LOCUS       NM_010073                877 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus dolichyl-phosphate mannosyltransferase subunit 2,
            regulatory (Dpm2), mRNA.
ACCESSION   NM_010073
VERSION     NM_010073.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 877)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 877)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   3  (bases 1 to 877)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 877)
  AUTHORS   Suzuki,H., Fukunishi,Y., Kagawa,I., Saito,R., Oda,H., Endo,T.,
            Kondo,S., Bono,H., Okazaki,Y. and Hayashizaki,Y.
  TITLE     Protein-protein interaction panel using mouse full-length cDNAs
  JOURNAL   Genome Res 11 (10), 1758-1765 (2001)
   PUBMED   11591653
REFERENCE   5  (bases 1 to 877)
  AUTHORS   Watanabe,R., Murakami,Y., Marmor,M.D., Inoue,N., Maeda,Y., Hino,J.,
            Kangawa,K., Julius,M. and Kinoshita,T.
  TITLE     Initial enzyme for glycosylphosphatidylinositol biosynthesis
            requires PIG-P and is regulated by DPM2
  JOURNAL   EMBO J 19 (16), 4402-4411 (2000)
   PUBMED   10944123
REFERENCE   6  (bases 1 to 877)
  AUTHORS   Maeda,Y., Tomita,S., Watanabe,R., Ohishi,K. and Kinoshita,T.
  TITLE     DPM2 regulates biosynthesis of dolichol phosphate-mannose in
            mammalian cells: correct subcellular localization and stabilization
            of DPM1, and binding of dolichol phosphate
  JOURNAL   EMBO J 17 (17), 4920-4929 (1998)
   PUBMED   9724629
REFERENCE   7  (bases 1 to 877)
  AUTHORS   Lennon,G., Auffray,C., Polymeropoulos,M. and Soares,M.B.
  TITLE     The I.M.A.G.E. Consortium: an integrated molecular analysis of
            genomes and their expression
  JOURNAL   Genomics 33 (1), 151-152 (1996)
   PUBMED   8617505
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC008256.1.
            
            On Jun 10, 2003 this sequence version replaced NM_010073.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC008256.1, DV044804.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..877
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 22.09 cM"
     gene            1..877
                     /gene="Dpm2"
                     /note="dolichyl-phosphate mannosyltransferase subunit 2,
                     regulatory"
                     /db_xref="GeneID:13481"
                     /db_xref="MGI:MGI:1330238"
     exon            1..55
                     /gene="Dpm2"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..307
                     /gene="Dpm2"
                     /EC_number="2.4.1.83"
                     /note="DPM synthase subunit 2; dolichol-phosphate mannose
                     synthase subunit 2; dolichol-phosphate (beta-D)
                     mannosyltransferase 2"
                     /codon_start=1
                     /product="dolichol phosphate-mannose biosynthesis
                     regulatory protein"
                     /protein_id="NP_034203.1"
                     /db_xref="CCDS:CCDS38104.1"
                     /db_xref="GeneID:13481"
                     /db_xref="MGI:MGI:1330238"
                     /translation="MATGTDQAVGFGLVAVSLIIFTYYTTWVILLPFIDSQHVIHKYF
                     LPRAYAVLLPLAAGLLLLLFVGLFITYVMLKSQKITKKAQ"
     exon            56..145
                     /gene="Dpm2"
                     /inference="alignment:Splign:2.1.0"
     exon            146..248
                     /gene="Dpm2"
                     /inference="alignment:Splign:2.1.0"
     exon            249..861
                     /gene="Dpm2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      841..846
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dpm2"
                     /note="hexamer: AATAAA"
     polyA_site      861
                     /gene="Dpm2"
                     /note="major polyA site"
ORIGIN      
        1 gcctaaacca ggaaccggat gtattttgtt gctccggcgg aacgctggag agatggccac
       61 cgggacagac caagcagtag gatttggcct tgtcgccgtt agcttgatca tcttcaccta
      121 ctacaccact tgggtgattc tcttgccatt cattgacagc cagcatgtca tccacaaata
      181 cttcctgccc cgcgcctacg ccgtcctcct cccgttggcc gcaggcctcc tgctgctcct
      241 atttgtggga ttgttcatca cctatgtgat gctgaagagc cagaagataa ccaagaaggc
      301 tcagtgaagg tccagcaggg atgaggctgt aggggccttc tccatatctc ctccagaaaa
      361 gggaccaagg gtcacagctt acaagatggt caagctggct gcactgcagc cctctttggg
      421 acatggggct gttttcttct cagtttgaca acctggagcc ctctctctct tggtcatcct
      481 tttagaagcc aagagaaagg tgggttggga agcctctcac ttcccttagg ctcagaggct
      541 gaacattgct ggttggtcct gtccatctca cagtcaaagc tccctgtccc ttccaccgag
      601 ttctctcctc tcacctctgt gctcctccca ctgtgctgat ggattgagca ggccttcccg
      661 cctctctgta caagtcctgt cccgtcacaa ggcagctctt ccgagtctga cacttcccag
      721 gctccatgag gacttctgga cccaggaagc cctggggaaa gactgacaaa ccccagaacc
      781 acagggttac atccaggcag ccacactaga ccacaattgg cctgtttggg aaaacttaca
      841 aataaatgtt aattgcgttg gaaaaaaaaa aaaaaaa
//
