LOCUS       NM_020329               2087 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus dolichyl pyrophosphate phosphatase 1 (Dolpp1),
            transcript variant 1, mRNA.
ACCESSION   NM_020329
VERSION     NM_020329.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2087)
  AUTHORS   Rush,J.S., Cho,S.K., Jiang,S., Hofmann,S.L. and Waechter,C.J.
  TITLE     Identification and characterization of a cDNA encoding a dolichyl
            pyrophosphate phosphatase located in the endoplasmic reticulum of
            mammalian cells
  JOURNAL   J Biol Chem 277 (47), 45226-45234 (2002)
   PUBMED   12198133
  REMARK    GeneRIF: Results support a role for dolichyl pyrophosphate
            (Dol-P-P) phosphatase (Dolpp1) in the recycling of Dol-P-P
            discharged during protein N-glycosylation reactions on the luminal
            leaflet of the endoplasmic reticulum in mammalian cells [Dolpp1].
REFERENCE   2  (bases 1 to 2087)
  AUTHORS   Inoue,S., Sano,H. and Ohta,M.
  TITLE     Growth suppression of Escherichia coli by induction of expression
            of mammalian genes with transmembrane or ATPase domains
  JOURNAL   Biochem Biophys Res Commun 268 (2), 553-561 (2000)
   PUBMED   10679242
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL954388.5.
            
            On Jan 6, 2022 this sequence version replaced NM_020329.4.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB030189.1, BC026544.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-97                AL954388.5         116441-116537
            98-198              AL954388.5         119684-119784
            199-283             AL954388.5         120002-120086
            284-383             AL954388.5         120178-120277
            384-482             AL954388.5         120457-120555
            483-611             AL954388.5         121044-121172
            612-701             AL954388.5         121493-121582
            702-2087            AL954388.5         123167-124552
FEATURES             Location/Qualifiers
     source          1..2087
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 21.68 cM"
     gene            1..2087
                     /gene="Dolpp1"
                     /gene_synonym="0610011H20Rik; LSFR2"
                     /note="dolichyl pyrophosphate phosphatase 1"
                     /db_xref="GeneID:57170"
                     /db_xref="MGI:MGI:1914093"
     exon            1..97
                     /gene="Dolpp1"
                     /gene_synonym="0610011H20Rik; LSFR2"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..738
                     /gene="Dolpp1"
                     /gene_synonym="0610011H20Rik; LSFR2"
                     /EC_number="3.6.1.43"
                     /note="isoform a is encoded by transcript variant 1;
                     dolichyldiphosphatase 1; protein 2-23"
                     /codon_start=1
                     /product="dolichyldiphosphatase 1 isoform a"
                     /protein_id="NP_065062.1"
                     /db_xref="CCDS:CCDS15881.1"
                     /db_xref="GeneID:57170"
                     /db_xref="MGI:MGI:1914093"
                     /translation="MAADGQCSLPASWRPVTLTHVEYPAGDLSGHLLAYLSLSPIFVV
                     VGFLTLIIFKRELHTISFLGGLALNQGVNWLIKHVIQEPRPCGGPHTAVGTKYGMPSS
                     HSQFMWFFSVYSFLFLYLRMHQTNNARFLDLLWRHVLSLGLLTAAFLVSYSRVYLLYH
                     TWSQVFYGGVAGSLMAVAWFIITQEILTPLFPRIAAWPISEFFLIRDTSLIPNVLWFE
                     YTVTRAEARNRQRKLGTKLQ"
     exon            98..198
                     /gene="Dolpp1"
                     /gene_synonym="0610011H20Rik; LSFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            199..283
                     /gene="Dolpp1"
                     /gene_synonym="0610011H20Rik; LSFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            284..383
                     /gene="Dolpp1"
                     /gene_synonym="0610011H20Rik; LSFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            384..482
                     /gene="Dolpp1"
                     /gene_synonym="0610011H20Rik; LSFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            483..611
                     /gene="Dolpp1"
                     /gene_synonym="0610011H20Rik; LSFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            612..701
                     /gene="Dolpp1"
                     /gene_synonym="0610011H20Rik; LSFR2"
                     /inference="alignment:Splign:2.1.0"
     exon            702..2087
                     /gene="Dolpp1"
                     /gene_synonym="0610011H20Rik; LSFR2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2069..2074
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dolpp1"
                     /gene_synonym="0610011H20Rik; LSFR2"
                     /note="hexamer: AATAAA"
     polyA_site      2087
                     /gene="Dolpp1"
                     /gene_synonym="0610011H20Rik; LSFR2"
                     /note="major polyA site"
ORIGIN      
        1 gaagcccggt ctccgggtaa gatggcagcg gacggacagt gctcgctccc cgcttcatgg
       61 cggccagtga ccctcaccca cgtcgaatac cctgcaggtg atctgtctgg ccacctcctg
      121 gcctacctga gcctcagccc tatttttgtc gttgttggtt ttttgactct catcatattc
      181 aagcgggagc tacacacgat ttcattcctt gggggactgg cactgaatca gggcgtcaac
      241 tggctgatca aacacgtcat ccaggagcct cggccctgtg gaggcccaca tacagcagtg
      301 ggcactaagt acgggatgcc ctccagccat tcccagttca tgtggttctt ctccgtctac
      361 tccttcctct tcctgtattt aagaatgcac caaacaaata acgccaggtt cttggacttg
      421 ctgtggaggc acgtgctgtc tctagggctc ctcaccgcgg cctttctcgt ctcctatagc
      481 agggtctacc tgctgtacca cacctggagc caggtgtttt atgggggcgt ggctggaagc
      541 ctcatggccg tcgcctggtt catcatcacg caggaaatcc tcactccgtt gttccccagg
      601 atagcagcct ggcccatctc cgagtttttc ctcatccggg acacgagcct cattcccaat
      661 gtgctctggt ttgagtacac agtaaccagg gcagaagcca ggaacagaca gcgcaaactt
      721 ggaacaaaac tgcagtgact ggtgggtgtg gctgcgtcta gcctccgaat ctggcctgca
      781 ccatgccttg caggatggac agaatgatgg atggaggggt gaagcagaga cctctacaga
      841 ccagagtcac caagtggagc cttttttttt cttattttaa tttcaatgga cacggtggac
      901 caaagtgctg agtcaggtcc tcagccagga ccctgggagg gcctgctgtg tgtgggtcac
      961 atggccagag cccatctctg ctgctgccag ctcctggctg ggtggaaagt gctcttggca
     1021 cgggcctcag cgtgcgtgta gagcgtgtgt acctctggtc ctgagatcag gaagtgcagg
     1081 tagcggaatg cgcactattt attcttttgg gattgtggag ttcatgctga agaggccact
     1141 ctgcagcagc tgccctgtgt acacagggcc caggttagct cccagaccct gtgctctgag
     1201 cctcaggcag tacagcctgc ctcctgctgg gcctgagcag ggcctagggc ccagggccca
     1261 ggagcgaggc ctcccctgct gtccctgcca ccatcgccat tccagaaccc ttgtcagtgt
     1321 ttcctcgtct ggggcagggc ccagagtcag cacctgttta tccgtctgtc ggctgggctg
     1381 ctggcttgtg ttcttccctc taccaacccg acatcacaag ggctttctcc ggtcctctat
     1441 cccttcctga caaaagagcc tgcacatacg ggtgagcaca cccaagcgtt tacagctcct
     1501 tttgtctggc catcgggtag cagtctgtct tcatccccac ttgaacaaaa gagaggaagc
     1561 aggagctggg atgctggctg tgtggcagtg cagacaccct cccccatcgc ctgcccatgt
     1621 gctctggatt tgtccctgtc cttcctggcc tgtcctggag gctggaaacc agtgcaggtt
     1681 gatcctgggg tctgcctggg agtgggctct gatcccagct gccaggagtc ccttttaagg
     1741 gactctctcc aggttgtcct gccacagctg tggagatgct tccagaactg aagcagcccc
     1801 tgggggagct gttgagccct cccccgtttc tccctggagg tccctaacct gctgctgaag
     1861 cacaagtttt tggtgctttc ctttgtgttt gttaaaggcc gtgtccaagc ccctcagatg
     1921 ccagggccag ggctggtttc tagggaggta ggtcagtcac atccatcccc cctcccccgt
     1981 aggattttta ttttttactt tttgcctgag acaagccaag tgtgaggtgg tttaagaaat
     2041 caaatgaaat tgtttactat tgttttaaaa taaaatctga aactctg
//
