LOCUS       NM_026344               2548 bp    mRNA    linear   ROD 08-AUG-2024
DEFINITION  Mus musculus DPH2 homolog (Dph2), transcript variant 1, mRNA.
ACCESSION   NM_026344
VERSION     NM_026344.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2548)
  AUTHORS   Martinez-Mayer,J., Brinkmeier,M.L., O'Connell,S.P., Ukagwu,A.,
            Marti,M.A., Miras,M., Forclaz,M.V., Benzrihen,M.G., Cheung,L.Y.M.,
            Camper,S.A., Ellsworth,B.S., Raetzman,L.T., Perez-Millan,M.I. and
            Davis,S.W.
  TITLE     Knockout mice with pituitary malformations help identify human
            cases of hypopituitarism
  JOURNAL   Genome Med 16 (1), 75 (2024)
   PUBMED   38822427
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2548)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2548)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2548)
  AUTHORS   Liu,S., Milne,G.T., Kuremsky,J.G., Fink,G.R. and Leppla,S.H.
  TITLE     Identification of the proteins required for biosynthesis of
            diphthamide, the target of bacterial ADP-ribosylating toxins on
            translation elongation factor 2
  JOURNAL   Mol Cell Biol 24 (21), 9487-9497 (2004)
   PUBMED   15485916
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL627128.16.
            
            On Mar 28, 2023 this sequence version replaced NM_026344.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK018638.1, BC031124.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-314               AL627128.16        130542-130855       c
            315-427             AL627128.16        130147-130259       c
            428-651             AL627128.16        129727-129950       c
            652-1335            AL627128.16        128850-129533       c
            1336-1512           AL627128.16        128587-128763       c
            1513-2548           AL627128.16        127473-128508       c
FEATURES             Location/Qualifiers
     source          1..2548
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 53.74 cM"
     gene            1..2548
                     /gene="Dph2"
                     /gene_synonym="9130020C19Rik; Dph2l2"
                     /note="DPH2 homolog"
                     /db_xref="GeneID:67728"
                     /db_xref="MGI:MGI:1914978"
     exon            1..314
                     /gene="Dph2"
                     /gene_synonym="9130020C19Rik; Dph2l2"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..1637
                     /gene="Dph2"
                     /gene_synonym="9130020C19Rik; Dph2l2"
                     /EC_number="2.5.1.108"
                     /note="isoform 1 is encoded by transcript variant 1;
                     diptheria toxin resistance protein required for
                     diphthamide biosynthesis (Saccharomyces)-like 1; diptheria
                     toxin resistance protein required for diphthamide
                     biosynthesis (Saccharomyces)-like 2; DPH2-like 2;
                     diphtheria toxin resistance protein 2; diphthamide
                     biosynthesis protein 2 homolog-like 2;
                     S-adenosyl-L-methionine:L-histidine
                     3-amino-3-carboxypropyltransferase DPH2;
                     2-(3-amino-3-carboxypropyl)histidine synthase subunit 2"
                     /codon_start=1
                     /product="2-(3-amino-3-carboxypropyl)histidine synthase
                     subunit 2 isoform 1"
                     /protein_id="NP_080620.1"
                     /db_xref="CCDS:CCDS18541.1"
                     /db_xref="GeneID:67728"
                     /db_xref="MGI:MGI:1914978"
                     /translation="MESTFSSPAEAALQREAGVPGQFTPPEDLDRVYELERVTKFVCD
                     LGCQRVTLQFPDQLLGDAGAVAARLEEVTGAKMFILGDTAYGSCCVDVLGAEQAGAQA
                     LVHFGPACLSPPASQLPITFVLGQRPVALELCAKAFEAQNPDPTAPVVLLSEPACAHA
                     LEPLAMLLLPKYQDLLISRPALPLPVGSPSSQPESLERFGRCFPLNPGRRLEEYGAFY
                     VGASQASSDSSLDPDLSRLLLGWTPGRPFFSCCPDTGQTQDQGAKAGRLRARRLYLIE
                     RARDARVVGLLAGTLGVARHREALAHLRKLTEAAGKRSYVLAVGKPTPAKLANFPEMD
                     VFVLLACPLGALAPQPSGGFFRPVLTPCELEAACNPAWPPPGLAPHLTHYAELLPGSP
                     FHVPLPPPESELWDTPDVSLISGELRPPPPWKSSDDTRCSALIPRPQLELAESSPAAS
                     FLSSRNWQGLEPRLGQTPVKEAVRGRRGIAIAYEDEGSS"
     exon            315..427
                     /gene="Dph2"
                     /gene_synonym="9130020C19Rik; Dph2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            428..651
                     /gene="Dph2"
                     /gene_synonym="9130020C19Rik; Dph2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            652..1335
                     /gene="Dph2"
                     /gene_synonym="9130020C19Rik; Dph2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1512
                     /gene="Dph2"
                     /gene_synonym="9130020C19Rik; Dph2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..2548
                     /gene="Dph2"
                     /gene_synonym="9130020C19Rik; Dph2l2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2263..2268
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dph2"
                     /gene_synonym="9130020C19Rik; Dph2l2"
                     /note="hexamer: AATAAA"
     polyA_site      2281
                     /gene="Dph2"
                     /gene_synonym="9130020C19Rik; Dph2l2"
                     /note="major polyA site"
     regulatory      2529..2534
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dph2"
                     /gene_synonym="9130020C19Rik; Dph2l2"
                     /note="hexamer: AATAAA"
     polyA_site      2548
                     /gene="Dph2"
                     /gene_synonym="9130020C19Rik; Dph2l2"
ORIGIN      
        1 agtaatctcc gtaggtccat gtgtagtgga gagccgggaa tttggaagcg tacggtttgg
       61 atcctaggac ccgaggacag gttggtccgg atccacaaac agagctgctg tgacctcgag
      121 gacttttgag ggtgcagctg catctcaccc cacccaagct gcgcccaatg gagtctacgt
      181 tcagcagccc tgcggaggca gccctgcaac gggaggcggg cgttccagga cagttcactc
      241 ctcctgaaga cctggaccgc gtgtatgagc tggagcgagt tacgaaattt gtctgcgatt
      301 taggttgtca gcgggtgact ttgcagttcc ctgaccagtt actaggagat gcgggagcgg
      361 tggctgcccg gctggaggaa gtcacaggag ctaagatgtt cattttaggg gacacagctt
      421 atggcagctg ctgtgtggat gtgctgggcg ccgagcaggc tggagctcaa gcccttgtgc
      481 acttcggtcc tgcctgctta agccccccag cctcgcagct gcccatcacc tttgtccttg
      541 gtcagcgacc cgttgcttta gagctctgtg caaaggcctt tgaagcccag aacccagatc
      601 cgacagcccc ggtggtactg ctgagtgagc cagcttgtgc ccatgcccta gagcctttgg
      661 ccatgctcct gctcccaaag taccaagatc tgctcatctc ccgcccagct cttcccctgc
      721 cagtgggatc cccgagctca cagcctgagt ccctggagcg ttttgggcgc tgcttccccc
      781 tgaatccagg gagacgtctg gaagaatatg gtgccttcta tgtaggggct tctcaagcaa
      841 gctcggactc cagccttgat cccgacctga gcagactgct cttgggttgg acaccagggc
      901 ggcccttctt ttcctgttgt ccagatacag gacagacaca agaccagggt gccaaggctg
      961 ggagactaag agcacgaaga ctgtatctca tagagagggc cagagatgcc cgtgtggttg
     1021 ggctgctggc aggcacatta ggtgtggctc gacaccgtga ggcactggca cacttgcgga
     1081 aactgacgga agctgctgga aaacgtagct atgtgttagc cgtggggaag cccacacccg
     1141 ccaagcttgc caacttccct gagatggacg tctttgtgct gttagcctgt cccctggggg
     1201 cactagcccc ccagccttcg ggtggcttct ttcggcctgt attgacgcca tgtgaattgg
     1261 aggctgcctg caaccctgcc tggcccccgc caggcctggc tccccacctc acacattatg
     1321 cagagctgtt gcctggttct cccttccatg tgccactccc tccacctgag tcagagttgt
     1381 gggatacccc agatgtgtca ctcatttctg gggagctccg accaccacct ccttggaagt
     1441 catcagatga cactagatgt tcggccttaa ttccgaggcc ccaactggag ctggcggaga
     1501 gcagccctgc agcttcattc cttagttctc ggaactggca ggggctggag ccacgcttgg
     1561 gccagacacc agtgaaagaa gccgtcagag gaagacgagg tatcgccatc gcctacgagg
     1621 atgaggggag cagctgatac cttgggaggc cagagccaga gtgataagtc tgccgggacc
     1681 tgttctccct gaccaacgtc tcgtcctgtc acagggacac ttgatgccta gacacaggga
     1741 gtgtaggtag ctctctctgt ggagctgtcc agcttatagc ctgtgcaggg aggggtccca
     1801 gggctcatcc cagttcctgg tgtgcaggag ttctgccctt ggtcaggggc agaagttgga
     1861 tgatccagac cagagttctt ccacctccct cagcactgtt gacagtttgg gcagagtaat
     1921 tctttaatgc agaggctact ctatatagag aaggatgtat aggttcagct gacagaaaca
     1981 gaaacacctc ccttcctccc caactgagct aggataaccc agattatctc tacaggttgg
     2041 cagatgtcat gtaactactc ctcattgaga gcctctggtc taaacctgca ctgtccaaga
     2101 caatattcac tggacacatg acttttgcca tttaaagtgg atgaaaaagt atttgtccat
     2161 tacactaatt acatttcaag cacttatgtg gctgctttca ggactttgtt gggctacatt
     2221 gacttagtta gacttgtttc ttggggacaa caaagacact gaaataaacg gaatactttt
     2281 tctcctgttt ctctttattc actaaagctc tgttctacac agatcctgtg ggtggatatg
     2341 tgagttatat ttaaccagat tactgtcctc aaaatgtgct tgggaggaaa taataacccc
     2401 acgaaatata attgtgtgaa gggagcccca ggtgcagctg gctctcatag caggctcctg
     2461 aaggggactc aagaggcaac ccagacagag gagtcttaag ctggatctta tagagaaaaa
     2521 atattcagaa taaacagagt gaaacgaa
//
