LOCUS       NM_029761               1774 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus docking protein 5 (Dok5), transcript variant 1, mRNA.
ACCESSION   NM_029761
VERSION     NM_029761.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1774)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1774)
  AUTHORS   Xu,L., Wu,J., Yu,Y., Li,H., Sun,S., Zhang,T. and Wang,M.
  TITLE     Dok5 regulates proliferation and differentiation of osteoblast via
            canonical Wnt/beta-catenin signaling
  JOURNAL   J Musculoskelet Neuronal Interact 22 (1), 113-122 (2022)
   PUBMED   35234166
  REMARK    GeneRIF: Dok5 regulates proliferation and differentiation of
            osteoblast via canonical Wnt/beta-catenin signaling.
REFERENCE   3  (bases 1 to 1774)
  AUTHORS   Zhang,L.Q., Cui,H., Yu,Y.B., Shi,H.Q., Zhou,Y. and Liu,M.J.
  TITLE     MicroRNA-141-3p inhibits retinal neovascularization and retinal
            ganglion cell apoptosis in glaucoma mice through the inactivation
            of Docking protein 5-dependent mitogen-activated protein kinase
            signaling pathway
  JOURNAL   J Cell Physiol 234 (6), 8873-8887 (2019)
   PUBMED   30515784
  REMARK    GeneRIF: The study suggests that miR-141-3p inhibits retinal
            neovascularization in glaucoma mice by impeding the activation of
            the DOK5-mediated MAPK signaling pathway.
REFERENCE   4  (bases 1 to 1774)
  AUTHORS   Loo,L., Simon,J.M., Xing,L., McCoy,E.S., Niehaus,J.K., Guo,J.,
            Anton,E.S. and Zylka,M.J.
  TITLE     Single-cell transcriptomic analysis of mouse neocortical
            development
  JOURNAL   Nat Commun 10 (1), 134 (2019)
   PUBMED   30635555
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1774)
  AUTHORS   Yasuoka,H., Yamaguchi,Y. and Feghali-Bostwick,C.A.
  TITLE     The membrane-associated adaptor protein DOK5 is upregulated in
            systemic sclerosis and associated with IGFBP-5-induced fibrosis
  JOURNAL   PLoS One 9 (2), e87754 (2014)
   PUBMED   24551065
  REMARK    GeneRIF: IGFBP-5 induces its pro-fibrotic effects, at least in
            part, via DOK5. IGFBP-5 and DOK5 are both increased in systemic
            sclerosis fibroblasts and tissues and may thus be acting in concert
            to promote fibrosis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1774)
  AUTHORS   Pan,Y., Zhang,J., Liu,W., Shu,P., Yin,B., Yuan,J., Qiang,B. and
            Peng,X.
  TITLE     Dok5 is involved in the signaling pathway of neurotrophin-3 against
            TrkC-induced apoptosis
  JOURNAL   Neurosci Lett 553, 46-51 (2013)
   PUBMED   23954828
  REMARK    GeneRIF: Dok5 is necessary for NT-3 signaling to block TrkC-induced
            apoptosis
REFERENCE   7  (bases 1 to 1774)
  AUTHORS   Wen,J., Xia,Q., Wang,C., Liu,W., Chen,Y., Gao,J., Gong,Y., Yin,B.,
            Ke,Y., Qiang,B., Yuan,J. and Peng,X.
  TITLE     Dok-5 is involved in cardiomyocyte differentiation through
            PKB/FOXO3a pathway
  JOURNAL   J Mol Cell Cardiol 47 (6), 761-769 (2009)
   PUBMED   19800350
  REMARK    GeneRIF: FOXO3a, the PI3K/PKB downstream substrate, acts as a
            transcriptional repressor to inhibit the expression of Dok-5.
REFERENCE   8  (bases 1 to 1774)
  AUTHORS   Ewart-Toland,A., Briassouli,P., de Koning,J.P., Mao,J.H., Yuan,J.,
            Chan,F., MacCarthy-Morrogh,L., Ponder,B.A., Nagase,H., Burn,J.,
            Ball,S., Almeida,M., Linardopoulos,S. and Balmain,A.
  TITLE     Identification of Stk6/STK15 as a candidate low-penetrance
            tumor-susceptibility gene in mouse and human
  JOURNAL   Nat Genet 34 (4), 403-412 (2003)
   PUBMED   12881723
REFERENCE   9  (bases 1 to 1774)
  AUTHORS   Grimm,J., Sachs,M., Britsch,S., Di Cesare,S., Schwarz-Romond,T.,
            Alitalo,K. and Birchmeier,W.
  TITLE     Novel p62dok family members, dok-4 and dok-5, are substrates of the
            c-Ret receptor tyrosine kinase and mediate neuronal differentiation
  JOURNAL   J Cell Biol 154 (2), 345-354 (2001)
   PUBMED   11470823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ064232.1, BY248468.1, AK044148.1 and BY657780.1.
            
            On Aug 4, 2009 this sequence version replaced NM_029761.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK044148.1, AK012430.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-304               CJ064232.1         10-313
            305-379             BY248468.1         221-295
            380-1767            AK044148.1         248-1635
            1768-1774           BY657780.1         344-350
FEATURES             Location/Qualifiers
     source          1..1774
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 92.26 cM"
     gene            1..1774
                     /gene="Dok5"
                     /gene_synonym="2700055C10Rik"
                     /note="docking protein 5"
                     /db_xref="GeneID:76829"
                     /db_xref="MGI:MGI:1924079"
     exon            1..382
                     /gene="Dok5"
                     /gene_synonym="2700055C10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            383..490
                     /gene="Dok5"
                     /gene_synonym="2700055C10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            491..605
                     /gene="Dok5"
                     /gene_synonym="2700055C10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            606..725
                     /gene="Dok5"
                     /gene_synonym="2700055C10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            726..915
                     /gene="Dok5"
                     /gene_synonym="2700055C10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1051
                     /gene="Dok5"
                     /gene_synonym="2700055C10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1172
                     /gene="Dok5"
                     /gene_synonym="2700055C10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1774
                     /gene="Dok5"
                     /gene_synonym="2700055C10Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttctcctcc tcctgggagc tggagcggct cctcctcctg gcaggctgcc gcccagtcag
       61 ctgacgccgc gctccagtct cgcctccccg ccgctctccc ccaaagtggc tgctgggcgc
      121 cggcgggccg cccactttca ggctttgggg agacagggga agcgatgtgc gccttctgac
      181 gcctggtttc accgcatcac cttgttaact ttcactccct cagtctctgt cctgaccctc
      241 ctccccacat ccctcctcga agccactcag ggtgccgagc gcacgctggg ggcagcaggg
      301 tcactgtctg tctgggatgg cttccaattt taatgacata gtgaagcagg ggtacgtgag
      361 gatccggagc agacgcctag ggatttatca acgatgctgg ttagtgttca agaaagcttc
      421 gagcaagggt ccaaagagac tggagaagtt ctcagatgaa cgggccgcgt acttcaggtg
      481 ttaccacaag gttacagaac tcaacaatgt gaaaaatgta gcccgattgc caaagagcac
      541 caagaaacat gctataggga tttatttcaa tgatgacacc tcgaagacct ttgcctgtga
      601 atcagatctt gaggcagacg aatggtgcaa agttctccag atggagtgtg tggggaccag
      661 aatcaatgac atcagcctcg gagagcctga tttattggct accggggtgg aacgcgagca
      721 gagcgagagg ttcaatgtgt atttgatgcc atctcctaac ttagatgtac atggcgaatg
      781 tgccttgcag attacatatg agtacatctg tctttgggac gtccagaatc ccagagttaa
      841 actcatctct tggccgctaa gtgccctgcg gcgttatgga cgagacacca cgtggttcac
      901 ttttgaggca gggaggatgt gtgagactgg cgaagggtta tttatttttc aaacacgaga
      961 cggagaggcc atctaccaga aggtccactc tgctgccttg gccatagctg agcagcatga
     1021 acggctgctg cagagcgtga aaaattccat gctccagatg aagaagagcg agcgggcagc
     1081 gtcgctgagc accgtggtgc ccctgccccg cagcgcctac tggcagcata tcacgaggca
     1141 gcacagcaca ggacagctgt accaccttca agatgtcacc agcccgctga agcttcaccg
     1201 gacagagact ttccccacct accggtctga gcactgacag caaccgccaa gagctgttag
     1261 cacatttgtg ctgtgtcagc cacagcagga ggacacagag ggacagccag ggagagtgca
     1321 gatgaagaag agcagcttcg caccctgcta atgtgtgtgg ccacgggaaa cgctgcagaa
     1381 caacatatgt ataaatattt ttccctttct ctctctctct ttcttcctct ctctctctct
     1441 ctctctctct ctctctctct ctctctctct ctcccttcct tccttccttt cttcctttct
     1501 ccctttctct ctttctctct ctttcttttc tttttttttt ttaaagatac agccctaacc
     1561 tcatggaaac gcactggata atatcagccc accctgtttt tatagctgga cagaggagtc
     1621 agtgttgcta ccacggactg attttctatt ggtgacaagt gccccctgtg cctctctgag
     1681 tctgtccctc tgtggatttg tgtgattttc cttgtaagtg tttccgtcgt aagacagtca
     1741 tcatggacaa taaaatgcct cttcagtatt cgtt
//
