LOCUS       NM_027960               1681 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus dipeptidase 3 (Dpep3), mRNA.
ACCESSION   NM_027960
VERSION     NM_027960.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1681)
  AUTHORS   Hayashi,K., Longenecker,K.L., Koenig,P., Prashar,A., Hampl,J.,
            Stoll,V. and Vivona,S.
  TITLE     Structure of human DPEP3 in complex with the SC-003 antibody Fab
            fragment reveals basis for lack of dipeptidase activity
  JOURNAL   J Struct Biol 211 (1), 107512 (2020)
   PUBMED   32325220
REFERENCE   2  (bases 1 to 1681)
  AUTHORS   Xie,Y., Khan,R., Wahab,F., Hussain,H.M.J., Ali,A., Ma,H., Jiang,H.,
            Xu,J., Zaman,Q., Khan,M., Jiang,X. and Shi,Q.
  TITLE     The testis-specifically expressed Dpep3 is not essential for male
            fertility in mice
  JOURNAL   Gene 711, 143925 (2019)
   PUBMED   31212048
  REMARK    GeneRIF: Data showed that Dpep3 mRNA was specifically detected in
            testis and DPEP3 is evolutionarily conserved among eutherians.
            Dpep3 knockout mice displayed normal fertility even a significant
            reduction in sperm count. These findings inferred that despite of
            the testis-specific expression pattern, Dpep3 is dispensable for
            mouse fertility.
REFERENCE   3  (bases 1 to 1681)
  AUTHORS   Lo,J.C., Jamsai,D., O'Connor,A.E., Borg,C., Clark,B.J.,
            Whisstock,J.C., Field,M.C., Adams,V., Ishikawa,T., Aitken,R.J.,
            Whittle,B., Goodnow,C.C., Ormandy,C.J. and O'Bryan,M.K.
  TITLE     RAB-like 2 has an essential role in male fertility, sperm
            intra-flagellar transport, and tail assembly
  JOURNAL   PLoS Genet 8 (10), e1002969 (2012)
   PUBMED   23055941
REFERENCE   4  (bases 1 to 1681)
  AUTHORS   Yoshitake,H., Yanagida,M., Maruyama,M., Takamori,K., Hasegawa,A.
            and Araki,Y.
  TITLE     Molecular characterization and expression of dipeptidase 3, a
            testis-specific membrane-bound dipeptidase: complex formation with
            TEX101, a germ-cell-specific antigen in the mouse testis
  JOURNAL   J Reprod Immunol 90 (2), 202-213 (2011)
   PUBMED   21724266
  REMARK    GeneRIF: DPEP3 forms complexes with Ts4-immunoreactive molecules,
            such as TEX101, on the surfaces of spermatocytes, spermatids, and
            testicular spermatozoa.
REFERENCE   5  (bases 1 to 1681)
  AUTHORS   Kogo,H., Kowa-Sugiyama,H., Yamada,K., Bolor,H., Tsutsumi,M.,
            Ohye,T., Inagaki,H., Taniguchi,M., Toda,T. and Kurahashi,H.
  TITLE     Screening of genes involved in chromosome segregation during
            meiosis I: toward the identification of genes responsible for
            infertility in humans
  JOURNAL   J Hum Genet 55 (5), 293-299 (2010)
   PUBMED   20339383
REFERENCE   6  (bases 1 to 1681)
  AUTHORS   Lin,Q., Donahue,S.L., Moore-Jarrett,T., Cao,S., Osipovich,A.B. and
            Ruley,H.E.
  TITLE     Mutagenesis of diploid mammalian genes by gene entrapment
  JOURNAL   Nucleic Acids Res 34 (20), e139 (2006)
   PUBMED   17062627
REFERENCE   7  (bases 1 to 1681)
  AUTHORS   Keegan,C.E., Hutz,J.E., Else,T., Adamska,M., Shah,S.P., Kent,A.E.,
            Howes,J.M., Beamer,W.G. and Hammer,G.D.
  TITLE     Urogenital and caudal dysgenesis in adrenocortical dysplasia (acd)
            mice is caused by a splicing mutation in a novel telomeric
            regulator
  JOURNAL   Hum Mol Genet 14 (1), 113-123 (2005)
   PUBMED   15537664
REFERENCE   8  (bases 1 to 1681)
  AUTHORS   Habib,G.M., Shi,Z.Z., Cuevas,A.A. and Lieberman,M.W.
  TITLE     Identification of two additional members of the membrane-bound
            dipeptidase family
  JOURNAL   FASEB J 17 (10), 1313-1315 (2003)
   PUBMED   12738806
  REMARK    GeneRIF: cloning and characterization of membrane-bound
            dipeptidase-2 and membrane-bound dipeptidase-3
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK006085.1.
            
            On Apr 6, 2007 this sequence version replaced NM_027960.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK006085.1, BC051148.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1681              AK006085.1         2-1682
FEATURES             Location/Qualifiers
     source          1..1681
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.07 cM"
     gene            1..1681
                     /gene="Dpep3"
                     /gene_synonym="1700018F16Rik; MBD-3; MLZ-136"
                     /note="dipeptidase 3"
                     /db_xref="GeneID:71854"
                     /db_xref="MGI:MGI:1919104"
     exon            1..406
                     /gene="Dpep3"
                     /gene_synonym="1700018F16Rik; MBD-3; MLZ-136"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..1610
                     /gene="Dpep3"
                     /gene_synonym="1700018F16Rik; MBD-3; MLZ-136"
                     /EC_number="3.4.13.19"
                     /note="putative membrane-bound dipeptidase 3; protein
                     expressed in male leptotene and zygotene spermatocytes
                     136"
                     /codon_start=1
                     /product="dipeptidase 3 precursor"
                     /protein_id="NP_082236.1"
                     /db_xref="CCDS:CCDS22624.1"
                     /db_xref="GeneID:71854"
                     /db_xref="MGI:MGI:1919104"
                     /translation="MQPAGLEGPRALGLRPLGHRLSLLGVLLLVPSLWVTCTLTTPSP
                     SSAPTTPEASNATTAPGIPNDTATSGVTSDPRLREQALALMRDFPLVDGHNDLPLLLR
                     ELFQNQLQDVNLRNFTRGQTNLDRLRDGLVGAQFWSAYIPCQTQDRDAVRLALEQIDL
                     IRRMCSAYPELELVTSADGLNNTQKLACLIGVEGGHSLDTSLAVLRSFYELGVRYLTL
                     TFTCSTPWAESATKFRHHFYTNISGLTSFGEKVVEEMNRLGMMIDLSHASDTLVKQTL
                     EVSQAPVIFSHSAARSVCDNLLNIPDDILQLLKKNGGIVMVTLSMGVLQCSLFANVST
                     VADHFDHIRTVIGSEFIGIGGSYDGSGRFPQGLEDVSTYPVLIEELLSRGWDERELQG
                     VLRGNLLRVFRQVEQVREKSLGQSPVEVKFPERQQSNTCHSHLLPQPQEDQHQDTHLK
                     VTKLPNILQRASKAPPHPLPGLMATLTSLALILWLCCSGHRAV"
     exon            407..533
                     /gene="Dpep3"
                     /gene_synonym="1700018F16Rik; MBD-3; MLZ-136"
                     /inference="alignment:Splign:2.1.0"
     exon            534..663
                     /gene="Dpep3"
                     /gene_synonym="1700018F16Rik; MBD-3; MLZ-136"
                     /inference="alignment:Splign:2.1.0"
     exon            664..805
                     /gene="Dpep3"
                     /gene_synonym="1700018F16Rik; MBD-3; MLZ-136"
                     /inference="alignment:Splign:2.1.0"
     exon            806..875
                     /gene="Dpep3"
                     /gene_synonym="1700018F16Rik; MBD-3; MLZ-136"
                     /inference="alignment:Splign:2.1.0"
     exon            876..1052
                     /gene="Dpep3"
                     /gene_synonym="1700018F16Rik; MBD-3; MLZ-136"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1137
                     /gene="Dpep3"
                     /gene_synonym="1700018F16Rik; MBD-3; MLZ-136"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1213
                     /gene="Dpep3"
                     /gene_synonym="1700018F16Rik; MBD-3; MLZ-136"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1349
                     /gene="Dpep3"
                     /gene_synonym="1700018F16Rik; MBD-3; MLZ-136"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1681
                     /gene="Dpep3"
                     /gene_synonym="1700018F16Rik; MBD-3; MLZ-136"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1681
                     /gene="Dpep3"
                     /gene_synonym="1700018F16Rik; MBD-3; MLZ-136"
                     /note="putative"
ORIGIN      
        1 agggtgactg gaagcccttc caagcgaggc cacgtcctag ggaccctgaa tcgaaggtcc
       61 gaacccattg tcgccctctg ccctatccct gcccttctca agcgctcttg tgaccaagac
      121 tgagcaccat gcagcccgcg ggtcttgagg gtccacgcgc gctcggcctg cggcctctgg
      181 ggcaccggct gtccctgctg ggggtgttac ttctagttcc gtctctgtgg gtaacctgca
      241 ccctgactac tccgagcccc tccagtgctc cgacaacacc ggaagcctcc aatgccacga
      301 ccgctccagg cattcctaat gacacggcca cgtcaggtgt gaccagtgac cctcgccttc
      361 gagagcaagc actggctctg atgcgagact tcccacttgt ggatggccac aacgacctgc
      421 ctctgctctt gagagaactt ttccagaacc agctgcagga tgtgaatctg cgcaatttca
      481 cccgtggcca gaccaacctg gataggctca gggacggcct tgtgggtgcc cagttctggt
      541 cagcctacat cccgtgccaa acccaggacc gggatgccgt acgcctagcc ctggagcaga
      601 ttgatctcat tcgtcgcatg tgctctgctt accctgagct ggagctggtg acctcagctg
      661 atggtctgaa taacactcag aagctggcct gcctcattgg tgtagagggt ggtcactcac
      721 tggacaccag cctcgctgtg ttgcgcagtt tctatgagct aggagtgcgc tacctgactc
      781 ttaccttcac ctgcagcaca ccgtgggcag aaagcgccac aaaattcaga caccatttct
      841 acaccaacat tagtgggttg acaagctttg gtgagaaagt agtggaagaa atgaaccgtc
      901 tgggcatgat gatagacttg tcccacgcct cggacacctt agtgaagcag accctggagg
      961 tgtctcaggc tcctgtgatc ttctcacact cggcggctag atcggtgtgt gacaatttgc
     1021 tgaatattcc tgatgacata ttgcaacttc tgaagaagaa cggtggcatc gtgatggtga
     1081 cactatccat gggggtgcta cagtgcagtc tgtttgctaa cgtgtccact gtagcagatc
     1141 attttgacca catcaggaca gtcattggat ctgagttcat tgggatcggt ggaagctatg
     1201 acgggtctgg aaggttccct cagggactgg aggatgtatc tacataccca gtgctgatag
     1261 aggagttgct gagtcgcggt tgggatgaac gagagcttca aggtgtcctt cgaggaaacc
     1321 tgcttcgggt cttcagacaa gtggaacagg tgagagagaa aagccttggg cagagccctg
     1381 tggaggtcaa gtttccagag aggcagcaga gcaacacctg ccactcccac ctgctgcctc
     1441 agcctcagga ggaccaacac caggatacac acctgaaggt gacaaagctg ccaaacatcc
     1501 tccagagagc ctcaaaagcc cctccccacc ccttgccagg cctcatggct acgctcacct
     1561 ccctagccct catcctttgg ctatgttgct ctggccacag ggcagtttag caaaacccac
     1621 aaagttcccc tcctcattgc tgagacccca gcttatgttg agaataaata cctgaaacat
     1681 c
//
