LOCUS       NM_021720               2336 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus downstream neighbor of SON (Donson), mRNA.
ACCESSION   NM_021720
VERSION     NM_021720.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2336)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2336)
  AUTHORS   Lim,Y., Tamayo-Orrego,L., Schmid,E., Tarnauskaite,Z.,
            Kochenova,O.V., Gruar,R., Muramatsu,S., Lynch,L., Schlie,A.V.,
            Carroll,P.L., Chistol,G., Reijns,M.A.M., Kanemaki,M.T.,
            Jackson,A.P. and Walter,J.C.
  TITLE     In silico protein interaction screening uncovers DONSON's role in
            replication initiation
  JOURNAL   Science 381 (6664), eadi3448 (2023)
   PUBMED   37590370
REFERENCE   3  (bases 1 to 2336)
  AUTHORS   Venkataramanappa,S., Schutz,D., Saaber,F., Kumar,P.A., Abe,P.,
            Schulz,S. and Stumm,R.
  TITLE     The microcephaly gene Donson is essential for progenitors of
            cortical glutamatergic and GABAergic neurons
  JOURNAL   PLoS Genet 17 (3), e1009441 (2021)
   PUBMED   33739968
  REMARK    GeneRIF: The microcephaly gene Donson is essential for progenitors
            of cortical glutamatergic and GABAergic neurons.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2336)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2336)
  AUTHORS   Evrony,G.D., Cordero,D.R., Shen,J., Partlow,J.N., Yu,T.W.,
            Rodin,R.E., Hill,R.S., Coulter,M.E., Lam,A.N., Jayaraman,D.,
            Gerrelli,D., Diaz,D.G., Santos,C., Morrison,V., Galli,A.,
            Tschulena,U., Wiemann,S., Martel,M.J., Spooner,B., Ryu,S.C.,
            Elhosary,P.C., Richardson,J.M., Tierney,D., Robinson,C.A.,
            Chibbar,R., Diudea,D., Folkerth,R., Wiebe,S., Barkovich,A.J.,
            Mochida,G.H., Irvine,J., Lemire,E.G., Blakley,P. and Walsh,C.A.
  TITLE     Integrated genome and transcriptome sequencing identifies a
            noncoding mutation in the genome replication factor DONSON as the
            cause of microcephaly-micromelia syndrome
  JOURNAL   Genome Res 27 (8), 1323-1335 (2017)
   PUBMED   28630177
REFERENCE   6  (bases 1 to 2336)
  AUTHORS   Gitton,Y., Dahmane,N., Baik,S., Ruiz i Altaba,A., Neidhardt,L.,
            Scholze,M., Herrmann,B.G., Kahlem,P., Benkahla,A., Schrinner,S.,
            Yildirimman,R., Herwig,R., Lehrach,H. and Yaspo,M.L.
  CONSRTM   HSA21 expression map initiative
  TITLE     A gene expression map of human chromosome 21 orthologues in the
            mouse
  JOURNAL   Nature 420 (6915), 586-590 (2002)
   PUBMED   12466855
REFERENCE   7  (bases 1 to 2336)
  AUTHORS   Reymond,A., Marigo,V., Yaylaoglu,M.B., Leoni,A., Ucla,C.,
            Scamuffa,N., Caccioppoli,C., Dermitzakis,E.T., Lyle,R., Banfi,S.,
            Eichele,G., Antonarakis,S.E. and Ballabio,A.
  TITLE     Human chromosome 21 gene expression atlas in the mouse
  JOURNAL   Nature 420 (6915), 582-586 (2002)
   PUBMED   12466854
REFERENCE   8  (bases 1 to 2336)
  AUTHORS   Wynn,S.L., Fisher,R.A., Pagel,C., Price,M., Liu,Q.Y., Khan,I.M.,
            Zammit,P., Dadrah,K., Mazrani,W., Kessling,A., Lee,J.S. and
            Buluwela,L.
  TITLE     Organization and conservation of the GART/SON/DONSON locus in mouse
            and human genomes
  JOURNAL   Genomics 68 (1), 57-62 (2000)
   PUBMED   10950926
REFERENCE   9  (bases 1 to 2336)
  AUTHORS   Sund,N.J., Ang,S.L., Sackett,S.D., Shen,W., Daigle,N.,
            Magnuson,M.A. and Kaestner,K.H.
  TITLE     Hepatocyte nuclear factor 3beta (Foxa2) is dispensable for
            maintaining the differentiated state of the adult hepatocyte
  JOURNAL   Mol Cell Biol 20 (14), 5175-5183 (2000)
   PUBMED   10866673
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC043316.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC043316.1, SRR7652917.162264.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142, SAMN01164143
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2336
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="FVB/N"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 53.25 cM"
     gene            1..2336
                     /gene="Donson"
                     /gene_synonym="1110025J21Rik; ORF60"
                     /note="downstream neighbor of SON"
                     /db_xref="GeneID:60364"
                     /db_xref="MGI:MGI:1890621"
     exon            1..322
                     /gene="Donson"
                     /gene_synonym="1110025J21Rik; ORF60"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..1699
                     /gene="Donson"
                     /gene_synonym="1110025J21Rik; ORF60"
                     /note="protein 3SG"
                     /codon_start=1
                     /product="protein downstream neighbor of Son"
                     /protein_id="NP_068366.1"
                     /db_xref="CCDS:CCDS28330.1"
                     /db_xref="GeneID:60364"
                     /db_xref="MGI:MGI:1890621"
                     /translation="MAVSVPGYSPSFKRPPETVRLRRKRSRDHGAAVPASLPEPAPRR
                     AALAAGLPLRPFPTAGGRGGAAATIARRNPFARLDNRPRVSDEASEEPLRGPQGASGP
                     LLDSNEENNLLWEDTSSHERTGTELSQSQRVSLSESDTWSSDGTELPVDWSIKTRLLF
                     TSSQPFSWADHLKAQEEAQGLVQHCRATEVTLPQSIQDPKLSTALRCAFQQALVYWLH
                     PAFSWLPLFPRIGADRKMAAKTSPWSADETLQHALMSDWSVSFTSLYNLLKTKLCPYF
                     YVCSYQFTVLFRAAGLAGSSVITALISPTTRGLREAMRNEGIEFSLPLLEEIGHKKKV
                     RDPSLESEEEQAVSDEDEEESFSWLEEIGVQDQIKKPDVISIKLRKEKHEVQMDHRPE
                     SVVLVKGLNTFKLLNFLINCKSLVATSGAQAGLPPTLLSPIAFRGASMQMLKARSSNV
                     KTQALSGYRDKFSLDITGPVMPHALHSMSMLLRSSQRGSFSAGLYAHEPTAVFNVGLS
                     LDKELDRKVAREDLANCGLHPKTLEQLSQRPVLGKSSLRSVEMSDYILSWRS"
     exon            323..403
                     /gene="Donson"
                     /gene_synonym="1110025J21Rik; ORF60"
                     /inference="alignment:Splign:2.1.0"
     exon            404..607
                     /gene="Donson"
                     /gene_synonym="1110025J21Rik; ORF60"
                     /inference="alignment:Splign:2.1.0"
     exon            608..786
                     /gene="Donson"
                     /gene_synonym="1110025J21Rik; ORF60"
                     /inference="alignment:Splign:2.1.0"
     exon            787..965
                     /gene="Donson"
                     /gene_synonym="1110025J21Rik; ORF60"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1044
                     /gene="Donson"
                     /gene_synonym="1110025J21Rik; ORF60"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1149
                     /gene="Donson"
                     /gene_synonym="1110025J21Rik; ORF60"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1348
                     /gene="Donson"
                     /gene_synonym="1110025J21Rik; ORF60"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1561
                     /gene="Donson"
                     /gene_synonym="1110025J21Rik; ORF60"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..2323
                     /gene="Donson"
                     /gene_synonym="1110025J21Rik; ORF60"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2010..2015
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Donson"
                     /gene_synonym="1110025J21Rik; ORF60"
                     /note="hexamer: ATTACA"
     polyA_site      2028
                     /gene="Donson"
                     /gene_synonym="1110025J21Rik; ORF60"
                     /note="major polyA site"
ORIGIN      
        1 gcctcggtgc tgcgcaatgg ctgtctcggt gcccggctac tcgcctagct tcaagaggcc
       61 gcctgagacc gtgcggctcc gccggaaaag gtctcgggac catggtgccg ccgtgcccgc
      121 ctcactgccg gagcccgcgc cccgccgcgc cgcgctggcg gctgggctgc ccttgcgccc
      181 cttcccgacc gccggcggca gaggaggcgc cgccgcgacc atcgcccgca ggaacccttt
      241 cgctcgcctg gacaaccggc cgcgagtctc ggacgaggcc agcgaagagc cgctccgcgg
      301 tcctcagggg gcgtcgggcc cgcttctaga ttctaatgaa gaaaataact tgctgtggga
      361 ggacacatca tctcatgaaa gaactggcac ggaactgtcc cagagtcaac gtgtatcgtt
      421 gtctgaatcg gacacttggt cgtcagatgg tactgagtta cctgtggact ggagtattaa
      481 aacccgactc cttttcacct cttctcaacc cttttcctgg gcagatcatc tgaaagcaca
      541 ggaagaagcc caaggacttg tccagcattg tagggcaaca gaagtgactt taccccagag
      601 tatacaggat cccaaactgt ccactgcgct gcgctgcgcc ttccagcagg ctctggtcta
      661 ctggcttcac cctgcctttt cgtggctgcc actcttccct agaattggag ctgataggaa
      721 aatggctgca aagacaagtc cgtggtcagc tgatgaaacc ctgcagcatg ctttaatgag
      781 cgactggtct gtgagtttca catctctgta taacctgctg aagacaaagc tttgtcccta
      841 tttctatgtc tgctcctatc agttcaccgt cctgttccgg gcagcaggac tggccggaag
      901 cagtgtgatc acagcgctca tatcccctac gacaagaggc ttaagagaag ctatgagaaa
      961 cgaaggtatt gaattttctc tgcctttact agaagaaatt ggccataaga agaaagttcg
     1021 agacccaagc ctggaatctg aggaggagca ggcagtcagt gacgaagatg aagaggagag
     1081 tttttcttgg ctggaagaga taggcgtgca agatcaaatt aagaagccag acgtgatctc
     1141 tatcaagcta cgtaaagaaa aacatgaagt acaaatggac cacagacctg agtctgtcgt
     1201 actggtgaaa ggactcaaca ccttcaaact gctcaatttt ttgatcaact gcaagagttt
     1261 agttgctacc tcaggtgcac aggcaggtct cccacccact ctcttatccc caatagcctt
     1321 ccgaggtgcc tcaatgcaaa tgcttaaggc acggagcagt aatgtaaaga cacaagctct
     1381 ttctggatac agagataagt ttagtttgga tatcacaggg cctgtcatgc ctcatgcatt
     1441 gcattctatg agcatgctac tccgatcttc acagagaggg tccttctctg caggactgta
     1501 tgcacacgag ccaactgcag ttttcaatgt tggcctgtct ctggataaag aactggacag
     1561 aaaagttgct cgtgaggacc ttgctaattg tgggctgcat cctaaaaccc tggagcagct
     1621 cagtcagagg ccagtgctgg ggaagtcatc cctgcggagt gtggaaatga gtgactacat
     1681 tttaagttgg agatcctgaa caccaaagta agcctaaaag gagtctgagg aaaaagcttc
     1741 ctagcaagga aatgcaagat gcgtaggccc ctggctttta aagttcattc ggaagaatat
     1801 attttaaaat actgaaatgt tcctaaacat ttttatatta acttattaca tgcaatagca
     1861 ttaggtttta aatcaagatt ttgcttttat tattttcata cattttcaga gatgaagatg
     1921 caaggagctt ccttaatacc tcagataatt caaataagag ttctatccct gcaacttatt
     1981 gttaacctga gtagaaaagt cagtgtttta ttacaattga gaaacagact acctgtagca
     2041 attattccaa tggagactaa agcatccaca ttgtacctta gacgagcagt gagttctttc
     2101 aagacgtagg gaaatgagca tttttactaa tgatttctag ttcctctgct ctcacgtatg
     2161 ttcatcttct gtgtcaagtc agaggggagg ctactttgta cttcatctaa gtgctgggcc
     2221 ctcagccatg tcaacttact acttagtatg cttacaggta atctgtgttt gcatgtgtgt
     2281 ataaaattca gtatttttaa ataaacgtgc atagaaatca caaaaaaaaa aaaaaa
//
