LOCUS       NM_010070               1803 bp    mRNA    linear   ROD 07-AUG-2024
DEFINITION  Mus musculus docking protein 1 (Dok1), transcript variant 1, mRNA.
ACCESSION   NM_010070
VERSION     NM_010070.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1803)
  AUTHORS   Laletin,V., Bernard,P.L., Montersino,C., Yamanashi,Y., Olive,D.,
            Castellano,R., Guittard,G. and Nunes,J.A.
  TITLE     DOK1 and DOK2 regulate CD8 T cell signaling and memory formation
            without affecting tumor cell killing
  JOURNAL   Sci Rep 14 (1), 15053 (2024)
   PUBMED   38956389
  REMARK    GeneRIF: DOK1 and DOK2 regulate CD8 T cell signaling and memory
            formation without affecting tumor cell killing.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1803)
  AUTHORS   Kajikawa,S., Taguchi,Y., Hayata,T., Ezura,Y., Ueta,R., Arimura,S.,
            Inoue,J.I., Noda,M. and Yamanashi,Y.
  TITLE     Dok-3 and Dok-1/-2 adaptors play distinctive roles in cell fusion
            and proliferation during osteoclastogenesis and cooperatively
            protect mice from osteopenia
  JOURNAL   Biochem Biophys Res Commun 498 (4), 967-974 (2018)
   PUBMED   29548825
  REMARK    GeneRIF: findings demonstrate that Dok-3 and Dok-1/-2 play
            distinctive but cooperative roles in osteoclastogenesis and protect
            mice from osteopenia, providing physiological and
            pathophysiological insight into bone homeostasis.
REFERENCE   3  (bases 1 to 1803)
  AUTHORS   Lahmidi,S., Yousefi,M., Dridi,S., Duplay,P. and Pearson,A.
  TITLE     Dok-1 and Dok-2 Are Required To Maintain Herpes Simplex Virus
            1-Specific CD8+ T Cells in a Murine Model of Ocular Infection
  JOURNAL   J Virol 91 (15), e02297-16 (2017)
   PUBMED   28490594
  REMARK    GeneRIF: Thus, Dok-1 and Dok-2 promote survival of glycoprotein
            B-specific CD8(+) T cells in trigeminal ganglia latently infected
            with herpes simplex virus 1.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1803)
  AUTHORS   Davidson,D., Zhong,M.C., Pandolfi,P.P., Bolland,S., Xavier,R.J.,
            Seed,B., Li,X., Gu,H. and Veillette,A.
  TITLE     The Csk-Associated Adaptor PAG Inhibits Effector T Cell Activation
            in Cooperation with Phosphatase PTPN22 and Dok Adaptors
  JOURNAL   Cell Rep 17 (10), 2776-2788 (2016)
   PUBMED   27926878
  REMARK    GeneRIF: in the absence of PAG, Csk becomes more associated with
            alternative partners; i.e., phosphatase PTPN22 and Dok adaptors.
            Combining PAG deficiency with PTPN22 or Dok adaptor deficiency
            further enhances effector T cell responses. Unlike PAG, Cbl
            ubiquitin ligases inhibit the activation of naive, but not of
            effector, T cells.
REFERENCE   5  (bases 1 to 1803)
  AUTHORS   Laroche-Lefebvre,C., Yousefi,M., Daudelin,J.F., Charpentier,T.,
            Tarrab,E., Klinck,R., Lamarre,A., Labrecque,N., Stager,S. and
            Duplay,P.
  TITLE     Dok-1 and Dok-2 Regulate the Formation of Memory CD8+ T Cells
  JOURNAL   J Immunol 197 (9), 3618-3627 (2016)
   PUBMED   27664281
  REMARK    GeneRIF: These results reveal the critical involvement of Dok-1 and
            Dok-2 in a negative-feedback loop that prevents overactivation of
            CD8(+) T cells and promotes memory formation.
REFERENCE   6  (bases 1 to 1803)
  AUTHORS   Encinas,J.A., Kikuchi,K., Chedotal,A., de Castro,F., Goodman,C.S.
            and Kimura,T.
  TITLE     Cloning, expression, and genetic mapping of Sema W, a member of the
            semaphorin family
  JOURNAL   Proc Natl Acad Sci U S A 96 (5), 2491-2496 (1999)
   PUBMED   10051670
REFERENCE   7  (bases 1 to 1803)
  AUTHORS   Jang,W., Hua,A., Spilson,S.V., Miller,W., Roe,B.A. and Meisler,M.H.
  TITLE     Comparative sequence of human and mouse BAC clones from the mnd2
            region of chromosome 2p13
  JOURNAL   Genome Res 9 (1), 53-61 (1999)
   PUBMED   9927484
REFERENCE   8  (bases 1 to 1803)
  AUTHORS   Weber,J.S., Jang,W., Simin,K., Lu,W., Yu,J. and Meisler,M.H.
  TITLE     High-resolution genetic, physical, and transcript map of the mnd2
            region of mouse chromosome 6
  JOURNAL   Genomics 54 (1), 107-115 (1998)
   PUBMED   9806835
REFERENCE   9  (bases 1 to 1803)
  AUTHORS   Nelms,K., Snow,A.J. and Noben-Trauth,K.
  TITLE     Dok1 encoding p62(dok) maps to mouse chromosome 6 and human
            chromosome 2 in a region of translocation in chronic lymphocytic
            leukemia
  JOURNAL   Genomics 53 (2), 243-245 (1998)
   PUBMED   9790776
REFERENCE   10 (bases 1 to 1803)
  AUTHORS   Yamanashi,Y. and Baltimore,D.
  TITLE     Identification of the Abl- and rasGAP-associated 62 kDa protein as
            a docking protein, Dok
  JOURNAL   Cell 88 (2), 205-211 (1997)
   PUBMED   9008161
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC104324.21 and AC158652.5.
            
            On Jul 20, 2022 this sequence version replaced NM_010070.4.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC013066.1, AK136382.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-97                AC104324.21        69912-70008         c
            98-158              AC104324.21        69547-69607         c
            159-397             AC158652.5         216808-217046       c
            398-491             AC158652.5         216576-216669       c
            492-676             AC158652.5         216272-216456       c
            677-1803            AC158652.5         214975-216101       c
FEATURES             Location/Qualifiers
     source          1..1803
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 35.94 cM"
     gene            1..1803
                     /gene="Dok1"
                     /gene_synonym="p62DOK"
                     /note="docking protein 1"
                     /db_xref="GeneID:13448"
                     /db_xref="MGI:MGI:893587"
     exon            1..97
                     /gene="Dok1"
                     /gene_synonym="p62DOK"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..1486
                     /gene="Dok1"
                     /gene_synonym="p62DOK"
                     /note="isoform 1 is encoded by transcript variant 1;
                     downstream of tyrosine kinase 1; p62(dok)"
                     /codon_start=1
                     /product="docking protein 1 isoform 1"
                     /protein_id="NP_034200.4"
                     /db_xref="CCDS:CCDS20265.1"
                     /db_xref="GeneID:13448"
                     /db_xref="MGI:MGI:893587"
                     /translation="MDGAVMEGPLFLQSQRFGTKRWRKTWAVLYPASPHGVARLEFFD
                     HKGSSSRGGRGGSRRLDCKMIRLAECVSVVPVTVESPPEPGAVAFRLDTAQRSHLLAA
                     DAVSSTAWVQTLCRTAFPKGGWALAQTENQPKFSALEMLENSLYSPTWEGSQFWVTSQ
                     KTEASERCGLQGSYILRVEAEKLTLLTLGAQSQILEPLLFWPYTLLRRYGRDKVMFSF
                     EAGRRCPSGPGTFTFQTSQGNDIFQAVEAAIQQQKAQGKVGQAQDILRTDSHDGETEG
                     KTVPPPVPQDPLGSPPALYAEPLDSLRIPPGPSQDSVYSDPLGSTPAGAGEGVHSKKP
                     LYWDLYGHVQQQLLKTKLTDSKEDPIYDEPEGLAPAPPRGLYDLPQEPRDAWWCQARL
                     KEEGYELPYNPATDDYAVPPPRSPKPAPAPKPQGLILPESGTTRGSGSKGFSSDTALY
                     SQVQKSGTSGAWDCGLSKVGNDRAGVKSEGST"
     exon            98..397
                     /gene="Dok1"
                     /gene_synonym="p62DOK"
                     /inference="alignment:Splign:2.1.0"
     exon            398..491
                     /gene="Dok1"
                     /gene_synonym="p62DOK"
                     /inference="alignment:Splign:2.1.0"
     exon            492..676
                     /gene="Dok1"
                     /gene_synonym="p62DOK"
                     /inference="alignment:Splign:2.1.0"
     exon            677..1803
                     /gene="Dok1"
                     /gene_synonym="p62DOK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1780..1785
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dok1"
                     /gene_synonym="p62DOK"
                     /note="hexamer: ATTAAA"
     polyA_site      1803
                     /gene="Dok1"
                     /gene_synonym="p62DOK"
                     /note="major polyA site"
ORIGIN      
        1 ctccgggcca ggaagcgcgg aaggaatcgc ctgggccatg gacggggctg tgatggaggg
       61 tccgcttttt ctgcagagtc agcgcttcgg gaccaagagg tggaggaaaa cttgggctgt
      121 gctttaccca gccagtcctc acggcgtggc gcggctggaa ttctttgatc acaaggggtc
      181 gagctctaga gggggtcgag gcggctctcg ccgtctagac tgcaagatga tacgcctggc
      241 tgaatgtgtg agcgtggtgc cggtgactgt ggagagtccc cctgagcccg gcgctgttgc
      301 cttccgcctg gacaccgcac agcgctcgca cctgctggcg gcggacgccg tatccagcac
      361 cgcctgggtg cagactttat gcagaaccgc ctttccgaaa ggcggctggg ctttggcgca
      421 gacggagaac caacctaagt tttctgcctt ggagatgctg gagaattcgc tgtacagccc
      481 cacctgggaa ggatcccagt tctgggtaac ctcgcagaag accgaggctt ctgaacgctg
      541 cggcttgcaa ggctcctaca tactgagggt ggaagctgag aagctgactc tcctgacttt
      601 gggtgcgcag agtcaaatcc tggagccgct ccttttctgg ccctacactc tgttgcgtcg
      661 ctatggccgg gacaaggtaa tgttctcctt tgaagctggt cgccgctgcc cctcaggccc
      721 tgggaccttc accttccaga cttctcaggg aaatgacatc tttcaggcag ttgaggctgc
      781 catccagcag cagaaagccc aaggaaaggt gggccaggca caggatatcc tcagaactga
      841 ctcccatgat ggggagacag aggggaagac agttccccct cctgttcccc aggaccccct
      901 gggcagccct ccagccctat atgcggagcc tttagactcc ttgcgaattc ctccaggccc
      961 ttctcaggac tctgtatatt cagaccccct gggcagcacc cctgctgggg caggggaagg
     1021 ggtgcattcc aagaaacctc tctattggga tttgtatggg catgtgcagc agcagttact
     1081 gaaaaccaag ctgacagact ccaaagagga ccccatctat gatgaacctg aaggcctggc
     1141 ccccgcccct ccccggggcc tttatgatct gcctcaggag cctcgggatg catggtggtg
     1201 ccaggctcgg ctgaaggaag agggctatga gctcccttac aaccctgcca ccgatgacta
     1261 tgctgtgcca cctccccgga gcccaaagcc tgctcctgcc cccaagccac agggcttgat
     1321 ccttcccgaa tcgggtacca ctcgtggcag tggcagcaaa ggcttcagct cagatacagc
     1381 tctgtacagc caggtccaga aaagtgggac ctcaggggct tgggactgtg gactctctaa
     1441 agtagggaat gacagggcgg gggtcaagtc tgagggttcc acctgagaca gttgctgata
     1501 ggaggtccaa tggggtggtg gcactgaaaa agaaaccgta gggtgggagg ggccagggac
     1561 cagaggagtc aagggatgac cagtcccagg agtagaacaa acagggctga gggataggcc
     1621 ctggggagcc ccagcagcgt taaggatggc tagctgatgg actaggccta tggaagcggc
     1681 ccactggtct gagtgggtgc cctttgggga gaccagtgtg gatcttcatt cttgttttgt
     1741 tctttgccag atacatattt aacttataag acaaatctca ttaaagccag cttgggttga
     1801 aaa
//
