LOCUS       NM_153413               9067 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus dedicator of cyto-kinesis 3 (Dock3), mRNA.
ACCESSION   NM_153413 XM_909742
VERSION     NM_153413.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 9067)
  AUTHORS   Samani,A., Karuppasamy,M., English,K.G., Siler,C.A., Wang,Y.,
            Widrick,J.J. and Alexander,M.S.
  TITLE     DOCK3 regulates normal skeletal muscle regeneration and glucose
            metabolism
  JOURNAL   FASEB J 37 (10), e23198 (2023)
   PUBMED   37742307
  REMARK    GeneRIF: DOCK3 regulates normal skeletal muscle regeneration and
            glucose metabolism.
REFERENCE   2  (bases 1 to 9067)
  AUTHORS   Reid,A.L., Wang,Y., Samani,A., Hightower,R.M., Lopez,M.A.,
            Gilbert,S.R., Ianov,L., Crossman,D.K., Dell'Italia,L.J.,
            Millay,D.P., van Groen,T., Halade,G.V. and Alexander,M.S.
  TITLE     DOCK3 is a dosage-sensitive regulator of skeletal muscle and
            Duchenne muscular dystrophy-associated pathologies
  JOURNAL   Hum Mol Genet 29 (17), 2855-2871 (2020)
   PUBMED   32766788
  REMARK    GeneRIF: DOCK3 is a dosage-sensitive regulator of skeletal muscle
            and Duchenne muscular dystrophy-associated pathologies.
REFERENCE   3  (bases 1 to 9067)
  AUTHORS   Helbig,K.L., Mroske,C., Moorthy,D., Sajan,S.A. and Velinov,M.
  TITLE     Biallelic loss-of-function variants in DOCK3 cause muscle
            hypotonia, ataxia, and intellectual disability
  JOURNAL   Clin Genet 92 (4), 430-433 (2017)
   PUBMED   28195318
  REMARK    GeneRIF: Common features in both affected individuals include
            severe developmental disability, ataxic gait, and severe hypotonia,
            which recapitulates the Dock3 knockout mouse phenotype. We show
            that complete DOCK3 deficiency in humans leads to developmental
            disability with significant hypotonia and gait ataxia, probably due
            to abnormal axonal development
            Erratum:[Clin Genet. 2018 May;93(5):1117. doi: 10.1111/cge.13212..
            PMID: 29655272]
REFERENCE   4  (bases 1 to 9067)
  AUTHORS   Semba,K., Namekata,K., Kimura,A., Harada,C., Katome,T., Yoshida,H.,
            Mitamura,Y. and Harada,T.
  TITLE     Dock3 overexpression and p38 MAPK inhibition synergistically
            stimulate neuroprotection and axon regeneration after optic nerve
            injury
  JOURNAL   Neurosci Lett 581, 89-93 (2014)
   PUBMED   25172145
  REMARK    GeneRIF: Overexpression of Dock3 and pharmacological interruption
            of p38 have synergistic effects for both neuroprotection and axon
            regeneration, thus combined application may be beneficial for the
            treatment of ONI.
REFERENCE   5  (bases 1 to 9067)
  AUTHORS   Namekata,K., Kimura,A., Harada,C., Yoshida,H., Matsumoto,Y. and
            Harada,T.
  TITLE     Dock3 protects myelin in the cuprizone model for demyelination
  JOURNAL   Cell Death Dis 5 (8), e1395 (2014)
   PUBMED   25165881
  REMARK    GeneRIF: Dock3 may be a therapeutic target for demyelinating
            disorders including optic neuritis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 9067)
  AUTHORS   Namekata,K., Enokido,Y., Iwasawa,K. and Kimura,H.
  TITLE     MOCA induces membrane spreading by activating Rac1
  JOURNAL   J Biol Chem 279 (14), 14331-14337 (2004)
   PUBMED   14718541
  REMARK    GeneRIF: MOCA may induce cytoskeletal reorganization and changes in
            cell adhesion by regulating the activity of Rac1.
REFERENCE   7  (bases 1 to 9067)
  AUTHORS   de Silva,M.G., Elliott,K., Dahl,H.H., Fitzpatrick,E., Wilcox,S.,
            Delatycki,M., Williamson,R., Efron,D., Lynch,M. and Forrest,S.
  TITLE     Disruption of a novel member of a sodium/hydrogen exchanger family
            and DOCK3 is associated with an attention deficit hyperactivity
            disorder-like phenotype
  JOURNAL   J Med Genet 40 (10), 733-740 (2003)
   PUBMED   14569117
REFERENCE   8  (bases 1 to 9067)
  AUTHORS   Chen,Q., Kimura,H. and Schubert,D.
  TITLE     A novel mechanism for the regulation of amyloid precursor protein
            metabolism
  JOURNAL   J Cell Biol 158 (1), 79-89 (2002)
   PUBMED   12093789
REFERENCE   9  (bases 1 to 9067)
  AUTHORS   Chen,Q., Yoshida,H., Schubert,D., Maher,P., Mallory,M. and
            Masliah,E.
  TITLE     Presenilin binding protein is associated with neurofibrillary
            alterations in Alzheimer's disease and stimulates tau
            phosphorylation
  JOURNAL   Am J Pathol 159 (5), 1597-1602 (2001)
   PUBMED   11696419
REFERENCE   10 (bases 1 to 9067)
  AUTHORS   Kashiwa,A., Yoshida,H., Lee,S., Paladino,T., Liu,Y., Chen,Q.,
            Dargusch,R., Schubert,D. and Kimura,H.
  TITLE     Isolation and characterization of novel presenilin binding protein
  JOURNAL   J Neurochem 75 (1), 109-116 (2000)
   PUBMED   10854253
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ124323.1, BF465833.1, BE656508.1, AC121608.3, CK781165.1,
            AK147385.1, CF744136.1, BC040770.1 and AI604896.1.
            
            On May 23, 2007 this sequence version replaced NM_153413.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single high-quality transcript was
            available for the full length of the gene. The extent of this
            transcript is supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY145302.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849376 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-437               CJ124323.1         1-437
            438-864             BF465833.1         112-538
            865-1085            BE656508.1         1-221               c
            1086-1147           AC121608.3         101198-101259
            1148-1229           AC121608.3         124352-124433
            1230-1290           AC121608.3         131328-131388
            1291-1311           AC121608.3         132834-132854
            1312-1687           CK781165.1         1-376
            1688-2340           AK147385.1         1-653
            2341-3010           CF744136.1         74-743
            3011-7704           AK147385.1         1324-6017
            7705-8782           BC040770.1         2870-3947
            8783-9054           AK147385.1         7095-7366
            9055-9067           AI604896.1         1-13                c
FEATURES             Location/Qualifiers
     source          1..9067
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 57.98 cM"
     gene            1..9067
                     /gene="Dock3"
                     /gene_synonym="mKIAA0299; MOCA; PBP"
                     /note="dedicator of cyto-kinesis 3"
                     /db_xref="GeneID:208869"
                     /db_xref="MGI:MGI:2429763"
     exon            1..438
                     /gene="Dock3"
                     /gene_synonym="mKIAA0299; MOCA; PBP"
                     /inference="alignment:Splign:2.1.0"
     CDS             402..6494
                     /gene="Dock3"
                     /gene_synonym="mKIAA0299; MOCA; PBP"
                     /note="presenilin-binding protein; modifier of cell
                     adhesion"
                     /codon_start=1
                     /product="dedicator of cytokinesis protein 3"
                     /protein_id="NP_700462.2"
                     /db_xref="CCDS:CCDS40760.1"
                     /db_xref="GeneID:208869"
                     /db_xref="MGI:MGI:2429763"
                     /translation="MWTPTEEEKYGVVICSFRGSVPQGLVLEIGETVQILEKCEGWYR
                     GVSTKKPNVKGLFPANYIHLKKAIVSNRGQYETVVPLEDSIVTEVTTTLQEWASLWKQ
                     LYVKHKVDLFYKLRHVMNELIDLRRQLLSGHLTQDQVREVKRHITVRLDWGNEHLGLD
                     LVPRKDFEVVDSDQISVSDLYKMHLSSRQSVQQSTSQVDTMRPRHGETCRMPVPHHFF
                     FSLKSFTYNTIGEDSDVFFSLYDMREGKQISERFLVRLNKNGGPRNPEKIERMCALFT
                     DLSSKDMKRDLYIVAHVIRIGRMLLNDSKKGPAHLHYRRPYGCAVLSILDVLQSLTEL
                     KEEKDFVLKVYTCNNESEWTQIHENIIRKSSTKYSAPSASHGLIISLQLFRGDMEQIR
                     RENPMIFNRGLAITRKLGFPDVIMPGDIRNDLYLTLEKGDFERGGKSVQKNIEVTMYV
                     LYADGEILKDCISLGSGEPNRSSYHSFVLYHSNSPRWGEIIKLPIPIDRFRGSHLRFE
                     FRHCSTKDKGEKKLFGFAFSPLMRDDGTTLSDDIHELYVYKCDENSTFNNHALYLGLP
                     CCKEDYNGCPNIPSSLIFQRSAKESFFISTQLSSTKLTQNVDLLALLKWKAFPDRIMD
                     ILGRLRHVSGEEIVKFLQDILDTLFVILDDNTEKYGLLVFQSLVFIINLLRDIKYFHF
                     RPVMDTYIQKHFAGALAYKELIRCLKWYMDCSAELIRQDHIQEAMRALEYLFKFIVQS
                     RILYSRATCGMEEEQFRSSIQELFQSIRFVLSLDSRNSETLLFTQAALLNSFPTIFDE
                     LLQMFTVQEVAEFVRGTLGSMPSTVHIGQSMDVVKLQSIARTVDSRLFSFSESRRILL
                     PVVLHHIHLHLRQQKELLICSGILGSIFSIVKTSSLEADVMEEVEMMVESLLDVLLQT
                     LLTIMSKSHAQEAVRGQRCPQCTAEITGEYVSCLLSLLRQMCDTHFQHLLDNFQSKDE
                     LKEFLLKIFCVFRNLMKMSVFPRDWMVMRLLTSNIIVTTVQYLSSALHKNFTETDFDF
                     KVWNSYFSLAVLFINQPSLQLEIITSAKRKKILDKYGDMRVMMAYELFSMWQNLGDHK
                     IHFIPGMIGPFLGVTLVPQPEVRNIMIPIFHDMMDWEQRKNGNFKQVEAELIDKLDSM
                     VSEGKGDESYRELFGLLTQLFGPYPSLLEKVEQETWRETGISFVTSVTRLMERLLDYR
                     DCMKGEETENKKVGCTVNLMNFYKSEINKEEMYIRYIHKLCDMHLQAENYTEAAFTLL
                     LYCELLQWEDRPLREFLHYPSQTEWQRKEGLCRKIIHYFNKGKSWEFGIPLCRELACQ
                     YESLYDYQSLSWIRKMEASYYDNIIEQQRLEPEFFRVGFYGRKFPFFLRNKEYVCRGH
                     DYERLEAFQQRMLSEFPQAVAMQHPNHPDDAILQCDAQYLQIYAVTPIPDYVDVLQMD
                     RVPDRVKSFYRVNNVRKFRYDRPFHKGPKDKDNEFKSLWIERTTLTLTHSLPGISRWF
                     EVERRELVEVSPLENAIQVVENKNQELRALISQYQHKQVHGNINLLSMCLNGVIDAAV
                     NGGIARYQEAFFDKDYITKHPGDAEKISQLKELMQEQVHVLGVGLAVHEKFVHPEMRP
                     LHKKLIDQFQMMRASLYHEFPGLDKLSPACSGTSTPRGNVLASHSPMSPENIKMTHRH
                     SPMNLMGTGRHSSSSLSSHASSEAGNMMMMGDNSMGEAPEDLYHHMQLAYHNPRYQGS
                     VTNVSVLSSSQASPSSSSLSSTHSAPSQMITSAPSSTRGSPSLPDKYRHAREMMLLLP
                     THRDRPSSAMYPAAILENGQPPNFQRALFQQVVGACKPCSDPNLSMAEKGHYSLHFDA
                     FHHPLGDTPPALPARTLRKSPLHPIPASPTSPQSGLDGSNSTLSGSASSGVSSLSESN
                     FGHSSEAPPRTDTMDSMPSQAWNGDEDLEPPYLPVHYSLSESAVLDAIKSQPCRSHSA
                     PGCVLPQDPMDPPALPPKPYHPRLPALEHDEGMLLREEAERPRGLHRKASLPPGSVKE
                     EQARLAWEHGRGEQ"
     exon            439..522
                     /gene="Dock3"
                     /gene_synonym="mKIAA0299; MOCA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            523..563
                     /gene="Dock3"
                     /gene_synonym="mKIAA0299; MOCA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            564..619
                     /gene="Dock3"
                     /gene_synonym="mKIAA0299; MOCA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            620..716
                     /gene="Dock3"
                     /gene_synonym="mKIAA0299; MOCA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            717..865
                     /gene="Dock3"
                     /gene_synonym="mKIAA0299; MOCA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            866..950
                     /gene="Dock3"
                     /gene_synonym="mKIAA0299; MOCA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            951..992
                     /gene="Dock3"
                     /gene_synonym="mKIAA0299; MOCA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1147
                     /gene="Dock3"
                     /gene_synonym="mKIAA0299; MOCA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1229
                     /gene="Dock3"
                     /gene_synonym="mKIAA0299; MOCA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1290
                     /gene="Dock3"
                     /gene_synonym="mKIAA0299; MOCA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1438
                     /gene="Dock3"
                     /gene_synonym="mKIAA0299; MOCA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1527
                     /gene="Dock3"
                     /gene_synonym="mKIAA0299; MOCA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1653
                     /gene="Dock3"
                     /gene_synonym="mKIAA0299; MOCA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1654..1778
                     /gene="Dock3"
                     /gene_synonym="mKIAA0299; MOCA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1779..1941
                     /gene="Dock3"
                     /gene_synonym="mKIAA0299; MOCA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1942..2048
                     /gene="Dock3"
                     /gene_synonym="mKIAA0299; MOCA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            2049..2220
                     /gene="Dock3"
                     /gene_synonym="mKIAA0299; MOCA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            2221..2318
                     /gene="Dock3"
                     /gene_synonym="mKIAA0299; MOCA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            2319..2402
                     /gene="Dock3"
                     /gene_synonym="mKIAA0299; MOCA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            2403..2503
                     /gene="Dock3"
                     /gene_synonym="mKIAA0299; MOCA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            2504..2585
                     /gene="Dock3"
                     /gene_synonym="mKIAA0299; MOCA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            2586..2756
                     /gene="Dock3"
                     /gene_synonym="mKIAA0299; MOCA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            2757..2949
                     /gene="Dock3"
                     /gene_synonym="mKIAA0299; MOCA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            2950..3077
                     /gene="Dock3"
                     /gene_synonym="mKIAA0299; MOCA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            3078..3224
                     /gene="Dock3"
                     /gene_synonym="mKIAA0299; MOCA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            3225..3323
                     /gene="Dock3"
                     /gene_synonym="mKIAA0299; MOCA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            3324..3418
                     /gene="Dock3"
                     /gene_synonym="mKIAA0299; MOCA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            3419..3494
                     /gene="Dock3"
                     /gene_synonym="mKIAA0299; MOCA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            3495..3595
                     /gene="Dock3"
                     /gene_synonym="mKIAA0299; MOCA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            3596..3654
                     /gene="Dock3"
                     /gene_synonym="mKIAA0299; MOCA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            3655..3803
                     /gene="Dock3"
                     /gene_synonym="mKIAA0299; MOCA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            3804..3889
                     /gene="Dock3"
                     /gene_synonym="mKIAA0299; MOCA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            3890..3916
                     /gene="Dock3"
                     /gene_synonym="mKIAA0299; MOCA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            3917..4012
                     /gene="Dock3"
                     /gene_synonym="mKIAA0299; MOCA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            4013..4073
                     /gene="Dock3"
                     /gene_synonym="mKIAA0299; MOCA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            4074..4167
                     /gene="Dock3"
                     /gene_synonym="mKIAA0299; MOCA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            4168..4316
                     /gene="Dock3"
                     /gene_synonym="mKIAA0299; MOCA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            4317..4403
                     /gene="Dock3"
                     /gene_synonym="mKIAA0299; MOCA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            4404..4508
                     /gene="Dock3"
                     /gene_synonym="mKIAA0299; MOCA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            4509..4650
                     /gene="Dock3"
                     /gene_synonym="mKIAA0299; MOCA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            4651..4817
                     /gene="Dock3"
                     /gene_synonym="mKIAA0299; MOCA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            4818..4904
                     /gene="Dock3"
                     /gene_synonym="mKIAA0299; MOCA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            4905..5084
                     /gene="Dock3"
                     /gene_synonym="mKIAA0299; MOCA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            5085..5168
                     /gene="Dock3"
                     /gene_synonym="mKIAA0299; MOCA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            5169..5285
                     /gene="Dock3"
                     /gene_synonym="mKIAA0299; MOCA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            5286..5407
                     /gene="Dock3"
                     /gene_synonym="mKIAA0299; MOCA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            5408..5546
                     /gene="Dock3"
                     /gene_synonym="mKIAA0299; MOCA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            5547..5694
                     /gene="Dock3"
                     /gene_synonym="mKIAA0299; MOCA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            5695..5813
                     /gene="Dock3"
                     /gene_synonym="mKIAA0299; MOCA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            5814..5901
                     /gene="Dock3"
                     /gene_synonym="mKIAA0299; MOCA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            5902..5984
                     /gene="Dock3"
                     /gene_synonym="mKIAA0299; MOCA; PBP"
                     /inference="alignment:Splign:2.1.0"
     exon            5985..9063
                     /gene="Dock3"
                     /gene_synonym="mKIAA0299; MOCA; PBP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8760..8765
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dock3"
                     /gene_synonym="mKIAA0299; MOCA; PBP"
                     /note="hexamer: TATAAA"
     polyA_site      8781
                     /gene="Dock3"
                     /gene_synonym="mKIAA0299; MOCA; PBP"
     regulatory      8805..8810
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dock3"
                     /gene_synonym="mKIAA0299; MOCA; PBP"
                     /note="hexamer: AAGAAA"
     polyA_site      8821
                     /gene="Dock3"
                     /gene_synonym="mKIAA0299; MOCA; PBP"
     regulatory      9039..9044
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dock3"
                     /gene_synonym="mKIAA0299; MOCA; PBP"
                     /note="hexamer: ATTAAA"
     polyA_site      9057
                     /gene="Dock3"
                     /gene_synonym="mKIAA0299; MOCA; PBP"
                     /note="major polyA site"
ORIGIN      
        1 gagcccccgc gcgccaggga gcggcgcatg cgcgggcgtc ccgcgagccc gctgaggcga
       61 tccgagccgc ggcggcgccg ggaagccagc gacggagctg tgagggaccg aacggcggcg
      121 cggggacggt ggagacggac aggtggtgag ccctcgcccg cgtcgccagg ggctcctcgg
      181 ccgcccgtgg agtctcgcgg tcggtcagga cgtggcatcc ggcggtggcg gtggcatccc
      241 ggacggcctg tgagggatgc gccgcctact gccccgcgcc gcctgaccgc ccccgccttg
      301 cctcgcggtg cgccacagcc gggcccgcgg ccgcccctgc ggccgtcccc tgcgagctgt
      361 cacccagccg ccgcgcccgc ggggctgcgc ccggcccggc catgtggacc cccacggagg
      421 aggagaaata cggcgtagtg atatgcagct ttcgaggatc tgtccctcaa ggcctggtct
      481 tagaaatagg agaaacagtt cagattcttg aaaaatgtga aggttggtac agaggagttt
      541 caacaaagaa gcctaatgta aaggggctct ttcctgcaaa ttatattcat ttgaaaaagg
      601 caattgtcag taacaggggg cagtatgaaa ctgtggttcc gctggaagat tctattgtga
      661 ctgaagttac aacaactcta caagagtggg ccagtctgtg gaaacaacta tatgtgaaac
      721 acaaagtaga tcttttctac aaactccgcc atgtgatgaa tgaacttatt gacctgcgaa
      781 ggcagctact gtctggtcac ctgacacagg atcaggtgcg ggaggttaag cggcacatca
      841 ccgtgcgtct ggactggggt aatgagcatt tgggcctgga cttggtgcct cggaaggact
      901 ttgaagtagt ggattcagac cagattagcg tctcagatct ctataaaatg catttatcta
      961 gccggcagag tgtacagcag agcacatccc aagtagatac aatgcgccca aggcatgggg
     1021 aaacctgtcg aatgccggta ccacatcatt tcttcttcag cctgaagagt ttcacctata
     1081 ataccattgg tgaagatagt gatgtcttct tttctctgta tgacatgaga gaaggcaagc
     1141 agatcagtga acggtttctg gtgagactga acaagaatgg tgggccaagg aacccagaga
     1201 agatagaacg aatgtgtgcc ctttttacag atctgagcag caaagatatg aagagagatt
     1261 tatacatagt tgcccatgtg atccgaatag gccggatgct cctgaatgac tccaaaaagg
     1321 gtcctgctca cctgcactac aggcgaccat atggctgtgc ggttctaagc atattggatg
     1381 ttctacagtc actaacagaa ttaaaagaag aaaaggattt tgttcttaag gtgtacacat
     1441 gtaacaacga gagtgaatgg acccagattc atgagaacat catccgaaag tcaagtacca
     1501 agtactctgc ccccagtgcc agccatggtc ttattatttc ccttcagctt tttcgtggtg
     1561 acatggaaca gatccggaga gaaaatccca tgatatttaa tagaggatta gcaattacaa
     1621 gaaaattggg atttcctgat gttattatgc caggtgatat ccgcaatgat ttgtacctaa
     1681 cactggagaa gggagacttt gaaagagggg gaaagagtgt acaaaagaat attgaagtaa
     1741 ccatgtatgt actttatgca gatggagaaa tcttgaagga ctgtatcagt ttgggttcag
     1801 gagagccaaa taggagttcc tatcactcct ttgttctcta ccacagtaat agtcctcgct
     1861 ggggagaaat tatcaaatta cctattccca ttgacagatt ccggggctcc catctccgct
     1921 ttgagttcag acattgttcc acaaaggaca aaggggaaaa gaaactcttt ggctttgcgt
     1981 tctctccgct gatgcgtgat gatggcacca cactctcaga tgatattcat gagctttatg
     2041 tgtataagtg tgatgagaat agcacattta acaaccatgc cctctacctg ggcctgccct
     2101 gctgcaaaga agactacaat ggctgcccta atatcccctc cagcctcatc ttccagcgca
     2161 gcgccaaaga gtctttcttc atttctacac aactctcttc taccaaactc acacaaaatg
     2221 tggacctcct tgctctgctg aaatggaagg ccttcccaga ccggatcatg gacatattag
     2281 ggcggttgcg gcatgtcagt ggggaagaaa ttgttaagtt tctgcaggat atcttagata
     2341 cactctttgt gattttggat gacaatacag aaaaatacgg ccttttggtt tttcagtctc
     2401 tggttttcat tatcaacctg cttcgagaca taaaatactt ccacttccga cctgtaatgg
     2461 acacatatat ccagaagcac tttgctggag ccctggcata taaggagctc atccgctgtt
     2521 tgaagtggta catggactgc tcagcagaac tgattcgaca ggaccacatt caggaagcca
     2581 tgcgggcctt ggagtacctt ttcaagttca ttgtgcagtc acgaatcctg tattcgagag
     2641 ccacatgtgg gatggaagag gagcagttcc ggtctagcat ccaggaactt ttccagtcca
     2701 tccggtttgt gctgagtctg gacagtagga actcagaaac actgctcttc actcaggctg
     2761 cactactcaa ctccttcccc accatcttcg acgagctgct acagatgttt acggtgcaag
     2821 aggtagcaga gtttgtgaga ggcacactgg gaagcatgcc tagcactgtg cacatcgggc
     2881 agtcaatgga tgtggtgaag ctgcagtcca tcgccaggac agtggatagt cgcctatttt
     2941 cattttcaga atcccgccgc atcctacttc ctgtggttct tcatcacatt catcttcacc
     3001 tgaggcaaca gaaagagttg ctaatctgct cagggattct gggcagcatc ttctccatcg
     3061 tcaagaccag ctctctggag gcagatgtca tggaggaggt agagatgatg gtggaaagcc
     3121 tcctggatgt tctcctacag actctcctca ccatcatgag taaatcacat gctcaggagg
     3181 cggtaagagg gcagcggtgc ccgcagtgca cagccgagat cactggtgaa tatgtgtcct
     3241 gcctcctctc attgctccgt cagatgtgtg acacccattt ccaacacctc ttagacaact
     3301 ttcagagtaa agatgaacta aaggaatttc tgctgaagat tttctgtgtg ttcagaaacc
     3361 taatgaagat gagtgtcttc cctcgagact ggatggtgat gagactgttg acaagcaaca
     3421 ttatagtcac tactgtccag tacctgtcct ctgcactgca taagaatttc acagaaacag
     3481 actttgactt caaggtgtgg aattcttatt ttagcctggc agttctgttc ataaaccagc
     3541 caagccttca gctagaaatc attacttcag ccaagaggaa gaagattcta gataagtatg
     3601 gggacatgcg tgtgatgatg gcatatgaac tgttcagcat gtggcagaat ctgggtgatc
     3661 ataagatcca ctttattcct ggaatgattg gtcctttcct gggtgtgaca ctggtcccac
     3721 agccagaagt gcggaatatc atgattccta tctttcatga catgatggac tgggaacaaa
     3781 ggaaaaatgg caacttcaag caggtggagg ctgagctgat tgacaagctg gacagcatgg
     3841 tgtcagaggg gaaaggtgat gagagctaca gggaactctt cggcctgcta acccagctgt
     3901 ttgggcccta ccccagcctt ctggaaaagg ttgaacagga aacatggcgt gagactggca
     3961 tttcctttgt tacctcagtc acgcgcctca tggaacgcct tcttgactac agggactgca
     4021 tgaagggaga agaaactgag aacaagaagg ttggctgcac tgttaacctg atgaactttt
     4081 acaaatctga gattaacaaa gaggaaatgt atatccgata catccataaa ctttgtgaca
     4141 tgcacttaca ggctgagaac tacacagagg ctgcattcac cctgcttctt tactgcgagc
     4201 tgctacaatg ggaagaccgg ccattacggg agttcctaca ctacccatcc caaactgagt
     4261 ggcagcggaa agagggactg tgtagaaaga tcatccacta cttcaacaaa ggcaagagct
     4321 gggagtttgg aattcctcta tgtagagagc tggcatgcca gtacgagagc ctctatgact
     4381 accagagcct cagctggatc cggaaaatgg aggccagcta ctatgacaac atcatagagc
     4441 agcaacgcct ggaacctgag ttcttccggg ttggttttta tggcaggaag tttcctttct
     4501 tccttcggaa caaagaatat gtgtgccgtg gtcatgacta cgagaggcta gaagccttcc
     4561 aacagaggat gctgagcgag ttcccacagg ccgttgctat gcagcacccc aatcatcctg
     4621 atgatgccat cctacagtgt gatgctcagt atttacagat ctatgcagtg acacctattc
     4681 cagattacgt ggatgttcta caaatggata gagtacctga tcgtgtcaag agcttctatc
     4741 gtgtcaataa tgtgaggaag ttccggtatg atagaccttt ccacaaaggc cccaaggaca
     4801 aagacaatga attcaagagc ctgtggattg agcgcaccac gctgacactg acccacagtt
     4861 tgcctggcat ctctcggtgg tttgaagtgg aaagaaggga actggtggag gtgagccctc
     4921 tggagaatgc aatccaggta gttgagaata agaaccagga actgcgagct ctgatcagcc
     4981 agtatcagca caagcaggta catggcaaca tcaatctgct cagcatgtgc ctgaacggag
     5041 tcattgacgc tgctgtcaat ggaggcattg cacgctacca ggaggccttt tttgataaag
     5101 attatatcac caagcaccca ggagacgctg agaagatctc ccagctcaaa gaactaatgc
     5161 aggaacaggt ccatgttctt ggagttgggc tggcggttca tgagaagttt gtgcatccgg
     5221 aaatgcggcc tctgcataag aagctgattg atcagttcca gatgatgagg gccagtctgt
     5281 accatgagtt tccaggtttg gataagctaa gtcctgcatg ttcaggcacc agcaccccac
     5341 ggggaaatgt tctggcatcc catagcccca tgagccctga gaacatcaag atgacccaca
     5401 ggcacagccc catgaacttg atgggcacag gccgccattc ctcatcctct ctctcctcac
     5461 atgcatctag tgaagcagga aacatgatga tgatgggtga caactctatg ggtgaagctc
     5521 ctgaagacct ctaccaccac atgcagcttg catatcacaa ccccaggtac cagggctcag
     5581 tcaccaacgt ctctgttctg tcctcgtccc aggcaagccc ttcttcctcc agcctgagtt
     5641 ctacacattc agctccgtcc cagatgatca cctctgcccc ttccagcacc cgaggctctc
     5701 cctctctgcc agataagtac cgacatgccc gggaaatgat gttgctgttg cctacacatc
     5761 gggaccgccc aagcagtgcc atgtatccag cagccatcct agagaatgga cagccaccaa
     5821 acttccagcg ggccctgttc cagcaagtag ttggagcctg taaaccctgc agtgacccca
     5881 atctgtctat ggctgaaaaa ggtcattact ccctacactt cgacgccttc caccaccctc
     5941 tgggtgatac ccccccggcc ctccctgccc ggacactgcg caagtctcct ctccacccca
     6001 tcccagcctc ccctacaagc ccccaatcgg gcctggatgg cagcaactcc acgctgtctg
     6061 gcagcgccag tagcggtgta tcctccttaa gtgagagtaa ctttgggcat tcctcagagg
     6121 ccccacctcg aacagacacc atggactcca tgccaagcca ggcctggaat ggcgatgaag
     6181 accttgagcc gccctacctc cctgtccact acagcctctc tgaatctgct gtccttgatg
     6241 ccatcaagtc ccagccatgc aggagccact cagccccagg gtgtgtcctc cctcaggatc
     6301 ccatggaccc acctgcgctg ccacccaagc cctatcaccc ccgcctgcca gccctagagc
     6361 atgatgaggg tatgctattg cgggaggagg ctgagaggcc aaggggcctg caccgcaagg
     6421 cctccctgcc tcctggaagt gtcaaggagg aacaggcccg cctggcctgg gagcacggcc
     6481 gaggggaaca gtgagaagca gagaggcagc tgcaccacca ccttccatga gcagcttgcc
     6541 caggcactcc aggtctgaga agcaagtccc tcccagggag ctagaggctt ggcactcagg
     6601 agaaagccac cagagtctct gttctactgc cgtgaactca tgtttcgcca tgttcagagg
     6661 ccacagcagc atgacgggtt gtggcttctt tcattttctt ttcgtttcca ttttctctgg
     6721 gtttttcttt atgcagtagt tgctttcttc ctcctgcagt tccagaccac atggagctat
     6781 atggaaatat tgcacagaca taattgtttt gcagcattgc agagtccagg agtaggagcc
     6841 caggccctcc ctccagggta gagatttgaa gaatggaaat tgcactaggg gcctcttcct
     6901 ttgccgtatg gacagaagca ttcttgattg cattcaggga ttgcaaggac cacatggact
     6961 acatgtcaca ggtggacaga ggggccacaa gccgttttgc acaaatgctt gcccacctgc
     7021 ccactcctcc tcctaggagt gtgcaataga ggggctggtc aggcacatgg tggcctaact
     7081 gcatgcccag ggcatactgc caggcttcca tgggccgggc tggtctctta tcccacttgg
     7141 acgttattca tcacttttat tttggacctt tcgctccttt ccactcaaaa cacctcatga
     7201 tctgcagaag cctccgtggc tcaaaatgga cttgaaaggg tgattatctc tcgtcctggg
     7261 gcttgactga aatgaagcta gaagggcttt cactcctgca gtgagttagg ccccttcctt
     7321 ggattagaaa gagctggtgt gagagtgagg ctggagtgtg gcaggagcca gagaaccttt
     7381 tgctttccca ggtggcccca aatgcctgcc gcttagagcc tgaatcaggg attttcagca
     7441 ctacctctga gccttggggt tggctgccca gcctggcttc caggccctga ggatgtgtgg
     7501 tcaggttcag caagctcctg ggtttaaaaa tatataaata aataaatggt gggaggaaac
     7561 ttctcctttt ggaggcagag agccacacag gtaaaactgt tatcttccaa gcagccaagt
     7621 actgagccct ccactccaaa cccataggga ctgcccacca ctcagggttc aggacaggca
     7681 gaagggcagt ttttcaaacc tccccagtct gttaagtagg gcacagtggt gactttatag
     7741 ggaattcttt catgtcaggg cactgacgtt actcttggta ttatggtggg ggtatggtaa
     7801 tatttcacca gggtgcttct aagttacttt ttaaaataac ttgtcttgag gcaattgttt
     7861 tccttttatt tgcttacatt cccatcagtg atggccataa aactgccttc tccttgatga
     7921 gcaggtatgt tgctcccctg ttcccttaac tagttggcct tctggcctgc tatggccaag
     7981 ttctggcccc agctgcttat cccttctcca caattctttc caaacagaaa aacccatggt
     8041 cacagtgttt ttctcttaga aacaagttta atagaactgt cagcaaataa cctataggaa
     8101 aagaaagaag gcccatttcc gttcacagta tgttggggcc caggtaccaa cagtgtaggg
     8161 ctttctgata ccctcaggat cattcaggca gagtggagac tgttgaggat gtaggtaggc
     8221 caatccaata gccccagcac caagggcaca cacacctgtt cctgagccca gactcactgg
     8281 taagcttgtt tctggaccgt ctgggttcac aggtatgagg gtcaagtcta gcttgggatg
     8341 tgattcttag gtagggcagc tttaggtttg tttccaggca cgtctgaacc tcagtccacg
     8401 gaggcagcca gtcatcacat gcagacatct cctttctcca cttgatggca caggaggtag
     8461 ggaggggaat gtagggttaa gttccttgac cttgctttat gcaaagtgaa atatatttgt
     8521 gttacttctc tccattttcc ccaactggat gaaatggacc tattctgaat actttttatt
     8581 gaaaaaccag ccagtgtgag ggaaatggga ggtcagagat cagaatcctt tgaaaagatt
     8641 gtgaaatact gattttcatt gtttaaagcg tatttgtaaa tacctatttg aatgctgtgt
     8701 atttgtacag gaatttgagc aaaaaaatgt atagagtatg tctaattggt aataagccct
     8761 ataaatgtgt ttttaacctc tggcattctg tgcttattta aaacaagaaa acttctaacc
     8821 atttcttttg tgtattcatg tctaaagaaa aactgactta aaattatctt acctgtacca
     8881 gaaaagttaa agaaaaaaat ttgtgccagt gtcccaagag gcattttact gtatatattg
     8941 tggtagcatg ttataaatcc aacaaaaaat gtgactttta gatgtaaata tctggcaact
     9001 gactccccca cctccatccc ttgactgctg tgatgtgaat taaagatgaa tacctgatat
     9061 tgaaaaa
//
