LOCUS       NM_028785               7810 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Mus musculus dedicator of cytokinesis 8 (Dock8), mRNA.
ACCESSION   NM_028785 XM_488529
VERSION     NM_028785.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7810)
  AUTHORS   Zhang,M., Cron,R.R., Chu,N., Nguyen,J., Gordon,S.M., Eloseily,E.M.,
            Atkinson,T.P., Weiser,P., Walter,M.R., Kreiger,P.A., Canna,S.W.,
            Behrens,E.M. and Cron,R.Q.
  TITLE     Role of DOCK8 in cytokine storm syndromes
  JOURNAL   J Allergy Clin Immunol (2024) In press
   PUBMED   39423879
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 7810)
  AUTHORS   Wilkie,H., Das,M., Pelovitz,T., Bainter,W., Woods,B., Alasharee,M.,
            Sobh,A., Baris,S., Eltan,S.B., Al-Herz,W., Barbouche,M.R.,
            Ben-Mustapha,I., Ben-Ali,M., Sallam,M.T.H., Awad,A., Lotfy,S., El
            Marsafy,A., Ezzelarab,M., Farrar,M., Schmidt,B.A.R.,
            NandyMazumdar,M., Guttman-Yassky,E., Sheets,A., Vidic,K.M.,
            Murphy,G., Schlievert,P.M., Chou,J., Leyva-Castillo,J.M.,
            Janssen,E., Timilshina,M. and Geha,R.S.
  TITLE     Regulatory T-cell dysfunction and cutaneous exposure to
            Staphylococcus aureus underlie eczema in DOCK8 deficiency
  JOURNAL   J Allergy Clin Immunol 154 (1), 143-156 (2024)
   PUBMED   38185418
  REMARK    GeneRIF: Regulatory T-cell dysfunction and cutaneous exposure to
            Staphylococcus aureus underlie eczema in DOCK8 deficiency.
REFERENCE   3  (bases 1 to 7810)
  AUTHORS   Zhang,B., Chen,S., Yin,X., McBride,C.D., Gertie,J.A., Yurieva,M.,
            Bielecka,A.A., Hoffmann,B., Travis Hinson,J., Grassmann,J., Xu,L.,
            Siniscalco,E.R., Soldatenko,A., Hoyt,L., Joseph,J., Norton,E.B.,
            Uthaman,G., Palm,N.W., Liu,E., Eisenbarth,S.C. and Williams,A.
  TITLE     Metabolic fitness of IgA+ plasma cells in the gut requires DOCK8
  JOURNAL   Mucosal Immunol 17 (3), 431-449 (2024)
   PUBMED   38159726
  REMARK    GeneRIF: Metabolic fitness of IgA[+] plasma cells in the gut
            requires DOCK8.
REFERENCE   4  (bases 1 to 7810)
  AUTHORS   Mandato,E., Yan,Q., Ouyang,J., Paczkowska,J., Qin,Y., Hao,Y.,
            Bojarczuk,K., Hansen,J., Chapuy,B., Rodig,S.J., Khan,S.J.,
            Redd,R.A. and Shipp,M.A.
  TITLE     MYD88L265P augments proximal B-cell receptor signaling in large
            B-cell lymphomas via an interaction with DOCK8
  JOURNAL   Blood 142 (14), 1219-1232 (2023)
   PUBMED   37467575
  REMARK    GeneRIF: MYD88L265P augments proximal B-cell receptor signaling in
            large B-cell lymphomas via an interaction with DOCK8.
REFERENCE   5  (bases 1 to 7810)
  AUTHORS   Wilkie,H., Timilshina,M., Rahmayanti,S., Das,M., Pelovitz,T. and
            Geha,R.S.
  TITLE     DOCK8 is essential for neutrophil mediated clearance of cutaneous
            S. aureus infection
  JOURNAL   Clin Immunol 254, 109681 (2023)
   PUBMED   37385324
  REMARK    GeneRIF: DOCK8 is essential for neutrophil mediated clearance of
            cutaneous S. aureus infection.
REFERENCE   6  (bases 1 to 7810)
  AUTHORS   Lambe,T., Crawford,G., Johnson,A.L., Crockford,T.L.,
            Bouriez-Jones,T., Smyth,A.M., Pham,T.H., Zhang,Q., Freeman,A.F.,
            Cyster,J.G., Su,H.C. and Cornall,R.J.
  TITLE     DOCK8 is essential for T-cell survival and the maintenance of CD8+
            T-cell memory
  JOURNAL   Eur J Immunol 41 (12), 3423-3435 (2011)
   PUBMED   21969276
  REMARK    GeneRIF: Characterisation of the DOCK8-deficient mouse revealed
            T-cell lymphopenia, with increased T-cell turnover and decreased
            survival.
REFERENCE   7  (bases 1 to 7810)
  AUTHORS   Randall,K.L., Lambe,T., Goodnow,C.C. and Cornall,R.J.
  TITLE     The essential role of DOCK8 in humoral immunity
  JOURNAL   Dis Markers 29 (3-4), 141-150 (2010)
   PUBMED   21178273
  REMARK    GeneRIF: Mutation of the DOCK8 protein in mice has profound effects
            on humoral immunity with a failure to sustain the antibody response
            and failure of germinal center B cell persistence. (Review)
            Review article
REFERENCE   8  (bases 1 to 7810)
  AUTHORS   Randall,K.L., Lambe,T., Johnson,A.L., Treanor,B., Kucharska,E.,
            Domaschenz,H., Whittle,B., Tze,L.E., Enders,A., Crockford,T.L.,
            Bouriez-Jones,T., Alston,D., Cyster,J.G., Lenardo,M.J., Mackay,F.,
            Deenick,E.K., Tangye,S.G., Chan,T.D., Camidge,T., Brink,R.,
            Vinuesa,C.G., Batista,F.D., Cornall,R.J. and Goodnow,C.C.
  TITLE     Dock8 mutations cripple B cell immunological synapses, germinal
            centers and long-lived antibody production
  JOURNAL   Nat Immunol 10 (12), 1283-1291 (2009)
   PUBMED   19898472
  REMARK    GeneRIF: Humoral immunodeficiency due to Dock8 mutation provides
            evidence that organization of the immunological synapse is critical
            for signaling the survival of B cell subsets required for
            long-lasting immunity.
            Erratum:[Nat Immunol. 2010 Jul;11(7):644. Johnson, Andy [corrected
            to Johnson, Andy L]]
REFERENCE   9  (bases 1 to 7810)
  AUTHORS   Pritsker,M., Doniger,T.T., Kramer,L.C., Westcot,S.E. and
            Lemischka,I.R.
  TITLE     Diversification of stem cell molecular repertoire by alternative
            splicing
  JOURNAL   Proc Natl Acad Sci U S A 102 (40), 14290-14295 (2005)
   PUBMED   16183747
REFERENCE   10 (bases 1 to 7810)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Kitamura,H., Nakagawa,T., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of FLJ
            genes: the complete nucleotide sequences of 110 mouse
            FLJ-homologous cDnas identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (2), 127-135 (2004)
   PUBMED   15449545
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK050543.1, DT909592.1, AK038285.1, AK131180.1 and AK028968.1.
            
            On Apr 6, 2005 this sequence version replaced NM_028785.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849375,
                              SAMN00849380 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-378               AK050543.1         2-379
            379-562             DT909592.1         392-575
            563-1410            AK050543.1         565-1412
            1411-3245           AK038285.1         1159-2993
            3246-6815           AK131180.1         209-3778
            6816-7810           AK028968.1         1874-2868
FEATURES             Location/Qualifiers
     source          1..7810
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 19.91 cM"
     gene            1..7810
                     /gene="Dock8"
                     /gene_synonym="1200017A24Rik; 5830472H07Rik;
                     A130095G14Rik"
                     /note="dedicator of cytokinesis 8"
                     /db_xref="GeneID:76088"
                     /db_xref="MGI:MGI:1921396"
     exon            1..175
                     /gene="Dock8"
                     /gene_synonym="1200017A24Rik; 5830472H07Rik;
                     A130095G14Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..6425
                     /gene="Dock8"
                     /gene_synonym="1200017A24Rik; 5830472H07Rik;
                     A130095G14Rik"
                     /codon_start=1
                     /product="dedicator of cytokinesis protein 8"
                     /protein_id="NP_083061.2"
                     /db_xref="CCDS:CCDS37943.1"
                     /db_xref="GeneID:76088"
                     /db_xref="MGI:MGI:1921396"
                     /translation="MATLPSAERRAFALKINRYSSSEIRKQFTLPPNLGQYHRHSIST
                     SGFPSLQLPQLYEPVEPVDFEGLVMTHLNSLDAELAQELGDLTDDDLHVAFTPKECRT
                     LQHSLPEEGVELDPHVRDCVQTYIREWLIVNRKNQGSSEFCSFKKTGSRRDFQKTLQK
                     QTFESETLECSEPDTQTGPRHPLNVLCDVSGKGPLTSCDFDLRSLQPDERLENLLQLV
                     SAEDFEKEKEEARKTNRPAELFALYPPVDEEDAVEIRPVPECPKEHLGNRILVKVLTL
                     KFEIEIEPLFASIALYDVKERKKISENFHCDLNSDQFKGFLRAHTPSIDPSSQARSAV
                     FSVTYPSSDIYLVVKIEKVLQQGEIADCAEPYMIIKESDGGKSKEKVEKLKLQAESFC
                     QRLGKYRMPFAWAPISLASFFNISTLERESTDVEPGVGRNSVGEKRSLSQSRRPSERT
                     LSLEENGVGSNFKATTLATNIFFKQEGDRLSDEDLFKFLADYKRSSSLQRRVKSIPGS
                     LRLEISPAPDVMNCCLTPEMLPVKPFPENRTRPHKEILEFPIREVYVPHTVYRNLLYV
                     YPQRLNFASKLASARNITIKIQFMCGEDPSNAMPVIFGKSSGPEFLQEVYTAITYHNK
                     SPDFYEEVKIKLPAKLTVNHHLLFTFYHISCQQKQGASGESLLGYSWLPILLNERLQT
                     GSYCLPVALEKLPPNYSIHSAEKVPLQNPPIKWAEGHKGVFNIEVQAVSSVHTQDNHL
                     EKFFTLCHSLESQVSFPIRVLDQKITESTLEHELKLSIICLNSSRLEPLVLFLHLVLD
                     KLFQLSVQPMVIAGQTANFSQFAFESVVAIANSLHNSKDLRKDQHGRNCLLASYVHYV
                     FRLPELHRDTSKSGGPTTVVPDPRYHTYGRTSAAAVSSKLMQARVMSSSNPDLTGSHC
                     AADEEVKNIMSSKIADRNCSRMSYYCSGNSDAPGSTAAPRPVSKKHFHEELALQMVVS
                     TGVVRETVFKYAWFFFELLVKSMAQYVHNLDKRDSFRRTRFSDRFKDDITTIVNVVTS
                     EIAALLVKPQKESEQAEKINISLAFFLYDLLSIMDRGFVFNLIKHYCSQLSAKLNILP
                     TLISMRLEFLRILCSHEHYLNLNLLFMNTDTAPASPCPSISSQNSSSCSSFQDQKIAS
                     MFDLTPEYRQQHFLTGLLFTELAVALDAEGDGISRVQRKAVSAIHSLLCSHDLDPRCR
                     KPEVKVKIAALYLPLVGIILDALPQLYDFTDARSGRSRASGSYEEQDVANGINQNVAL
                     AIAGNHFNLKTSGAMLSSLPYKQYNMLNADTTRHLMICFLWIMKNADQSLIRKWIADL
                     PSMQLNRILDLLFICVSCFEYKGKQSSDKVSNQVLQKSRDVKAKLEEALLRGEGARGE
                     MMRRRIPGTDRFPGINENLRWRKEQTQWRQANEKLDKTKAELDQEALISGNLATEANL
                     IILDMQENIIQASSALDCKDSLLGGVLRVLVNSLSCDQSTTYLTHCFATLRALIAKFG
                     DLLFEEEMEQCADLCQRVLHHCSSSMDVTRSQACATLYLLMRFSFGATSNFARVKMQV
                     TMALASLVGKAPDFNEEHLRRSLRTILAYSEEDTAMQTTPFPMQVEELLCNLNSILYD
                     TVKMREFQEDPEMLMDLMYRIAKSYQASPDLRLTWLQNMAEKHTKKKCFTEAAMCLVH
                     AAALVAEYLSMLEDHSYLPVGSVSFQNISSNVLEESAVSDDTLSPDEDGVCSGRYFTE
                     SGLVGLLEQAAELFSTGGLYETVNEVYKLVIPILEAHRDFRKLTSTHDKLQKAFDNII
                     NKDHKRMFGTYFRVGFYGSRFGDLDEQEFVYKEPAITKLPEISHRLEGFYGQCFGAEF
                     VEVIKDSTPVDKTKLDPNKAYIQITFVEPYFDEYEMKDRVTYFEKNFNLRRFMYTTPF
                     TLEGRPRGELHEQHRRNTVLTTMHAFPYIKTRIRVSQKEEFVLTPIEVAIEDMKKKTL
                     QLAVATHQEPPDAKMLQMVLQGSVGATVNQGPLEVAQVFLAEIPADPKLYRHHNKLRL
                     CFKEFIMRCGEAVEKNRRLITAEQREYQQELKKNYNKLRDSLRPMIERKIPELYKPIF
                     RVDSQKRDSFHRSSFRKCETQLSQGS"
     exon            176..278
                     /gene="Dock8"
                     /gene_synonym="1200017A24Rik; 5830472H07Rik;
                     A130095G14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            279..454
                     /gene="Dock8"
                     /gene_synonym="1200017A24Rik; 5830472H07Rik;
                     A130095G14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            455..526
                     /gene="Dock8"
                     /gene_synonym="1200017A24Rik; 5830472H07Rik;
                     A130095G14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            527..650
                     /gene="Dock8"
                     /gene_synonym="1200017A24Rik; 5830472H07Rik;
                     A130095G14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            651..866
                     /gene="Dock8"
                     /gene_synonym="1200017A24Rik; 5830472H07Rik;
                     A130095G14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            867..952
                     /gene="Dock8"
                     /gene_synonym="1200017A24Rik; 5830472H07Rik;
                     A130095G14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1019
                     /gene="Dock8"
                     /gene_synonym="1200017A24Rik; 5830472H07Rik;
                     A130095G14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1169
                     /gene="Dock8"
                     /gene_synonym="1200017A24Rik; 5830472H07Rik;
                     A130095G14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1250
                     /gene="Dock8"
                     /gene_synonym="1200017A24Rik; 5830472H07Rik;
                     A130095G14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1410
                     /gene="Dock8"
                     /gene_synonym="1200017A24Rik; 5830472H07Rik;
                     A130095G14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1547
                     /gene="Dock8"
                     /gene_synonym="1200017A24Rik; 5830472H07Rik;
                     A130095G14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1641
                     /gene="Dock8"
                     /gene_synonym="1200017A24Rik; 5830472H07Rik;
                     A130095G14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1642..1804
                     /gene="Dock8"
                     /gene_synonym="1200017A24Rik; 5830472H07Rik;
                     A130095G14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1805..1922
                     /gene="Dock8"
                     /gene_synonym="1200017A24Rik; 5830472H07Rik;
                     A130095G14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1923..1993
                     /gene="Dock8"
                     /gene_synonym="1200017A24Rik; 5830472H07Rik;
                     A130095G14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1994..2132
                     /gene="Dock8"
                     /gene_synonym="1200017A24Rik; 5830472H07Rik;
                     A130095G14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2133..2234
                     /gene="Dock8"
                     /gene_synonym="1200017A24Rik; 5830472H07Rik;
                     A130095G14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2235..2330
                     /gene="Dock8"
                     /gene_synonym="1200017A24Rik; 5830472H07Rik;
                     A130095G14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2331..2565
                     /gene="Dock8"
                     /gene_synonym="1200017A24Rik; 5830472H07Rik;
                     A130095G14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2566..2730
                     /gene="Dock8"
                     /gene_synonym="1200017A24Rik; 5830472H07Rik;
                     A130095G14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2731..2903
                     /gene="Dock8"
                     /gene_synonym="1200017A24Rik; 5830472H07Rik;
                     A130095G14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2904..2999
                     /gene="Dock8"
                     /gene_synonym="1200017A24Rik; 5830472H07Rik;
                     A130095G14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3000..3095
                     /gene="Dock8"
                     /gene_synonym="1200017A24Rik; 5830472H07Rik;
                     A130095G14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3096..3245
                     /gene="Dock8"
                     /gene_synonym="1200017A24Rik; 5830472H07Rik;
                     A130095G14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3246..3359
                     /gene="Dock8"
                     /gene_synonym="1200017A24Rik; 5830472H07Rik;
                     A130095G14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3360..3515
                     /gene="Dock8"
                     /gene_synonym="1200017A24Rik; 5830472H07Rik;
                     A130095G14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3516..3655
                     /gene="Dock8"
                     /gene_synonym="1200017A24Rik; 5830472H07Rik;
                     A130095G14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3656..3825
                     /gene="Dock8"
                     /gene_synonym="1200017A24Rik; 5830472H07Rik;
                     A130095G14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3826..3965
                     /gene="Dock8"
                     /gene_synonym="1200017A24Rik; 5830472H07Rik;
                     A130095G14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3966..4148
                     /gene="Dock8"
                     /gene_synonym="1200017A24Rik; 5830472H07Rik;
                     A130095G14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4149..4278
                     /gene="Dock8"
                     /gene_synonym="1200017A24Rik; 5830472H07Rik;
                     A130095G14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4279..4366
                     /gene="Dock8"
                     /gene_synonym="1200017A24Rik; 5830472H07Rik;
                     A130095G14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4367..4463
                     /gene="Dock8"
                     /gene_synonym="1200017A24Rik; 5830472H07Rik;
                     A130095G14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4464..4598
                     /gene="Dock8"
                     /gene_synonym="1200017A24Rik; 5830472H07Rik;
                     A130095G14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4599..4751
                     /gene="Dock8"
                     /gene_synonym="1200017A24Rik; 5830472H07Rik;
                     A130095G14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4752..4910
                     /gene="Dock8"
                     /gene_synonym="1200017A24Rik; 5830472H07Rik;
                     A130095G14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4911..5011
                     /gene="Dock8"
                     /gene_synonym="1200017A24Rik; 5830472H07Rik;
                     A130095G14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5012..5204
                     /gene="Dock8"
                     /gene_synonym="1200017A24Rik; 5830472H07Rik;
                     A130095G14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5205..5348
                     /gene="Dock8"
                     /gene_synonym="1200017A24Rik; 5830472H07Rik;
                     A130095G14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5349..5480
                     /gene="Dock8"
                     /gene_synonym="1200017A24Rik; 5830472H07Rik;
                     A130095G14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5481..5615
                     /gene="Dock8"
                     /gene_synonym="1200017A24Rik; 5830472H07Rik;
                     A130095G14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5616..5705
                     /gene="Dock8"
                     /gene_synonym="1200017A24Rik; 5830472H07Rik;
                     A130095G14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5706..5942
                     /gene="Dock8"
                     /gene_synonym="1200017A24Rik; 5830472H07Rik;
                     A130095G14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5943..6086
                     /gene="Dock8"
                     /gene_synonym="1200017A24Rik; 5830472H07Rik;
                     A130095G14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            6087..6193
                     /gene="Dock8"
                     /gene_synonym="1200017A24Rik; 5830472H07Rik;
                     A130095G14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            6194..6364
                     /gene="Dock8"
                     /gene_synonym="1200017A24Rik; 5830472H07Rik;
                     A130095G14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            6365..7810
                     /gene="Dock8"
                     /gene_synonym="1200017A24Rik; 5830472H07Rik;
                     A130095G14Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7495..7500
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dock8"
                     /gene_synonym="1200017A24Rik; 5830472H07Rik;
                     A130095G14Rik"
                     /note="hexamer: AATAAA"
     polyA_site      7512
                     /gene="Dock8"
                     /gene_synonym="1200017A24Rik; 5830472H07Rik;
                     A130095G14Rik"
                     /note="major polyA site"
     regulatory      7527..7532
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dock8"
                     /gene_synonym="1200017A24Rik; 5830472H07Rik;
                     A130095G14Rik"
                     /note="hexamer: AATAAA"
     regulatory      7539..7544
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dock8"
                     /gene_synonym="1200017A24Rik; 5830472H07Rik;
                     A130095G14Rik"
                     /note="hexamer: AATAAA"
     polyA_site      7547
                     /gene="Dock8"
                     /gene_synonym="1200017A24Rik; 5830472H07Rik;
                     A130095G14Rik"
                     /note="major polyA site"
     polyA_site      7556
                     /gene="Dock8"
                     /gene_synonym="1200017A24Rik; 5830472H07Rik;
                     A130095G14Rik"
                     /note="major polyA site"
ORIGIN      
        1 gcggcgcggc tgacagatga ggctggcgcc gggcgcgccg ggctctgcag cggctgtgcg
       61 ttcgggtccc gtccccccgc agccccgcga gccccgaagc cgtggaaccg cgcgcgcgcg
      121 ccatggccac gctgccgagc gccgagcgcc gcgccttcgc gctcaagatc aacaggtatt
      181 catcgtcaga aataaggaag cagtttacgc tcccacccaa cctcggacag taccatcggc
      241 acagtatcag tacatctggt ttcccctctc ttcagctacc tcagctttat gagcctgtcg
      301 agccagtgga ctttgaagga ctcgtgatga cacacttaaa cagcttggat gcagagctgg
      361 cccaggagct gggggacctc accgatgacg acctgcatgt ggccttcaca cccaaagaat
      421 gtaggacttt gcagcactct ctgccagagg aaggagttga actggatcct cacgtcagag
      481 actgtgttca gacctatatt cgagagtggc tgattgtaaa ccggaaaaac caaggaagtt
      541 cagagttttg cagctttaaa aagacgggat ctcgcagaga ttttcagaag acgcttcaga
      601 aacagacgtt tgagtcagaa accttggagt gcagtgaacc ggacactcag acaggacccc
      661 gtcatccctt aaacgtgctg tgtgacgtgt ctgggaaggg ccccctcact tcttgtgact
      721 tcgacctccg cagcctgcag cctgatgagc ggctggaaaa cctgctccag cttgtgagcg
      781 ctgaggactt tgagaaggag aaggaggagg cccgcaagac caatcggccg gctgagctct
      841 ttgccctcta tccgcccgtg gatgaggagg atgctgtgga aatacgtcca gtacctgaat
      901 gtcctaagga acatctgggc aacagaatat tggtcaaggt gctgactctg aagtttgaga
      961 ttgaaattga acctctgttt gccagtattg ccctctatga cgttaaagaa aggaaaaaga
     1021 tctcagaaaa tttccactgt gacctgaact ccgaccagtt caaagggttt ctgcgagctc
     1081 acacaccctc gattgaccca tcgagtcagg ctaggtctgc cgtgttctct gtcacctacc
     1141 catcttcaga catctacctg gttgtcaaga ttgaaaaggt ccttcagcaa ggagagattg
     1201 cagactgtgc agaaccctac atgatcatca aagaaagcga tggtggaaag agtaaagaaa
     1261 aggttgaaaa actaaaactt caagctgaat ccttctgcca acgtttgggg aaataccgga
     1321 tgcccttcgc ctgggccccc attagcttag caagcttctt caacatctcc acccttgaaa
     1381 gggagagcac agatgtggag cctggggttg ggaggaactc tgtgggtgag aagaggagct
     1441 tgtcccaatc caggaggccc tctgagcgaa ccctctcctt ggaggaaaat ggagttggat
     1501 ccaacttcaa agccaccacc ttggccacca acatcttctt caaacaggag ggagatcgcc
     1561 ttagtgatga agacttgttc aagtttttag ctgactacaa gagatcttca tccctacagc
     1621 gaagagtcaa atccatccca ggctcactga ggctggagat atccccagct cccgacgtga
     1681 tgaactgctg cctgacgccc gagatgctgc cagtcaaacc ttttcctgaa aatcggacgc
     1741 gtccacacaa ggagattttg gaatttccga tccgggaggt gtacgtccct cacactgtgt
     1801 acagaaacct tctgtacgta tacccccagc gactgaactt cgctagcaag ctagcatctg
     1861 cccggaacat cacaataaag attcagttta tgtgcggaga agaccccagc aatgctatgc
     1921 cggtcatctt tggcaagtcc agtgggcctg aatttctgca ggaagtatat acagctatta
     1981 cataccataa taagtctcct gacttttacg aagaagtgaa aattaagctc cctgccaagc
     2041 tcacagtgaa tcatcacctc ctcttcacct tctaccacat cagctgtcag cagaagcaag
     2101 gggcctccgg agaaagcctt ctggggtact cgtggctgcc gattctgtta aacgaacgtc
     2161 ttcaaaccgg atcctactgt ctgcctgttg ccttggaaaa actaccaccc aactactcca
     2221 tacattctgc tgagaaagtc cctttacaga atcctcccat taagtgggcc gagggccata
     2281 agggggtatt taatattgaa gtgcaagctg tttcttccgt ccacacccag gataaccacc
     2341 tggagaagtt cttcaccctt tgccactccc tggagagcca ggtgagcttc cctatccgtg
     2401 tgctggacca gaagatcacc gagagcacgc tggagcacga gctgaaactc agcatcatct
     2461 gcctcaactc ctcccgcctg gagcccctcg tgctcttcct ccacctggtg cttgacaagc
     2521 tgttccagct ttccgtgcag cccatggtca ttgctggcca aacagcaaac ttctcccagt
     2581 ttgccttcga gtctgtggtg gccattgcca atagcctgca caacagcaag gacctgagga
     2641 aggaccagca cgggaggaac tgccttctgg cctcctacgt gcactacgtg ttccggctgc
     2701 cggaactgca cagggataca tccaagtcag gtggccccac caccgtagtc cccgaccccc
     2761 gataccacac atatggacgc acatctgccg ctgcagtgag ttcaaagctg atgcaggccc
     2821 gtgtgatgag cagcagcaac ccagacctga ctgggtcaca ctgtgcagcc gatgaggaag
     2881 ttaagaacat catgtcttca aagattgccg atcgcaactg cagccggatg tcttactatt
     2941 gctctggcaa tagtgatgcg ccaggttcaa ctgcagcccc aagaccagtc agcaaaaagc
     3001 atttccatga ggagcttgcc ctgcagatgg tggtcagcac tggagtagtg agagaaacgg
     3061 tcttcaagta cgcctggttc ttctttgagc ttctggtgaa aagcatggca cagtatgtcc
     3121 ataacctgga taaacgggac agttttcgga ggactcgttt ttctgaccgc ttcaaagatg
     3181 acataactac cattgttaat gtggtcacct cggagatagc agccctttta gtgaaacctc
     3241 agaaggaaag cgagcaggca gaaaagatca acatcagcct tgccttcttc ctgtatgacc
     3301 tcctgtcaat catggacaga ggcttcgtgt tcaacctcat caagcattac tgcagccagc
     3361 tgtcagccaa gctgaatatc cttccaacgc tcatctccat gcggctggaa ttcctgagga
     3421 tcctctgcag ccatgagcac tacctcaact tgaacctcct cttcatgaat accgacaccg
     3481 caccagcatc tccctgcccc tccatatcct cccagaactc gagttcctgc tccagtttcc
     3541 aggaccaaaa gattgccagc atgttcgatc tgaccccgga gtaccggcag cagcacttcc
     3601 ttacagggct gctcttcacg gagctggctg ttgccctgga tgctgagggg gatggaatta
     3661 gcagagtaca gagaaaagcc gtgagtgcca tccacagcct tctgtgttct cacgacctgg
     3721 atccacggtg tcgcaaaccg gaagtgaaag tcaaaatcgc cgccctttac ctgccgttgg
     3781 tcggcatcat tctggacgct ctgccacagc tctatgactt tacagatgct cgcagtggaa
     3841 ggagtcgtgc cagtggctcg tatgaagaac aagatgtggc caacggaatc aaccagaatg
     3901 tggccctggc catagcgggg aatcacttta atttgaagac cagtggagca atgctgtctt
     3961 ccttgcccta taagcagtac aacatgctga atgcagacac cacccgccac ctcatgattt
     4021 gcttcctgtg gatcatgaaa aatgctgatc agagcctcat caggaagtgg atcgctgacc
     4081 tgccttccat gcagctcaat aggattctgg acctgctgtt catctgtgtc tcctgctttg
     4141 aatacaaggg aaagcagagt tctgacaaag tcagtaacca ggtcctgcag aagtcaagag
     4201 acgtcaaggc caagctggaa gaggccctgc tccgtgggga aggagcccgt ggggagatga
     4261 tgcgccgtcg cattccaggg actgaccggt ttccaggcat aaatgaaaat ctgagatgga
     4321 ggaaagagca gacacagtgg cggcaggcta atgagaagct ggacaaaaca aaggcagagt
     4381 tagatcaaga agccttgatc agtggcaacc tggctacaga agctaatttg atcatcctgg
     4441 atatgcagga gaacatcatc caggcaagct ccgccctgga ctgtaaagac agcctgctgg
     4501 gaggtgtcct ccgggtcctg gtgaattctc tgagctgtga ccagagcacc acctacctga
     4561 ctcactgttt cgcaaccctc cgagccctca tcgccaagtt tggagacctg ctgttcgagg
     4621 aggagatgga gcagtgtgct gacctgtgtc agcgggtgct acatcactgc agcagcagca
     4681 tggacgtcac acggagccaa gcctgcgcca ccctctacct cctcatgcgg ttcagcttcg
     4741 gagccaccag taactttgca agggtaaaga tgcaagtgac catggcactg gcatccctgg
     4801 taggcaaagc accagacttc aacgaagagc acctgagaag gtccttaagg acaattttgg
     4861 cctattcaga agaggacacg gccatgcaga caactccttt tcccatgcag gtggaggaac
     4921 ttctctgcaa tctgaacagc attctgtacg acacagtgaa gatgagggaa ttccaggaag
     4981 accctgagat gcttatggac ctcatgtaca gaattgccaa gagctaccag gcatcgcctg
     5041 acctgcggct gacttggctc cagaacatgg cagagaaaca cactaagaag aagtgcttca
     5101 cagaggccgc catgtgcctg gtgcatgcag ccgccctggt ggccgagtac ctgagcatgc
     5161 tggaggacca cagctacctg ccggtgggca gcgtcagctt tcagaatatt tcttccaatg
     5221 tgcttgagga gtctgcagtc tctgatgaca ccttgtcacc tgatgaggac ggcgtatgct
     5281 ctggtcggta cttcactgag agtggcctgg tgggcctcct ggagcaggct gcggagctct
     5341 tcagcacggg aggcttgtac gagacggtta atgaagtcta caagctggtc atccctatcc
     5401 tggaggcaca cagagatttc cggaagctga cctccactca cgacaagctg cagaaggcct
     5461 tcgataacat catcaacaag gaccataaga ggatgtttgg gacctacttc cgagttggtt
     5521 tctacggatc ccgatttggg gatttggatg agcaggagtt cgtgtacaag gaacccgcaa
     5581 tcacgaagct cccggagatc tcacatagac tagagggatt ttatggccag tgtttcggtg
     5641 cagagtttgt ggaagtgata aaagactcta ctccagtgga caaaaccaag ttggatccta
     5701 acaaggccta cattcagatc acttttgtgg agccttactt tgatgaatat gagatgaaag
     5761 accgggtgac ctacttcgag aagaatttca acctccggag gttcatgtac accaccccct
     5821 tcaccctgga ggggagaccc cggggcgagc ttcatgagca acaccgcaga aacaccgtgc
     5881 tcaccaccat gcacgccttc ccctacatca agaccaggat ccgagtcagc cagaaagagg
     5941 agttcgtttt gactccgatt gaggttgcca ttgaagatat gaagaagaag accctgcagt
     6001 tagccgtggc cactcaccag gagccccctg atgcaaagat gctgcaaatg gtactgcagg
     6061 gctctgtagg agccactgta aatcagggac cactggaggt ggcccaagtg ttcttggctg
     6121 aaattccagc tgacccaaag ctctaccgac atcacaacaa gctgaggttg tgcttcaagg
     6181 agttcataat gcgatgcgga gaggccgtgg agaagaacag gcgactcatc accgcagagc
     6241 agcgggagta ccagcaggag ctgaagaaga actacaacaa gctgagagac agcctcaggc
     6301 ccatgattga gcggaaaatc ccagagctct acaagcccat attcagagtt gacagtcaga
     6361 agagggactc tttccacaga tctagtttca ggaaatgtga aacccagttg tcacagggca
     6421 gctgaaaaaa gccacctttg ccggtgacga ctggggcccc actacctgga aggactcgct
     6481 ggtacgtcca cagcagccac ccaagactga ctccacagtc cctgcccagc cagtgctctg
     6541 gaaacttggg gggtctatga ccacagaatg atacccaagt gtattgtgga ctatcttgac
     6601 catgtcaggg gttggggtgg ggtgggtaaa tcaggggata attgtattta ttaaagtatt
     6661 tttcacagtg ctgtagaagg aaggcctaag ctgtttctgc tgagtggctt ggctggtcac
     6721 aggcctccca gaaagtgact tcttctgacc tatgtttgaa ttcctaagat aaactcaaat
     6781 tgtggacaga agagtggaac actgtccagc aacctattcc gagtgaattt cactcatccc
     6841 tttggtgaga agaaaagata aaactccaga agagtgaacc attttccaat atatctgtga
     6901 gaaaaagtct tacaggaaat agatggagcg ctccacacct ctcctgagct gccggactat
     6961 gtgccgtcta gttattgctg cattgttgct tctgttaagc tgagtgagtc cacctctacg
     7021 caggggacag ttgtacgaga cagacagtcc aggtcgcccg gccacacagc actgacagca
     7081 catgccccag agcgggagca gttctcctag gacatcttgc cggttccctg tacacttgct
     7141 ctcactgcct cctttttctc cgggataagg tcatttttct acaagacatt catttcagaa
     7201 cattgtgtcc tctgtgtgct acagggatat atgctttgga ttgtttttac agtgaacttg
     7261 gaagagggaa agaaacctat ggtttgagaa ttaaattata tattttcata caactcatga
     7321 ccttacctaa tgctaaagac agaataagaa tgataagcaa gtggggtgac aatgcacgcc
     7381 tttagtccca gcactcagaa gacagagaca ggtggatctc tgagtttaag gccagcctgg
     7441 tctacagagc gagttccagg acagccagat tacacaatga gaccatgtct cataaataaa
     7501 taaataaata aataaacaaa caaataaata aataaataaa taaattgcaa aatgcttccc
     7561 tgtgccactg ctgtttgtga ctttgacaac tcaaagtgct gtgaagcttc agagaccctg
     7621 gtaggactgg ccttagtcaa gcagtgccct ccagagtggc cctagtgcaa tgtcctaatc
     7681 cttctggttg gaacagagtt ctcagttgtc agtactgaaa tgttcacaca taccattggg
     7741 catgagtgac cttattctga aggaagatgt tggaaaaaat aaatggcttg ctggctgcac
     7801 ttatttaaac
//
