LOCUS       NM_177208               7908 bp    mRNA    linear   ROD 20-OCT-2024
DEFINITION  Mus musculus DOP1 leucine zipper like protein A (Dop1a), transcript
            variant 1, mRNA.
ACCESSION   NM_177208
VERSION     NM_177208.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7908)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 7908)
  AUTHORS   Nakano,Y., Wiechert,S. and Banfi,B.
  TITLE     Overlapping Activities of Two Neuronal Splicing Factors Switch the
            GABA Effect from Excitatory to Inhibitory by Regulating REST
  JOURNAL   Cell Rep 27 (3), 860-871 (2019)
   PUBMED   30995482
REFERENCE   3  (bases 1 to 7908)
  AUTHORS   Nakano,Y., Jahan,I., Bonde,G., Sun,X., Hildebrand,M.S.,
            Engelhardt,J.F., Smith,R.J., Cornell,R.A., Fritzsch,B. and Banfi,B.
  TITLE     A mutation in the Srrm4 gene causes alternative splicing defects
            and deafness in the Bronx waltzer mouse
  JOURNAL   PLoS Genet 8 (10), e1002966 (2012)
   PUBMED   23055939
REFERENCE   4  (bases 1 to 7908)
  AUTHORS   Bae,S., Ha,T.S., Yoon,Y., Lee,J., Cha,H.J., Yoo,H., Choe,T.B.,
            Li,S., Sohn,I., Kim,J.Y., Kim,C.S., Jin,H.O., Lee,H.C., Park,I.C.,
            Kim,C.S., Jin,Y.W. and Ahn,S.K.
  TITLE     Genome-wide screening and identification of novel proteolytic
            cleavage targets of caspase-8 and -10 in vitro
  JOURNAL   Int J Mol Med 21 (3), 381-386 (2008)
   PUBMED   18288386
  REMARK    GeneRIF: Six putative caspase substrates, including five novel
            proteins (ABCF1, AKAP1, CPE, DOPEY1 and GOPC1) that may be targeted
            specifically by the initiator caspases 8 and 10 during the early
            stages of apoptosis, were identified.[caspase 10]
REFERENCE   5  (bases 1 to 7908)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   6  (bases 1 to 7908)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC157998.2.
            
            On Jun 14, 2022 this sequence version replaced NM_177208.3.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164131,
                              SAMN01164132 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-103               AC157998.2         112400-112502       c
            104-157             AC157998.2         100018-100071       c
            158-348             AC157998.2         94093-94283         c
            349-530             AC157998.2         92261-92442         c
            531-701             AC157998.2         89948-90118         c
            702-891             AC157998.2         87526-87715         c
            892-990             AC157998.2         85202-85300         c
            991-1090            AC157998.2         78801-78900         c
            1091-1200           AC157998.2         77713-77822         c
            1201-1309           AC157998.2         76595-76703         c
            1310-1430           AC157998.2         75399-75519         c
            1431-1550           AC157998.2         73382-73501         c
            1551-1665           AC157998.2         73177-73291         c
            1666-1695           AC157998.2         72796-72825         c
            1696-1929           AC157998.2         71959-72192         c
            1930-2548           AC157998.2         66517-67135         c
            2549-2823           AC157998.2         65597-65871         c
            2824-2976           AC157998.2         64286-64438         c
            2977-3074           AC157998.2         62632-62729         c
            3075-3334           AC157998.2         61283-61542         c
            3335-5321           AC157998.2         57837-59823         c
            5322-5433           AC157998.2         56822-56933         c
            5434-5616           AC157998.2         56560-56742         c
            5617-5742           AC157998.2         55347-55472         c
            5743-5877           AC157998.2         52790-52924         c
            5878-5933           AC157998.2         47926-47981         c
            5934-6038           AC157998.2         46662-46766         c
            6039-6105           AC157998.2         43722-43788         c
            6106-6250           AC157998.2         43437-43581         c
            6251-6330           AC157998.2         43174-43253         c
            6331-6440           AC157998.2         37228-37337         c
            6441-6590           AC157998.2         36812-36961         c
            6591-6652           AC157998.2         36626-36687         c
            6653-6805           AC157998.2         34303-34455         c
            6806-6942           AC157998.2         31390-31526         c
            6943-6998           AC157998.2         30840-30895         c
            6999-7163           AC157998.2         29529-29693         c
            7164-7293           AC157998.2         27921-28050         c
            7294-7908           AC157998.2         25066-25680         c
FEATURES             Location/Qualifiers
     source          1..7908
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 46.58 cM"
     gene            1..7908
                     /gene="Dop1a"
                     /gene_synonym="B130005I07Rik; C130028L17; D9Ertd809e;
                     Dopey1"
                     /note="DOP1 leucine zipper like protein A"
                     /db_xref="GeneID:320615"
                     /db_xref="MGI:MGI:1289294"
     exon            1..103
                     /gene="Dop1a"
                     /gene_synonym="B130005I07Rik; C130028L17; D9Ertd809e;
                     Dopey1"
                     /inference="alignment:Splign:2.1.0"
     exon            104..157
                     /gene="Dop1a"
                     /gene_synonym="B130005I07Rik; C130028L17; D9Ertd809e;
                     Dopey1"
                     /inference="alignment:Splign:2.1.0"
     exon            158..348
                     /gene="Dop1a"
                     /gene_synonym="B130005I07Rik; C130028L17; D9Ertd809e;
                     Dopey1"
                     /inference="alignment:Splign:2.1.0"
     CDS             211..7599
                     /gene="Dop1a"
                     /gene_synonym="B130005I07Rik; C130028L17; D9Ertd809e;
                     Dopey1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein dopey-1; dopey family member 1; protein DOP1A"
                     /codon_start=1
                     /product="protein DOP1A isoform 1"
                     /protein_id="NP_796182.2"
                     /db_xref="CCDS:CCDS52876.1"
                     /db_xref="GeneID:320615"
                     /db_xref="MGI:MGI:1289294"
                     /translation="MNTEELELLSDSKYRNYVAAIDKALKNFEYSSEWADLISALGKL
                     NKVLQNNAKYQVVPKKLTIGKRLAQCLHPALPGGVHRKALETYEIIFKIIGPKRLAKD
                     LFLYSSGLFPLLANAAMSVKPALLGLYEMYYLPLGKTLKPGLQGLLTGILPGLEEGSE
                     YYERTNTLLEKVAAAVEQSAFYSALWGSLLTSPAVRLPGITYVLAHLNRKLSMEDQLY
                     IIGSDIELMVEAVSTSVQDSSVLVQRSTLDLILFCFPFHMSQATRPDMIRILSAALHV
                     VLRRDMSLNRRLYAWLLGFDNNGAIIGPRSTRHSNPEEHATYYFTTFSKELLVQAMVG
                     ILQVNGFGEESTLMQDLKPFRILISLLDKPELGPVILEDVLIEVFRTLYSQCKAELDL
                     QMEPPFSKDHAQLSSKLRENKKTAELIKTANLLFNSFEPYYMWDYIARWFEECCRRTL
                     HARLQVGPGDSSDSSELQLTNFCLLVDFLLDIVSLPTRSMRVLCQETYIEIQTEHLPQ
                     LLLRMISALTSHLQTLRLSELTDSLRLCSKILSKVQPPLLSAGNGGVVQFPSGQNSTV
                     KEWEDKKVSSVSMENPAEVFEDGENPPSSRSSESGFTEFIQYQADRPDDLDRELNGQG
                     AATIPIGSTSSETETASTVGSEETVIQPPSTFTQGAAGRSGKAVQKTAMQCCLEYVQQ
                     FLSRLINLYIIHSDSFPQALAADHQGDFSRIQRETSKWDRDSQGDAKERNIHTPKTSK
                     EYLSAFLAACQLFLECSSFPVYIAEGNHTSESHSEKPDTDCEHAHPPQWLRTLMSACS
                     QARDFRVQSAAVSLVMDLVGLTQSVAMVTGENINSMEPAQPLSPNQGRVAVVIRPPLT
                     QGNLKYIAEKTEFFKHVALTLWDQLGDGTPQHHQKSVELFYQLHNLVPSSSICEDVVS
                     QQLTHKDKKIRMEAHAKFAVLWHLTRDLHINKSSFARSFDRSLFIMLDSLTSLDGSTS
                     SVGQAWLNQVLQRHDIARVLEPLLLLLLHPKTQRVSVQRVQAERYWSKTSCYPGEEND
                     KHFMQNFTCNNVSQVHLIASKGNGEKPLTMDEMENFSLTVNPLSDRLSLLSTSSETIP
                     MVVSDFDLPDQQMEILQSSDSGCSQSSAGDNFSYEVDPENANAHEDSHMAKASSPDDD
                     VQQVVFDLICKVVSGLEAESESVTSELEIESLQTKSSDLDPGKEATKIEDQAPQHSQH
                     VLLSDDSPRFLSVSTEEGCECLANGISRNSSSPCISGTAQTLNDSSVPSETKSRQRSH
                     SSIQFSFKEKLSEKVSEKETIVKESGKQPGAKPKVKLARKKDEDKKKAASEKLKQANV
                     FFSEGLDLENWYSCGEGEISEIESDMGSPGSRKSPNFNIHPLYQHVLLYLQLYDSSRT
                     LYAFSAIKSILKTNPIAFVNAISTTSVNNAYTPQLSLLQNLLARHRISVMGKDFYSHI
                     PVDSNHNFRSSMYIEILISLCLYYMRSHYPTHVKVTTQDLIGNRNMQMMSIEILTLLF
                     TELAKVIESSAKGFPSFISDMLSKCKVQKVILHCLLSSIFSVQKWHSEKTAGKSMVAV
                     EEGFSEDSLINFSEDELDNGSTLQSQLLRVLQRLIVLEHHVMTIPEENEAGFDFVVSD
                     LEHISPHQPMTSLQYLHAQPITCQGMFLCAVIRALHQHCACKMHPQWIGLITSTLPYM
                     GKVLQRVVVSVTLQLCRNLDNLIQQYKYETGLSDSRPLWVASIIPPDMILTLLEGITA
                     IIHYCLLDPTTQYHQLLVNVDQKHLVEARSGILSILHMIMSSVTLLWSILHQADASEK
                     MAVAASASVTTINLGATKNLRQQILELLGPISMNHGVHFMAAIAFVWNERRQNKTPSR
                     TKVIPAASEEQLLLVELVRSISVMRAETVIQTVKEVLKQPPAIAKDKKHLSLEVCMLQ
                     FFYAYIQRIPVPNIVDSWTSLLVLLKDSIQLSLPAPGQFLILGVLNEFIMKNPSLENK
                     KDQRDLQDVTHKIVDAIGAIAGSSLEQTTWLRRNLEVKPSPKIMVDGTNLESDVEDML
                     SPAMETSNITPSVYSVHALTLLSEVLAHLLDMVFYSDEKERVIPLLVNIMHYVVPYLR
                     NHSAHNAPSYRACVQLLSSLSGYQYTRRAWKKEAFDLFMDPSFFQMDASCVSHWRAIM
                     DNLMTHDKTTFRDLMTRVAVAQSSSLNLFANRDVELEQRAMLLKRLAFAVLSSESDQY
                     QKYLPDIQERLVESLRLPQVPTLHSQVFLFFRVLLLRMSPQHLTSLWPTMITELVQVF
                     LLMEQELTADEDISRTSGPSAAGLETTYTGGNGFSTSYNSQRWLNLYLSACKFLDLAL
                     ALPSENLPQFQMYRWAFIPEASDDSGLEVRRQGIHQREFKPYVVRLAKLLRKRAKKNP
                     EEDCSGRTLGWEPGHLLLTLCTMRNMEQLLPFFNVLSQVFNSKVTSRCGGHSGSPVLY
                     PNSFPNKDMKLENHKAFSSKARQKIEEMIEKDFLEGVIKT"
     exon            349..530
                     /gene="Dop1a"
                     /gene_synonym="B130005I07Rik; C130028L17; D9Ertd809e;
                     Dopey1"
                     /inference="alignment:Splign:2.1.0"
     exon            531..701
                     /gene="Dop1a"
                     /gene_synonym="B130005I07Rik; C130028L17; D9Ertd809e;
                     Dopey1"
                     /inference="alignment:Splign:2.1.0"
     exon            702..891
                     /gene="Dop1a"
                     /gene_synonym="B130005I07Rik; C130028L17; D9Ertd809e;
                     Dopey1"
                     /inference="alignment:Splign:2.1.0"
     exon            892..990
                     /gene="Dop1a"
                     /gene_synonym="B130005I07Rik; C130028L17; D9Ertd809e;
                     Dopey1"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1090
                     /gene="Dop1a"
                     /gene_synonym="B130005I07Rik; C130028L17; D9Ertd809e;
                     Dopey1"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1200
                     /gene="Dop1a"
                     /gene_synonym="B130005I07Rik; C130028L17; D9Ertd809e;
                     Dopey1"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1309
                     /gene="Dop1a"
                     /gene_synonym="B130005I07Rik; C130028L17; D9Ertd809e;
                     Dopey1"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1430
                     /gene="Dop1a"
                     /gene_synonym="B130005I07Rik; C130028L17; D9Ertd809e;
                     Dopey1"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1550
                     /gene="Dop1a"
                     /gene_synonym="B130005I07Rik; C130028L17; D9Ertd809e;
                     Dopey1"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..1665
                     /gene="Dop1a"
                     /gene_synonym="B130005I07Rik; C130028L17; D9Ertd809e;
                     Dopey1"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..1695
                     /gene="Dop1a"
                     /gene_synonym="B130005I07Rik; C130028L17; D9Ertd809e;
                     Dopey1"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..1929
                     /gene="Dop1a"
                     /gene_synonym="B130005I07Rik; C130028L17; D9Ertd809e;
                     Dopey1"
                     /inference="alignment:Splign:2.1.0"
     exon            1930..2548
                     /gene="Dop1a"
                     /gene_synonym="B130005I07Rik; C130028L17; D9Ertd809e;
                     Dopey1"
                     /inference="alignment:Splign:2.1.0"
     exon            2549..2823
                     /gene="Dop1a"
                     /gene_synonym="B130005I07Rik; C130028L17; D9Ertd809e;
                     Dopey1"
                     /inference="alignment:Splign:2.1.0"
     exon            2824..2976
                     /gene="Dop1a"
                     /gene_synonym="B130005I07Rik; C130028L17; D9Ertd809e;
                     Dopey1"
                     /inference="alignment:Splign:2.1.0"
     exon            2977..3074
                     /gene="Dop1a"
                     /gene_synonym="B130005I07Rik; C130028L17; D9Ertd809e;
                     Dopey1"
                     /inference="alignment:Splign:2.1.0"
     exon            3075..3334
                     /gene="Dop1a"
                     /gene_synonym="B130005I07Rik; C130028L17; D9Ertd809e;
                     Dopey1"
                     /inference="alignment:Splign:2.1.0"
     exon            3335..5321
                     /gene="Dop1a"
                     /gene_synonym="B130005I07Rik; C130028L17; D9Ertd809e;
                     Dopey1"
                     /inference="alignment:Splign:2.1.0"
     exon            5322..5433
                     /gene="Dop1a"
                     /gene_synonym="B130005I07Rik; C130028L17; D9Ertd809e;
                     Dopey1"
                     /inference="alignment:Splign:2.1.0"
     exon            5434..5616
                     /gene="Dop1a"
                     /gene_synonym="B130005I07Rik; C130028L17; D9Ertd809e;
                     Dopey1"
                     /inference="alignment:Splign:2.1.0"
     exon            5617..5742
                     /gene="Dop1a"
                     /gene_synonym="B130005I07Rik; C130028L17; D9Ertd809e;
                     Dopey1"
                     /inference="alignment:Splign:2.1.0"
     exon            5743..5877
                     /gene="Dop1a"
                     /gene_synonym="B130005I07Rik; C130028L17; D9Ertd809e;
                     Dopey1"
                     /inference="alignment:Splign:2.1.0"
     exon            5878..5933
                     /gene="Dop1a"
                     /gene_synonym="B130005I07Rik; C130028L17; D9Ertd809e;
                     Dopey1"
                     /inference="alignment:Splign:2.1.0"
     exon            5934..6038
                     /gene="Dop1a"
                     /gene_synonym="B130005I07Rik; C130028L17; D9Ertd809e;
                     Dopey1"
                     /inference="alignment:Splign:2.1.0"
     exon            6039..6105
                     /gene="Dop1a"
                     /gene_synonym="B130005I07Rik; C130028L17; D9Ertd809e;
                     Dopey1"
                     /inference="alignment:Splign:2.1.0"
     exon            6106..6250
                     /gene="Dop1a"
                     /gene_synonym="B130005I07Rik; C130028L17; D9Ertd809e;
                     Dopey1"
                     /inference="alignment:Splign:2.1.0"
     exon            6251..6330
                     /gene="Dop1a"
                     /gene_synonym="B130005I07Rik; C130028L17; D9Ertd809e;
                     Dopey1"
                     /inference="alignment:Splign:2.1.0"
     exon            6331..6440
                     /gene="Dop1a"
                     /gene_synonym="B130005I07Rik; C130028L17; D9Ertd809e;
                     Dopey1"
                     /inference="alignment:Splign:2.1.0"
     exon            6441..6590
                     /gene="Dop1a"
                     /gene_synonym="B130005I07Rik; C130028L17; D9Ertd809e;
                     Dopey1"
                     /inference="alignment:Splign:2.1.0"
     exon            6591..6652
                     /gene="Dop1a"
                     /gene_synonym="B130005I07Rik; C130028L17; D9Ertd809e;
                     Dopey1"
                     /inference="alignment:Splign:2.1.0"
     exon            6653..6805
                     /gene="Dop1a"
                     /gene_synonym="B130005I07Rik; C130028L17; D9Ertd809e;
                     Dopey1"
                     /inference="alignment:Splign:2.1.0"
     exon            6806..6942
                     /gene="Dop1a"
                     /gene_synonym="B130005I07Rik; C130028L17; D9Ertd809e;
                     Dopey1"
                     /inference="alignment:Splign:2.1.0"
     exon            6943..6998
                     /gene="Dop1a"
                     /gene_synonym="B130005I07Rik; C130028L17; D9Ertd809e;
                     Dopey1"
                     /inference="alignment:Splign:2.1.0"
     exon            6999..7163
                     /gene="Dop1a"
                     /gene_synonym="B130005I07Rik; C130028L17; D9Ertd809e;
                     Dopey1"
                     /inference="alignment:Splign:2.1.0"
     exon            7164..7293
                     /gene="Dop1a"
                     /gene_synonym="B130005I07Rik; C130028L17; D9Ertd809e;
                     Dopey1"
                     /inference="alignment:Splign:2.1.0"
     exon            7294..7908
                     /gene="Dop1a"
                     /gene_synonym="B130005I07Rik; C130028L17; D9Ertd809e;
                     Dopey1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7881..7886
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dop1a"
                     /gene_synonym="B130005I07Rik; C130028L17; D9Ertd809e;
                     Dopey1"
                     /note="hexamer: AATACA"
     polyA_site      7908
                     /gene="Dop1a"
                     /gene_synonym="B130005I07Rik; C130028L17; D9Ertd809e;
                     Dopey1"
                     /note="major polyA site"
ORIGIN      
        1 gcacgctggt agctgtcact aggccctggg ctggcggcct tcgtgcggct gccgcggttg
       61 ccaagagagc ggcgccagcg gggagcagca gagcccgcgg cagatgagga aacccagact
      121 tgagaaaact aagtgcttag ttcaaaccat tcatctggga atgattttgc atgactttgg
      181 aactggtgtc tagtagaaca cggtgggaga atgaacacag aagagctaga gttattgagt
      241 gactccaaat acagaaacta tgtagctgcc attgacaaag cactaaagaa ttttgaatac
      301 tccagtgaat gggcagactt gatctcagca cttggaaaac tcaacaaggt tttacaaaat
      361 aatgccaagt accaggtagt acccaaaaaa ctgaccatag gcaaacgcct agctcaatgt
      421 ctgcacccag cattaccagg tggggttcat cggaaagcac ttgaaaccta tgaaatcatc
      481 ttcaaaatca ttggccctaa gcgacttgcc aaagatctct ttttatatag ttctgggttg
      541 tttcctcttc ttgccaatgc tgctatgtct gtgaagccag cactgctcgg tttgtatgag
      601 atgtactact tgcccttggg gaaaaccctg aaacctggtc tccaggggtt gctgactggt
      661 atccttcctg gcttagaaga agggtcggag tattatgaga gaacaaacac cctgctggaa
      721 aaggttgctg cggctgtaga gcagtctgca ttctacagtg ccctatgggg cagtctgctc
      781 accagtcctg ctgtgcgctt acctggaatc acatatgttc tggcccatct gaacaggaaa
      841 ctttcaatgg aagatcagct gtatataatt ggcagcgaca ttgagctcat ggtagaagca
      901 gtaagcactt cagtgcagga ctcgagtgta cttgtacaga gaagcacgct ggacctcatc
      961 ctcttctgtt tcccattcca tatgagtcag gccactcgac cagatatgat caggatcttg
     1021 tcagcagccc ttcatgtagt actaaggagg gatatgtcct tgaaccgaag actttatgca
     1081 tggcttcttg gttttgataa caacggtgct atcataggac caaggagcac acgacacagt
     1141 aatcctgaag aacacgccac ttactatttt acaacctttt caaaagaatt gttagtccag
     1201 gccatggtgg ggatcttaca agtgaatgga tttggagaag aaagcactct catgcaggat
     1261 ctaaaacctt ttcgtatttt aatcagttta ttggacaaac ctgaactagg acctgtaatc
     1321 ctagaagatg ttctgattga ggtgtttaga actttgtatt ctcagtgcaa agcagaattg
     1381 gatcttcaga tggaaccacc cttcagcaag gaccatgctc aattaagcag taaattaagg
     1441 gaaaataaga aaacagccga actgattaaa actgcaaatc tgctttttaa ttccttcgaa
     1501 ccttattata tgtgggatta cattgcacgc tggtttgaag aatgttgtcg gagaactctg
     1561 cacgccagac ttcaggttgg acctggagac agtagtgatt cgtctgagtt acaactgact
     1621 aatttctgct tactggtgga ttttttgttg gatatagtct ccttgcctac tagaagtatg
     1681 agggtgctgt gtcaggagac ctatattgaa atccagacag aacacctgcc ccagttactg
     1741 cttagaatga tttctgcctt gacaagccat ctccagacat tgcgcttatc tgagctcaca
     1801 gactctttaa ggctctgctc gaagatcctt agcaaggttc agcccccatt gttatctgct
     1861 ggcaatggag gtgtggtaca gtttccaagt gggcagaaca gtacagtcaa agaatgggaa
     1921 gacaaaaagg tatcatcagt ttctatggaa aatcctgctg aagtatttga agatggagaa
     1981 aatccaccaa gtagtcgatc atcagaaagt gggttcactg agtttatcca gtatcaagca
     2041 gaccggcctg acgacctcga cagagagctg aatggacagg gggcagctac catcccaatt
     2101 ggcagcacat cttcggaaac agaaacagca tccacagtgg gttctgagga aaccgtcatc
     2161 cagccacctt ccaccttcac tcagggggca gcaggccgaa gcgggaaggc ggtacagaag
     2221 actgcaatgc agtgctgctt ggagtatgtc cagcagtttc tttccaggct catcaacctc
     2281 tacatcatcc acagtgactc ctttcctcaa gctttggctg cagatcatca gggagacttc
     2341 agtcgaatac aaagggagac ttcaaaatgg gacagggatt cccaagggga tgcaaaagaa
     2401 agaaacatac atactccaaa aacatcaaaa gaataccttt ctgccttcct tgctgcctgt
     2461 cagctcttct tagagtgctc aagtttccca gtctacatcg ctgagggaaa ccatacatca
     2521 gagtcacatt ctgagaaacc ggacactgac tgtgagcacg cccaccctcc acagtggctc
     2581 cggacgctga tgagcgcttg cagccaagca cgtgatttca gggttcagag tgctgctgtg
     2641 tctctagtca tggacctggt gggactgact caatctgttg ccatggtcac tggagaaaac
     2701 atcaacagca tggagcctgc acaacccttg agtccaaacc aaggaagagt ggctgtggtt
     2761 attagacctc ccctcacaca gggcaacctg aagtatatag ctgagaagac tgaatttttc
     2821 aagcatgtgg ccttaacatt atgggaccag ctgggagatg ggacacctca gcaccatcag
     2881 aagagtgtgg aactatttta tcaattacat aatttggttc cttcttctag catctgtgag
     2941 gacgttgtaa gtcagcagtt aacccataaa gacaagaaaa taaggatgga agcacatgca
     3001 aaatttgcag ttctttggca tctaacaagg gatctccaca taaataagtc atcttttgca
     3061 cgttcctttg acaggtcact gttcatcatg ctagatagcc ttactagttt agatggttct
     3121 acgagctctg tgggacaagc ctggctgaac caggtgctac aaaggcatga cattgcaagg
     3181 gtgctggaac cactgttact gctcctgctt catccaaaaa ctcagagggt ttcagtgcag
     3241 cgggtacaag cagaacggta ctggagtaag acgtcctgtt atccaggaga ggaaaatgat
     3301 aagcatttca tgcaaaattt tacctgcaac aatgtaagcc aagtgcacct cattgcatcc
     3361 aaaggaaatg gtgaaaagcc ccttaccatg gatgaaatgg agaatttcag tcttactgtt
     3421 aatccattga gtgatagact ttccctccta agcaccagca gcgagacgat tccaatggtt
     3481 gtatctgact ttgacctccc agatcagcag atggaaatac ttcagagctc tgactctgga
     3541 tgctcacagt cttctgctgg agacaacttt agttacgaag ttgatcctga aaatgcgaat
     3601 gcccatgaag attctcacat ggcaaaggca agctccccag atgatgatgt tcagcaagtt
     3661 gtctttgacc tgatatgtaa agttgtgagt ggcctggaag cagagtctga atcagttaca
     3721 tctgaattag aaatcgaatc tctgcaaaca aagagtagtg acttagatcc aggtaaagaa
     3781 gcaactaaga ttgaagacca ggcccctcaa cacagccagc atgttttgct gagcgatgac
     3841 agccctcggt ttctgtctgt gtctacagag gaaggctgtg agtgcttggc caatggaatc
     3901 tccagaaata gctcctcacc ttgcatttca ggaacagcac agactctgaa cgattcttct
     3961 gttccctcag aaaccaaatc tagacagagg agtcacagta gtattcaatt tagcttcaaa
     4021 gaaaaattat cagaaaaagt ctcagagaaa gaaacaattg ttaaggaatc aggtaaacaa
     4081 ccaggtgcaa aacccaaagt aaagctggcc aggaaaaaag atgaggacaa gaaaaaagct
     4141 gcaagtgaga aactgaagca agcaaatgtc ttcttcagtg agggcctgga cttagagaac
     4201 tggtacagct gtggggaggg cgaaatttct gaaattgaga gtgacatggg ttctccagga
     4261 tctaggaaat ctcccaactt caacatccat cctctctatc aacacgtgct cctgtatctg
     4321 cagctgtatg attcatcgag gactctgtat gctttttctg ccatcaaatc catcttgaaa
     4381 actaacccca ttgcttttgt aaacgccatt tcaacaacaa gtgtaaacaa tgcatacacc
     4441 cctcagctgt ctctgcttca gaacctgctg gctagacacc gaatctctgt tatgggcaaa
     4501 gacttttaca gtcacattcc agtggattca aaccataact tccggagttc catgtacatt
     4561 gaaattctta tttccctctg cttatattat atgcgtagcc attacccaac tcatgtcaag
     4621 gtcactaccc aagacttaat aggcaatcga aacatgcaaa tgatgagcat agaaatcttg
     4681 actctcctct ttacagagct agcaaaagta atagagagct ctgcaaaggg tttccctagt
     4741 tttatctctg atatgctgtc taagtgcaaa gttcagaaag tgattcttca ttgtttgctg
     4801 tcgtctatct tcagcgtaca aaagtggcac agtgagaaaa cagcaggtaa gagcatggtt
     4861 gctgtggagg agggcttctc agaagacagc ctcatcaatt tctcagagga tgaacttgac
     4921 aatggcagca cactgcagtc gcagcttctg agggtgcttc agaggctgat tgttctagag
     4981 caccacgtga tgactattcc tgaggagaat gaagcaggct ttgattttgt tgtgtctgat
     5041 ctggaacata tcagtcccca tcagcccatg acttctcttc agtatttaca tgctcagcca
     5101 atcacatgtc aaggcatgtt cctctgtgca gtgattagag ctttgcatca gcactgtgca
     5161 tgtaagatgc atccacaatg gattggctta atcacttcca ctctgcctta catgggaaaa
     5221 gttctacaaa gagtcgtggt ttctgtgaca ctacagctgt gcaggaattt ggataatcta
     5281 attcagcagt acaaatacga aacaggatta tctgatagta ggcctttgtg ggtggcatca
     5341 attatcccac cagatatgat tcttactctt ttggaaggaa tcacagccat tatccattac
     5401 tgcttgctgg atccgactac ccagtatcat caacttttgg tcaatgtaga tcagaaacac
     5461 ttggttgaag ctcgcagtgg aatcctctca atccttcaca tgatcatgtc ctctgtaact
     5521 ctgctttgga gcatactgca ccaggctgat gcttcagaaa agatggcagt tgctgcatcc
     5581 gcgtctgtta ctacaatcaa tctgggagcc acaaagaact tgagacaaca aatcctggaa
     5641 ttactgggac ccatttcaat gaatcatggt gttcatttca tggctgccat tgcatttgta
     5701 tggaatgaaa gaagacagaa caaaacccct tccagaacaa aggtcatccc tgcagccagt
     5761 gaagaacagc ttttactagt agaactggtt cgctccatca gtgtcatgag ggcagaaact
     5821 gttatccaga ctgtgaaaga agttttaaag cagcctccag ccatagccaa ggacaagaaa
     5881 catctttctc tggaagtctg catgcttcag tttttctacg cttatataca aagaattcca
     5941 gtgcccaata tagtggacag ttggacatca ttattggtcc ttctaaaaga ttctatacag
     6001 ctgagtctgc cagccccagg gcagtttctt atacttgggg ttttgaatga gtttattatg
     6061 aaaaacccta gtttggaaaa taaaaaggac caaagagacc ttcaggatgt gactcacaaa
     6121 atagtggatg ctattggtgc aattgctggt tcctctctgg aacagacaac atggctccga
     6181 cggaatctgg aagttaagcc ttctcccaaa ataatggtgg atggaaccaa tttagagtct
     6241 gatgttgaag atatgttatc ccctgcaatg gaaacctcaa acataactcc ttctgtatat
     6301 agtgtccatg cactgacgtt gctctcagag gtattggctc atcttctgga tatggttttc
     6361 tacagcgatg aaaaagagcg tgttatccct ttacttgtaa acattatgca ttatgttgta
     6421 ccctacctcc gaaatcacag tgcacataat gcccctagtt accgagcctg tgtccagctg
     6481 ctcagtagtc ttagtgggta tcagtataca aggagagcct ggaaaaaaga agcctttgac
     6541 ctttttatgg atcccagctt ctttcagatg gatgcttcct gtgttagtca ctggagagca
     6601 atcatggaca acctgatgac acatgataag acaaccttca gagatttgat gactcgagta
     6661 gccgtggccc agagcagttc tctcaatctt tttgcaaacc gggatgtgga gctagaacag
     6721 cgagccatgc ttctcaaaag actggccttc gccgttctta gcagtgaaag tgaccagtac
     6781 caaaagtacc ttccagacat acaagagaga ttggttgaga gtctccgttt gccccaggtg
     6841 ccgacccttc actctcaagt gttcctgttt ttcagagtgt tacttttaag aatgtctcca
     6901 caacacctca cctcactctg gcctaccatg atcacagaac ttgtgcaggt gttcttactg
     6961 atggagcagg agctcactgc tgatgaagat atttcacgga cgtcagggcc gtctgctgct
     7021 ggtctggaga caacctatac tggaggtaat ggcttctcca catcatataa cagccagagg
     7081 tggttaaacc tctatctctc tgcttgcaag tttttggatt tggctctggc attgccctct
     7141 gaaaatcttc ctcagtttca gatgtaccga tgggccttta ttcctgaagc ttcagatgac
     7201 tcgggcttag aagtcagaag gcagggcata catcagcgag aatttaagcc atatgtggtt
     7261 cgactagcaa aacttcttcg gaagagggca aagaaaaacc cagaggaaga ctgctcgggg
     7321 aggacactgg gctgggagcc agggcacttg ctgctgacgc tctgcaccat gcgcaacatg
     7381 gagcagcttc tgcctttctt caatgtcctc agccaagtct tcaacagcaa agtcacaagc
     7441 cgctgtggcg gacactcagg gagccccgtc ctctacccaa actccttccc aaacaaggac
     7501 atgaaactgg agaatcacaa agccttttcc agcaaagcca ggcaaaaaat tgaagagatg
     7561 atagaaaagg actttctaga aggagtcata aagacttgac caccaccagt ggttctccag
     7621 agcctaaatg gaatacttaa aacacactgc tgagttgtat agtttctttt tcttttatat
     7681 atatatatat gtgtatatgt aacaaagcat tattcaggtt gtatttaatt taaatatttg
     7741 taaataagag cttatgtctg aatgtggcct gaatcaagtt taaatatata ggtggctcat
     7801 actgatgatg gtgcctacaa ggtctatatt tgcatatata gtccattgtt tcactgtctt
     7861 gggttgtctt aaacctgcaa aatacacacc acgttttctt ttttcctg
//
