LOCUS       NM_177780              10335 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus dedicator of cytokinesis 5 (Dock5), mRNA.
ACCESSION   NM_177780 NM_172811 XM_001001588 XM_001001616 XM_001003628
            XM_001003634 XM_001003638 XM_001003643 XM_619261 XM_619262
            XM_990099 XM_990127
VERSION     NM_177780.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 10335)
  AUTHORS   Qu,H., Liu,X., Zhu,J., Xiong,X., Li,L., He,Q., Wang,Y., Yang,G.,
            Zhang,L., Yang,Q., Luo,G., Zheng,Y. and Zheng,H.
  TITLE     Dock5 Deficiency Promotes Proteinuric Kidney Diseases via
            Modulating Podocyte Lipid Metabolism
  JOURNAL   Adv Sci (Weinh) 11 (11), e2306365 (2024)
   PUBMED   38161229
  REMARK    GeneRIF: Dock5 Deficiency Promotes Proteinuric Kidney Diseases via
            Modulating Podocyte Lipid Metabolism.
REFERENCE   2  (bases 1 to 10335)
  AUTHORS   Kunimura,K., Akiyoshi,S., Uruno,T., Matsubara,K., Sakata,D.,
            Morino,K., Hirotani,K. and Fukui,Y.
  TITLE     DOCK2 regulates MRGPRX2/B2-mediated mast cell degranulation and
            drug-induced anaphylaxis
  JOURNAL   J Allergy Clin Immunol 151 (6), 1585-1594 (2023)
   PUBMED   36804596
REFERENCE   3  (bases 1 to 10335)
  AUTHORS   Qu,H., Miao,T., Wang,Y., Tan,L., Huang,B., Zhang,L., Liu,X.,
            Long,M., Zhang,R., Liao,X., Gong,X., Wang,J., Xiong,X., Liu,J.,
            Li,X., Yu,J., Yang,G., Zhu,Z., Zheng,H. and Zheng,Y.
  TITLE     Dedicator of Cytokinesis 5 Regulates Keratinocyte Function and
            Promotes Diabetic Wound Healing
  JOURNAL   Diabetes 70 (5), 1170-1184 (2021)
   PUBMED   33627322
REFERENCE   4  (bases 1 to 10335)
  AUTHORS   Lai,Y., Zhao,A., Tan,M., Yang,M., Lin,Y., Li,S., Song,J., Zheng,H.,
            Zhu,Z., Liu,D., Liu,C., Li,L. and Yang,G.
  TITLE     DOCK5 regulates energy balance and hepatic insulin sensitivity by
            targeting mTORC1 signaling
  JOURNAL   EMBO Rep 21 (2), e49473 (2020)
   PUBMED   31885214
  REMARK    GeneRIF: DOCK5 regulates energy balance and hepatic insulin
            sensitivity by targeting mTORC1 signaling.
REFERENCE   5  (bases 1 to 10335)
  AUTHORS   Guimbal,S., Morel,A., Guerit,D., Chardon,M., Blangy,A. and Vives,V.
  TITLE     Dock5 is a new regulator of microtubule dynamic instability in
            osteoclasts
  JOURNAL   Biol Cell 111 (11), 271-283 (2019)
   PUBMED   31461543
  REMARK    GeneRIF: The authors show that Dock5 is as a new regulator of
            microtubule dynamic instability in osteoclast through Rac-dependent
            and -independent pathways.
REFERENCE   6  (bases 1 to 10335)
  AUTHORS   Hiai,H.
  TITLE     Hereditary cataract mouse with lens rupture: disputed priority
  JOURNAL   Lab Anim 31 (4), 389-390 (1997)
   PUBMED   9350710
REFERENCE   7  (bases 1 to 10335)
  AUTHORS   Shvarts,A., Bazuine,M., Dekker,P., Ramos,Y.F., Steegenga,W.T.,
            Merckx,G., van Ham,R.C., van der Houven van Oordt,W., van der
            Eb,A.J. and Jochemsen,A.G.
  TITLE     Isolation and identification of the human homolog of a new
            p53-binding protein, Mdmx
  JOURNAL   Genomics 43 (1), 34-42 (1997)
   PUBMED   9226370
REFERENCE   8  (bases 1 to 10335)
  AUTHORS   Song,C.W., Okumoto,M., Mori,N., Yamate,J., Sakuma,S., Kim,J.S.,
            Han,S.S., Hilgers,J. and Esaki,K.
  TITLE     A new hereditary cataract mouse with lens rupture
  JOURNAL   Lab Anim 31 (3), 248-253 (1997)
   PUBMED   9230506
REFERENCE   9  (bases 1 to 10335)
  AUTHORS   Iida,F., Matsushima,Y., Hiai,H., Uga,S. and Honda,Y.
  TITLE     Rupture of lens cataract: a novel hereditary recessive cataract
            model in the mouse
  JOURNAL   Exp Eye Res 64 (1), 107-113 (1997)
   PUBMED   9093026
REFERENCE   10 (bases 1 to 10335)
  AUTHORS   Matsushima,Y., Kamoto,T., Iida,F., Abujiang,P., Honda,Y. and
            Hiai,H.
  TITLE     Mapping of rupture of lens cataract (rlc) on mouse chromosome 14
  JOURNAL   Genomics 36 (3), 553-554 (1996)
   PUBMED   8884285
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC090431.9, AK147975.1, CF746784.1, BC050992.1, AC093020.6 and
            AK004325.1.
            
            On or before Jun 12, 2008 this sequence version replaced
            NM_172811.1, XM_001003634.1, XM_001003643.1, XM_001003628.1,
            XM_001003638.1, XM_990099.1, XM_619261.3, XM_619262.3, XM_990127.1,
            XM_001001616.1, XM_001001588.1, NM_177780.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC158046.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-239               AC090431.9         95811-96049
            240-2406            AK147975.1         101-2267
            2407-2997           CF746784.1         118-708
            2998-3069           AK147975.1         2861-2932
            3070-4644           AK147975.1         2934-4508
            4645-6644           BC050992.1         1843-3842
            6645-10329          AC093020.6         138997-142681       c
            10330-10335         AK004325.1         1405-1410
FEATURES             Location/Qualifiers
     source          1..10335
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 34.66 cM"
     gene            1..10335
                     /gene="Dock5"
                     /gene_synonym="1110060D06Rik; E130320D18; lr2; rlc"
                     /note="dedicator of cytokinesis 5"
                     /db_xref="GeneID:68813"
                     /db_xref="MGI:MGI:2652871"
     exon            1..281
                     /gene="Dock5"
                     /gene_synonym="1110060D06Rik; E130320D18; lr2; rlc"
                     /inference="alignment:Splign:2.1.0"
     CDS             239..5845
                     /gene="Dock5"
                     /gene_synonym="1110060D06Rik; E130320D18; lr2; rlc"
                     /note="lens rupture protein 2; rupture of lens cataract
                     protein; lens rupture 2"
                     /codon_start=1
                     /product="dedicator of cytokinesis protein 5"
                     /protein_id="NP_808448.2"
                     /db_xref="CCDS:CCDS36963.1"
                     /db_xref="GeneID:68813"
                     /db_xref="MGI:MGI:2652871"
                     /translation="MARWIPTKRQKYGVAIYNYNASQDVELSLQIGDTVHILEMYEGW
                     YRGYALQNRSKKGIFPETYIHLKEATVEDGGQHETVIPGELPLVQELTNTLREWAVIW
                     RKLYVNNKVTLFRQLQQMTYSLIEWRSQILSGTLPKDELAELKKKVTAKIDHGNRMLG
                     LDLVVRDDNGNILDPDETSTVALFRAHEVASKRIEEKIQEEKSILQNLDLRGQAIFST
                     VHTYGLYVNFKNFVCNIGEDAELFIALYDPDQSTFISENYLIRWGSNGMPKEIEKLNN
                     LQAVFTDLSSTDLIRPRISLVCQIVRVGRMELKEGKKHTCGLRRPFGVAVMDISDIVH
                     GKVDDEEKQHFIPFQQIAMETYIRQRQLIMSPLITSHVIGENEPLTSVLNKVIAAKEV
                     NHKGQGLWVSLKLLPGDLTQVQKNFSHLVDRSTAIARKMGFPEIILPGDVRNDIYVTL
                     IHGEFDKGKKKTPKNVEVTMSVFDEEGNLLEKAIHPGAGYEGVSEYKSVVYYQVKQPC
                     WYETVKVFIAIEEVTRCHIRFTFRHRSSQESRDKSERAFGVAFVKLMNADGTTLQDGR
                     HDLVVYKGDNKKMEDAKYYLTLPGTKAELEEKELQASKNPSVFTPSKDSTKDSFQIAT
                     LICSTKLTQNVDLLGLLNWRSNSQNIKHNLKKLMEVDGGEIVKFLQDTLDALFNIMME
                     MSDNETYDFLVFDALVFIISLIGDIKFQHFNPVLETYIYKHFSATLAHVKLSKVLNFY
                     VANAEDPSKTELLFAALKALKYLFRFIIQSRVLYLRFYGQSEDGDEFNDSIRQLFLAF
                     NTLMDRPLEEAVKIKGAALKYLPSIINDVKLVFDPMELSVLFCKFIQSIPDNQLVRQK
                     LNCMTKIVESSLFQQAECREVLLPLLTDQLSGQLDDHSTKPDHEASSQLLSNILEVLD
                     RTDVGPTSAHVQLIMERLLRRINRTVIGMSRQSPHIGSFVACMIAVLRQMEDSHYSHY
                     ISTFKTRQDIIDFLMETFIMFKDLIGKNVYAKDWMVMNMTQNRVFLRAINQFAEVLTK
                     SFMDQASFELQLWNNYFHLAVAFLTHESLQLETFSEAKRNKIVKKYGDMRKEIGFRIR
                     DMWYNLGPHKIKFIPSMVGPILEVTLTPEVELRKATIPIFFDMMQCEFNLSGNGNFHM
                     FENELITKLDQEVEGGRGDEQYKVLLEKLLLEHCRKHKYLANSGEAFAFLVSSLLENL
                     LDYRTIIIHDESKENRMSCTVNVLNFYKDKKREDIYIRYLYKLRDLHRDCENYTEAAY
                     TLLLHAELLQWSDKPCVPHLLQRDSYYVYTQQELKEKLYQEIISYFDKGKMWEKAIKL
                     SKELAETYESKVFDYEGLGSLLKKRALFYENIIKAMRPQPEYFAVGYYGQGFPSFLRN
                     KIFIYRGKEYERREDFSLRLLTQFPNAEKMTSTTPPGEDIKSSPKQYLQCFTVKPVMS
                     LPPSYKDKPVPEQILNYYRANEVQQFSYSRPFRKGEKDPENEFATMWIERTTYRTAYT
                     FPGILKWFEAKEISVEEISPLENAIETMELTNERVSNCVQQHAWDHSLSVHPLSMLLS
                     GIVDPAVMGGFSNYEKAFFTEKYLQEHPEDQEKVELLKRLIALQIPLLTEGIRIHGEK
                     LTEQLKPLHARLSSCFRELKEKVEKLYGVITLPPSMTERKPSRAGSMVLPYILSSTLR
                     RLSVTSVASSVISTSSNSSDNASSRPGSDGSILEPLFERRASSGARVEDLPPKEDSEN
                     RISKFKRKDWNLSKSQVIAEKAPEPDVMSPGKKTQRPKSLQLVDSRLTPFHSPSPLQS
                     TALSPPPLTPKATRTLSSPSLQTDGLTASVPPPPPPKSKPYESSQRNSAEIAPPLPVR
                     RDSKAPPPPPPKARKSGILSSEPGSQ"
     exon            282..365
                     /gene="Dock5"
                     /gene_synonym="1110060D06Rik; E130320D18; lr2; rlc"
                     /inference="alignment:Splign:2.1.0"
     exon            366..406
                     /gene="Dock5"
                     /gene_synonym="1110060D06Rik; E130320D18; lr2; rlc"
                     /inference="alignment:Splign:2.1.0"
     exon            407..462
                     /gene="Dock5"
                     /gene_synonym="1110060D06Rik; E130320D18; lr2; rlc"
                     /inference="alignment:Splign:2.1.0"
     exon            463..559
                     /gene="Dock5"
                     /gene_synonym="1110060D06Rik; E130320D18; lr2; rlc"
                     /inference="alignment:Splign:2.1.0"
     exon            560..708
                     /gene="Dock5"
                     /gene_synonym="1110060D06Rik; E130320D18; lr2; rlc"
                     /inference="alignment:Splign:2.1.0"
     exon            709..844
                     /gene="Dock5"
                     /gene_synonym="1110060D06Rik; E130320D18; lr2; rlc"
                     /inference="alignment:Splign:2.1.0"
     exon            845..1002
                     /gene="Dock5"
                     /gene_synonym="1110060D06Rik; E130320D18; lr2; rlc"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1084
                     /gene="Dock5"
                     /gene_synonym="1110060D06Rik; E130320D18; lr2; rlc"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1214
                     /gene="Dock5"
                     /gene_synonym="1110060D06Rik; E130320D18; lr2; rlc"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1287
                     /gene="Dock5"
                     /gene_synonym="1110060D06Rik; E130320D18; lr2; rlc"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1430
                     /gene="Dock5"
                     /gene_synonym="1110060D06Rik; E130320D18; lr2; rlc"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1556
                     /gene="Dock5"
                     /gene_synonym="1110060D06Rik; E130320D18; lr2; rlc"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1681
                     /gene="Dock5"
                     /gene_synonym="1110060D06Rik; E130320D18; lr2; rlc"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1780
                     /gene="Dock5"
                     /gene_synonym="1110060D06Rik; E130320D18; lr2; rlc"
                     /inference="alignment:Splign:2.1.0"
     exon            1781..1853
                     /gene="Dock5"
                     /gene_synonym="1110060D06Rik; E130320D18; lr2; rlc"
                     /inference="alignment:Splign:2.1.0"
     exon            1854..1957
                     /gene="Dock5"
                     /gene_synonym="1110060D06Rik; E130320D18; lr2; rlc"
                     /inference="alignment:Splign:2.1.0"
     exon            1958..2141
                     /gene="Dock5"
                     /gene_synonym="1110060D06Rik; E130320D18; lr2; rlc"
                     /inference="alignment:Splign:2.1.0"
     exon            2142..2239
                     /gene="Dock5"
                     /gene_synonym="1110060D06Rik; E130320D18; lr2; rlc"
                     /inference="alignment:Splign:2.1.0"
     exon            2240..2329
                     /gene="Dock5"
                     /gene_synonym="1110060D06Rik; E130320D18; lr2; rlc"
                     /inference="alignment:Splign:2.1.0"
     exon            2330..2430
                     /gene="Dock5"
                     /gene_synonym="1110060D06Rik; E130320D18; lr2; rlc"
                     /inference="alignment:Splign:2.1.0"
     exon            2431..2565
                     /gene="Dock5"
                     /gene_synonym="1110060D06Rik; E130320D18; lr2; rlc"
                     /inference="alignment:Splign:2.1.0"
     exon            2566..2677
                     /gene="Dock5"
                     /gene_synonym="1110060D06Rik; E130320D18; lr2; rlc"
                     /inference="alignment:Splign:2.1.0"
     exon            2678..2748
                     /gene="Dock5"
                     /gene_synonym="1110060D06Rik; E130320D18; lr2; rlc"
                     /inference="alignment:Splign:2.1.0"
     exon            2749..2855
                     /gene="Dock5"
                     /gene_synonym="1110060D06Rik; E130320D18; lr2; rlc"
                     /inference="alignment:Splign:2.1.0"
     exon            2856..2992
                     /gene="Dock5"
                     /gene_synonym="1110060D06Rik; E130320D18; lr2; rlc"
                     /inference="alignment:Splign:2.1.0"
     exon            2993..3088
                     /gene="Dock5"
                     /gene_synonym="1110060D06Rik; E130320D18; lr2; rlc"
                     /inference="alignment:Splign:2.1.0"
     exon            3089..3187
                     /gene="Dock5"
                     /gene_synonym="1110060D06Rik; E130320D18; lr2; rlc"
                     /inference="alignment:Splign:2.1.0"
     exon            3188..3282
                     /gene="Dock5"
                     /gene_synonym="1110060D06Rik; E130320D18; lr2; rlc"
                     /inference="alignment:Splign:2.1.0"
     exon            3283..3361
                     /gene="Dock5"
                     /gene_synonym="1110060D06Rik; E130320D18; lr2; rlc"
                     /inference="alignment:Splign:2.1.0"
     exon            3362..3462
                     /gene="Dock5"
                     /gene_synonym="1110060D06Rik; E130320D18; lr2; rlc"
                     /inference="alignment:Splign:2.1.0"
     exon            3463..3521
                     /gene="Dock5"
                     /gene_synonym="1110060D06Rik; E130320D18; lr2; rlc"
                     /inference="alignment:Splign:2.1.0"
     exon            3522..3676
                     /gene="Dock5"
                     /gene_synonym="1110060D06Rik; E130320D18; lr2; rlc"
                     /inference="alignment:Splign:2.1.0"
     exon            3677..3762
                     /gene="Dock5"
                     /gene_synonym="1110060D06Rik; E130320D18; lr2; rlc"
                     /inference="alignment:Splign:2.1.0"
     exon            3763..3922
                     /gene="Dock5"
                     /gene_synonym="1110060D06Rik; E130320D18; lr2; rlc"
                     /inference="alignment:Splign:2.1.0"
     exon            3923..3963
                     /gene="Dock5"
                     /gene_synonym="1110060D06Rik; E130320D18; lr2; rlc"
                     /inference="alignment:Splign:2.1.0"
     exon            3964..4054
                     /gene="Dock5"
                     /gene_synonym="1110060D06Rik; E130320D18; lr2; rlc"
                     /inference="alignment:Splign:2.1.0"
     exon            4055..4174
                     /gene="Dock5"
                     /gene_synonym="1110060D06Rik; E130320D18; lr2; rlc"
                     /inference="alignment:Splign:2.1.0"
     exon            4175..4264
                     /gene="Dock5"
                     /gene_synonym="1110060D06Rik; E130320D18; lr2; rlc"
                     /inference="alignment:Splign:2.1.0"
     exon            4265..4369
                     /gene="Dock5"
                     /gene_synonym="1110060D06Rik; E130320D18; lr2; rlc"
                     /inference="alignment:Splign:2.1.0"
     exon            4370..4511
                     /gene="Dock5"
                     /gene_synonym="1110060D06Rik; E130320D18; lr2; rlc"
                     /inference="alignment:Splign:2.1.0"
     exon            4512..4593
                     /gene="Dock5"
                     /gene_synonym="1110060D06Rik; E130320D18; lr2; rlc"
                     /inference="alignment:Splign:2.1.0"
     exon            4594..4678
                     /gene="Dock5"
                     /gene_synonym="1110060D06Rik; E130320D18; lr2; rlc"
                     /inference="alignment:Splign:2.1.0"
     exon            4679..4765
                     /gene="Dock5"
                     /gene_synonym="1110060D06Rik; E130320D18; lr2; rlc"
                     /inference="alignment:Splign:2.1.0"
     exon            4766..4942
                     /gene="Dock5"
                     /gene_synonym="1110060D06Rik; E130320D18; lr2; rlc"
                     /inference="alignment:Splign:2.1.0"
     exon            4943..5026
                     /gene="Dock5"
                     /gene_synonym="1110060D06Rik; E130320D18; lr2; rlc"
                     /inference="alignment:Splign:2.1.0"
     exon            5027..5164
                     /gene="Dock5"
                     /gene_synonym="1110060D06Rik; E130320D18; lr2; rlc"
                     /inference="alignment:Splign:2.1.0"
     exon            5165..5331
                     /gene="Dock5"
                     /gene_synonym="1110060D06Rik; E130320D18; lr2; rlc"
                     /inference="alignment:Splign:2.1.0"
     exon            5332..5500
                     /gene="Dock5"
                     /gene_synonym="1110060D06Rik; E130320D18; lr2; rlc"
                     /inference="alignment:Splign:2.1.0"
     exon            5501..5639
                     /gene="Dock5"
                     /gene_synonym="1110060D06Rik; E130320D18; lr2; rlc"
                     /inference="alignment:Splign:2.1.0"
     exon            5640..5740
                     /gene="Dock5"
                     /gene_synonym="1110060D06Rik; E130320D18; lr2; rlc"
                     /inference="alignment:Splign:2.1.0"
     exon            5741..10335
                     /gene="Dock5"
                     /gene_synonym="1110060D06Rik; E130320D18; lr2; rlc"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      6644
                     /gene="Dock5"
                     /gene_synonym="1110060D06Rik; E130320D18; lr2; rlc"
                     /note="major polyA site"
     regulatory      10100..10105
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dock5"
                     /gene_synonym="1110060D06Rik; E130320D18; lr2; rlc"
                     /note="hexamer: ATTAAA"
     polyA_site      10128
                     /gene="Dock5"
                     /gene_synonym="1110060D06Rik; E130320D18; lr2; rlc"
     regulatory      10163..10168
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dock5"
                     /gene_synonym="1110060D06Rik; E130320D18; lr2; rlc"
                     /note="hexamer: AATAAA"
     polyA_site      10181
                     /gene="Dock5"
                     /gene_synonym="1110060D06Rik; E130320D18; lr2; rlc"
                     /note="major polyA site"
     regulatory      10310..10315
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dock5"
                     /gene_synonym="1110060D06Rik; E130320D18; lr2; rlc"
                     /note="hexamer: AATAAA"
     polyA_site      10334
                     /gene="Dock5"
                     /gene_synonym="1110060D06Rik; E130320D18; lr2; rlc"
ORIGIN      
        1 gggcggcgcc ggggagggcg cgcggggctg cacggccgcc ggtcccagca ggtgaccgcg
       61 ggcgagcggg cgtgcgtgcg gggccccggg cgcgagcgag gcgggacggc gtagacgcgg
      121 ccggcgcgcc aaagtcgtcc aagttttgcc ggaacatggc ggaggagtcc ggccggcgca
      181 gcagcgctcc gagcacgagt gtctgtagcc gctagcgccg cggggcgagg tcgtcgccat
      241 ggcccgttgg atccctacca agaggcagaa gtatggggtt gccatctaca actacaatgc
      301 atctcaagat gtggagctct ccttgcagat cggcgacacc gtccacatcc tggagatgta
      361 tgagggctgg tacagaggat acgcgctcca gaacagatct aaaaagggca tttttcctga
      421 gacatacatc catttgaaag aggcaaccgt ggaagatgga gggcagcatg agaccgtgat
      481 tcccggggag ttgcccctgg ttcaggagct cacaaacacg ctacgagaat gggccgtcat
      541 ctggcgcaag ctctatgtga acaacaaggt cacactattc cgccagctgc agcaaatgac
      601 atacagtctg atcgagtggc gttcccagat cctatctggg acacttccca aggatgaact
      661 tgcagagctg aagaagaagg tcacagccaa aatcgatcat gggaacagaa tgcttggact
      721 ggatctggtt gtgcgggacg acaatggaaa cattttagat ccagatgaga ccagcactgt
      781 cgccctattc agggcccatg aagtggcttc taaaaggata gaggaaaaga tccaagagga
      841 gaagagcatt ttgcagaacc tggacttgag aggccaggca atcttcagta ctgtccacac
      901 ctatgggctc tatgtgaact tcaagaactt tgtctgtaac attggggagg atgcggagct
      961 gttcatagcc ctgtatgatc cagaccagtc caccttcatc agtgagaact acctaattcg
     1021 ctggggcagt aacgggatgc ccaaggagat cgagaagctg aataacctgc aagcagtgtt
     1081 caccgacctc agcagcacag acctcatccg gccacgcatc agcctcgtgt gccagattgt
     1141 ccgggtgggc cgcatggagc tgaaggaggg caagaagcac acctgtgggc tccggaggcc
     1201 ctttggagta gcagtgatgg atattagtga tattgtacat gggaaggtgg atgatgaaga
     1261 aaagcaacat tttatcccct ttcagcaaat tgccatggag acctacatcc gccagagaca
     1321 gctcatcatg tcccccttga taacctccca cgtgatcgga gagaatgagc cactcacgtc
     1381 ggtcctaaat aaagtcatag ctgcaaagga agtgaatcac aaaggacaag gtctttgggt
     1441 gtccttaaag ttactgccag gtgacctcac acaggtgcag aagaactttt cacacctggt
     1501 ggacagatca acagcaatag cacggaaaat gggctttcca gaaataatcc tgccagggga
     1561 tgttcgaaat gatatttatg tcaccctgat ccatggggag tttgacaagg ggaagaagaa
     1621 gacacctaaa aacgtggagg tgaccatgtc tgtgtttgat gaggaaggca accttttaga
     1681 gaaagccatt catcccggtg ctgggtacga aggcgtctcg gagtacaagt cagtggtgta
     1741 ttaccaggtc aagcaaccct gttggtacga gacggtcaag gtcttcattg ccattgaaga
     1801 ggtcacacgc tgccacatac gatttacctt ccgacacaga tcatctcaag aatccagaga
     1861 taaatcagag cgagcctttg gggtggcctt tgtgaaactg atgaacgcag atggtaccac
     1921 gctgcaggat gggaggcacg acctggtggt gtacaagggt gataataaga aaatggaaga
     1981 tgctaaatat tatctgactc tgcctgggac caaagcagag ctggaagaaa aagaactcca
     2041 agcgtccaaa aacccatccg tcttcacacc cagcaaagac agcacgaagg acagctttca
     2101 gatcgccact ctcatctgct ccacaaagct cacccaaaat gtggacctgc taggcttact
     2161 aaactggcgt tctaattctc agaacattaa gcacaacctg aaaaagttaa tggaagtgga
     2221 tggaggagag attgttaagt ttttacagga cacactagac gcacttttta acataatgat
     2281 ggaaatgtca gacaatgaaa catatgactt ccttgtgttt gacgctctgg tcttcatcat
     2341 ttcgctgata ggagacatca agtttcagca ttttaaccct gtcctcgaaa cctacattta
     2401 taagcacttc agcgccacct tggcacacgt gaaactctcc aaggtactga acttttatgt
     2461 ggccaatgcc gaggacccta gcaagacgga attgctattt gctgctttga aagccttgaa
     2521 gtacctgttc cgattcatca tccagtctcg ggtactctac ttgaggtttt atggtcagag
     2581 tgaagatgga gatgaattta acgactcaat ccgccagctg tttcttgctt tcaacacgct
     2641 gatggacagg cctctggaag aagctgtcaa gatcaagggg gcagccttga agtaccttcc
     2701 cagcataatt aatgatgtca aactggtgtt tgatcccatg gagctcagcg tgctcttctg
     2761 caagttcatt caaagcatcc ctgacaacca gttggtgcgg cagaaactta actgcatgac
     2821 caagatagtg gagagcagcc ttttccagca ggcagagtgc agggaagtgc tgctgccgct
     2881 actgacagac cagctcagtg gccagctgga cgaccactca accaaaccgg accacgaggc
     2941 aagctcacag cttctaagca acatcctaga ggtgctagac aggacggatg tgggccccac
     3001 ttcagctcac gtacagctga tcatggagag gctgctgaga aggatcaacc ggaccgtgat
     3061 tgggatgagc cgacagtctc ctcacattgg cagctttgtg gcttgcatga ttgccgtctt
     3121 acgacaaatg gaggacagcc actacagcca ctacatcagc accttcaaaa ccaggcagga
     3181 catcattgac tttctcatgg aaaccttcat tatgtttaag gatctgattg gaaagaatgt
     3241 gtatgccaaa gattggatgg tcatgaacat gacccagaac agagttttcc tccgtgccat
     3301 caatcagttt gctgaggttc tcaccaagag cttcatggac caggcaagct ttgaacttca
     3361 gctctggaac aattacttcc atttggctgt agcttttctc acccacgagt ccctccagct
     3421 tgaaaccttc tcagaagcca agcgcaacaa aattgtgaaa aaatatgggg acatgagaaa
     3481 agaaattggc ttcaggatcc gggacatgtg gtataacctg gggccacaca aaatcaaatt
     3541 catcccatcc atggtgggtc ccattctgga agtcactctg acccctgaag tggagctccg
     3601 taaagccacg atccccattt tctttgatat gatgcagtgc gagttcaatt tgagtggaaa
     3661 tggcaacttc cacatgtttg agaatgagtt gatcacaaag ctggatcagg aagtggaagg
     3721 tggccgagga gacgaacaat acaaggttct tctggaaaag ctactcttag agcattgccg
     3781 gaaacataaa tacctcgcga actctgggga agcctttgcc ttcctggtca gcagcctctt
     3841 ggagaacctg ctggattaca gaacgatcat catacatgat gagagcaagg agaaccgcat
     3901 gagctgtaca gtgaacgtcc tgaatttcta taaagataag aaacgagagg acatatacat
     3961 acggtattta tacaagcttc gggatttgca cagagactgt gagaactaca cagaagctgc
     4021 ctatacactc ctcctacatg ctgagcttct gcagtggtcg gacaagccct gtgtgcccca
     4081 tttgctgcag agggatagtt actatgttta tacccagcag gagcttaaag agaaactgta
     4141 tcaagagatc atatcctatt ttgataaagg caaaatgtgg gagaaagcca tcaaactgag
     4201 caaggagttg gcggagacct acgagagcaa agtgtttgac tacgagggcc taggcagtct
     4261 cttgaaaaaa agagccttgt tttacgagaa catcattaag gccatgaggc cccagcctga
     4321 atactttgct gtgggatact acggacaggg cttcccttcc ttcctgcgga acaaaatctt
     4381 tatctaccgg ggtaaggagt atgagaggcg ggaagacttc agcttgaggt tgctgaccca
     4441 gttccccaat gctgagaaga tgaccagtac cacaccacca ggagaagaca tcaagtcatc
     4501 cccaaagcag tacctgcagt gcttcacggt aaaacctgtg atgagcttgc cgcccagcta
     4561 caaggacaaa ccggttccag agcagatctt gaactactac agagccaacg aagtgcagca
     4621 gttcagctat tcccggccat tccggaaagg agaaaaagac ccagaaaatg agtttgccac
     4681 catgtggatt gaaagaacca cgtacagaac ggcctatacc ttccctggga tcctcaagtg
     4741 gttcgaagcc aaggagattt cagtagaaga aatcagccct ttggagaatg ccatagaaac
     4801 catggagctg accaacgaga gggtcagcaa ctgcgtgcag cagcacgcct gggaccattc
     4861 tctctctgtg cacccgctct ccatgctgct cagcggcata gtggacccag ctgtcatggg
     4921 gggattctcc aactacgaaa aggctttttt tacagaaaag tacttacaag agcatcccga
     4981 ggaccaggag aaggtggagc tgctcaagcg actgattgcc ttacaaatac ctctgcttac
     5041 ggaagggatc cgcatccacg gggagaagct gacggagcag ctcaagccgc tgcatgcccg
     5101 gctatcttcg tgcttccgtg aactcaagga gaaagtagag aagctgtatg gagtcataac
     5161 gctgccaccc agcatgacag agaggaagcc aagccgtgca ggctcgatgg tactgcccta
     5221 catcctgtcc tccacgctgc gcaggctgtc tgtcacctct gtggcctcct cggtgatctc
     5281 cacctcctcc aactcttctg acaatgcatc gtccaggcca ggatcggatg ggtccatcct
     5341 ggaacccctg tttgaacgca gagcttcatc gggtgccaga gttgaagatc tgccacccaa
     5401 agaagacagt gagaaccgga ttagcaagtt caagaggaaa gactggaatc tgagcaaatc
     5461 acaagtcatt gcagagaagg ctccagaacc tgatgtgatg agcccaggca aaaaaacaca
     5521 aaggccaaag agtctccagt tggtggacag ccggctgaca ccattccaca gtccctcgcc
     5581 tctgcagtct acagccttga gcccaccccc actcactccc aaagccacga gaaccctaag
     5641 ctccccatct ttgcagacag atgggctgac ggcttctgtc cctcctccac ctccccccaa
     5701 aagcaaaccg tatgagagca gtcagaggaa ctcggctgag attgctcccc cactgcctgt
     5761 ccggagagac tccaaagccc cacctccacc ccctccaaag gctcggaaat caggcatcct
     5821 ctcttctgag ccaggctctc agtgaggcag tcaccctgac tttgcacctc cgagtgcctt
     5881 ggaccactgc tgcctgagaa tggcgcccag gaagggcggc ctgtggagca gggctccctg
     5941 ccagcgctgc ttcctgcact gagacggcga acgctgagtc ccatcccctt cagcccgtgg
     6001 aacgtccaga actggccatc tgtctgcatg aacaaacctt tcccatggtg gcatgctggg
     6061 ctcaaccact aacttgttag gcctgcagat gcccctgcct gtggtgacac agggacagtg
     6121 gagaggggga cagcccctgc actgatgcct gtgtggattt ctcacttagc ttctggacag
     6181 ctgtgctgaa gacttcttcc ttctcttctg cctgcatccc tgacatgtac aacctcctga
     6241 aagtgccaga tactaagtac actccaggag ccacatggtt ctctctccct aaagtctact
     6301 gtctcctttg agggaaagag cccacgtgca tagttggggt gggccactct caggtgtgga
     6361 tgccttctct ggagataccg caggctcaca ttctgacatt ctcctgacaa atggcccaca
     6421 ccacacagca gtcacttgct atgccttgga ttccatggaa gctctttggt acttgttttt
     6481 catcttcttc ctttgagctc aaatcctggg ctctaagggt tcctaggagc ctgggctcta
     6541 ctggctacat ttccagaccc tgttggattg acgaggtggt ccctgtctgc tacttgattt
     6601 taccctggag agtacagtgc aatatgatta tttattcctc ttgatcatag agtgaatttt
     6661 attgattact cgtggtacta gtgcccatac tcctttcaga aggaaaaatt agggtgactt
     6721 ggaagtccaa atattatgtc aacataaatg accacaagat gttatcaatg ctttgagtta
     6781 gatgggtttt taaatacaca cacacacaca ctcacctcat tttgcaggta aagacattga
     6841 ggcttcacac aaaaagtgga ctataggctt ttactaacaa gcccagcttg ctcacatatg
     6901 acatacccca agataacatc tctaacaagg tcttgactgc ctagccccag tgaagatggt
     6961 atttgaaaag tcccagatag ttcttttttt tttccatttt ttattaggta tttagctcat
     7021 ttactgtccc agatagttct aacagacttg agtgttattg gcaaaactga aagctttctg
     7081 gctatgactt ggatatgccc tgggcattct cgaatctctc caatggcctt gccctgagtc
     7141 ttttcttcca agttcaagtg aacaggagga ttcaagcatt tgcatacccg cctcttcacg
     7201 tctttgctaa gggggatgca agatgcccct ggttcatcac agccatcaga ggagcaaaat
     7261 acagaggcat gcctggcaca gcactagaaa agttagtata cacaccccag aaagccacaa
     7321 gagtctcttt acttccatga tggagcaccc aatgcagcca tggaaagcac acgggctctg
     7381 aaatggtctc aaagctcccg tgtcaccata agatttgcac ttgaaaatct gagtgtttgt
     7441 tttctcactt ttcaaagtgg gggatagtcc ctcccacatg ggtggttgtg gggtgcaatt
     7501 aaggtttgga acggggtgtg catcagtgac tttcttctct ctgctaaggt aaggtctgat
     7561 acggtttggt ttttcttcag ggtatatgag gttgaattca gatatgcatc ttccctaaaa
     7621 aaaagaaggc agcctggggc accatttgca cggaagggtt aataagagtt gaagattatt
     7681 ttaagtacaa agaaccaggc cctggtgtga agaaggaggg aaggaaccag aagggtgcta
     7741 gagggtttcc agggagcttg ggacttctga gaagacccta gcaggctggt gaaaaaggac
     7801 tcgaagatgt caccttgctt tgcaggccgc cattgaaaac ctgggtggga aaagaaccaa
     7861 atcctctgcc tcttcttgca gtgacagtag caggggtgag tcctcaacca gtgaacagta
     7921 gcaggggtga gtcctcaacc agtgaacagt agcaggggtg agtcctcaac cagtgaacag
     7981 tagcaggggt gagtcctcaa ccagtgaaca gtagcagggg tgagtcctca accagtgaac
     8041 agtagcaggg gtgagtcctc aaccagtgaa cagtagcagg ggtgagtgag tcctcaccct
     8101 ggtctctgag cagagctggg cctattggtg cctagatgtg ccaatccctt cttgtcaggc
     8161 attttcctgt gattcccttt ccatagtcat gaaaataata gctttcagct gccccaacgc
     8221 aaaggactct gggtgatggc gtaggtaggt gctggtttac aaggccctgg cagaataacc
     8281 tctttgggaa ggtgtcttag ggcttctatt gttatgatta gcttgtatca agttgtcata
     8341 aaaactacct ggcctgaagc tatggatgaa ggagttaact tgattaaaag aagaatcact
     8401 atcagtacta aagttgaaga cttcaatgcc gtttaaatac agacaggaca agaagagggg
     8461 gacagaagaa ccagtcttta ttgcccttgc taagatctct gaggtattga aaggcactga
     8521 aatctgtcct gagattgtca cagtctttat gaatgaatat tgattgatgg cttgtgactc
     8581 cgtgatattg ttacatgtct ctctcttttc cttctttccc tctctgccat gacgacttct
     8641 cttactttga ggtttttttt ttttctttta aagaaagatt tccttcagta tacacttgct
     8701 gagggccagg cacagttcta gccccttggt acattcaata gaaacagcct gctatacaat
     8761 tcacgctagt gtgctatagg atcagaaagt caggagtgta cggcaaagca gcctgccgga
     8821 atcaggctgc ttggcggtgg gcggcctcct ccctctacct ccaccccttg cttgactcca
     8881 gaaatgaagt catctctcca gccagagaaa tcatacagtt agccacactg cagatcccct
     8941 gggtaaaaca aggcgtgtca cgggagctga gatgggacaa tggccacctt gtcactgctt
     9001 tccaagtcga gtctttccct tccaggtgct tccagatcga ggggcaggtt ttgcagatta
     9061 catatcacga ggacacaaag cacaggagtg cggacaaaga cgtcactaga taggagacat
     9121 acaggtgacc ttttctcaga cagacatgag tcccatatcc cagaaagtgc ctgagtgcct
     9181 gcagcaccat tctgtaaaac ggacttggga ggtccttctg agtttgtgtc tctatccctc
     9241 acacttctca ggtataataa aacgggcctt agaccctccc atcaacacaa gacggtggag
     9301 atggtatccc atgcccccag ttcacttcct tacgtatttg agactgcatg ggtgtggcca
     9361 ggtcttttct gccctggcct cctttattct aaggaaacca aagtgagatt tctgtccaaa
     9421 ggcttttgct ctaggaactg gaatccacat ttctcatcct tactggtgct ttgagcctcc
     9481 catgcctgga tagaatgatc aaaagctttg tgaatgttaa tgagtctagc atctattttt
     9541 gaggcattgg tacaaattgt cctaattctc gcagcggcct ctggatagct atcttcagaa
     9601 tcactaacct aggctgctga gcccagatct ccagctcctc actcgggatc agacttccct
     9661 tgtgtacttc ggggcagtgg atgactactg ttttcttgga catttttatt cctccataag
     9721 tatgttattc agaattttaa gtcagaagtg ctgaaggtgt agctcacttg cttattagct
     9781 catgtgaggg tcctgggttc tattcttggt ccagctaaag gaatgaaaat tggcaaacgt
     9841 gaaggatctc tttgggtggg ttcagagtca agccatcagt tgttagctgc gaaagaaatg
     9901 gttttcctct tgaggtcttt acctctagct gactcttcag acccccacag gcatgcctga
     9961 gctcatctaa gttgcctctt gctcaccctg tcacaattcc ttcaccatga gtttataact
    10021 tactgggttt catacatgga cagttaggaa gatgtgtgtt gaagagtttt gttcatattt
    10081 gctgttattt attttgtaaa ttaaacatgg aaatgtattt taaaagttta ttttgtgttt
    10141 agctggttat tgttcttaga tgaataaaat gagaacatgg agtttatggc ttttccctac
    10201 tgacagctcc tccaagacac ttcaccctca ggagccctct gctcatttca ttaaaggagc
    10261 ctgttgagat gtctactgtg ggatcttggt gtctgtctta cccagaacta ataaaatctg
    10321 cagtttgttc ctttc
//
