LOCUS       NM_010072               2303 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus dolichyl-phosphate mannosyltransferase subunit 1,
            catalytic (Dpm1), transcript variant 1, mRNA.
ACCESSION   NM_010072
VERSION     NM_010072.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2303)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2303)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2303)
  AUTHORS   Perez-Garcia,V., Fineberg,E., Wilson,R., Murray,A., Mazzeo,C.I.,
            Tudor,C., Sienerth,A., White,J.K., Tuck,E., Ryder,E.J., Gleeson,D.,
            Siragher,E., Wardle-Jones,H., Staudt,N., Wali,N., Collins,J.,
            Geyer,S., Busch-Nentwich,E.M., Galli,A., Smith,J.C., Robertson,E.,
            Adams,D.J., Weninger,W.J., Mohun,T. and Hemberger,M.
  TITLE     Placentation defects are highly prevalent in embryonic lethal mouse
            mutants
  JOURNAL   Nature 555 (7697), 463-468 (2018)
   PUBMED   29539633
REFERENCE   4  (bases 1 to 2303)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (bases 1 to 2303)
  AUTHORS   Tuck,E., Estabel,J., Oellrich,A., Maguire,A.K., Adissu,H.A.,
            Souter,L., Siragher,E., Lillistone,C., Green,A.L., Wardle-Jones,H.,
            Carragher,D.M., Karp,N.A., Smedley,D., Adams,N.C., Bussell,J.N.,
            Adams,D.J., Ramirez-Solis,R., Steel,K.P., Galli,A. and White,J.K.
  CONSRTM   Sanger Institute Mouse Genetics Project
  TITLE     A gene expression resource generated by genome-wide lacZ profiling
            in the mouse
  JOURNAL   Dis Model Mech 8 (11), 1467-1478 (2015)
   PUBMED   26398943
REFERENCE   6  (bases 1 to 2303)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   7  (bases 1 to 2303)
  AUTHORS   Mallakin,A., Sugiyama,T., Taneja,P., Matise,L.A., Frazier,D.P.,
            Choudhary,M., Hawkins,G.A., D'Agostino,R.B. Jr., Willingham,M.C.
            and Inoue,K.
  TITLE     Mutually exclusive inactivation of DMP1 and ARF/p53 in lung cancer
  JOURNAL   Cancer Cell 12 (4), 381-394 (2007)
   PUBMED   17936562
REFERENCE   8  (bases 1 to 2303)
  AUTHORS   Tomita,S., Inoue,N., Maeda,Y., Ohishi,K., Takeda,J. and
            Kinoshita,T.
  TITLE     A homologue of Saccharomyces cerevisiae Dpm1p is not sufficient for
            synthesis of dolichol-phosphate-mannose in mammalian cells
  JOURNAL   J Biol Chem 273 (15), 9249-9254 (1998)
   PUBMED   9535917
REFERENCE   9  (bases 1 to 2303)
  AUTHORS   Nishimura,H., Okamoto,H., Ogawa,S., Hirose,S. and Shirai,T.
  TITLE     Ebz of NZW mice is identical with Ebu of B10.PL mice
  JOURNAL   Immunogenetics 33 (5-6), 413-414 (1991)
   PUBMED   2050394
REFERENCE   10 (bases 1 to 2303)
  AUTHORS   Ogawa,S., Nishimura,H., Awaji,M., Nozawa,S., Hirose,S. and
            Shirai,T.
  TITLE     Nucleotide sequence analysis of MHC class II genes in autoimmune
            disease-prone (NZB x NZW)F1 mice
  JOURNAL   Immunogenetics 32 (1), 63-67 (1990)
   PUBMED   2165036
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX005039.11, AK005268.1 and BM941163.1.
            
            On Jun 29, 2015 this sequence version replaced NM_010072.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK005268.1, AK004834.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                BX005039.11        62611-62625         c
            16-2280             AK005268.1         2-2266
            2281-2303           BM941163.1         349-371
FEATURES             Location/Qualifiers
     source          1..2303
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 88.46 cM"
     gene            1..2303
                     /gene="Dpm1"
                     /note="dolichyl-phosphate mannosyltransferase subunit 1,
                     catalytic"
                     /db_xref="GeneID:13480"
                     /db_xref="MGI:MGI:1330239"
     exon            1..187
                     /gene="Dpm1"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..809
                     /gene="Dpm1"
                     /EC_number="2.4.1.83"
                     /note="isoform 1 is encoded by transcript variant 1; MPD
                     synthase; DPM synthase subunit 1; mannose-P-dolichol
                     synthase subunit 1; dolichol-phosphate mannose synthase
                     subunit 1; dolichyl-phosphate beta-D-mannosyltransferase
                     subunit 1; dolichol-phosphate (beta-D) mannosyltransferase
                     1"
                     /codon_start=1
                     /product="dolichol-phosphate mannosyltransferase subunit 1
                     isoform 1"
                     /protein_id="NP_034202.1"
                     /db_xref="CCDS:CCDS17109.1"
                     /db_xref="GeneID:13480"
                     /db_xref="MGI:MGI:1330239"
                     /translation="MASTGASRSLAASPRPPQGRSSRQDKYSVLLPTYNERENLPLIV
                     WLLVKSFSESAINYEIIIIDDGSPDGTREVAEQLAEIYGPDRILLRPREKKLGLGTAY
                     IHGIKHATGNYVIIMDADLSHHPKFIPEFIRKQKEGNFDIVSGTRYKGNGGVYGWDLK
                     RKIISRGANFITQILLRPGASDLTGSFRLYRKEVLQKLIEKCVSKGYVFQMEMIVRAR
                     QMNYTIGEVPISFVDRVYGESKLGGNEIVSFLKGLLTLFATT"
     exon            188..287
                     /gene="Dpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            288..321
                     /gene="Dpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            322..398
                     /gene="Dpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            399..424
                     /gene="Dpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            425..520
                     /gene="Dpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            521..589
                     /gene="Dpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            590..704
                     /gene="Dpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            705..2293
                     /gene="Dpm1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      810..815
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dpm1"
                     /note="hexamer: AAGAAA"
     polyA_site      826
                     /gene="Dpm1"
                     /note="major polyA site"
     regulatory      1033..1038
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dpm1"
                     /note="hexamer: AATAAA"
     regulatory      1054..1059
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dpm1"
                     /note="hexamer: CATAAA"
     polyA_site      1060
                     /gene="Dpm1"
                     /note="major polyA site"
     polyA_site      1078
                     /gene="Dpm1"
     regulatory      2262..2267
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dpm1"
                     /note="hexamer: ATTAAA"
     polyA_site      2284
                     /gene="Dpm1"
ORIGIN      
        1 cttccggcgc ctctcgcaga gccgtcatgg cttccacggg ggcgagtcgc agtcttgctg
       61 cgtctccgcg gccgccgcag ggccgctcct cgcgacagga caagtactcg gtgctgttgc
      121 ccacctacaa cgaacgggag aacctgccgc tcatcgtgtg gctgctggtg aagagcttct
      181 ccgagagtgc aatcaactat gaaattataa tcatagatga tggaagccca gacgggacaa
      241 gagaagttgc tgaacaactg gcagagatct atgggcccga cagaattctc ctaagaccac
      301 gagagaaaaa gctgggtctc ggaactgcct acattcatgg aatcaaacac gccacgggga
      361 actatgtgat catcatggat gctgacctct cccaccatcc caaatttatt cctgaattta
      421 tcaggaaaca aaaggagggt aattttgata ttgtctctgg aactcgatac aaggggaatg
      481 ggggtgttta tggatgggat ttgaaaagaa agataatcag ccgtggggcc aattttataa
      541 ctcaaattct gctgagacct ggagcgtcag acttaacagg aagcttcaga ttataccgaa
      601 aagaagttct acagaaatta atagaaaaat gtgtctccaa aggctatgtc tttcagatgg
      661 aaatgattgt tcgagcaaga cagatgaatt acactattgg tgaggttcca atttcatttg
      721 tggatcgagt ttatggtgaa tccaagttgg gaggaaatga aatagtctcg ttcctgaaag
      781 ggttattgac tctctttgct accacataaa agaaatgatt cacttatgct tcccgtgttc
      841 atttcaatta aaagtagaga agcccgggtc actgattttt atcaatgttg tcttaacaca
      901 tgagccaaag gtaagatgca tttaatgtgg atctttttct ctggagaagc tccattttat
      961 atttcaaatt aaaatttaaa gttcttggtt tagtgagcaa tgttctcaat tttcatgtac
     1021 attacaccta taaataaatg tatataggtt ttgcataaaa tgttgctgct ttcatttaga
     1081 taatgtgagt gcaagtttct tatgaaaaaa atgtggaata cttcataaaa ctagattgtt
     1141 agttctttat ccctagatgg tagaaaggga agcttaattg catttacgaa atacagttag
     1201 tgtatgaact agaaaagaag taaaacctct gacctgaagt ccatggcaga tgtctgaacc
     1261 tagatgaagc agtgctccct gcatgtgctc cctgcatgca gactgagcat agcctggtcc
     1321 gtcagagcag acctgtgcag agtacagtgt gggctgggaa gcagttaagc agtgggtcac
     1381 attagctgtg ctcttggctt tgtcttcttg agcaacaact cctattggaa agagaagtat
     1441 tttatctctt tttatctcaa aatatttgta cattatttca atacctcaac aaaacttgat
     1501 accacaacag aaaaatacct gtactatttt tcttcatcca gaaaaatgtt ctattgttaa
     1561 aatgaaggat aagttgctcc atactgtcag ggaagatact tcacttatca gtcagtgaac
     1621 ttctgtctgt agcatagctt tcagatcatg tagtatgttt cagggtctct ctgtgtaata
     1681 gccctggctg tcctagaact ggctttgtag accaaactca gagatccatc tgcctctgtc
     1741 tccaaagagc atgttttagg ttttgagtga atacatgaga tctagttgca tgtcctttgc
     1801 aagaaaaaaa gaacagacat ctgtctctta agttactgca taatcacatt tagtgaacag
     1861 tgtcatagcc caagctgact tccagcttac tctgtagtca aagctagtct tgaattactg
     1921 gtcctgtttc cttcatctct caagtgtgag gactgtggtg tgcatcatca tacaccccaa
     1981 cctgtatact tgtttcccac cttacttggg ctgctaaaga aattgaaagt cttaaatgtt
     2041 cacttccttt ttctagctga ttgtaacaag aacaaacgtg agctacacct tcactttgtt
     2101 ttgagcatga aagccttgcc atgtagtcac atagctgggc ccacagtgca tattccaata
     2161 agaactactg ttgttgtgtt cccctttgcc aaaacttgtc gcacatccat ggggaagtga
     2221 cttgtttcat ccttaataac tagaatattt attagtgttc aattaaattt tgttttaagc
     2281 caaagtcata ggaaaaaaaa aaa
//
