LOCUS       NM_011262               3314 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus double PHD fingers 2 (Dpf2), transcript variant 2,
            mRNA.
ACCESSION   NM_011262
VERSION     NM_011262.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3314)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3314)
  AUTHORS   Mas,G., Man,N., Nakata,Y., Martinez-Caja,C., Karl,D.,
            Beckedorff,F., Tamiro,F., Chen,C., Duffort,S., Itonaga,H.,
            Mookhtiar,A.K., Kunkalla,K., Valencia,A.M., Collings,C.K.,
            Kadoch,C., Vega,F., Kogan,S.C., Shiekhattar,R., Morey,L., Bilbao,D.
            and Nimer,S.D.
  TITLE     The SWI/SNF chromatin-remodeling subunit DPF2 facilitates
            NRF2-dependent antiinflammatory and antioxidant gene expression
  JOURNAL   J Clin Invest 133 (13), e158419 (2023)
   PUBMED   37200093
  REMARK    GeneRIF: The SWI/SNF chromatin-remodeling subunit DPF2 facilitates
            NRF2-dependent antiinflammatory and antioxidant gene expression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3314)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3314)
  AUTHORS   Basta,J.M., Singh,A.P., Robbins,L., Stout,L., Pherson,M. and
            Rauchman,M.
  TITLE     The core SWI/SNF catalytic subunit Brg1 regulates nephron
            progenitor cell proliferation and differentiation
  JOURNAL   Dev Biol 464 (2), 176-187 (2020)
   PUBMED   32504627
REFERENCE   5  (bases 1 to 3314)
  AUTHORS   Zhang,W., Chronis,C., Chen,X., Zhang,H., Spalinskas,R., Pardo,M.,
            Chen,L., Wu,G., Zhu,Z., Yu,Y., Yu,L., Choudhary,J., Nichols,J.,
            Parast,M.M., Greber,B., Sahlen,P. and Plath,K.
  TITLE     The BAF and PRC2 Complex Subunits Dpf2 and Eed Antagonistically
            Converge on Tbx3 to Control ESC Differentiation
  JOURNAL   Cell Stem Cell 24 (1), 138-152 (2019)
   PUBMED   30609396
  REMARK    GeneRIF: Dpf2 Loss Affects ESC Self-Renewal and Leads to Increased
            Apoptosis and Cell-Cycle Defects.
REFERENCE   6  (bases 1 to 3314)
  AUTHORS   Phelan,M.L., Sif,S., Narlikar,G.J. and Kingston,R.E.
  TITLE     Reconstitution of a core chromatin remodeling complex from SWI/SNF
            subunits
  JOURNAL   Mol Cell 3 (2), 247-253 (1999)
   PUBMED   10078207
REFERENCE   7  (bases 1 to 3314)
  AUTHORS   Gabig,T.G., Crean,C.D., Klenk,A., Long,H., Copeland,N.G.,
            Gilbert,D.J., Jenkins,N.A., Quincey,D., Parente,F., Lespinasse,F.,
            Carle,G.F., Gaudray,P., Zhang,C.X., Calender,A., Hoeppener,J.,
            Kas,K., Thakker,R.V., Farnebo,F., Teh,B.T., Larsson,C., Piehl,F.,
            Lagercrantz,J., Khodaei,S., Carson,E. and Weber,G.
  TITLE     Expression and chromosomal localization of the Requiem gene
  JOURNAL   Mamm Genome 9 (8), 660-665 (1998)
   PUBMED   9680388
REFERENCE   8  (bases 1 to 3314)
  AUTHORS   Wang,W., Xue,Y., Zhou,S., Kuo,A., Cairns,B.R. and Crabtree,G.R.
  TITLE     Diversity and specialization of mammalian SWI/SNF complexes
  JOURNAL   Genes Dev 10 (17), 2117-2130 (1996)
   PUBMED   8804307
REFERENCE   9  (bases 1 to 3314)
  AUTHORS   Chestkov,A.V., Baka,I.D., Kost,M.V., Georgiev,G.P. and Buchman,V.L.
  TITLE     The d4 gene family in the human genome
  JOURNAL   Genomics 36 (1), 174-177 (1996)
   PUBMED   8812431
REFERENCE   10 (bases 1 to 3314)
  AUTHORS   Gabig,T.G., Mantel,P.L., Rosli,R. and Crean,C.D.
  TITLE     Requiem: a novel zinc finger gene essential for apoptosis in
            myeloid cells
  JOURNAL   J Biol Chem 269 (47), 29515-29519 (1994)
   PUBMED   7961935
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB839618.1, BY294588.1, AK004812.1 and AC142098.2.
            
            On Mar 22, 2014 this sequence version replaced NM_011262.4.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon, compared to variant 1. The encoded isoform (2) is shorter
            than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK144954.1, AK144848.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 BB839618.1         3-10
            9-63                BY294588.1         2-56
            64-2454             AK004812.1         1-2391
            2455-3314           AC142098.2         181805-182664       c
FEATURES             Location/Qualifiers
     source          1..3314
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 4.34 cM"
     gene            1..3314
                     /gene="Dpf2"
                     /gene_synonym="2210010M07Rik; BAF45D; Req; ubi-d4"
                     /note="double PHD fingers 2"
                     /db_xref="GeneID:19708"
                     /db_xref="MGI:MGI:109529"
     exon            1..131
                     /gene="Dpf2"
                     /gene_synonym="2210010M07Rik; BAF45D; Req; ubi-d4"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..1275
                     /gene="Dpf2"
                     /gene_synonym="2210010M07Rik; BAF45D; Req; ubi-d4"
                     /note="isoform 2 is encoded by transcript variant 2; zinc
                     finger protein ubi-d4; BRG1-associated factor 45D;
                     apoptosis response zinc finger protein; protein requiem;
                     neuro-d4/requiem; D4, zinc and double PHD fingers family
                     2"
                     /codon_start=1
                     /product="zinc finger protein ubi-d4 isoform 2"
                     /protein_id="NP_035392.1"
                     /db_xref="CCDS:CCDS37892.1"
                     /db_xref="GeneID:19708"
                     /db_xref="MGI:MGI:109529"
                     /translation="MAAVVENVVKLLGEQYYKDAMEQCHNYNARLCAERSVRLPFLDS
                     QTGVAQSNCYIWMEKRHRGPGLASGQLYSYPARRWRKKRRAHPPEDPRLSFPSIKPDT
                     DQTLKKEGLISQDGSSLEALLRTDPLEKRGAPDPRVDDDSLGEFPVSNSRARKRIIEP
                     DDFLDDLDDEDYEEDTPKRRGKGKSKSKGVSSARKKLDASILEDRDKPYACDICGKRY
                     KNRPGLSYHYAHSHLAEEEGEDKEDSRPPTPVSQRSEEQKSKKGPDGLALPNNYCDFC
                     LGDSKINKKTGQPEELVSCSDCGRSGHPSCLQFTPVMMAAVKTYRWQCIECKCCNLCG
                     TSENDDQLLFCDDCDRGYHMYCLTPSMSEPPEGSWSCHLCLDLLKEKASIYQNQNSS"
     exon            132..292
                     /gene="Dpf2"
                     /gene_synonym="2210010M07Rik; BAF45D; Req; ubi-d4"
                     /inference="alignment:Splign:2.1.0"
     exon            293..400
                     /gene="Dpf2"
                     /gene_synonym="2210010M07Rik; BAF45D; Req; ubi-d4"
                     /inference="alignment:Splign:2.1.0"
     exon            401..564
                     /gene="Dpf2"
                     /gene_synonym="2210010M07Rik; BAF45D; Req; ubi-d4"
                     /inference="alignment:Splign:2.1.0"
     exon            565..657
                     /gene="Dpf2"
                     /gene_synonym="2210010M07Rik; BAF45D; Req; ubi-d4"
                     /inference="alignment:Splign:2.1.0"
     exon            658..736
                     /gene="Dpf2"
                     /gene_synonym="2210010M07Rik; BAF45D; Req; ubi-d4"
                     /inference="alignment:Splign:2.1.0"
     exon            737..874
                     /gene="Dpf2"
                     /gene_synonym="2210010M07Rik; BAF45D; Req; ubi-d4"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1003
                     /gene="Dpf2"
                     /gene_synonym="2210010M07Rik; BAF45D; Req; ubi-d4"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1116
                     /gene="Dpf2"
                     /gene_synonym="2210010M07Rik; BAF45D; Req; ubi-d4"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1198
                     /gene="Dpf2"
                     /gene_synonym="2210010M07Rik; BAF45D; Req; ubi-d4"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..3314
                     /gene="Dpf2"
                     /gene_synonym="2210010M07Rik; BAF45D; Req; ubi-d4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2425..2430
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dpf2"
                     /gene_synonym="2210010M07Rik; BAF45D; Req; ubi-d4"
                     /note="hexamer: AATAAA"
     polyA_site      2455
                     /gene="Dpf2"
                     /gene_synonym="2210010M07Rik; BAF45D; Req; ubi-d4"
                     /note="major polyA site"
     regulatory      2673..2678
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dpf2"
                     /gene_synonym="2210010M07Rik; BAF45D; Req; ubi-d4"
                     /note="hexamer: AATACA"
     polyA_site      2697
                     /gene="Dpf2"
                     /gene_synonym="2210010M07Rik; BAF45D; Req; ubi-d4"
ORIGIN      
        1 cctgcgcaga gggtcgagga ccctgtgtcc tgagaaggct tagcgcctgc gcgttgtagg
       61 tttcggggcc tcccggcctg agggagagga acagggaaga tggcggctgt ggtggagaat
      121 gtagtgaagc tccttggcga gcaatactac aaagatgcca tggaacagtg ccacaattat
      181 aacgcccgcc tctgtgctga acgtagtgtg cgcctgcctt tcctggactc acagactgga
      241 gtagcccaga gcaattgtta tatctggatg gaaaagcgac accggggacc aggattggcc
      301 tctggacagt tatactccta tcctgccaga cgctggcgga aaaagcgccg agcccaccca
      361 cctgaggatc ccaggctttc tttcccatcg attaaaccag acactgacca gactctgaag
      421 aaagaggggc ttatctctca ggatggcagc agtttagagg ctctgttgcg tactgatccc
      481 ctggagaaac ggggtgcccc agatccccga gttgacgatg acagcctggg cgagtttcct
      541 gttagcaaca gtcgagcacg gaagcggatc attgaacccg atgacttcct tgatgacctt
      601 gatgatgagg actatgaaga agatacgcca aagcgtcggg ggaaggggaa gtccaagagt
      661 aagggtgtga gcagtgcccg gaagaagctg gatgcttcca tcctggagga ccgggataag
      721 ccctatgcct gtgacatttg tggaaaacgt tacaagaacc gacctggcct cagttaccac
      781 tatgcccact cccacctggc tgaagaggaa ggagaggaca aagaagactc ccgacccccc
      841 actcctgtgt cccagaggtc tgaggagcag aaatccaaga aaggacctga tggattggcc
      901 ctgcctaaca actactgtga cttctgccta ggagactcaa aaatcaacaa gaagacaggg
      961 cagcccgagg agctagtgtc ctgttccgac tgtggccgct cagggcatcc gtcctgcctg
     1021 cagttcaccc ctgtgatgat ggcggccgtg aagacctacc gctggcagtg catcgaatgc
     1081 aagtgctgca acctctgcgg cacgtcggag aacgatgacc agctactttt ctgtgatgac
     1141 tgtgaccgtg gctaccacat gtactgtctc actccttcca tgtctgagcc tcctgaagga
     1201 agttggagtt gccacctgtg tctggatctg ctgaaggaga aagcatccat ctaccagaac
     1261 cagaactcct cctgatgtgc cacccagctc ccctgcatct aaggccgttg ctctcctctc
     1321 taccttggtt tccattgccc ctctctcctc tttcactctg tagtcctgcc aacctccgtt
     1381 ggcaacagca cagggaggtg gcagctctga ctgcctctag ccccgagccc tcagggagta
     1441 aggagcagcg tgctgctcca gggctgacct gtgggtccaa cttctctctg ctctccaaga
     1501 agtgcattca ctctgcctgc cttgggccta agaccctggt gattacaggg ctcaaatggg
     1561 gtcctctgag aaggaatatg agagcagctc acttgtctca agccttgccc acccctcttc
     1621 ccccaaaccc cctttggttt ccagggtttt gccccagaga tgagccaggc tgggcctttc
     1681 ctggaagcag ctggagtgag ctggctgagt ggcacttgcc aggacctttt cataccctag
     1741 ttctgcttcc ctttgcctcc tgccaaagca gtcccctgtc ctctgtcatg ctacatgggg
     1801 ttctgtgctt gagctagaat gttctcgggc acctcctggc tctgccctgt cccacaaagg
     1861 gacgagcagc ttcaaacctg tcctccctgt gcttggtggc ttgctcacag gtgcgctctg
     1921 gctacccaga catttcctat cctcagaact tcccatcttc tgcccccatc cttagtccct
     1981 ttgcttttgt agggagaggg atagtgtcag gggctgggcc agcagcttgg gggccacagg
     2041 gagaagttgg ataatgtgcc tgttttttaa ctcgataaaa aagcctacct ccaaaattcc
     2101 ctttttgttc ttcctgaacc tgggcattca gcctcctgtc cttaactaaa ttaggagcct
     2161 ctgcctcctg cctgtgtatc ctggctccca ggacacagga tggtcccctt tccttgcacg
     2221 ctagctagta gctggtaagg tcttcacacc ctgagttttc tgtttcctgc ttagtggcac
     2281 tgacattaag taggagggga cagtcctctg cagtactcta gagagtgggc ttcccccttg
     2341 gctgtgggca ggccctaact gttttctgca aagttgaggg ccccccctcg catatttagt
     2401 tcctgtattc aaaacattag taaaaataaa catttttaca gagtcttctg ctggacagtt
     2461 tgtctcttga ctccttgttg aaaggttgtt tcatttcaaa cttacgacaa tagggttttt
     2521 tgttggtggt ggttggttgt tttaaattga aacaactttt tctcccaaaa tcaaagtttt
     2581 tgttaaactc caccatgtaa aattattttg ttagttttgt tatgtaaatt cagatttata
     2641 acaatttagt ggtataaagg atgaagctaa ttaatacaaa aattgggtta aaatcaactt
     2701 tagcattttc tctgtatctg tgcttttggc tggttggaaa gactttactc ggtgtgaata
     2761 tgtaggcgga ggtgcggcag atctatggca ctgcagtgtc tcctggttaa agtgaaccca
     2821 gaagcttgtt tgtgctttaa actccaagga gttatgagtt aagcctggag agagagcgca
     2881 gcagaggaga ggatgctcgt tgttcttgca gagggccaag tttggttccc agcactcaaa
     2941 tccggtggct cacaaccacc tgtagctcca gctccaggag ctggggaggt caactgtgct
     3001 cctgcaaaca cccacctgcc cactcatctt catccatcta caaacctacc agtgtcatcg
     3061 tagaacaaaa gaagccgaga ggagagtaac ctcagatcct gtcatctgat gaaccttttc
     3121 attgcctgtc ggattgctaa gccaaagcag agttgcaaag ccagaattgt ccacagtgca
     3181 gggtgtcatg tgcagaccgt gagtgagttt atatccagcc agattagtac ttggatgtta
     3241 tatagtggat cttgtatagc tcacttggta tgtattaaca ttttaacttt tttcttttaa
     3301 agatttattt attt
//
