LOCUS       NM_027293               7331 bp    mRNA    linear   ROD 20-OCT-2024
DEFINITION  Mus musculus DOP1 leucine zipper like protein B (Dop1b), transcript
            variant 1, mRNA.
ACCESSION   NM_027293 XM_354972 XM_489606
VERSION     NM_027293.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7331)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 7331)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7331)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7331)
  AUTHORS   Liakath-Ali,K., Vancollie,V.E., Heath,E., Smedley,D.P., Estabel,J.,
            Sunter,D., Ditommaso,T., White,J.K., Ramirez-Solis,R., Smyth,I.,
            Steel,K.P. and Watt,F.M.
  TITLE     Novel skin phenotypes revealed by a genome-wide mouse reverse
            genetic screen
  JOURNAL   Nat Commun 5, 3540 (2014)
   PUBMED   24721909
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7331)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   6  (bases 1 to 7331)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   7  (bases 1 to 7331)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 7331)
  AUTHORS   Gitton,Y., Dahmane,N., Baik,S., Ruiz i Altaba,A., Neidhardt,L.,
            Scholze,M., Herrmann,B.G., Kahlem,P., Benkahla,A., Schrinner,S.,
            Yildirimman,R., Herwig,R., Lehrach,H. and Yaspo,M.L.
  CONSRTM   HSA21 expression map initiative
  TITLE     A gene expression map of human chromosome 21 orthologues in the
            mouse
  JOURNAL   Nature 420 (6915), 586-590 (2002)
   PUBMED   12466855
REFERENCE   9  (bases 1 to 7331)
  AUTHORS   Reymond,A., Marigo,V., Yaylaoglu,M.B., Leoni,A., Ucla,C.,
            Scamuffa,N., Caccioppoli,C., Dermitzakis,E.T., Lyle,R., Banfi,S.,
            Eichele,G., Antonarakis,S.E. and Ballabio,A.
  TITLE     Human chromosome 21 gene expression atlas in the mouse
  JOURNAL   Nature 420 (6915), 582-586 (2002)
   PUBMED   12466854
REFERENCE   10 (bases 1 to 7331)
  AUTHORS   Pletcher,M.T., Wiltshire,T., Cabin,D.E., Villanueva,M. and
            Reeves,R.H.
  TITLE     Use of comparative physical and sequence mapping to annotate mouse
            chromosome 16 and human chromosome 21
  JOURNAL   Genomics 74 (1), 45-54 (2001)
   PUBMED   11374901
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY195296.1, AK147255.1, BC075639.1, BC057081.1 and BE945779.1.
            
            On or before May 17, 2005 this sequence version replaced
            XM_354972.3, XM_489606.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147255.1, SRR10223970.18755.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                BY195296.1         1-39
            40-488              AK147255.1         18-466
            489-5404            BC075639.1         1-4916
            5405-6341           BC057081.1         2851-3787
            6342-7311           BC075639.1         5857-6826
            7312-7331           BE945779.1         1-20                c
FEATURES             Location/Qualifiers
     source          1..7331
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 54.63 cM"
     gene            1..7331
                     /gene="Dop1b"
                     /gene_synonym="0610038M01Rik; 2610510B01Rik; C21orf5;
                     Dopey2; mKIAA0933"
                     /note="DOP1 leucine zipper like protein B"
                     /db_xref="GeneID:70028"
                     /db_xref="MGI:MGI:1917278"
     exon            1..162
                     /gene="Dop1b"
                     /gene_synonym="0610038M01Rik; 2610510B01Rik; C21orf5;
                     Dopey2; mKIAA0933"
                     /inference="alignment:Splign:2.1.0"
     exon            163..325
                     /gene="Dop1b"
                     /gene_synonym="0610038M01Rik; 2610510B01Rik; C21orf5;
                     Dopey2; mKIAA0933"
                     /inference="alignment:Splign:2.1.0"
     CDS             188..7075
                     /gene="Dop1b"
                     /gene_synonym="0610038M01Rik; 2610510B01Rik; C21orf5;
                     Dopey2; mKIAA0933"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein dopey-2; dopey family member 2; protein DOP1B"
                     /codon_start=1
                     /product="protein DOP1B isoform 1"
                     /protein_id="NP_081569.1"
                     /db_xref="CCDS:CCDS28343.1"
                     /db_xref="GeneID:70028"
                     /db_xref="MGI:MGI:1917278"
                     /translation="MDPEEQELLNDYRYRSYSSVIEKALRNFESSSEWADLISSLGKL
                     NKALQSNLKYSLLPRRLIISKRLAQCLHPALPSGVHLKALETYEIIFKIVGTKWLAKD
                     LFLYSCGLFPLLAYAAMSVRPVLLGLYEKYFLPLQKLLLPSLQAFLVGLLPGLEEGSE
                     IYERTDALLLRLSVVVGREVFYAALWGSVLTSPSIRLPASLFVVNHISRDSPGKEQKC
                     MLGTDYQLTVRSLCASLLDANVLVQRNNLEIILFFFPFYTCLDPEERAIPLLRRDVVH
                     ILSAATQTLLRRDMSLNRRLYAWLLGSDIKGNTIVPKSEISNSYEDQCSYFFDKYSKD
                     LLVEALAEILHQKFLDADLEERHHAYLKPFRILVSLLDKPEIGPQVVENLFLEVIRAF
                     YSYCHDVLGSDLKLSYTQSGNPLISTIKENRHASEIVKTVNLLVSSLSSDFLWDYMAR
                     RFEACFRPVTQTTAIGEAISPPPTVSELCTLLVFLLDVIPLELYSEVQTQYLPQVLGC
                     LLQPLAEEVEALSLPELTHALKTCFKVLSKVQMPPSYLDLEPSSGNSSPVKGRNSGIA
                     METEAVVAGDEEPSFPPLKSEDSGIGLSASSPELSEHLRVPRVSAERDDIWKKDGTMQ
                     ATFLCIQELIANFASKNIFAASLTVSGEENKPEEPPGKGNKGQTQSTEHPGRKSSWDP
                     KPITVPQFKQMLSDLFTVRGSPFKTRSSESLSSVPSSPHRKAATEWGVDQVVVELVGS
                     KEDCREALAAACHLLLDCATFPVYLSEEETEQLCETLFQTPGASDCSFPPWLKSLMTI
                     CCCVSDCSLQNIAIATLLEVINHSQSLALVIEDKMKRYKTSGNNPFFGKLQMVTVPPI
                     APGILKVIAEKTDFYQRVARVLWNQLNKETREHHITCVELFYRLHCLAPTANICEDII
                     CHALLDPDKGTRLEALFRFSVIWHLTREIQGSRVTSHNRSFDRSLFVVLDSLACTDGA
                     ISAAAQGWLVRALSLGDVARILEPMLLLLLQPKTQRTSIQCLKQENSAEDLHRWFNRK
                     KPTCKEACGESEPQEGAPEERLPRGQFTTVDREAIWAEVEKEPEKCPPRSDLSEEDLP
                     YYVDLPDRMTSGGGDSSEHTESADTSSGHTDSENTSTFSSPSHDLQDLSHEENCCAPI
                     PIGGRAYSKRAALLAAFQPESPRSNARLSLVRADSDKTQASESFSSDEEADVELQAIT
                     TSRLLKQQREKQETVEALFKHILLYLQPYDSQRVLYAFSVLEAVLKTNPKEFIEAVSR
                     TGIDTSSTAHLNLISNLLARHQEALIGQSFYGKLQTQAPNVCPHSLLIELLTYLCLSF
                     LRSYYPCYLKVCHRDILGNRDVQVKSVEVLIRITAQLVSMAKSAEGKNTEFIHSLLQR
                     CKVQEFVLLSLSASMYTSQKRYGLATADRGGRLLAEDSLFEESLINLGQDQIWSEHPL
                     QIELLKLLQALIVLEHHLGQGQEEAETQPALSREWQRALNFQQAIGAMQYVQPHPLTS
                     QGLLVSAVVRGLQPAYGYGMHPAWVSLVTHSLPYFGKSLGWTVTPFVIQICKNLDDLV
                     KQYESESVKFTISTTSKKENISPDYPLTLLEGLTTISHFCLLEQPTQHKKTAAVSDPI
                     NLRNAKNAILEELPRIVNTMALIWNVLRKEETQKRPVDLLGATKGSSSVYFKTTKTIR
                     QKILDLLNPLTGHLGVQLIAAVATVWNRKQARRHSKTKMVPVANTSQHTLVDLVCALS
                     TLQTDSVLQLVKEVVKRPAQIKGDEKSPLVDIPVLQFCYAFIQRLSIPDLQEAFPSLL
                     GVLKEAAQLNLAPPGYFLLLSMLNDFVTRTPNLESKKDQKDLQEITQRILEAVGTIAG
                     SSLEQTSWLSRNLEVKAQPQVSLEESDAEDDVHSAAEASTMVSASAPSVYSVQALSLL
                     AEVLASLLDMVYRSDEKEKAVPLISRLLYYVFPYLRNHSAYNAPSFRAGAQLLSSLSG
                     YAYTKRAWKKEVLELFLDPAFFQMDTSCVHWKSVIDHLLTHEKTMFKDLMNMQSSSLK
                     LFSSFEQKAMLLKRQAFAVFSGELDQYHLYLPLIQERLTDNLRVGQTSIVAGQMFLFF
                     RVLLLRISPQHLTSLWPIMVSELIQTFIQLEEDLKEEDESRNSHKSNRIKAPVADGNG
                     SAGRVLSPSDLTMYLSACKFLDTALAFPPDKMPLFQIYRWAFVPEVDTEHPAFLSELE
                     ENHQECRPHTVRILELLRSRYGEIGSSDEITRKKEFPLLRQHSVSCIRQLIPFFTTLN
                     CAFKTQSQLPADVPGTAAPECPVTENPRVLRQLEECVEQDFLEHPEC"
     exon            326..507
                     /gene="Dop1b"
                     /gene_synonym="0610038M01Rik; 2610510B01Rik; C21orf5;
                     Dopey2; mKIAA0933"
                     /inference="alignment:Splign:2.1.0"
     exon            508..678
                     /gene="Dop1b"
                     /gene_synonym="0610038M01Rik; 2610510B01Rik; C21orf5;
                     Dopey2; mKIAA0933"
                     /inference="alignment:Splign:2.1.0"
     exon            679..868
                     /gene="Dop1b"
                     /gene_synonym="0610038M01Rik; 2610510B01Rik; C21orf5;
                     Dopey2; mKIAA0933"
                     /inference="alignment:Splign:2.1.0"
     exon            869..967
                     /gene="Dop1b"
                     /gene_synonym="0610038M01Rik; 2610510B01Rik; C21orf5;
                     Dopey2; mKIAA0933"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1091
                     /gene="Dop1b"
                     /gene_synonym="0610038M01Rik; 2610510B01Rik; C21orf5;
                     Dopey2; mKIAA0933"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1201
                     /gene="Dop1b"
                     /gene_synonym="0610038M01Rik; 2610510B01Rik; C21orf5;
                     Dopey2; mKIAA0933"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1316
                     /gene="Dop1b"
                     /gene_synonym="0610038M01Rik; 2610510B01Rik; C21orf5;
                     Dopey2; mKIAA0933"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1437
                     /gene="Dop1b"
                     /gene_synonym="0610038M01Rik; 2610510B01Rik; C21orf5;
                     Dopey2; mKIAA0933"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1557
                     /gene="Dop1b"
                     /gene_synonym="0610038M01Rik; 2610510B01Rik; C21orf5;
                     Dopey2; mKIAA0933"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1660
                     /gene="Dop1b"
                     /gene_synonym="0610038M01Rik; 2610510B01Rik; C21orf5;
                     Dopey2; mKIAA0933"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1852
                     /gene="Dop1b"
                     /gene_synonym="0610038M01Rik; 2610510B01Rik; C21orf5;
                     Dopey2; mKIAA0933"
                     /inference="alignment:Splign:2.1.0"
     exon            1853..2531
                     /gene="Dop1b"
                     /gene_synonym="0610038M01Rik; 2610510B01Rik; C21orf5;
                     Dopey2; mKIAA0933"
                     /inference="alignment:Splign:2.1.0"
     exon            2532..2803
                     /gene="Dop1b"
                     /gene_synonym="0610038M01Rik; 2610510B01Rik; C21orf5;
                     Dopey2; mKIAA0933"
                     /inference="alignment:Splign:2.1.0"
     exon            2804..2956
                     /gene="Dop1b"
                     /gene_synonym="0610038M01Rik; 2610510B01Rik; C21orf5;
                     Dopey2; mKIAA0933"
                     /inference="alignment:Splign:2.1.0"
     exon            2957..3057
                     /gene="Dop1b"
                     /gene_synonym="0610038M01Rik; 2610510B01Rik; C21orf5;
                     Dopey2; mKIAA0933"
                     /inference="alignment:Splign:2.1.0"
     exon            3058..3248
                     /gene="Dop1b"
                     /gene_synonym="0610038M01Rik; 2610510B01Rik; C21orf5;
                     Dopey2; mKIAA0933"
                     /inference="alignment:Splign:2.1.0"
     exon            3249..4881
                     /gene="Dop1b"
                     /gene_synonym="0610038M01Rik; 2610510B01Rik; C21orf5;
                     Dopey2; mKIAA0933"
                     /inference="alignment:Splign:2.1.0"
     exon            4882..4993
                     /gene="Dop1b"
                     /gene_synonym="0610038M01Rik; 2610510B01Rik; C21orf5;
                     Dopey2; mKIAA0933"
                     /inference="alignment:Splign:2.1.0"
     exon            4994..5182
                     /gene="Dop1b"
                     /gene_synonym="0610038M01Rik; 2610510B01Rik; C21orf5;
                     Dopey2; mKIAA0933"
                     /inference="alignment:Splign:2.1.0"
     exon            5183..5305
                     /gene="Dop1b"
                     /gene_synonym="0610038M01Rik; 2610510B01Rik; C21orf5;
                     Dopey2; mKIAA0933"
                     /inference="alignment:Splign:2.1.0"
     exon            5306..5440
                     /gene="Dop1b"
                     /gene_synonym="0610038M01Rik; 2610510B01Rik; C21orf5;
                     Dopey2; mKIAA0933"
                     /inference="alignment:Splign:2.1.0"
     exon            5441..5496
                     /gene="Dop1b"
                     /gene_synonym="0610038M01Rik; 2610510B01Rik; C21orf5;
                     Dopey2; mKIAA0933"
                     /inference="alignment:Splign:2.1.0"
     exon            5497..5601
                     /gene="Dop1b"
                     /gene_synonym="0610038M01Rik; 2610510B01Rik; C21orf5;
                     Dopey2; mKIAA0933"
                     /inference="alignment:Splign:2.1.0"
     exon            5602..5668
                     /gene="Dop1b"
                     /gene_synonym="0610038M01Rik; 2610510B01Rik; C21orf5;
                     Dopey2; mKIAA0933"
                     /inference="alignment:Splign:2.1.0"
     exon            5669..5813
                     /gene="Dop1b"
                     /gene_synonym="0610038M01Rik; 2610510B01Rik; C21orf5;
                     Dopey2; mKIAA0933"
                     /inference="alignment:Splign:2.1.0"
     exon            5814..5893
                     /gene="Dop1b"
                     /gene_synonym="0610038M01Rik; 2610510B01Rik; C21orf5;
                     Dopey2; mKIAA0933"
                     /inference="alignment:Splign:2.1.0"
     exon            5894..6003
                     /gene="Dop1b"
                     /gene_synonym="0610038M01Rik; 2610510B01Rik; C21orf5;
                     Dopey2; mKIAA0933"
                     /inference="alignment:Splign:2.1.0"
     exon            6004..6150
                     /gene="Dop1b"
                     /gene_synonym="0610038M01Rik; 2610510B01Rik; C21orf5;
                     Dopey2; mKIAA0933"
                     /inference="alignment:Splign:2.1.0"
     exon            6151..6212
                     /gene="Dop1b"
                     /gene_synonym="0610038M01Rik; 2610510B01Rik; C21orf5;
                     Dopey2; mKIAA0933"
                     /inference="alignment:Splign:2.1.0"
     exon            6213..6341
                     /gene="Dop1b"
                     /gene_synonym="0610038M01Rik; 2610510B01Rik; C21orf5;
                     Dopey2; mKIAA0933"
                     /inference="alignment:Splign:2.1.0"
     exon            6342..6478
                     /gene="Dop1b"
                     /gene_synonym="0610038M01Rik; 2610510B01Rik; C21orf5;
                     Dopey2; mKIAA0933"
                     /inference="alignment:Splign:2.1.0"
     exon            6479..6531
                     /gene="Dop1b"
                     /gene_synonym="0610038M01Rik; 2610510B01Rik; C21orf5;
                     Dopey2; mKIAA0933"
                     /inference="alignment:Splign:2.1.0"
     exon            6532..6693
                     /gene="Dop1b"
                     /gene_synonym="0610038M01Rik; 2610510B01Rik; C21orf5;
                     Dopey2; mKIAA0933"
                     /inference="alignment:Splign:2.1.0"
     exon            6694..6823
                     /gene="Dop1b"
                     /gene_synonym="0610038M01Rik; 2610510B01Rik; C21orf5;
                     Dopey2; mKIAA0933"
                     /inference="alignment:Splign:2.1.0"
     exon            6824..7316
                     /gene="Dop1b"
                     /gene_synonym="0610038M01Rik; 2610510B01Rik; C21orf5;
                     Dopey2; mKIAA0933"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7289..7294
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dop1b"
                     /gene_synonym="0610038M01Rik; 2610510B01Rik; C21orf5;
                     Dopey2; mKIAA0933"
                     /note="hexamer: AATAAA"
     polyA_site      7316
                     /gene="Dop1b"
                     /gene_synonym="0610038M01Rik; 2610510B01Rik; C21orf5;
                     Dopey2; mKIAA0933"
                     /note="major polyA site"
ORIGIN      
        1 ttccggcccc gcccccagcc gcccagttcc cgggagtggc ggcagctggg cggaggcgca
       61 gcgatacctc cgccttcgag gtctctgccg aagcgcagag ccgccttgtc ccgcagccga
      121 cgggctccgt cccacgccca ccgccgaggt ccgcggccgc cgatccctcc ttctgtgagg
      181 atgtaagatg gacccggagg agcaggagct actgaacgat tacagataca gaagctactc
      241 ctcagtaatc gagaaggcgt tgagaaactt tgagtcctcc agcgaatggg cagatctcat
      301 ctcttcgctc ggcaagctca acaaggctct ccagagcaac ctgaagtatt ccctcctacc
      361 acggcggctc atcatcagca agaggctagc tcagtgcttg catcctgccc tgcccagtgg
      421 cgttcaccta aaagccctag aaacctacga gatcatcttc aagattgtgg gaaccaaatg
      481 gctggccaag gacttgttct tgtacagctg tggcttattc cccctactgg cctatgccgc
      541 catgtcggtc cggcccgtgc tgcttggcct gtatgagaag tacttcctcc cgctgcagaa
      601 gctgctcctg cccagtcttc aggccttcct tgtgggtctg ctgcccggcc tggaagaagg
      661 ctctgagatc tatgaaagaa ctgacgccct gctcctgaga ctgtctgtgg ttgtggggcg
      721 agaggtgttc tatgctgccc tgtggggcag cgttctgaca agcccttcca tccgcctccc
      781 tgcctcctta tttgtggtga accacatcag cagggactca ccaggcaagg agcagaagtg
      841 catgctgggt actgattacc agctcacggt gagatccctg tgtgcttcac tgctagacgc
      901 caatgttctt gtgcaaagaa ataacctgga gatcatcctg tttttcttcc cgttttatac
      961 ctgcctggac cctgaggagc gagccatccc tcttctcaga cgggatgttg tgcacatcct
     1021 ctcagctgcc acccagacac tcctgagaag ggacatgtct ctcaacagaa gactctacgc
     1081 ctggttacta ggttcagaca ttaaaggaaa taccattgtg ccaaaatctg aaatttcaaa
     1141 ttcttacgaa gaccaatgct catacttttt tgataaatac tccaaggatc ttttagttga
     1201 ggctctggct gagatactgc accagaagtt cttagacgct gacttagagg agcgccacca
     1261 tgcatatctg aagcctttcc gaatccttgt cagtctgctg gacaagccgg aaataggacc
     1321 tcaagtggtt gagaatttat ttctggaagt catcagggcc ttttattctt actgccacga
     1381 tgtcctcggc tctgacctta agcttagcta cactcagagt gggaatccac taataagcac
     1441 aatcaaagaa aacagacacg cctcagagat tgtgaagacg gtcaacttgc tagtctcatc
     1501 gctcagctca gacttcctgt gggattacat ggcacggcgt ttcgaggcat gcttcagacc
     1561 agtgacacaa accacggcta ttggagaagc catcagccct ccccccaccg tctcggagct
     1621 ctgcaccctc ctggtgttcc tcctggatgt aattcccttg gaactctact ctgaggtgca
     1681 gactcagtac ctcccacagg tgcttggctg cctgctgcag cctcttgccg aggaggtgga
     1741 ggccctgagc ttacctgagc tcacacacgc cttgaagaca tgtttcaagg tgcttagcaa
     1801 agtccagatg ccgccctcct acctagatct ggagcccagc agcgggaact cgagtccagt
     1861 aaaaggaaga aacagtggca tcgctatgga aacggaggcc gtggtggcgg gtgatgagga
     1921 accttccttt cctccactga agtctgaaga cagtgggatt gggctcagcg cctcgtcgcc
     1981 agagctctct gagcacctca gggtgcctcg ggtgtctgcg gaaagagacg acatctggaa
     2041 gaaagacggg accatgcagg cgacatttct ctgcatccag gagctcattg caaactttgc
     2101 cagcaagaac atctttgcag cgtcgctgac tgtgtctggg gaggaaaaca agcccgagga
     2161 gcccccaggg aagggcaaca agggccagac acagagcacc gagcaccctg gcaggaagag
     2221 ctcctgggac cctaagccca tcaccgtgcc ccagtttaaa cagatgcttt cggacttgtt
     2281 cacggttcga gggtctccct ttaagacaag aagctcagag tcgctgtcgt ctgtgcccag
     2341 cagcccacac aggaaggcag caaccgaatg gggtgttgac caggtggtcg ttgagttggt
     2401 gggctccaag gaagactgca gggaggcctt ggctgccgcc tgccacctgc tgctggactg
     2461 tgccaccttc cctgtgtatc tgtctgagga ggagactgag cagctatgtg agacgctctt
     2521 ccagactcca ggagccagcg attgcagttt tcctccgtgg ctgaaatccc tcatgacaat
     2581 ttgctgctgt gtgagcgact gctccctcca gaacatagcc atcgccacac tgctggaagt
     2641 gataaaccac tcccagtccc tcgctcttgt catcgaagac aagatgaagc gctacaaaac
     2701 ctctgggaac aacccttttt ttggcaagtt acagatggtg acagtccctc ccattgctcc
     2761 tgggatactg aaagtcattg ccgagaaaac agacttctat cagagggtgg ctcgtgtgct
     2821 ctggaaccag ctgaacaagg agacccgtga acatcacatc acctgtgtag agctgttcta
     2881 ccgcctgcac tgcctggccc cgactgccaa catctgtgag gatatcatct gccatgccct
     2941 cctggaccct gacaagggaa caaggttgga agctctgttt aggttttctg tgatctggca
     3001 cctgacacga gaaatccaag gtagtcgtgt gacgtcccac aatcgctcct ttgacaggtc
     3061 cttgtttgtc gtcctggata gcctggcttg cacagacggt gctatcagtg cagcagccca
     3121 gggctggctg gtgcgagcgc tctccctcgg ggatgtggcc cgcatcctcg aacccatgct
     3181 cctgctgttg ctccagccca aaacccagag gacgtccatc cagtgtctca agcaggagaa
     3241 ctcagccgag gatttacacc gttggtttaa caggaagaag cccacgtgca aagaggcgtg
     3301 tggtgaatct gagccgcagg agggtgcccc tgaggaacgc ctgcctcgag gacagttcac
     3361 caccgtggat cgagaagcca tctgggctga agtagagaag gaaccagaga aatgcccacc
     3421 aagaagtgat ctaagtgagg aagacctgcc ctactatgtg gaccttccag acaggatgac
     3481 ctctggtggc ggggatagca gtgagcacac agagtctgca gacacgagct ctggccacac
     3541 tgacagtgag aacacatcca ctttctcatc tccctcccac gatctgcagg acctgagcca
     3601 cgaggaaaac tgctgtgctc cgatccccat cgggggcagg gcatactcca agcgagcggc
     3661 cttgctggca gccttccagc cagaaagccc caggtccaat gccaggttaa gcctggtgcg
     3721 agcagactca gacaagacac aggcttccga gtcgttttcc agtgacgagg aggctgacgt
     3781 ggagctccaa gccatcacca catcgaggct gttgaagcag cagagggaga agcaggagac
     3841 agtcgaggcc ttgttcaaac acatcttgct ctacctgcag ccctacgact cccagagggt
     3901 cctgtatgcc ttctccgtac tggaggccgt gcttaagacc aatcccaagg agttcattga
     3961 ggctgtgtcc aggacgggca tagacaccag ctccaccgcg cacctcaacc tcatctccaa
     4021 cctcctggca cgccaccagg aggccctcat cggccagagc ttttatggca agctgcagac
     4081 ccaggccccc aatgtctgcc cccactccct gctcattgaa ctccttacct acctctgcct
     4141 gagcttcctc cgctcctact acccctgcta cctgaaggtc tgccacaggg acatccttgg
     4201 caaccgcgac gtgcaggtca agagcgtgga ggtcctcatt aggattacag cacagctggt
     4261 ctccatggcc aagtcggcgg aagggaagaa cacggagttc atccacagcc tgctgcagag
     4321 gtgcaaggtc caggagttcg tcctgctctc gctgtccgcg tccatgtaca ccagccagaa
     4381 gcgctacggc ctggccaccg ccgaccgggg cggcaggctc ctcgcggagg acagcctctt
     4441 tgaggagagc ctcatcaatc tggggcagga ccagatctgg agcgagcacc cactgcagat
     4501 cgagctgctc aagctgctgc aggccctcat cgtcctggag caccacctgg gccagggcca
     4561 ggaggaggcg gagactcagc cggccctatc ccgagagtgg cagagggctc tcaacttcca
     4621 gcaggccatc ggtgccatgc agtacgtgca gccccacccc ctcacctccc agggccttct
     4681 ggtctcagct gtggtgagag ggctgcagcc cgcctatggc tacggcatgc accccgcctg
     4741 ggtgagcctg gtcacgcatt ccttgccata ctttggaaag tctctgggct ggacagtgac
     4801 accctttgtt atccagattt gcaaaaattt ggacgatctg gtcaagcaat atgaaagtga
     4861 atctgtcaag ttcaccatca gtacaacctc aaagaaggaa aacatttctc ctgactaccc
     4921 gctcactctt ctggaaggtc ttacgaccat tagccatttt tgtcttttgg aacagcctac
     4981 ccaacataaa aagactgctg ccgtaagcga tcccatcaac ctgagaaatg ccaagaacgc
     5041 cattttggaa gagctacctc gaatagtgaa caccatggcc cttatctgga atgttctcag
     5101 aaaggaggaa actcagaaga gaccagtgga tctcctggga gccaccaaag ggtcatcctc
     5161 tgtttacttt aaaaccacca agaccatcag acaaaaaatt ttagacttgc tgaacccctt
     5221 gacaggccat cttggggtcc agctgatagc tgcggttgcc accgtgtgga acagaaagca
     5281 ggcacggcgc cacagcaaga ccaagatggt ccccgtggca aacacgtccc agcacaccct
     5341 tgtcgacctg gtctgtgctc tcagcaccct gcagacagac tcagtgctgc agctggtgaa
     5401 ggaggtggtg aagaggccag cgcagatcaa aggggatgag aagtctcccc tggtggacat
     5461 tcctgtgttg cagttctgct atgctttcat ccaaagactg tccataccag acctgcagga
     5521 ggccttccct tccctcctgg gcgtcctgaa ggaggctgcg cagctgaacc tggctccccc
     5581 tggatacttt ctgcttctca gcatgttgaa tgactttgtg acaagaacac ccaacctgga
     5641 aagcaagaag gaccaaaaag acctgcagga aatcactcag agaatcctgg aagctgtagg
     5701 taccatcgct ggctcctcct tggaacaaac aagctggctc agcagaaatc tggaggtgaa
     5761 agcccaacct caggtctctc tggaagagtc agatgccgag gacgacgtgc acagtgctgc
     5821 tgaagcctcc accatggtat ctgcttctgc cccctccgtt tacagtgtgc aagcgctctc
     5881 tctcttggca gaggttctgg cttctctcct ggacatggtt taccgcagcg acgagaaaga
     5941 gaaagctgta ccactaatct cccgcttgct atactacgtg tttccttacc tgcgcaatca
     6001 cagtgcgtac aatgctccca gcttccgagc cggcgcccag ctgctgagct ccctgagtgg
     6061 ctatgcctac accaagcggg cgtggaagaa ggaagtgctg gagctgttct tggaccccgc
     6121 tttctttcag atggatacgt cttgcgtcca ctggaagtcc gtcattgacc atctcctgac
     6181 tcacgagaaa accatgttta aggatttaat gaacatgcag agcagttcct taaaactctt
     6241 ctccagcttt gagcagaagg ccatgctgct gaagcgccag gcttttgccg tcttcagtgg
     6301 cgagcttgac cagtaccacc tctaccttcc cctgatacaa gagcgcctga cagacaacct
     6361 cagagtcgga cagacgtcca tagttgctgg tcagatgttt ctttttttca gagttctgct
     6421 gctaagaatc tctccccagc acctgacctc gctgtggccc atcatggtgt ctgaattgat
     6481 ccagacattc atacaacttg aggaagatct gaaagaggaa gatgaatcaa gaaacagcca
     6541 caaaagcaac agaataaaag ccccagttgc tgatggcaat gggtctgcag gcagggtgtt
     6601 gtcccccagc gatctcacca tgtacctctc tgcctgcaag ttcctggaca cagcacttgc
     6661 cttccctcca gacaagatgc ccttgtttca gatttacaga tgggcatttg ttccagaagt
     6721 ggacactgag cacccagcct tcctgtcaga actggaagag aatcaccaag aatgcaggcc
     6781 tcacactgtc aggattctag aacttctgag gtcaagatac ggggaaatcg gcagctccga
     6841 cgagatcacc aggaagaaag agtttcctct tttgcgccaa cattcagttt cctgcatcag
     6901 gcagttgata ccattcttca ccacgttaaa ctgtgctttc aaaacccaaa gccagctgcc
     6961 tgctgatgtg ccaggaaccg cagcgccaga gtgccctgtc acagagaacc cgagggtcct
     7021 gcggcagctg gaggagtgtg tggagcagga ctttctggag catccggagt gttagcgcct
     7081 aggagggctt cttcattctt ctccccaccc ctggccagga cagctgtgtg ctgtaaagaa
     7141 gaggggactg ggggatttga accaaccctg ccacagtcct gaagtgctgt tcaggtattt
     7201 tctgttcagc ggccaaacat gtctccctta aaggccttgt aatatattcc agtcccagtt
     7261 tgtattcttc ctcagtttat gtaatggaaa taaaattaac atatcatcta accacaaaaa
     7321 aaaaaaaaaa a
//
