LOCUS       NM_007875               2230 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus dolichyl-phosphate
            N-acetylglucosaminephosphotransferase 1 (Dpagt1), transcript
            variant 1, mRNA.
ACCESSION   NM_007875
VERSION     NM_007875.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2230)
  AUTHORS   Hyde,L.F., Kong,Y., Zhao,L., Rao,S.R., Wang,J., Stone,L., Njaa,A.,
            Collin,G.B., Krebs,M.P., Chang,B., Fliesler,S.J., Nishina,P.M. and
            Naggert,J.K.
  TITLE     A Dpagt1 Missense Variant Causes Degenerative Retinopathy without
            Myasthenic Syndrome in Mice
  JOURNAL   Int J Mol Sci 23 (19), 12005 (2022)
   PUBMED   36233305
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2230)
  AUTHORS   Richards,C.M., Jabs,S., Qiao,W., Varanese,L.D., Schweizer,M.,
            Mosen,P.R., Riley,N.M., Klussendorf,M., Zengel,J.R., Flynn,R.A.,
            Rustagi,A., Widen,J.C., Peters,C.E., Ooi,Y.S., Xie,X., Shi,P.Y.,
            Bartenschlager,R., Puschnik,A.S., Bogyo,M., Bertozzi,C.R.,
            Blish,C.A., Winter,D., Nagamine,C.M., Braulke,T. and Carette,J.E.
  TITLE     The human disease gene LYSET is essential for lysosomal enzyme
            transport and viral infection
  JOURNAL   Science 378 (6615), eabn5648 (2022)
   PUBMED   36074821
REFERENCE   3  (bases 1 to 2230)
  AUTHORS   Li,H., You,L., Tian,Y., Guo,J., Fang,X., Zhou,C., Shi,L. and
            Su,Y.Q.
  TITLE     DPAGT1-Mediated Protein N-Glycosylation Is Indispensable for Oocyte
            and Follicle Development in Mice
  JOURNAL   Adv Sci (Weinh) 7 (14), 2000531 (2020)
   PUBMED   32714760
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2230)
  AUTHORS   Won,J., Shi,L.Y., Hicks,W., Wang,J., Hurd,R., Naggert,J.K.,
            Chang,B. and Nishina,P.M.
  TITLE     Mouse model resources for vision research
  JOURNAL   J Ophthalmol 2011, 391384 (2011)
   PUBMED   21052544
REFERENCE   5  (bases 1 to 2230)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
REFERENCE   6  (bases 1 to 2230)
  AUTHORS   Yagi,H., Kato,T., Nagata,T., Habu,T., Nozaki,M., Matsushiro,A.,
            Nishimune,Y. and Morita,T.
  TITLE     Regulation of the mouse histone H2A.X gene promoter by the
            transcription factor E2F and CCAAT binding protein
  JOURNAL   J Biol Chem 270 (32), 18759-18765 (1995)
   PUBMED   7642525
REFERENCE   7  (bases 1 to 2230)
  AUTHORS   Crick,D.C., Scocca,J.R., Rush,J.S., Frank,D.W., Krag,S.S. and
            Waechter,C.J.
  TITLE     Induction of dolichyl-saccharide intermediate biosynthesis
            corresponds to increased long chain cis-isoprenyltransferase
            activity during the mitogenic response in mouse B cells
  JOURNAL   J Biol Chem 269 (14), 10559-10565 (1994)
   PUBMED   8144643
REFERENCE   8  (bases 1 to 2230)
  AUTHORS   Rajput,B., Ma,J. and Vijay,I.K.
  TITLE     Structure and organization of mouse GlcNAc-1-phosphate transferase
            gene
  JOURNAL   J Biol Chem 269 (13), 9590-9597 (1994)
   PUBMED   8043075
  REMARK    Erratum:[J Biol Chem 1994 Jul 15;269(28):18703]
REFERENCE   9  (bases 1 to 2230)
  AUTHORS   Rajput,B., Ma,J., Muniappa,N., Schantz,L., Naylor,S.L., Lalley,P.A.
            and Vijay,I.K.
  TITLE     Mouse UDP-GlcNAc: dolichyl-phosphate
            N-acetylglucosaminephosphotransferase. Molecular cloning of the
            cDNA, generation of anti-peptide antibodies and chromosomal
            localization
  JOURNAL   Biochem J 285 (Pt 3) (Pt 3), 985-992 (1992)
   PUBMED   1323278
REFERENCE   10 (bases 1 to 2230)
  AUTHORS   Varki,A., Reitman,M.L., Vannier,A., Kornfeld,S., Grubb,J.H. and
            Sly,W.S.
  TITLE     Demonstration of the heterozygous state for I-cell disease and
            pseudo-Hurler polydystrophy by assay of
            N-acetylglucosaminylphosphotransferase in white blood cells and
            fibroblasts
  JOURNAL   Am J Hum Genet 34 (5), 717-729 (1982)
   PUBMED   6289658
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124577.5 and AC122428.4.
            
            On Jun 16, 2018 this sequence version replaced NM_007875.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC010474.1, X65603.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-391               AC124577.5         217162-217552
            392-512             AC124577.5         217899-218019
            513-726             AC122428.4         156609-156822       c
            727-873             AC122428.4         155638-155784       c
            874-958             AC122428.4         153573-153657       c
            959-1147            AC122428.4         152683-152871       c
            1148-1235           AC122428.4         152125-152212       c
            1236-1391           AC122428.4         151804-151959       c
            1392-2230           AC122428.4         150880-151718       c
FEATURES             Location/Qualifiers
     source          1..2230
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 24.84 cM"
     gene            1..2230
                     /gene="Dpagt1"
                     /gene_synonym="Dpagt2; G1PT; Gnpta; GPT"
                     /note="dolichyl-phosphate
                     N-acetylglucosaminephosphotransferase 1"
                     /db_xref="GeneID:13478"
                     /db_xref="MGI:MGI:1196396"
     exon            1..391
                     /gene="Dpagt1"
                     /gene_synonym="Dpagt2; G1PT; Gnpta; GPT"
                     /inference="alignment:Splign:2.1.0"
     CDS             225..1457
                     /gene="Dpagt1"
                     /gene_synonym="Dpagt2; G1PT; Gnpta; GPT"
                     /EC_number="2.7.8.15"
                     /note="isoform 1 is encoded by transcript variant 1;
                     UDP-N-acetylglucosamine--dolichyl-phosphate
                     N-acetylglucosaminephosphotransferase;
                     N-acetylglucosamine-1-phosphate transferase;
                     UDP-N-acetylglucosamine lysosomal enzyme
                     N-acetylglucosamine phosphotransferase; dolichyl-phosphate
                     alpha-N-acetylglucosaminephosphotransferase 2;
                     dolichyl-phosphate (UDP-N-acetylglucosamine)
                     acetylglucosaminephosphotransferase 1 (GlcNAc-1-P
                     transferase)"
                     /codon_start=1
                     /product="UDP-N-acetylglucosamine--dolichyl-phosphate
                     N-acetylglucosaminephosphotransferase isoform 1"
                     /protein_id="NP_031901.2"
                     /db_xref="CCDS:CCDS23104.1"
                     /db_xref="GeneID:13478"
                     /db_xref="MGI:MGI:1196396"
                     /translation="MWAFPELPLPLPLLVNLIGSLLGFVATVTLIPAFRSHFIAARLC
                     GQDLNKLSQQQIPESQGVISGAVFLIILFCFIPFPFLNCFVEEQCKAFPHHEFVALIG
                     ALLAICCMIFLGFADDVLNLRWRHKLLLPTAASLPLLMVYFTNFGNTTIVVPKPFRWI
                     LGLHLDLGILYYVYMGLLAVFCTNAINILAGINGLEAGQSLVISASIIVFNLVELEGD
                     YRDDHIFSLYFMIPFFFTTLGLLYHNWYPSRVFVGDTFCYFAGMTFAVVGILGHFSKT
                     MLLFFMPQVFNFLYSLPQLFHIIPCPRHRMPRLNAKTGKLEMSYSKFKTKNLSFLGTF
                     ILKVAENLRLVTVHQGESEDGAFTECNNMTLINLLLKVFGPIHERNLTLLLLLLQVLS
                     SAATFSIRYQLVRLFYDV"
     exon            392..512
                     /gene="Dpagt1"
                     /gene_synonym="Dpagt2; G1PT; Gnpta; GPT"
                     /inference="alignment:Splign:2.1.0"
     exon            513..726
                     /gene="Dpagt1"
                     /gene_synonym="Dpagt2; G1PT; Gnpta; GPT"
                     /inference="alignment:Splign:2.1.0"
     exon            727..873
                     /gene="Dpagt1"
                     /gene_synonym="Dpagt2; G1PT; Gnpta; GPT"
                     /inference="alignment:Splign:2.1.0"
     exon            874..958
                     /gene="Dpagt1"
                     /gene_synonym="Dpagt2; G1PT; Gnpta; GPT"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1147
                     /gene="Dpagt1"
                     /gene_synonym="Dpagt2; G1PT; Gnpta; GPT"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1235
                     /gene="Dpagt1"
                     /gene_synonym="Dpagt2; G1PT; Gnpta; GPT"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1391
                     /gene="Dpagt1"
                     /gene_synonym="Dpagt2; G1PT; Gnpta; GPT"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..2230
                     /gene="Dpagt1"
                     /gene_synonym="Dpagt2; G1PT; Gnpta; GPT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1911..1916
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dpagt1"
                     /gene_synonym="Dpagt2; G1PT; Gnpta; GPT"
                     /note="hexamer: AATAAA"
     polyA_site      1941
                     /gene="Dpagt1"
                     /gene_synonym="Dpagt2; G1PT; Gnpta; GPT"
                     /note="major polyA site"
ORIGIN      
        1 aatgggtagg tgcagcgggg cagagccgag gttgcttcct aagagcttct tgctggtcag
       61 gagggagggt caggtcctag cgtcctagct gggttttgtt cccgctggcg ccggaatcct
      121 ctgcgggttg ggagccgcac tgccggctgc cgaggccacg ggattgttcc tggcttacca
      181 gttagctgag taggcggcgg ggcggcggcc accggagggt caccatgtgg gccttcccgg
      241 agttgcccct gccgctgccg ctgctggtga atttgatcgg ctcgctgttg ggattcgtgg
      301 ctacagtcac cctcatccct gccttccgta gccactttat cgccgcgcgc ctctgtggcc
      361 aggacctcaa caagctcagc cagcagcaga tcccagagtc ccagggagtg atcagcggtg
      421 ctgttttcct tatcatcctc ttctgcttca tccctttccc cttcctgaac tgcttcgtgg
      481 aggagcagtg taaggcattc ccccaccatg aatttgtggc cctaataggt gccctccttg
      541 ccatctgctg catgatcttc ctggggtttg ctgatgatgt cctcaatctc cgctggcgcc
      601 acaagctgct gctgcccaca gctgcctcac tacctctcct catggtctac ttcacaaact
      661 ttggcaatac aaccatcgtg gtgcccaagc ccttccgctg gattctgggc ctgcatttgg
      721 acttggggat cctgtactac gtctacatgg ggctgcttgc agtgttctgt accaatgcca
      781 tcaacatcct ggcgggcatt aatggcctag aggccggtca gtcactagtc atctctgctt
      841 ctatcattgt cttcaacctg gtggaactgg aaggtgatta tcgagatgat catatctttt
      901 ccctttactt catgatacca tttttcttta ccaccttggg actgctttac cacaactggt
      961 acccgtcccg cgtgtttgtg ggagacacct tctgttactt tgcgggcatg acttttgccg
     1021 tggtggggat cttgggacac ttcagcaaga ccatgctgct cttctttatg ccacaagtat
     1081 tcaatttcct ctactcactg cctcagctct tccatatcat cccctgccct cgacaccgga
     1141 tgcccagact caacgcaaag acaggcaaac tggaaatgag ctattccaag ttcaagacca
     1201 agaacctctc tttcctgggc acctttattt taaaggtagc agagaacctc cggttagtga
     1261 cagttcacca aggtgagagt gaggacggtg ccttcactga gtgtaacaac atgaccctca
     1321 tcaacttgct acttaaagtc tttgggccta tacatgagag aaacctcacc ctgctcctgc
     1381 tgctcctgca ggtcctaagc agcgccgcca ccttctccat tcgttaccaa ctcgtccgac
     1441 tcttctatga tgtctgagct ccctgacagc tgccctttac ctcacagtct ccattggacc
     1501 tcagccagga ccagcctctg tctggtccga gatgaccctc tggtccaggc ctcgctgaca
     1561 cttttgttct cagcttctgc catctgtgac tactgatatc ctggatggac accttgctgg
     1621 acttgaagtc cgctagttgg actttgccta gggctttcat cttgccttgc cctccctttc
     1681 tgtcccatct gcagcctcac caggtgggct tgtagcctct attatgcaaa tattcgtagc
     1741 tcagctttca gagcgctaac tctaaaggaa ttcacctgag ccttgagaga gaacctgggc
     1801 tagggctaga gttagggcta catactccaa ggtgacctca catttgacta tcaaatgaag
     1861 tgttgtgatt gggaagcgta gaggcagggc catgtgctca gaacggtgac aataaaggac
     1921 tgccttttac ttgttcctct agtgtagcat cccctccctc tgtccttttt aaccttcgtg
     1981 gtgcttcagg agtgaacacc ggggcttcct tatacttaac tgctctacca ctgaactata
     2041 tgccaagtct ggtatattta ttttttatat aggcatttta ggatagattg gaagggttag
     2101 accgggtacc tttcccaata ggataccgat ctctgttcca tcagaccctt tcttgcaaaa
     2161 aaggcctgtc acaaactaag accagacaga acatgttgaa taaatatcgc agcacaaact
     2221 tgtgatagca
//
