LOCUS       NM_001348478            2723 bp    mRNA    linear   ROD 10-OCT-2024
DEFINITION  Mus musculus docking protein 7 (Dok7), transcript variant 1, mRNA.
ACCESSION   NM_001348478
VERSION     NM_001348478.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2723)
  AUTHORS   Ohkawara,B., Kurokawa,M., Kanai,A., Imamura,K., Chen,G., Zhang,R.,
            Masuda,A., Higashi,K., Mori,H., Suzuki,Y., Kurokawa,K. and Ohno,K.
  TITLE     Transcriptome profile of subsynaptic myonuclei at the neuromuscular
            junction in embryogenesis
  JOURNAL   J Neurochem 168 (4), 342-354 (2024)
   PUBMED   37994470
REFERENCE   2  (bases 1 to 2723)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2723)
  AUTHORS   Eguchi,T., Tezuka,T., Watanabe,Y., Inoue-Yamauchi,A., Sagara,H.,
            Ozawa,M. and Yamanashi,Y.
  TITLE     Calcium-binding protein 7 expressed in muscle negatively regulates
            age-related degeneration of neuromuscular junctions in mice
  JOURNAL   iScience 27 (2), 108997 (2024)
   PUBMED   38327785
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2723)
  AUTHORS   Sugimoto,T., Sakamaki,C., Kimura,T., Eguchi,T., Miura,S. and
            Kamei,Y.
  TITLE     Peroxisome proliferator-activated receptor gamma coactivator 1alpha
            regulates downstream of tyrosine kinase-7 (Dok-7) expression
            important for neuromuscular junction formation
  JOURNAL   Sci Rep 14 (1), 1780 (2024)
   PUBMED   38245592
  REMARK    GeneRIF: Peroxisome proliferator-activated receptor gamma
            coactivator 1alpha regulates downstream of tyrosine kinase-7
            (Dok-7) expression important for neuromuscular junction formation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2723)
  AUTHORS   Kosco,E.D., Jing,H., Chen,P., Xiong,W.C., Samuels,I.S. and Mei,L.
  TITLE     DOK7 Promotes NMJ Regeneration After Nerve Injury
  JOURNAL   Mol Neurobiol 60 (3), 1453-1464 (2023)
   PUBMED   36464749
  REMARK    GeneRIF: DOK7 Promotes NMJ Regeneration After Nerve Injury.
REFERENCE   6  (bases 1 to 2723)
  AUTHORS   Hamuro,J., Higuchi,O., Okada,K., Ueno,M., Iemura,S., Natsume,T.,
            Spearman,H., Beeson,D. and Yamanashi,Y.
  TITLE     Mutations causing DOK7 congenital myasthenia ablate functional
            motifs in Dok-7
  JOURNAL   J Biol Chem 283 (9), 5518-5524 (2008)
   PUBMED   18165682
  REMARK    GeneRIF: the COOH-terminal NES and Src homology 2 target motifs
            play key roles in Dok-7/MuSK signaling for neuromuscular
            synaptogenesis.
REFERENCE   7  (bases 1 to 2723)
  AUTHORS   Okada,K., Inoue,A., Okada,M., Murata,Y., Kakuta,S., Jigami,T.,
            Kubo,S., Shiraishi,H., Eguchi,K., Motomura,M., Akiyama,T.,
            Iwakura,Y., Higuchi,O. and Yamanashi,Y.
  TITLE     The muscle protein Dok-7 is essential for neuromuscular
            synaptogenesis
  JOURNAL   Science 312 (5781), 1802-1805 (2006)
   PUBMED   16794080
  REMARK    GeneRIF: Dok-7 is essential for neuromuscular synaptogenesis
            through its interaction with MuSK
REFERENCE   8  (bases 1 to 2723)
  AUTHORS   Luo,Z.G., Je,H.S., Wang,Q., Yang,F., Dobbins,G.C., Yang,Z.H.,
            Xiong,W.C., Lu,B. and Mei,L.
  TITLE     Implication of geranylgeranyltransferase I in synapse formation
  JOURNAL   Neuron 40 (4), 703-717 (2003)
   PUBMED   14622576
REFERENCE   9  (bases 1 to 2723)
  AUTHORS   Fu,X. and Kamps,M.P.
  TITLE     E2a-Pbx1 induces aberrant expression of tissue-specific and
            developmentally regulated genes when expressed in NIH 3T3
            fibroblasts
  JOURNAL   Mol Cell Biol 17 (3), 1503-1512 (1997)
   PUBMED   9032278
REFERENCE   10 (bases 1 to 2723)
  AUTHORS   Glass,D.J., Bowen,D.C., Stitt,T.N., Radziejewski,C., Bruno,J.,
            Ryan,T.E., Gies,D.R., Shah,S., Mattsson,K., Burden,S.J.,
            DiStefano,P.S., Valenzuela,D.M., DeChiara,T.M. and Yancopoulos,G.D.
  TITLE     Agrin acts via a MuSK receptor complex
  JOURNAL   Cell 85 (4), 513-523 (1996)
   PUBMED   8653787
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC126447.3, AK044445.1 and AW120776.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849374,
                              SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-223               AC126447.3         80040-80262         c
            224-1806            AK044445.1         10-1592
            1807-1807           AC126447.3         50383-50383         c
            1808-2698           AK044445.1         1594-2484
            2699-2723           AW120776.1         1-25                c
FEATURES             Location/Qualifiers
     source          1..2723
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 18.0 cM"
     gene            1..2723
                     /gene="Dok7"
                     /gene_synonym="A930013K19Rik; Dok-7; EF-12; Oit5"
                     /note="docking protein 7"
                     /db_xref="GeneID:231134"
                     /db_xref="MGI:MGI:3584043"
     exon            1..223
                     /gene="Dok7"
                     /gene_synonym="A930013K19Rik; Dok-7; EF-12; Oit5"
                     /inference="alignment:Splign:2.1.0"
     CDS             170..1993
                     /gene="Dok7"
                     /gene_synonym="A930013K19Rik; Dok-7; EF-12; Oit5"
                     /note="isoform 1 is encoded by transcript variant 1;
                     downstream of tyrosine kinase 7; oncoprotein induced
                     transcript 5; protein Dok-7"
                     /codon_start=1
                     /product="protein Dok-7 isoform 1"
                     /protein_id="NP_001335407.1"
                     /db_xref="GeneID:231134"
                     /db_xref="MGI:MGI:3584043"
                     /translation="MTEAALVEGQVKLRDGKKWKSRWLVLRKPSPVADCLLMLVYKDK
                     CERSKGLRERSSLTLEDICGLEPALPYEGLAHTLAIICLSQAVMLGFDSHEAMCAWDT
                     RIRYALGEVHRFHVTVAPGTKLESGPATLHLCNDILVLARDIPPTVMGQWKLSDLRRY
                     GAVPNGFIFEGGTRCGYWAGVFFLSSAEGEQMSFLFDCIVRGISPTKGPFGLRPVLPD
                     PSSGGPSASEERVAQEALEALQLEKRLSLLSHSGRPGSGGDDRSLSSSSSEASHSDIS
                     ASSRLTAWPEQSSSSAGTSQEGPGLVAAQGPGEAMLGASRPPLKPLRPRQLQEVGRQS
                     SSDSGIATGSHSSYSGSFSSYAGSNLDVWRAGEEFGSLLSLPPGASAPEPRLCACPPG
                     AAEYQVPTSLRHHYDTPRSLRQAPRDPSPASQGSSDHGSATDLGGQAPTGCPSSWLGA
                     RRRGQATEGPGSDAALPSPSPGESWEAGSPHAGPPPAFFLSCSICGGLKVMATSSPGF
                     TVTHPGSPGRVAADSPGPERPHSEMPTYVNIPISPISRPQLHYMDLELPGASAGVRGA
                     STSRYAQIDIAATETAHRVGVRHAQTREERLPELEQRKKGP"
     exon            224..269
                     /gene="Dok7"
                     /gene_synonym="A930013K19Rik; Dok-7; EF-12; Oit5"
                     /inference="alignment:Splign:2.1.0"
     exon            270..500
                     /gene="Dok7"
                     /gene_synonym="A930013K19Rik; Dok-7; EF-12; Oit5"
                     /inference="alignment:Splign:2.1.0"
     exon            501..701
                     /gene="Dok7"
                     /gene_synonym="A930013K19Rik; Dok-7; EF-12; Oit5"
                     /inference="alignment:Splign:2.1.0"
     exon            702..821
                     /gene="Dok7"
                     /gene_synonym="A930013K19Rik; Dok-7; EF-12; Oit5"
                     /inference="alignment:Splign:2.1.0"
     exon            822..941
                     /gene="Dok7"
                     /gene_synonym="A930013K19Rik; Dok-7; EF-12; Oit5"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1666
                     /gene="Dok7"
                     /gene_synonym="A930013K19Rik; Dok-7; EF-12; Oit5"
                     /inference="alignment:Splign:2.1.0"
     exon            1667..1709
                     /gene="Dok7"
                     /gene_synonym="A930013K19Rik; Dok-7; EF-12; Oit5"
                     /inference="alignment:Splign:2.1.0"
     exon            1710..1862
                     /gene="Dok7"
                     /gene_synonym="A930013K19Rik; Dok-7; EF-12; Oit5"
                     /inference="alignment:Splign:2.1.0"
     exon            1863..2706
                     /gene="Dok7"
                     /gene_synonym="A930013K19Rik; Dok-7; EF-12; Oit5"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2702
                     /gene="Dok7"
                     /gene_synonym="A930013K19Rik; Dok-7; EF-12; Oit5"
                     /note="major polyA site"
ORIGIN      
        1 gtctccccca catccaggtc cccgtgtcgc tgcgccccgc ccgccgcgcc gggcccgccc
       61 tcctggcgca gcccaaggcc ctcccggagc tattttgaaa gtgaccctgg gctcaggcgc
      121 ccaggacgcg tggagagggc gcagcgggcg gcgggaacca tgacagaaga tgaccgaggc
      181 agcgctggtg gagggccagg tcaagctgcg ggacggcaag aagtggaaga gtaggtggct
      241 ggtgctgcgc aagccatcgc cggtggcaga ctgcctgctg atgctggtct acaaggacaa
      301 atgtgaacgc tccaagggcc ttcgggagcg cagcagcctc accctggagg acatctgtgg
      361 cctggagcct gccctgccct atgagggcct ggcccacact ctggccatca tctgcctgtc
      421 tcaggctgtt atgctgggct tcgatagcca tgaggccatg tgtgcctggg atacccgtat
      481 ccgctacgca ctgggcgagg tgcacaggtt ccatgtgaca gtagctcctg gtaccaaact
      541 ggagagtggt ccagccactc ttcacctctg caatgacatt ctggtcctgg ccagagacat
      601 ccctccaacc gtcatggggc agtggaagct gtctgacctc cggcgttacg gggctgttcc
      661 gaatggattc atcttcgaag gcgggaccag gtgtgggtac tgggctggag tcttcttctt
      721 gtcatcagct gagggagagc agatgagctt cctgtttgac tgcatcgtcc gaggcatctc
      781 cccgaccaaa ggcccgtttg ggcttcggcc agttctccca gacccgagtt ctgggggacc
      841 ctcagcctca gaagagcgtg ttgcccagga agcactggaa gccctgcagc tagagaagag
      901 gctcagcctg ctttctcact ctggccggcc aggcagtgga ggggatgaca gaagtctatc
      961 cagttcctct tctgaggcta gccactcgga catcagcgcc agcagcaggc tcactgcgtg
     1021 gccggagcag tcctcatcct cggccggcac atcacaagaa ggaccagggc tggtggctgc
     1081 ccagggccca ggagaagcca tgctgggagc ctcaaggcca cccctcaagc cactgcggcc
     1141 tcggcagtta caggaggttg gccgccagag ctcctctgac agtggcattg ccacaggcag
     1201 ccactcctct tactctggca gcttctcctc ttatgccggc agcaacctgg acgtgtggcg
     1261 ggccggtgag gaattcggtt ctctgctcag tctgccccct ggagccagcg cacctgagcc
     1321 cagactgtgt gcctgcccac ctggggcggc cgagtaccag gtgcccacgt cactgagaca
     1381 ccactatgac acacctcgaa gcctgcgcca ggcccccaga gacccaagcc cagcttctca
     1441 gggcagctct gaccacggtt cagccacaga cttgggtggt caggcgccca cagggtgtcc
     1501 ctccagttgg ctgggagctc gccgacgggg acaggcaacg gaaggcccag gcagtgacgc
     1561 tgcgctgccg agtccatccc ctggcgagtc ctgggaagca ggcagccccc atgcagggcc
     1621 gcctccagct ttctttttgt catgttcaat ctgtggcgga ctcaaggtca tggctacttc
     1681 atcccctgga ttcactgtga cgcatccagg atctccaggg cgggtggctg ctgatagccc
     1741 tgggcctgag cgaccacaca gtgagatgcc cacgtatgtg aatatcccca tcagccccat
     1801 ctccagaccg cagctgcact acatggactt ggagctcccg ggggccagtg ctggtgttcg
     1861 aggggccagc acctcccgct atgcccagat tgacattgca gctaccgaga cagcacatcg
     1921 cgtcggggtc cggcatgcgc agactcggga ggaacggtta ccagagttgg agcagcggaa
     1981 gaaggggccc tgaggctggg actggctggg cacatggcca gctggactgt ccaacatggc
     2041 caggcaggga tggtggcctt ttggggctag agaccttggc ctgtctgtgt actctggtgg
     2101 tcagtaattg aagctgagtc ttgacctcct gctgcagtgg aggctgtggc tggtctttgt
     2161 gcattggaat gagtagtcag aggttctggg cccagaccat atcagttcat tccaatatgt
     2221 gaaaggcatg tagtagcctc ctttttgcca gcagggtctc ttgcctcact ggtggccaag
     2281 acttgacttg aacaagttct cctatgccat ggggccacca agagacccat ctccaggaat
     2341 cggtagcctc agcatctgac acaacagcac tactagctgc ccggttgaaa tggaaagtct
     2401 cccaggcctg gaatgcaagc tgtattaccc atcctggacg aggtgaccac gatgacagtt
     2461 tgcactagca gaacactctg cactggtcct gtactcagag ggacctgtga cttgccactg
     2521 gagccccctc cccttttcct acagtgtctc tcttgagcaa ggccctgtac cttgggatga
     2581 agaccagggt ggggacaagt ctgtttccac ttgtcatctt gttgggacct actccagcag
     2641 tcgggtacat ggttttaaat ccccactgtt acatttttaa caatttatat tattttccaa
     2701 aagctgaaaa aaaaaaaaaa aaa
//
