LOCUS       NP_068366                560 aa            linear   ROD 27-APR-2025
DEFINITION  protein downstream neighbor of Son [Mus musculus].
ACCESSION   NP_068366
VERSION     NP_068366.1
DBSOURCE    REFSEQ: accession NM_021720.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 560)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 560)
  AUTHORS   Lim,Y., Tamayo-Orrego,L., Schmid,E., Tarnauskaite,Z.,
            Kochenova,O.V., Gruar,R., Muramatsu,S., Lynch,L., Schlie,A.V.,
            Carroll,P.L., Chistol,G., Reijns,M.A.M., Kanemaki,M.T.,
            Jackson,A.P. and Walter,J.C.
  TITLE     In silico protein interaction screening uncovers DONSON's role in
            replication initiation
  JOURNAL   Science 381 (6664), eadi3448 (2023)
   PUBMED   37590370
REFERENCE   3  (residues 1 to 560)
  AUTHORS   Venkataramanappa,S., Schutz,D., Saaber,F., Kumar,P.A., Abe,P.,
            Schulz,S. and Stumm,R.
  TITLE     The microcephaly gene Donson is essential for progenitors of
            cortical glutamatergic and GABAergic neurons
  JOURNAL   PLoS Genet 17 (3), e1009441 (2021)
   PUBMED   33739968
  REMARK    GeneRIF: The microcephaly gene Donson is essential for progenitors
            of cortical glutamatergic and GABAergic neurons.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 560)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 560)
  AUTHORS   Evrony,G.D., Cordero,D.R., Shen,J., Partlow,J.N., Yu,T.W.,
            Rodin,R.E., Hill,R.S., Coulter,M.E., Lam,A.N., Jayaraman,D.,
            Gerrelli,D., Diaz,D.G., Santos,C., Morrison,V., Galli,A.,
            Tschulena,U., Wiemann,S., Martel,M.J., Spooner,B., Ryu,S.C.,
            Elhosary,P.C., Richardson,J.M., Tierney,D., Robinson,C.A.,
            Chibbar,R., Diudea,D., Folkerth,R., Wiebe,S., Barkovich,A.J.,
            Mochida,G.H., Irvine,J., Lemire,E.G., Blakley,P. and Walsh,C.A.
  TITLE     Integrated genome and transcriptome sequencing identifies a
            noncoding mutation in the genome replication factor DONSON as the
            cause of microcephaly-micromelia syndrome
  JOURNAL   Genome Res 27 (8), 1323-1335 (2017)
   PUBMED   28630177
REFERENCE   6  (residues 1 to 560)
  AUTHORS   Gitton,Y., Dahmane,N., Baik,S., Ruiz i Altaba,A., Neidhardt,L.,
            Scholze,M., Herrmann,B.G., Kahlem,P., Benkahla,A., Schrinner,S.,
            Yildirimman,R., Herwig,R., Lehrach,H. and Yaspo,M.L.
  CONSRTM   HSA21 expression map initiative
  TITLE     A gene expression map of human chromosome 21 orthologues in the
            mouse
  JOURNAL   Nature 420 (6915), 586-590 (2002)
   PUBMED   12466855
REFERENCE   7  (residues 1 to 560)
  AUTHORS   Reymond,A., Marigo,V., Yaylaoglu,M.B., Leoni,A., Ucla,C.,
            Scamuffa,N., Caccioppoli,C., Dermitzakis,E.T., Lyle,R., Banfi,S.,
            Eichele,G., Antonarakis,S.E. and Ballabio,A.
  TITLE     Human chromosome 21 gene expression atlas in the mouse
  JOURNAL   Nature 420 (6915), 582-586 (2002)
   PUBMED   12466854
REFERENCE   8  (residues 1 to 560)
  AUTHORS   Wynn,S.L., Fisher,R.A., Pagel,C., Price,M., Liu,Q.Y., Khan,I.M.,
            Zammit,P., Dadrah,K., Mazrani,W., Kessling,A., Lee,J.S. and
            Buluwela,L.
  TITLE     Organization and conservation of the GART/SON/DONSON locus in mouse
            and human genomes
  JOURNAL   Genomics 68 (1), 57-62 (2000)
   PUBMED   10950926
REFERENCE   9  (residues 1 to 560)
  AUTHORS   Sund,N.J., Ang,S.L., Sackett,S.D., Shen,W., Daigle,N.,
            Magnuson,M.A. and Kaestner,K.H.
  TITLE     Hepatocyte nuclear factor 3beta (Foxa2) is dispensable for
            maintaining the differentiated state of the adult hepatocyte
  JOURNAL   Mol Cell Biol 20 (14), 5175-5183 (2000)
   PUBMED   10866673
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC043316.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC043316.1, SRR7652917.162264.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142, SAMN01164143
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..560
                     /organism="Mus musculus"
                     /strain="FVB/N"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 53.25 cM"
     Protein         1..560
                     /product="protein downstream neighbor of Son"
                     /note="protein 3SG"
                     /calculated_mol_wt=61857
     Region          1..140
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QXP4.2)"
     CDS             1..560
                     /gene="Donson"
                     /gene_synonym="1110025J21Rik; ORF60"
                     /coded_by="NM_021720.1:17..1699"
                     /db_xref="CCDS:CCDS28330.1"
                     /db_xref="GeneID:60364"
                     /db_xref="MGI:MGI:1890621"
ORIGIN      
        1 mavsvpgysp sfkrppetvr lrrkrsrdhg aavpaslpep aprraalaag lplrpfptag
       61 grggaaatia rrnpfarldn rprvsdease eplrgpqgas gplldsneen nllwedtssh
      121 ertgtelsqs qrvslsesdt wssdgtelpv dwsiktrllf tssqpfswad hlkaqeeaqg
      181 lvqhcratev tlpqsiqdpk lstalrcafq qalvywlhpa fswlplfpri gadrkmaakt
      241 spwsadetlq halmsdwsvs ftslynllkt klcpyfyvcs yqftvlfraa glagssvita
      301 lispttrglr eamrnegief slplleeigh kkkvrdpsle seeeqavsde deeesfswle
      361 eigvqdqikk pdvisiklrk ekhevqmdhr pesvvlvkgl ntfkllnfli nckslvatsg
      421 aqaglpptll spiafrgasm qmlkarssnv ktqalsgyrd kfslditgpv mphalhsmsm
      481 llrssqrgsf saglyahept avfnvglsld keldrkvare dlancglhpk tleqlsqrpv
      541 lgksslrsve msdyilswrs
//
