LOCUS       NM_013739               1546 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus docking protein 3 (Dok3), mRNA.
ACCESSION   NM_013739 XM_984466
VERSION     NM_013739.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1546)
  AUTHORS   Loh,J.T., Teo,J.K.H., Kannan,S., Verma,C.S., Andiappan,A.K.,
            Lim,H.H. and Lam,K.P.
  TITLE     DOK3 promotes atopic dermatitis by enabling the phosphatase PP4C to
            inhibit the T cell signaling mediator CARD11
  JOURNAL   Sci Signal 16 (809), eadg5171 (2023)
   PUBMED   37906628
  REMARK    GeneRIF: DOK3 promotes atopic dermatitis by enabling the
            phosphatase PP4C to inhibit the T cell signaling mediator CARD11.
REFERENCE   2  (bases 1 to 1546)
  AUTHORS   Arimura,S., Inoue-Yamauchi,A., Katayama,K., Kanno,T., Jozawa,H.,
            Imoto,S. and Yamanashi,Y.
  TITLE     Loss of Dok-3 in Non-tumor Cells Induces Malignant Transformation
            of Benign Epithelial Tumor Cells of the Intestine
  JOURNAL   Cancer Res Commun 2 (12), 1590-1600 (2022)
   PUBMED   36970719
  REMARK    GeneRIF: Loss of Dok-3 in Non-tumor Cells Induces Malignant
            Transformation of Benign Epithelial Tumor Cells of the Intestine.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1546)
  AUTHORS   Loh,J.T., Teo,J.K.H. and Lam,K.P.
  TITLE     Dok3 restrains neutrophil production of calprotectin during TLR4
            sensing of SARS-CoV-2 spike protein
  JOURNAL   Front Immunol 13, 996637 (2022)
   PUBMED   36172386
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1546)
  AUTHORS   Loh,J.T., Lee,K.G., Lee,A.P., Teo,J.K.H., Lim,H.L., Kim,S.S.,
            Tan,A.H. and Lam,K.P.
  TITLE     DOK3 maintains intestinal homeostasis by suppressing JAK2/STAT3
            signaling and S100a8/9 production in neutrophils
  JOURNAL   Cell Death Dis 12 (11), 1054 (2021)
   PUBMED   34743196
  REMARK    GeneRIF: DOK3 maintains intestinal homeostasis by suppressing
            JAK2/STAT3 signaling and S100a8/9 production in neutrophils.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1546)
  AUTHORS   Yang,Y.Y., Ye,L., Chen,J., Qiu,Y., Yin,Y.L. and Li,P.
  TITLE     Dok3 is involved in cisplatin-induced acute kidney injury via
            regulation of inflammation and apoptosis
  JOURNAL   Biochem Biophys Res Commun 569, 132-138 (2021)
   PUBMED   34245977
  REMARK    GeneRIF: Dok3 is involved in cisplatin-induced acute kidney injury
            via regulation of inflammation and apoptosis.
REFERENCE   6  (bases 1 to 1546)
  AUTHORS   Robson,J.D., Davidson,D. and Veillette,A.
  TITLE     Inhibition of the Jun N-terminal protein kinase pathway by SHIP-1,
            a lipid phosphatase that interacts with the adaptor molecule Dok-3
  JOURNAL   Mol Cell Biol 24 (6), 2332-2343 (2004)
   PUBMED   14993273
REFERENCE   7  (bases 1 to 1546)
  AUTHORS   Yang,Y. and Seed,B.
  TITLE     Site-specific gene targeting in mouse embryonic stem cells with
            intact bacterial artificial chromosomes
  JOURNAL   Nat Biotechnol 21 (4), 447-451 (2003)
   PUBMED   12627171
REFERENCE   8  (bases 1 to 1546)
  AUTHORS   Grimm,J., Sachs,M., Britsch,S., Di Cesare,S., Schwarz-Romond,T.,
            Alitalo,K. and Birchmeier,W.
  TITLE     Novel p62dok family members, dok-4 and dok-5, are substrates of the
            c-Ret receptor tyrosine kinase and mediate neuronal differentiation
  JOURNAL   J Cell Biol 154 (2), 345-354 (2001)
   PUBMED   11470823
REFERENCE   9  (bases 1 to 1546)
  AUTHORS   Lemay,S., Davidson,D., Latour,S. and Veillette,A.
  TITLE     Dok-3, a novel adapter molecule involved in the negative regulation
            of immunoreceptor signaling
  JOURNAL   Mol Cell Biol 20 (8), 2743-2754 (2000)
   PUBMED   10733577
REFERENCE   10 (bases 1 to 1546)
  AUTHORS   Cong,F., Yuan,B. and Goff,S.P.
  TITLE     Characterization of a novel member of the DOK family that binds and
            modulates Abl signaling
  JOURNAL   Mol Cell Biol 19 (12), 8314-8325 (1999)
   PUBMED   10567556
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CT009762.8.
            
            On Nov 17, 2006 this sequence version replaced NM_013739.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF179242.1, AF237580.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                CT009762.8         4252-4341
            91-396              CT009762.8         5153-5458
            397-496             CT009762.8         8210-8309
            497-669             CT009762.8         8399-8571
            670-1546            CT009762.8         8679-9555
FEATURES             Location/Qualifiers
     source          1..1546
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 30.06 cM"
     gene            1..1546
                     /gene="Dok3"
                     /gene_synonym="Dokl"
                     /note="docking protein 3"
                     /db_xref="GeneID:27261"
                     /db_xref="MGI:MGI:1351490"
     exon            1..90
                     /gene="Dok3"
                     /gene_synonym="Dokl"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..1359
                     /gene="Dok3"
                     /gene_synonym="Dokl"
                     /note="DOK-L; p62(dok)-like protein; downstream of
                     tyrosine kinase 3; p62Dok-like protein; Dok-like protein"
                     /codon_start=1
                     /product="docking protein 3"
                     /protein_id="NP_038767.1"
                     /db_xref="CCDS:CCDS26548.1"
                     /db_xref="GeneID:27261"
                     /db_xref="MGI:MGI:1351490"
                     /translation="MESVEPPVKDGILYQQHVKFGKKCWRKVWALLYAGGPSGVARLE
                     SWDVRDGGLGPAGDRSTGPSRRGERRVIRLADCVSVLPADGESCPRDTGAFLITTTER
                     SHLLAAQHRQSWVDPICQLAFPGTGECSSGSGQAESPKRGFVPMEENSIYSSWQEVTE
                     FPVIVQRTEATSRCQLKGPYLLVLGQDDIQLRETSKPQACFSWPYRFLRKYGSDKGVF
                     SFEAGRRCDSGEGLFAFSSPRAPDICGVVAAAIARQRERLPELAMSPPCPLPRALSLP
                     SLEPPGELREVAPGFELPTPRKLPLTDPGPQSLPLLLSPTQEGPASGLYASVCKQTSK
                     HTGTAEHLYENVCMLEASPGLTNGGPEAQEGPPGGRSPLGSPIYHNTEDLSWPGSAQD
                     SNLEAQYRRLLELELDEAGSAGRSGAQAGIKAKLVTLLTRERKKGPAPCDRP"
     exon            91..396
                     /gene="Dok3"
                     /gene_synonym="Dokl"
                     /inference="alignment:Splign:2.1.0"
     exon            397..496
                     /gene="Dok3"
                     /gene_synonym="Dokl"
                     /inference="alignment:Splign:2.1.0"
     exon            497..669
                     /gene="Dok3"
                     /gene_synonym="Dokl"
                     /inference="alignment:Splign:2.1.0"
     exon            670..1546
                     /gene="Dok3"
                     /gene_synonym="Dokl"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1523..1528
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dok3"
                     /gene_synonym="Dokl"
                     /note="hexamer: AATAAA"
     polyA_site      1546
                     /gene="Dok3"
                     /gene_synonym="Dokl"
                     /note="major polyA site"
ORIGIN      
        1 cggaacttca gaactgcggt ggccatggag tctgtggagc ccccggtcaa agacggcatc
       61 ctctaccagc agcacgtaaa gtttggcaag aaatgctggc gcaaagtgtg ggctctgctg
      121 tatgcgggag gcccatcagg ggtagctcgg ctagaaagct gggacgtgcg tgatggtggc
      181 ctgggaccag caggcgacag gtccacaggg cccagccgtc gaggggaacg ccgggtcata
      241 cgcttggctg actgtgtatc tgtcctgcct gcggatggcg agagctgtcc cagggacact
      301 ggtgccttcc tgattaccac cactgagcga agccacctgt tggctgcaca gcaccgccag
      361 tcctgggtgg accccatctg tcagctggcc ttcccgggta ccggagaatg ttcgtcagga
      421 tcaggacagg ctgagagtcc aaaaaggggc tttgttccca tggaggaaaa ctctatctac
      481 tcctcctggc aggaagtgac cgagtttccg gtgatcgtgc agaggacaga ggccacctcc
      541 cgctgccagc tgaaaggacc ctacctcctg gtgctgggcc aagatgacat ccaactgagg
      601 gagacatcca agccccaggc ctgttttagc tggccctacc gtttcctgcg caagtacggc
      661 tctgacaagg gtgtgttctc gtttgaggct ggccgccgct gtgactcagg tgagggcctt
      721 tttgccttca gtagcccgcg tgccccagac atatgtgggg ttgtggctgc cgccattgcc
      781 cgccagcggg agcgtcttcc agagctggcc atgtccccac cctgccccct gcctcgggcc
      841 ctctccctgc cctccctaga gccccctgga gagcttcggg aggtggcccc aggatttgag
      901 ctgcccactc ccagaaagct gcctctaact gatcccgggc ctcaaagcct accactgctg
      961 ctcagcccca cacaagaagg accggcatcc ggtctctatg cgtccgtgtg caagcagacc
     1021 agcaagcaca caggcacggc ggagcatctc tatgagaacg tgtgcatgct ggaggccagc
     1081 cctgggctga ccaatggggg tcctgaagcc caagagggcc cccctggtgg ccgcagcccc
     1141 ctgggcagcc ctatctacca taacactgag gatctgagtt ggccgggctc ggcccaggac
     1201 agcaatctgg aagcccagta ccggaggctg ctggaactgg agctggatga ggccggaagc
     1261 gccggccgct ctggagcgca ggcaggcatc aaggccaagc tggtgaccct gctgacccgt
     1321 gaacggaaga agggccccgc cccctgtgac cggccctgaa ggcctgagcg gccagccact
     1381 gcaggacaga ggtgatcacc caagaccagg aacaacttcg aacataaccc gtctactctg
     1441 acctgcaggg acaagccagg tggcccgggg aggagccaca ctctgcccta cctcctccct
     1501 cagactgtac agattgaaca gtaataaagc ttgcctatca acttcc
//
