LOCUS       NM_007876               2148 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus dipeptidase 1 (Dpep1), transcript variant 1, mRNA.
ACCESSION   NM_007876
VERSION     NM_007876.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2148)
  AUTHORS   Nevorankova,P., Sulcova,M., Kavkova,M., Zimcik,D., Balkova,S.M.,
            Peleskova,K., Kristekova,D., Jakesova,V., Zikmund,T., Kaiser,J.,
            Hola,L.I., Kolar,M. and Buchtova,M.
  TITLE     Region-specific gene expression profiling of early mouse mandible
            uncovered SATB2 as a key molecule for teeth patterning
  JOURNAL   Sci Rep 14 (1), 18212 (2024)
   PUBMED   39107332
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2148)
  AUTHORS   Li,Y., Wang,X., Zhang,Q., Tian,D., Bai,Y., Feng,Y., Liu,W. and
            Diao,Z.
  TITLE     Dipeptidase 1 promotes ferroptosis in renal tubular epithelial
            cells in diabetic nephropathy via inhibition of the GSH/GPX4 axis
  JOURNAL   Int Immunopharmacol 133, 111955 (2024)
   PUBMED   38626544
  REMARK    GeneRIF: Dipeptidase 1 promotes ferroptosis in renal tubular
            epithelial cells in diabetic nephropathy via inhibition of the
            GSH/GPX4 axis.
REFERENCE   3  (bases 1 to 2148)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2148)
  AUTHORS   Lau,A., Rahn,J.J., Chappellaz,M., Chung,H., Benediktsson,H.,
            Bihan,D., von Massenhausen,A., Linkermann,A., Jenne,C.N.,
            Robbins,S.M., Senger,D.L., Lewis,I.A., Chun,J. and Muruve,D.A.
  TITLE     Dipeptidase-1 governs renal inflammation during ischemia
            reperfusion injury
  JOURNAL   Sci Adv 8 (5), eabm0142 (2022)
   PUBMED   35108057
  REMARK    GeneRIF: Dipeptidase-1 governs renal inflammation during ischemia
            reperfusion injury.
REFERENCE   5  (bases 1 to 2148)
  AUTHORS   Guan,Y., Liang,X., Ma,Z., Hu,H., Liu,H., Miao,Z., Linkermann,A.,
            Hellwege,J.N., Voight,B.F. and Susztak,K.
  TITLE     A single genetic locus controls both expression of DPEP1/CHMP1A and
            kidney disease development via ferroptosis
  JOURNAL   Nat Commun 12 (1), 5078 (2021)
   PUBMED   34426578
  REMARK    GeneRIF: A single genetic locus controls both expression of
            DPEP1/CHMP1A and kidney disease development via ferroptosis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2148)
  AUTHORS   Habib,G.M. and Lieberman,M.W.
  TITLE     Cleavage of leukotriene D4 in mice with targeted disruption of a
            membrane-bound dipeptidase gene
  JOURNAL   Adv Exp Med Biol 469, 295-300 (1999)
   PUBMED   10667344
REFERENCE   7  (bases 1 to 2148)
  AUTHORS   Habib,G.M., Shi,Z.Z., Cuevas,A.A., Guo,Q., Matzuk,M.M. and
            Lieberman,M.W.
  TITLE     Leukotriene D4 and cystinyl-bis-glycine metabolism in
            membrane-bound dipeptidase-deficient mice
  JOURNAL   Proc Natl Acad Sci U S A 95 (9), 4859-4863 (1998)
   PUBMED   9560193
REFERENCE   8  (bases 1 to 2148)
  AUTHORS   Becker-Follmann,J., Gaa,A., Bausch,E., Natt,E., Scherer,G. and von
            Deimling,O.
  TITLE     High-resolution mapping of a linkage group on mouse chromosome 8
            conserved on human chromosome 16Q
  JOURNAL   Mamm Genome 8 (3), 172-177 (1997)
   PUBMED   9069116
REFERENCE   9  (bases 1 to 2148)
  AUTHORS   Habib,G.M., Barrios,R., Shi,Z.Z. and Lieberman,M.W.
  TITLE     Four distinct membrane-bound dipeptidase RNAs are differentially
            expressed and show discordant regulation with gamma-glutamyl
            transpeptidase
  JOURNAL   J Biol Chem 271 (27), 16273-16280 (1996)
   PUBMED   8663190
REFERENCE   10 (bases 1 to 2148)
  AUTHORS   Satoh,S., Keida,Y., Konta,Y., Maeda,M., Matsumoto,Y., Niwa,M. and
            Kohsaka,M.
  TITLE     Purification and molecular cloning of mouse renal dipeptidase
  JOURNAL   Biochim Biophys Acta 1163 (3), 234-242 (1993)
   PUBMED   8507661
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163617.5.
            
            On Feb 23, 2023 this sequence version replaced NM_007876.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC003492.1, D13139.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-112               AC163617.5         65359-65470         c
            113-266             AC163617.5         57614-57767         c
            267-399             AC163617.5         52954-53086         c
            400-532             AC163617.5         52623-52755         c
            533-683             AC163617.5         52356-52506         c
            684-753             AC163617.5         52109-52178         c
            754-930             AC163617.5         51683-51859         c
            931-1015            AC163617.5         51509-51593         c
            1016-1091           AC163617.5         51358-51433         c
            1092-1227           AC163617.5         51027-51162         c
            1228-2148           AC163617.5         49988-50908         c
FEATURES             Location/Qualifiers
     source          1..2148
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 72.08 cM"
     gene            1..2148
                     /gene="Dpep1"
                     /gene_synonym="DPEP-1; MBD"
                     /note="dipeptidase 1"
                     /db_xref="GeneID:13479"
                     /db_xref="MGI:MGI:94917"
     exon            1..112
                     /gene="Dpep1"
                     /gene_synonym="DPEP-1; MBD"
                     /inference="alignment:Splign:2.1.0"
     exon            113..266
                     /gene="Dpep1"
                     /gene_synonym="DPEP-1; MBD"
                     /inference="alignment:Splign:2.1.0"
     CDS             163..1395
                     /gene="Dpep1"
                     /gene_synonym="DPEP-1; MBD"
                     /EC_number="3.4.13.19"
                     /EC_number="3.5.2.6"
                     /note="MBD-1; renal dipeptidase; microsomal dipeptidase;
                     membrane-bound dipeptidase 1; membrane bound dipeptidase
                     type II; dipeptidase 1 (renal); beta-lactamase"
                     /codon_start=1
                     /product="dipeptidase 1 precursor"
                     /protein_id="NP_031902.2"
                     /db_xref="CCDS:CCDS22750.1"
                     /db_xref="GeneID:13479"
                     /db_xref="MGI:MGI:94917"
                     /translation="MVIIWWFWSLLAICASDSFRDQAVAIMRTTPVIDGHNDLPWQLL
                     NLFNNQLLRPDADLNKLAQTHTNIPKLKAGFVGGQFWSAYMPCDTQNKDAVKRILEQM
                     DVIHRMCQLYPETFMCVTNSSDILQAFRRGKVASLIGVEGGHLIDSSLGVLRTLYHLG
                     MRYLTLTHNCNTPWADNWLVDRGDDEAESHGLSPFGKRLLNEMNRLGVMIDLSHVSVA
                     TMKDALQISRAPVIFSHSSAYSLCPHRRNVPDDVLQLVKNTSSLVMVNFFSNFVSCSD
                     SATLPQVADHLDHIKKVAGAGAVGLGGDYDGVTMLPVGLEDVSKYPDLIAELLRRNWT
                     ETEVRGLLADNLIRVFSEVELVSNNMQSPEEVPITLKELDGSCRTYYGYSQAHSIHLQ
                     TGALVASLASLLFRLHLL"
     exon            267..399
                     /gene="Dpep1"
                     /gene_synonym="DPEP-1; MBD"
                     /inference="alignment:Splign:2.1.0"
     exon            400..532
                     /gene="Dpep1"
                     /gene_synonym="DPEP-1; MBD"
                     /inference="alignment:Splign:2.1.0"
     exon            533..683
                     /gene="Dpep1"
                     /gene_synonym="DPEP-1; MBD"
                     /inference="alignment:Splign:2.1.0"
     exon            684..753
                     /gene="Dpep1"
                     /gene_synonym="DPEP-1; MBD"
                     /inference="alignment:Splign:2.1.0"
     exon            754..930
                     /gene="Dpep1"
                     /gene_synonym="DPEP-1; MBD"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1015
                     /gene="Dpep1"
                     /gene_synonym="DPEP-1; MBD"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1091
                     /gene="Dpep1"
                     /gene_synonym="DPEP-1; MBD"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1227
                     /gene="Dpep1"
                     /gene_synonym="DPEP-1; MBD"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..2148
                     /gene="Dpep1"
                     /gene_synonym="DPEP-1; MBD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1542..1547
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dpep1"
                     /gene_synonym="DPEP-1; MBD"
                     /note="hexamer: AATAAA"
     polyA_site      1561
                     /gene="Dpep1"
                     /gene_synonym="DPEP-1; MBD"
                     /note="major polyA site"
     regulatory      2117..2122
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dpep1"
                     /gene_synonym="DPEP-1; MBD"
                     /note="hexamer: AATAAA"
     polyA_site      2148
                     /gene="Dpep1"
                     /gene_synonym="DPEP-1; MBD"
                     /note="major polyA site"
ORIGIN      
        1 aaagaggtgg cccttcaaag ctggaggact caggagcagg ctgtcccgtc tctctgggtg
       61 tcagccacag gactgaagcc acattggcac ccctgacccg cgtgtgctcg tggcacggag
      121 gtgccaaagc cgctgtggaa gcagatccct ggggaccttg aaatggtgat catctggtgg
      181 ttctggtctc tgctggccat ctgtgcttcg gactcattcc gggaccaggc agtggctatc
      241 atgagaacca caccggtcat cgacgggcac aacgacttgc cttggcaact gctaaatttg
      301 ttcaacaacc agctgctgag accagatgct gacttgaaca agctagccca aacacacacc
      361 aacatcccca agctgaaggc tggctttgtc ggaggccagt tctggtccgc atacatgcct
      421 tgtgacaccc aaaacaaaga tgccgtgaag agaatactgg aacagatgga tgtgatacac
      481 cgcatgtgcc agctctatcc tgagaccttc atgtgtgtta ccaatagttc agacatccta
      541 caggctttcc ggagggggaa agtggccagt ctgatcggcg tggaaggcgg ccacttaatt
      601 gacagcagcc ttggtgtcct gcggacactc taccatctgg gcatgcggta tctgaccctc
      661 acccacaatt gcaacacgcc ctgggccgac aactggcttg tggacagagg agatgatgag
      721 gctgagagcc atggactgtc accctttggg aagcgcctgc tgaacgagat gaaccgcttg
      781 ggtgtcatga ttgacctgtc ccacgtgtct gtggccacca tgaaggacgc tttgcagatc
      841 tccagggcac cagtcatctt cagccactcc tctgcctaca gcctgtgtcc acacaggcgg
      901 aatgtgcccg atgacgtact gcagctggtg aagaacacaa gtagtctggt gatggtgaac
      961 ttcttcagca actttgtgtc ctgttcagac agcgccacct tgccccaagt ggctgaccac
     1021 ctggaccaca tcaagaaggt ggcaggcgct ggggctgtgg gccttggagg agattatgat
     1081 ggtgttacta tgcttcctgt gggactggag gatgtttcta agtacccaga cctgatagct
     1141 gagcttctca ggaggaactg gacagagacc gaggtcagag gtttgctagc tgacaacctg
     1201 attcgggtct tctctgaagt ggaactggta agcaataaca tgcagtctcc tgaggaagtc
     1261 cctatcaccc tgaaagagct ggacggctcc tgcaggacat actatggcta ctctcaagct
     1321 cacagcatcc acttgcagac aggagccctg gtggcctctc tggcttccct gctcttccgt
     1381 ctccatcttc tgtgacatcc aaaggaccgg aacctcctcc agtgctctct gagctcaggg
     1441 aagactggac aagcccagag tccctgttgt ccgtgcagaa ccacaccctt tcctgaataa
     1501 gcagcaggct tacctgggga cagctcaaga cacaggcatg caataaacgc aatgagcctt
     1561 agtgctgagt gggcacgctg tatctcagcc ctgggagatt cttctgagcc tctggagagc
     1621 agatgctgag aacggccctg tgtgaacagg atgtgggagc acctgagttc ttggagggga
     1681 ggactagaag ggacccagaa gttagcaaag ggtctcacgt aagcactggc tagtttgaaa
     1741 aatcatggtc cacatttaag tggctacctt cccccctcac tgtgcatgta ccacatgcac
     1801 atgaacccct cctcccccct tacacatgta ctcatgtgca cacaggcaca tatagatatt
     1861 cagatgcatt atacatatca tacacgggca catgtattct gacgcatacc atatgagagt
     1921 cacacatatc tctctgggtt ctgtaattca gattacatag gtaatgggta acctcgatct
     1981 ggtccagcct tggcgggtgg gatccaggta gaatgggtgc cggggatgat cacacagcta
     2041 actgcgggtc tttcctgaat cacagggcag aggtggtctc ctatgttacc tagcatggtt
     2101 gaggatgagt cttgtgaata aacttatgag ggacagcgtt cacctgaa
//
