LOCUS       NM_001301204            1721 bp    mRNA    linear   ROD 27-JUL-2024
DEFINITION  Mus musculus dipeptidase 2 (Dpep2), transcript variant 1, mRNA.
ACCESSION   NM_001301204 XM_006531079
VERSION     NM_001301204.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1721)
  AUTHORS   Yang,X., Yue,Y. and Xiong,S.
  TITLE     Dpep2 Emerging as a Modulator of Macrophage Inflammation Confers
            Protection Against CVB3-Induced Viral Myocarditis
  JOURNAL   Front Cell Infect Microbiol 9, 57 (2019)
   PUBMED   30899700
  REMARK    GeneRIF: Taken together, this study revealed that Dpep2 could
            protect against Coxsackievirus B3-induced viral myocarditis by
            acting as a suppressor of macrophage inflammation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1721)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   3  (bases 1 to 1721)
  AUTHORS   Habib,G.M., Shi,Z.Z., Cuevas,A.A. and Lieberman,M.W.
  TITLE     Identification of two additional members of the membrane-bound
            dipeptidase family
  JOURNAL   FASEB J 17 (10), 1313-1315 (2003)
   PUBMED   12738806
  REMARK    GeneRIF: cloning and characterization of membrane-bound
            dipeptidase-2 and membrane-bound dipeptidase-3
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY209853.1, AK171503.1 and BX634751.1.
            
            On Jul 26, 2014 this sequence version replaced XM_006531079.1.
            
            Transcript Variant: This variant (1) represents the most abundant
            transcript and encodes isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK089244.1, AK155417.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                BY209853.1         1-49
            50-1716             AK171503.1         2-1668
            1717-1721           BX634751.1         2-6                 c
FEATURES             Location/Qualifiers
     source          1..1721
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.07 cM"
     gene            1..1721
                     /gene="Dpep2"
                     /gene_synonym="F630103D06Rik; MBD-2"
                     /note="dipeptidase 2"
                     /db_xref="GeneID:319446"
                     /db_xref="MGI:MGI:2442042"
     exon            1..126
                     /gene="Dpep2"
                     /gene_synonym="F630103D06Rik; MBD-2"
                     /inference="alignment:Splign:2.1.0"
     exon            127..441
                     /gene="Dpep2"
                     /gene_synonym="F630103D06Rik; MBD-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             173..1609
                     /gene="Dpep2"
                     /gene_synonym="F630103D06Rik; MBD-2"
                     /EC_number="3.4.13.19"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; putative membrane-bound dipeptidase 2"
                     /codon_start=1
                     /product="dipeptidase 2 isoform 1 precursor"
                     /protein_id="NP_001288133.1"
                     /db_xref="CCDS:CCDS80926.1"
                     /db_xref="GeneID:319446"
                     /db_xref="MGI:MGI:2442042"
                     /translation="MSLTGLKGHWVLGHGLSVFLLVLLLLGPSQPLIWTQTKPGFSGA
                     STTSSIPRALTKPDISSIPTTPGNPNFPDLRDRARALMQEFPLIDGHNDMPLVLRQFY
                     QNGLQDANLRNFTHGQTSLDRLKDGLVGAQFWSAYVPCQTQDRDALRLTLEQIDLIRR
                     ICASYSELELVTSVKALNSTQKLACLIGVEGGHSLDNSLAVLRSFYLLGVRYLTLTHT
                     CNTPWAETSSKGVHAFYSSVTGLTSFGEKVVAEMNRLGMMVDLSHVSDAAARRALEVS
                     QAPVIFSHSAARAVCPNARNLPDDLLQLLKKNGGIVMVTFSVGVLPCNPLANVSTVAD
                     HFDHIRSVIGSEFIGIGGDYDGTKQFPQGLEDVSTYPVLIEELLRRGWNEQELQGILR
                     GNLLRVFRQVEQVRDKSKWQSPLEDMIPEEQLDSACHSALRPQKQHPEKNQPETPEYH
                     ILKFSHSKSSPHIVPSLAIVATLLGLIV"
     exon            442..568
                     /gene="Dpep2"
                     /gene_synonym="F630103D06Rik; MBD-2"
                     /inference="alignment:Splign:2.1.0"
     exon            569..698
                     /gene="Dpep2"
                     /gene_synonym="F630103D06Rik; MBD-2"
                     /inference="alignment:Splign:2.1.0"
     exon            699..840
                     /gene="Dpep2"
                     /gene_synonym="F630103D06Rik; MBD-2"
                     /inference="alignment:Splign:2.1.0"
     exon            841..910
                     /gene="Dpep2"
                     /gene_synonym="F630103D06Rik; MBD-2"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1087
                     /gene="Dpep2"
                     /gene_synonym="F630103D06Rik; MBD-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1172
                     /gene="Dpep2"
                     /gene_synonym="F630103D06Rik; MBD-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1248
                     /gene="Dpep2"
                     /gene_synonym="F630103D06Rik; MBD-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1384
                     /gene="Dpep2"
                     /gene_synonym="F630103D06Rik; MBD-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1721
                     /gene="Dpep2"
                     /gene_synonym="F630103D06Rik; MBD-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1699..1704
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dpep2"
                     /gene_synonym="F630103D06Rik; MBD-2"
                     /note="hexamer: AGTAAA"
     polyA_site      1721
                     /gene="Dpep2"
                     /gene_synonym="F630103D06Rik; MBD-2"
                     /note="major polyA site"
ORIGIN      
        1 ggaactaagt ccttgaggtt tctgggagag ctctggcctc aagagcctca gacaccaggc
       61 gtggagccgc tggacacaag tagcaggtct gagggcttat ccatctgccc tggcttccac
      121 actgaggctt tcgcgaccct catccgtgcc ggcttgctcc gccctgagca agatgtcgct
      181 cacgggcctc aagggtcatt gggtgcttgg ccatgggctt tcagtgttcc tgttggtgct
      241 gctgctgtta gggccttcac agcctctaat atggacccag acaaaaccag gcttctctgg
      301 tgcttccact acatcaagca tccccagagc actcaccaag cccgacattt ccagcattcc
      361 aaccactcct ggcaacccca atttcccaga cctgcgagat cgcgcaagag ctctgatgca
      421 ggagttcccg cttatagatg gccacaatga catgcctctt gtcctgagac aattttacca
      481 gaatggacta caagatgcta acctgagaaa cttcacccat ggccagacca gcctggatag
      541 gcttaaagat ggcttggtgg gagcccagtt ctggtctgct tacgtaccat gccagacgca
      601 ggaccgggat gccctgcgtc tcactctgga gcagatagac ctcattcgca gaatatgtgc
      661 ctcttattct gagctggaac ttgtgacctc agttaaagct ctgaacagca cccagaaatt
      721 ggcttgcctc attggtgtgg aaggtggcca ttcactagac aacagcctcg ctgtgcttcg
      781 aagtttctac ctgctggggg tgcgctacct gacgctcaca cacacctgca acacaccctg
      841 ggcagagacc tcatccaagg gtgtccacgc attctacagc agtgtcactg gactgaccag
      901 ctttggtgag aaggtggtgg cagaaatgaa tcgcttaggt atgatggttg atctgtccca
      961 cgtctcggat gctgcagcca ggcgggcctt ggaagtatcc caagcccctg tgattttctc
     1021 ccactccgct gccagggctg tgtgcccaaa tgctcggaat cttcctgatg acctcctgca
     1081 gcttctgaag aagaacggtg gcatcgtgat ggtgaccttc tccgtaggag tgttaccgtg
     1141 caacccttta gccaatgtat ccactgtggc agatcacttt gaccacatca ggtcagtcat
     1201 cggatccgag ttcatcggaa ttggcggaga ttatgatggt accaaacagt tccctcaggg
     1261 cctggaggat gtgtctacat acccagtgct catagaggag ttgctgagac gaggctggaa
     1321 tgaacaggaa ctccaaggca tccttcgagg aaacctgctt cgggtcttcc gacaagtgga
     1381 gcaggtccga gacaaaagca aatggcaaag tcccctggaa gacatgatcc cagaggagca
     1441 gctggacagt gcttgccact cagccctgcg acctcagaaa cagcatccag aaaagaacca
     1501 accggagact ccagaatatc atatactcaa gttctcacac tcgaaatcct ctccccacat
     1561 tgtcccaagc ctcgccattg ttgcgacctt attaggcctt attgtgtgac ttttagagga
     1621 tacccaccca gtcctctcag atatcattct ggtgccctgg aagtccctcc acttgtgaag
     1681 gggcaaatat ttcctagaag taaatgcttt ggacatagaa a
//
