LOCUS       NM_053246               2604 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus docking protein 4 (Dok4), mRNA.
ACCESSION   NM_053246 XM_001475534
VERSION     NM_053246.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2604)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2604)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2604)
  AUTHORS   Hooker,E., Baldwin,C., Roodman,V., Batra,A., Isa,N.N., Takano,T.
            and Lemay,S.
  TITLE     Binding and inhibition of the ternary complex factor Elk-4/Sap1 by
            the adapter protein Dok-4
  JOURNAL   Biochem J 474 (9), 1509-1528 (2017)
   PUBMED   28275114
  REMARK    GeneRIF: Dok-4 can target Elk-4 activity through multiple
            mechanisms, including binding of the transactivation domain,
            nuclear exclusion and protein destabilization.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2604)
  AUTHORS   Tedeschi,A., Dupraz,S., Laskowski,C.J., Xue,J., Ulas,T., Beyer,M.,
            Schultze,J.L. and Bradke,F.
  TITLE     The Calcium Channel Subunit Alpha2delta2 Suppresses Axon
            Regeneration in the Adult CNS
  JOURNAL   Neuron 92 (2), 419-434 (2016)
   PUBMED   27720483
REFERENCE   5  (bases 1 to 2604)
  AUTHORS   Huang,T. and Krimm,R.F.
  TITLE     BDNF and NT4 play interchangeable roles in gustatory development
  JOURNAL   Dev Biol 386 (2), 308-320 (2014)
   PUBMED   24378336
REFERENCE   6  (bases 1 to 2604)
  AUTHORS   Hooker,E., Baldwin,C. and Lemay,S.
  TITLE     New insights into Dok-4 PTB domain structure and function
  JOURNAL   Biochem Biophys Res Commun 427 (1), 67-72 (2012)
   PUBMED   22982678
  REMARK    GeneRIF: the current study have explored in more detail the
            structure and function of the Dok-4 PTB domain.
REFERENCE   7  (bases 1 to 2604)
  AUTHORS   Narumiya,H., Hidaka,K., Shirai,M., Terami,H., Aburatani,H. and
            Morisaki,T.
  TITLE     Endocardiogenesis in embryoid bodies: novel markers identified by
            gene expression profiling
  JOURNAL   Biochem Biophys Res Commun 357 (4), 896-902 (2007)
   PUBMED   17462595
REFERENCE   8  (bases 1 to 2604)
  AUTHORS   Bedirian,A., Baldwin,C., Abe,J., Takano,T. and Lemay,S.
  TITLE     Pleckstrin homology and phosphotyrosine-binding domain-dependent
            membrane association and tyrosine phosphorylation of Dok-4, an
            inhibitory adapter molecule expressed in epithelial cells
  JOURNAL   J Biol Chem 279 (18), 19335-19349 (2004)
   PUBMED   14963042
  REMARK    GeneRIF: Dok-4 is a constitutively membrane-localized adapter
            molecule that may function as an inhibitor of tyrosine kinase
            signaling in epithelial cells.
REFERENCE   9  (bases 1 to 2604)
  AUTHORS   Grimm,J., Sachs,M., Britsch,S., Di Cesare,S., Schwarz-Romond,T.,
            Alitalo,K. and Birchmeier,W.
  TITLE     Novel p62dok family members, dok-4 and dok-5, are substrates of the
            c-Ret receptor tyrosine kinase and mediate neuronal differentiation
  JOURNAL   J Cell Biol 154 (2), 345-354 (2001)
   PUBMED   11470823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC129606.4.
            
            On Jul 11, 2009 this sequence version replaced NM_053246.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK156485.1, BC004705.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-182               AC129606.4         128745-128926       c
            183-391             AC129606.4         123474-123682       c
            392-499             AC129606.4         120006-120113       c
            500-614             AC129606.4         119742-119856       c
            615-734             AC129606.4         119362-119481       c
            735-924             AC129606.4         119071-119260       c
            925-1063            AC129606.4         118235-118373       c
            1064-1184           AC129606.4         117956-118076       c
            1185-2604           AC129606.4         116442-117861       c
FEATURES             Location/Qualifiers
     source          1..2604
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 46.93 cM"
     gene            1..2604
                     /gene="Dok4"
                     /note="docking protein 4"
                     /db_xref="GeneID:114255"
                     /db_xref="MGI:MGI:2148865"
     exon            1..182
                     /gene="Dok4"
                     /inference="alignment:Splign:2.1.0"
     exon            183..391
                     /gene="Dok4"
                     /inference="alignment:Splign:2.1.0"
     CDS             326..1303
                     /gene="Dok4"
                     /note="downstream of tyrosine kinase 4"
                     /codon_start=1
                     /product="docking protein 4"
                     /protein_id="NP_444476.1"
                     /db_xref="CCDS:CCDS40443.1"
                     /db_xref="GeneID:114255"
                     /db_xref="MGI:MGI:2148865"
                     /translation="MATNFNDIVKQGYVKMKSRKLGIYRRCWLVFRKSSSKGPQRLEK
                     YPDEKSVCLRGCPKVTEISNVKCVTRLPKETKRQAVAIIFTDDSARTFTCDSELEAEE
                     WYKTLSVECLGSRLNDISLGEPDLLAPGVQCEQTDRFNVFLLPCPNLDVYGECKLQIT
                     HENIYLWDIHNPRVKLVSWPLCSLRRYGRDATRFTFEAGRMCDAGEGLYTFQTQEGEQ
                     IYQRVHSATLAIAEQHKRVLLEMEKNVRLLNKGTEHYSYPCTPTAMLPRSAYWHHITG
                     SQNIAEASSYGESYGAAQASSETDLLNRFILLKPKPSQEDSSEAKTPAQ"
     exon            392..499
                     /gene="Dok4"
                     /inference="alignment:Splign:2.1.0"
     exon            500..614
                     /gene="Dok4"
                     /inference="alignment:Splign:2.1.0"
     exon            615..734
                     /gene="Dok4"
                     /inference="alignment:Splign:2.1.0"
     exon            735..924
                     /gene="Dok4"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1063
                     /gene="Dok4"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1184
                     /gene="Dok4"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..2604
                     /gene="Dok4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2176..2181
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dok4"
                     /note="hexamer: ATTAAA"
     polyA_site      2196
                     /gene="Dok4"
                     /note="major polyA site"
     regulatory      2550..2555
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dok4"
                     /note="hexamer: AATAAA"
     polyA_site      2572
                     /gene="Dok4"
                     /note="major polyA site"
ORIGIN      
        1 agaaccagct acctcccgag tctcctctgg atccggagct ggcggctgcg cttcacttct
       61 agcttacaac cagagccgcg cgccgccacc ctaccttccc ctcccggccg cgccgagacg
      121 cgggcatgag cccgccccgc gtcccgcgga gccagcgccc cggcccgggc ctcggcgcct
      181 aggagctggg cgaaggatct gctagaacaa tgctgaggcg ggggaggtga ggagtgtctt
      241 aaacaggtga tcgggggaca ccaagccacc tgggcacccc tcccggactc agcccggccg
      301 gcaccccaaa gacagcgggg caaccatggc gaccaatttc aacgacatcg tcaagcaagg
      361 ctatgtgaag atgaagagca ggaagctcgg gatttaccgg aggtgctggc tggtgttccg
      421 gaaatcttcc agcaaggggc cccagcggct ggagaagtat cctgatgaga agtccgtgtg
      481 cctccgaggc tgccccaagg tgactgagat tagcaacgtc aagtgtgtca cacggctccc
      541 caaggagacc aagaggcagg cggtggccat catattcaca gacgactccg ctcgcacctt
      601 cacttgtgac tcagagctgg aggcagaaga gtggtacaag acactgtccg tggaatgtct
      661 gggatcacgg ctcaatgaca tcagcctggg agagcctgac ctcctggctc caggagtaca
      721 gtgtgagcag acagatcgct tcaacgtctt cctgttaccc tgccccaacc tggacgtgta
      781 tggggagtgc aagctgcaga tcactcacga gaacatctac ctctgggaca tacacaaccc
      841 ccgcgtgaag ctcgtctcgt ggcccctctg ctctttgcgc cgttatggcc gagatgctac
      901 gcgctttacc tttgaggcgg gcaggatgtg tgacgctggg gaagggctct atacctttca
      961 gacacaggag ggggagcaga tttaccagcg ggttcacagt gccaccctgg ccatcgccga
     1021 gcagcacaag cgggtcctgc tggagatgga gaagaatgtg aggctgctga acaagggcac
     1081 cgagcactac tcctatccct gcacacccac ggccatgctg ccccgcagcg cgtactggca
     1141 ccatatcaca ggttctcaga acattgctga agcctccagc tatggggaaa gttatggggc
     1201 agcccaggcc agctcggaaa cagacctcct gaacaggttc atcttgctta agccaaagcc
     1261 cagtcaggag gatagcagtg aggccaagac ccctgcccag tgacagccag actggagaga
     1321 actcatgatt tgccgggcca cctgttgaaa ggctcactgt cgcagcccat ggacagcctc
     1381 gaggagctgg tggccaagag ccagaggaga gcaagctatc cctccttgcc ctcaagggtg
     1441 aggctggacc tcagcacatg gctggccaca ccacctgagc atgaggggct aagagccacc
     1501 gtgggactat acactgttaa tggttttaat atatatggct tataacatat actgtataaa
     1561 cgaggcttcc ctctatccct ccccaccaac acatacccat ttttaattcc acgaccaggc
     1621 atggtcaagg ctgtttttga gtatgagggt ggcagtgcct gtcctcagtg atacaactct
     1681 cctgctgcca agatggcctg agctgccagg gtcagaggag ggggacaatc agactggtgc
     1741 tgtctgctgg ctcttcctca gaagcccaag ggccaggaca gcaggtagct ctgtcctctg
     1801 ggcctacagt gacacaggaa gagtcctaaa cttcactgta ccgtgtggca gccttgcact
     1861 tgggagtgtt tagcagaggc ggcatctggt ttttaaatgc actttctgca ctggcccctt
     1921 cctgctcagt aggctgaaga tgtctttggg cagggctccc gttacctcgg cagcagagga
     1981 cagttggggc cagcccggag ggaggactgc agcaggactg ctgtggggag caccttgctg
     2041 ctctccttca ctgaccaggg gtataaagct ccagcagggg gagtcccttg cccaggccag
     2101 ccaccccagg ccagattcca aaactaagac tttcctatct ccccacacgg tgctgaggct
     2161 ccctgctgaa atgcaattaa agcaattgat tttctagtgc tggtatttat tgactaccgt
     2221 gcagaagggc tatctttcta ttcacatcaa accttttgtt gcgtgtttct gttttttaat
     2281 actttagggt tctgatttgt gggaacagac cttgtaaata accactgttc acatgtgtgg
     2341 cagaatgata aggggcccct cccagggggt gccctagagc cagggaggtg gcacagccag
     2401 cccaactctg tgacccagga aatgaccacc cagaggtcag ctagtttgta caagaaatgg
     2461 gcccaaccct ttgggaggga ggcaaaactg gctcagttag tggcacgatg acgcatgaag
     2521 gagattatgt tgtgctcttt attgccaaaa ataaaaactt ttaaaaagac aactactgtt
     2581 gatcaataaa tattccttct tttc
//
