LOCUS       NM_177648               2126 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus dolichol kinase (Dolk), mRNA.
ACCESSION   NM_177648
VERSION     NM_177648.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2126)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2126)
  AUTHORS   Gohlke,S., Zagoriy,V., Cuadros Inostroza,A., Meret,M., Mancini,C.,
            Japtok,L., Schumacher,F., Kuhlow,D., Graja,A., Stephanowitz,H.,
            Jahnert,M., Krause,E., Wernitz,A., Petzke,K.J., Schurmann,A.,
            Kleuser,B. and Schulz,T.J.
  TITLE     Identification of functional lipid metabolism biomarkers of brown
            adipose tissue aging
  JOURNAL   Mol Metab 24, 1-17 (2019)
   PUBMED   31003944
REFERENCE   3  (bases 1 to 2126)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   4  (bases 1 to 2126)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL954388.5.
            
            On Sep 2, 2006 this sequence version replaced NM_177648.2.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2126              AL954388.5         8254-10379          c
FEATURES             Location/Qualifiers
     source          1..2126
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 21.49 cM"
     gene            1..2126
                     /gene="Dolk"
                     /gene_synonym="mKIAA1094; Tmem15"
                     /note="dolichol kinase"
                     /db_xref="GeneID:227697"
                     /db_xref="MGI:MGI:2677836"
     exon            1..2126
                     /gene="Dolk"
                     /gene_synonym="mKIAA1094; Tmem15"
                     /inference="alignment:Splign:2.1.0"
     CDS             324..1928
                     /gene="Dolk"
                     /gene_synonym="mKIAA1094; Tmem15"
                     /EC_number="2.7.1.108"
                     /note="transmembrane protein 15"
                     /codon_start=1
                     /product="dolichol kinase"
                     /protein_id="NP_808316.1"
                     /db_xref="CCDS:CCDS15877.1"
                     /db_xref="GeneID:227697"
                     /db_xref="MGI:MGI:2677836"
                     /translation="MTRQCPPQESGAALSGSVLAEAAVVFAVVLSIHAAVWDRYSWCA
                     VALAVQAFYVQYKWDRLLQQGNAVFQFRMSANSGLLPASMVMPLLGLVMKERCQTAGN
                     PYFERFGIVVAATGMAVALFSSVLALGITRPVPTNTCAISGLAGGVIIYIMRHSLSVG
                     EVIEVLEVLLIFVYLNMILLYLLPRCFTPGEALLVLGGISFVLNQLIKRSLTESQGDP
                     VDFFLLVVVVGMVLMGVFFSTLFVFMDSGTWASSIFFHLMTCVLGLGVVLPWLHWLIR
                     RNPLLWLLQFLFYTETRIYLLAYWSLLASVACLVVLYQNAKRSSSESKKHRAPTITRK
                     YFHFIVVATYIPGIIFDRPLLYVAATVCLAVFIFLEYVRYFRIKPLGHTLRSLLSLFL
                     DERDSGPLILTHIYLLLGMSLPIWLIPRPCTQKDSLEGARALVPYAGVLAVGVGDTVA
                     SIFGSTMGEIRWPGTKKTFEGTMTSIFAQIISVALILIFDSGVDLNYSYAWILGSIST
                     VSLLEAYTTQIDNLLLPLYLLILLMA"
     regulatory      2076..2081
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dolk"
                     /gene_synonym="mKIAA1094; Tmem15"
                     /note="hexamer: AATAAA"
     polyA_site      2093
                     /gene="Dolk"
                     /gene_synonym="mKIAA1094; Tmem15"
                     /note="major polyA site"
ORIGIN      
        1 acgtgatggt gggcgtggtc aagatggggc tgtcaagatg gcgctgccct ggtgcgaggg
       61 gagtccgcgg tggaggcggt ggagactgtg agcggtgaag agggcaaaca tctgctacac
      121 cgtaggttga cagcggaggc gggtgactgg gcgccggctc ccaggcctca gagtggcccg
      181 tggtggaaca cccttttgga agctggagaa ggttgctggc tgggtgaaat tgctgcccct
      241 ctgcttggcg ggttgagggc cccagaggcc aaggcgtccc tagtcaccaa acttcttctc
      301 ccaagagcgc cagacctaga gacatgaccc gacagtgccc tccccaggag tctggggctg
      361 cgctgagcgg gtcggtgctg gcggaggctg cagtggtgtt cgccgtggtg ttgagcatcc
      421 acgctgcagt gtgggaccga tactcctggt gcgcggtggc cctcgcggtg caggccttct
      481 acgtccagta caagtgggac cggctgctcc agcagggcaa tgccgttttc cagttccgga
      541 tgtccgcgaa cagcggctta ctgccggcct ccatggtcat gcctttgctt gggctagtca
      601 tgaaggagcg ctgccagact gcagggaacc catacttcga gcgcttcggc attgtggttg
      661 cagctactgg catggcagtg gccctcttct cctccgtgtt ggcactgggc attactcgcc
      721 cggtgcccac caatacttgt gccatctctg gtttggctgg aggcgttatc atttatatta
      781 tgaggcactc gctcagtgta ggcgaggtga tcgaggtcct ggaagtcctg ctaatatttg
      841 tttatctcaa catgatcctg ctgtacctgc tgccccgatg cttcactcct ggggaggcac
      901 tgctggtatt gggtggcatt agcttcgtcc ttaaccaact catcaagcgc tctctgactg
      961 aaagccaggg ggacccagtg gacttcttcc tgttggtggt ggtggtaggg atggtgctca
     1021 tgggtgtctt tttcagcacc ctctttgtct tcatggattc aggcacctgg gcctcttcca
     1081 tcttcttcca cctcatgacc tgtgtgctgg gccttggtgt ggttctgccc tggctgcact
     1141 ggctcattcg taggaacccc ctgctttggc ttcttcagtt cctcttctac actgaaactc
     1201 gcatctacct ccttgcctat tggtctttgc tggcctctgt ggcctgcctg gtggtgctgt
     1261 accagaatgc taagcggtcg tcttctgagt ccaagaagca cagggcgcct accattacaa
     1321 gaaagtattt ccacttcatt gtggtagcca cttatatccc gggcatcatc tttgaccggc
     1381 cactgctgta tgtggccgcc actgtgtgcc tggcagtctt catcttcctg gagtatgtgc
     1441 gctatttccg aataaagccc ttgggtcaca ctctgcgaag ccttctgtcc ctcttcctgg
     1501 atgaacgaga cagtggaccc cttatcctaa cacacatcta cctgcttctg ggcatgtctc
     1561 ttcctatttg gctgatcccc agaccctgta cacagaagga cagcctggaa ggagcaagag
     1621 ccctggtccc ctatgctggg gtcttggctg tgggtgtggg tgatactgtg gcctccatat
     1681 ttggcagcac catgggagag atccgctggc ctggaactaa gaaaaccttc gaggggacta
     1741 tgacatctat atttgcacaa atcatctctg tagctctaat cttaatcttt gacagtggag
     1801 tagacctgaa ctacagttat gcctggattt tggggtccat cagcactgta tcccttctgg
     1861 aagcgtacac tactcagata gacaatctcc tgttgcctct ctacctactg atattgctga
     1921 tggcctagta ccagtagcag ctgtgatggg gaaacaggga aatagaatga atggtcccca
     1981 cagcagctag ccacctggac accaagaatc aagagatgga aagcagattt tgcttcatcc
     2041 aggaagatga agccagaaag ttgtttcaga cttaaaataa agaagcaaag ctctcctggt
     2101 tttatttttg ctgatattta aaatac
//
