym="6430601K09Rik; DPP X; Dprp3"
                     /note="major polyA site"
ORIGIN      
        1 agtggggagc gcgtacgggg ctgtctcccg cgcgctttaa ggttgctcgg gagatgctgg
       61 agcgcaaagc ctggctgctg ctgctgctgc tactactgct actgctgctg ctgcacctgg
      121 cgcgctgagc accgtgcggg gagccccgag ggccggcggc ggtgcgggtg cgcgggtggc
      181 ggactgcggt agaatgaaag cctggctcct ccggcgttgc aagccaccgc tccggcgcga
      241 tcaggtgctg gcagccagcc gcccgccgct ccactaactt gccacttggt cgcatctggt
      301 gtctgcattt tcgggtggtg gtgggggggc ggggacagtg gggagtccga ggatctgcgg
      361 tagtggaaaa gagggatcct gcaaaagagg gagactactt gcttctgctg ccgctctccg
      421 tcccctccct ggcgctcccc ttcccccccc ccccccaaac cccaccgctg ccgccgctgc
      481 ttttctcttc cgccaattcc gagagcgacg gggcgtctgt gacatgcgat cgcttgccaa
      541 gtgacggtcc ccgagtgtga agtgcccgcg aggaagtgtg agctccgacg cgggcggcaa
      601 ggggatgaca gccatgaagc aggagcagca acccacccca ggggccaggg caacccagtc
      661 gcagccagcc gaccaggaac taggaagtaa cagccctcca caaagaaact ggaagggaat
      721 cgccattgcc ctgctggtga tcttggtggt atgctcactc atcacaatgt ctgtcatcct
      781 gttaacacca gatgaactaa caaattcttc agaaacaaga ctgtcactag aggagctttt
      841 ggggaaagga ttcggacttc ataatccaga acctcggtgg atcaatgata cagtcgtggt
      901 atataaaacc aacaatggac acgtcatgaa actgaataca gaatcaaatg cttccacatt
      961 gttattggac aactcaactt ttgtaacgtt taaagcctcc agacactcac tttccccaga
     1021 tttaaagtat gttctcctgg catacgacgt taagcagatt tttcattact catttaccgc
     1081 ttcatatttg atttacaaca tacacactgg ggaagtgtgg gagttgaatc ccccagaagt
     1141 tgaggactca gtgttgcagt atgcggcctg gggtgtgcaa ggacagcagc tgatttatat
     1201 ttttgaaaac aatatctact atcaacctga tatcaagagc agttctttac gactaacatc
     1261 ttcaggaaag gaaggcatta tttttaatgg gattgctgac tggttatatg aagaagaact
     1321 tctgcattct catatcgccc actggtggtc ccccgatgga gagagacttg ccttcctgat
     1381 gataaatgac tcgttggtgc ctaacatgat catacctcgg tttactggag cactgtaccc
     1441 caaagcaaag cagtacccat accccaaggc aggtcaagcg aacccatcag tgaagttata
     1501 tgttgtaaac ctgtatggac caactcatac tttggagctg atgccacccg acatttttaa
     1561 atcaagagaa tattacatca ccatggttaa atgggtgagc aacacgagga cagtggtcag
     1621 gtggttgaat cggcctcaga acatctccat cctcacactc tgtgaatcta ccaccggggc
     1681 atgcagcagg aaatatgaga tgacgtccga cacctggctc tctaaacaga acgaggagcc
     1741 agtgttttcc agagatggaa gcaagttctt catgactgtt cctgttaaac aaggtggaag
     1801 aggagaattc caccacatag ctatgttcct ggtccagagt aaaagcgagc aaattacggt
     1861 gcggcatctg acatcaggaa actgggaagt gataaggatc ttggcctatg atgaaacaac
     1921 tcaaaaaatt tactttctga gcacagaatc ttctccccaa gggaggcaac tatacagtgc
     1981 ttctactgag ggactattga atcgtgattg catctcatgc aactttatga aagaagattg
     2041 cacgtatttt gatgccagct ttagccccat gaatcaacat ttcttgttat tctgtgaagg
     2101 tccaaaggtc ccagtggtca gccttcacat cacagacaac ccatcaaggt atttcctctt
     2161 ggaaaacaat tctgtgatga aagaaactat tcagaagaag aagctcgcaa agagagagac
     2221 tagaatactt cacattgatg actatgaact tcctttacag ttgtcctttc ccaaagattt
     2281 tatggagaaa aaccagtatg ctcttctatt aataatggat gaagaaccag gaggccaaat
     2341 ggtgacagat aagttccatg ttgactggga ttcagttctt attgacaccg ataatgtcat
     2401 tgtagcaaga tttgatggca gaggaagtgg attccagggc ctgaaagttt tgcaggagat
     2461 tcacagaagg ataggctcag tggaggcaaa ggaccaagta gctgctgtaa aatatttact
     2521 gaaacagcca tatattgact ccaaaagatt aagcattttt ggaaagggat atgggggcta
     2581 tattgcatca atgatcttaa aatcagatga gaagtttttc aaatgtggag ccgtggttgc
     2641 acccatctca gacatgaagt tgtatgcctc agctttctct gaacggtacc ttggcatgcc
     2701 atcaaaggaa gaaagcactt accaggcatc cagtgtactg cataacattc atggtttaaa
     2761 agaagaaaat ttattaataa ttcacggaac tgctgataca aaagttcatt tccagcattc
     2821 agcagaattg atcaagcatc tgataaaagc tggggtgaat tacactctgc aggtctatcc
     2881 agatgaagga tatcacattt cagacaagag caagcatcat ttttacagca caattctcag
     2941 attcttcagt gattgtctaa aggaagaggt atctgtgctg ccacaggaac cagaagaaga
     3001 tgaataatgg actacactta tacagagctg aagggaatat tgaggctcaa tgaaactgaa
     3061 ccaagagact gtcttgttgt agacgctcca gaattctaag ggcagcttga ggagataaac
     3121 ctggaacagc acactcagac agtgaactag accttggaga cagacatcca cactactgtg
     3181 ctgccaaggg tgcagaaggt gtttcattgt aaagggaagt tgcaagggtt ggtttcctgg
     3241 gggaaaaaaa attagtttca cattaaagta ggaatagtgc atgtttcctt ctgttatccc
     3301 cttttgttct gtgactagtt accctcactt tgatttcaat ggtcatgatc acctttgcat
     3361 aaagtgcata acgtaccatc agtaccacag tccctgatct ttgatggctg agctgcaatc
     3421 taacatgtta atgtatcttt ataataagtg caattctctc attgtctatt attatgctta
     3481 agaaaatatt cagttaataa acaaaaagca gagtatttta cataaagttc tgtttttaaa
     3541 aaggaattat taaatgagtc aaggctatgt agaaatatgg atttcagcac cttccaaagt
     3601 tcaggcagtt gtcagtagat agaatacttt taaatcaaca cacacgagtg tttgtctcac
     3661 agtataatat aaatatatat atacacgcac gtgtgcatat gcagacagtg agtctatctt
     3721 tatatgttac tcatgctaca aagggtaaac tttaatgaat tacagtggct actcttttac
     3781 aggctgcaat ggatgcttct ttattgagcc aaatatgatg agaccctttt gtttccagtt
     3841 cagattctag caattgcttt cctataaatg tttgggttat gtttggtatt gtttctagtg
     3901 gttaatagtt ttctagttgc agtttacttt tttgaatatg atatcttgtc acatgtaaat
     3961 tagatattaa atattaaatt atagtttctg ataaagaaat tttgttaaac aaatgcaatg
     4021 ccactgagtg gcatattgct ctcttggtgg agaaggcttt tttaaacact caaacctttt
     4081 acttcaaact ctcagtgcag taaagtcaat tctcattttc attataaaag cagaaataag
     4141 aattcatttt tccccagagt ctactcagca ttccatgcct gctcaatgca tctattgctg
     4201 ttaaactaag cccttactat aagaattaaa agaagtcatt tttattcatt gcccctcacc
     4261 cccagaacac aaacagcaat acgtggtatt gcatttaaat ggacaggaca cggggtacca
     4321 aatcctacaa tgtgtcagtt tggagcaatt agtaactgag aatggaaatt aaacttaact
     4381 gtgtgaagtt tcagtcatga gagggcagag agctatggtg actgaagttg ggtgtgtttt
     4441 cagtccatat aacagatctt ccagaagatg ttgcaaagtc tgaaaccaaa gtccgatgct
     4501 cagaaaaatc ccagtggtct aatgtctatt cacagcctaa atctgatctt tgggaaagct
     4561 gggtttctct gtcctctgaa aaccaggaag aaaattttaa agtaaagaat ttcttcagcc
     4621 accctaggct ttatcaactg cacagcctgg gattctaagg tgtggacttg aaagctggtt
     4681 ctccctcttt tttcttcagt gctttgggat tgtgtcttca ctgctccatt agattcaatt
     4741 taataaggga aagatgccct ctccagaaag acacatttta ggtctttttc aaaggatagt
     4801 gaacacattt tttaacaaaa taggttgtaa tgtttccaag gaaagttttg cctattttat
     4861 taagatggaa atttcttttt aggctgattt gaagtccaac tgaagctttt taatcaatat
     4921 tttagaattc aaccactaga gatttttatg atgcaaaaaa attatgttgt ctgaaagatg
     4981 tggttttatt gaatgtctat ttgagtaaca tttaaaaagt gtttaccttt tcctgtccat
     5041 catttctctt gtttatggtt attatcaatg tttatctatt ttttgattta tttaatacag
     5101 tttgtaatgt gaaa
//
