LOCUS       NM_033374               6431 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus dedicator of cyto-kinesis 2 (Dock2), mRNA.
ACCESSION   NM_033374
VERSION     NM_033374.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6431)
  AUTHORS   Churchhouse,A.M.D., Billard,C.V., Suzuki,T., Pohl,S.O.G.,
            Doleschall,N.J., Donnelly,K., Nixon,C., Arends,M.J., Din,S.,
            Kirkwood,K., Marques Junior,J., Von Kriegsheim,A., Coffelt,S.B. and
            Myant,K.B.
  TITLE     Loss of DOCK2 potentiates Inflammatory Bowel Disease-associated
            colorectal cancer via immune dysfunction and IFNgamma induction of
            IDO1 expression
  JOURNAL   Oncogene 43 (42), 3094-3107 (2024)
   PUBMED   39242821
REFERENCE   2  (bases 1 to 6431)
  AUTHORS   Qian,G., Adeyanju,O., Cai,D., Tucker,T.A., Idell,S., Chen,S.Y. and
            Guo,X.
  TITLE     DOCK2 Promotes Atherosclerosis by Mediating the Endothelial Cell
            Inflammatory Response
  JOURNAL   Am J Pathol 194 (4), 599-611 (2024)
   PUBMED   37838011
  REMARK    GeneRIF: DOCK2 Promotes Atherosclerosis by Mediating the
            Endothelial Cell Inflammatory Response.
REFERENCE   3  (bases 1 to 6431)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 6431)
  AUTHORS   Machin,P.A., Johnsson,A.E., Massey,E.J., Pantarelli,C.,
            Chetwynd,S.A., Chu,J.Y., Okkenhaug,H., Segonds-Pichon,A.,
            Walker,S., Malliri,A., Fukui,Y. and Welch,H.C.E.
  TITLE     Dock2 generates characteristic spatiotemporal patterns of Rac
            activity to regulate neutrophil polarisation, migration and
            phagocytosis
  JOURNAL   Front Immunol 14, 1180886 (2023)
   PUBMED   37383235
  REMARK    GeneRIF: Dock2 generates characteristic spatiotemporal patterns of
            Rac activity to regulate neutrophil polarisation, migration and
            phagocytosis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6431)
  AUTHORS   Guo,X., Cai,D., Dong,K., Li,C., Xu,Z. and Chen,S.Y.
  TITLE     DOCK2 Deficiency Attenuates Abdominal Aortic Aneurysm
            Formation-Brief Report
  JOURNAL   Arterioscler Thromb Vasc Biol 43 (6), e210-e217 (2023)
   PUBMED   37021575
  REMARK    GeneRIF: DOCK2 Deficiency Attenuates Abdominal Aortic Aneurysm
            Formation-Brief Report.
REFERENCE   6  (bases 1 to 6431)
  AUTHORS   Nombela-Arrieta,C., Lacalle,R.A., Montoya,M.C., Kunisaki,Y.,
            Megias,D., Marques,M., Carrera,A.C., Manes,S., Fukui,Y.,
            Martinez-A,C. and Stein,J.V.
  TITLE     Differential requirements for DOCK2 and phosphoinositide-3-kinase
            gamma during T and B lymphocyte homing
  JOURNAL   Immunity 21 (3), 429-441 (2004)
   PUBMED   15357953
REFERENCE   7  (bases 1 to 6431)
  AUTHORS   Sanui,T., Inayoshi,A., Noda,M., Iwata,E., Oike,M., Sasazuki,T. and
            Fukui,Y.
  TITLE     DOCK2 is essential for antigen-induced translocation of TCR and
            lipid rafts, but not PKC-theta and LFA-1, in T cells
  JOURNAL   Immunity 19 (1), 119-129 (2003)
   PUBMED   12871644
  REMARK    GeneRIF: DOCK2 regulates T cell responsiveness through remodeling
            of actin cytoskeleton via Rac activation.
REFERENCE   8  (bases 1 to 6431)
  AUTHORS   Fukui,Y.
  TITLE     [A critical role of the CDM family molecule DOCK2 in lymphocyte
            migration]
  JOURNAL   Tanpakushitsu Kakusan Koso 47 (16 Suppl), 2194-2199 (2002)
   PUBMED   12518436
  REMARK    GeneRIF: plays a role in lymphocyte migration via Rac activation in
            the cytoskeleton
            Review article
REFERENCE   9  (bases 1 to 6431)
  AUTHORS   Reif,K. and Cyster,J.
  TITLE     The CDM protein DOCK2 in lymphocyte migration
  JOURNAL   Trends Cell Biol 12 (8), 368-373 (2002)
   PUBMED   12191913
  REMARK    GeneRIF: A review article on the role of DOCK2 in lymphocyte
            migration.
            Review article
REFERENCE   10 (bases 1 to 6431)
  AUTHORS   Fukui,Y., Hashimoto,O., Sanui,T., Oono,T., Koga,H., Abe,M.,
            Inayoshi,A., Noda,M., Oike,M., Shirai,T. and Sasazuki,T.
  TITLE     Haematopoietic cell-specific CDM family protein DOCK2 is essential
            for lymphocyte migration
  JOURNAL   Nature 412 (6849), 826-831 (2001)
   PUBMED   11518968
  REMARK    GeneRIF: haematopoietic cell-specific CDM protein family member is
            indispensable for lymphocyte chemotaxis
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CR392356.5, AK037611.1, AK172915.1 and BC040427.1.
            
            On Mar 9, 2013 this sequence version replaced NM_033374.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY027438.1, SRR10223970.13068.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                CR392356.5         24198-24210         c
            14-511              AK037611.1         2-499
            512-864             AK037611.1         501-853
            865-6041            AK172915.1         1-5177
            6042-6431           BC040427.1         510-899
FEATURES             Location/Qualifiers
     source          1..6431
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 19.68 cM"
     gene            1..6431
                     /gene="Dock2"
                     /gene_synonym="CED-5; Hch; MBC"
                     /note="dedicator of cyto-kinesis 2"
                     /db_xref="GeneID:94176"
                     /db_xref="MGI:MGI:2149010"
     exon            1..125
                     /gene="Dock2"
                     /gene_synonym="CED-5; Hch; MBC"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..5569
                     /gene="Dock2"
                     /gene_synonym="CED-5; Hch; MBC"
                     /codon_start=1
                     /product="dedicator of cytokinesis protein 2"
                     /protein_id="NP_203538.2"
                     /db_xref="CCDS:CCDS83791.1"
                     /db_xref="GeneID:94176"
                     /db_xref="MGI:MGI:2149010"
                     /translation="MAPWRKTDKERHGVAIYNFQGSEAQHLTLQIGDVVRIQETCGDW
                     YRGYLIKHKLSQGIFPTSFIHLKEVTVEKRRNIENIIPAEIPLAQEVTTTLWEWGSIW
                     KQLYVASKKERFLQVQSMMYDLMEWRSQLLSGTLPKDELKELKQKVTSKIDYGNKILE
                     LDLIVRDEDGNILDPDKTSVISLFHAHEEATYKITERIKEEMSKDQPDYGVYSRISSS
                     PTHSLYVFVRNFVCRIGEDAELFMSLYDPHKQTVISENYLVRWGSKGFPKEIEMLNNL
                     KVVFTDLGNKDLNRDKIFLICQIVRIGKMDLKDINAKKCTQGLRRPFGVAVMDITDII
                     KGKAESDEEKQHFIPFHPVSAENDFLHSLLGKVIASKGDSGGQGLWVTMKMLVGDIIQ
                     IRKDYPHLVDRTTVVARKLGFPEIIMPGDVRNDIYITLLQGDFDKYTKTTQRNVEVIM
                     CVCTEDGKVLPNAICVGAGDKAMNEYHSVVYYQVKQPRWMETVKVAVPIEDMQRIHLR
                     FMFRHRSSLESKDKGEKNFAMSYVKLMKEDGTTLHDGYHELVVLKGDSKKMEDASAYL
                     TLPSYRHPVENKGATLSRSSSSVGGLSVSSRDVFSISTLVCSTKLTQNVGLLGLLKWR
                     MKPQLLQENLEKLKIVDGEEVVKFLQDTLDALFNIMMEHSQSNEYDILVFDALIYIIG
                     LIADRKFQHFNTVLEAYIQQHFSATLAYKKLMTVLKTYLDTSSRGEQCEPILRTLKAL
                     EYVFKFIVRSRTLFSQLYEGKEQMEFEESMRRLFESINNLMKSQYKTTILLQVAALKY
                     IPSVLHDVETVFDAKLLSQLLYEFYTCIPPVKLQKQKVQSMNEIVQSNLFKKQECRDI
                     LLPVITKELKELLEQRDDGQHQAEKKHCVELLNSILEVLSCQDAAFTYDHIQEIMVQL
                     LRTVNRTVITMGRDHALISHFVACMTAILDQMGDQHYSFYIETFQTSSDLVDFLMETF
                     IMFKDLIGKNVYPGDWMAMSMVQNRVFLRAINKFAETMNQKFLEHTSFEFQLWNNYFH
                     LAVAFITQDSLQLEQFTHAKYNKILNKYGDMRRLIGFSIRDMWYKLGQNKICFIPGMV
                     GPILEMTLIPEAELRKATIPIFFDMMLCEYQRTGAFKKFENEIILKLDHEVEGGRGDE
                     QYMQLLESILMECTAEHPTIAKSVENFVSLVKGLLEKLLDYRGVMTDESKDNRMSCTV
                     NLLNFYKDNNREEMYIRYLYKLRDLHLDCENYTEAAYTLLLHTWLLKWSDEQCASQVM
                     QTGQQHPQTHRQLKETLYETIIGYFDKGKMWEEAISLCKELAEQYEMEIFDYELLSQN
                     LTQQAKFYENIMKILRTKPDYFAVGYYGQGFPSFLRNKVFIYRGKEYERREDFQMQLL
                     SQFPNAEKMNTTSAPGDDVRNAPGQYIQCFTVQPVLDEHPRFKNKPVPDQIINFYKSN
                     YVQKFHYSRPVRRGKVDPENEFASMWIERTSFLTAYKLPGILRWFEVVHMSQTTISPL
                     ENAIETMSTVNEKILMMINQYQSDESLPINPLSMLLNGIVDPAVMGGFAKYEKAFFTE
                     EYSREHPEDQDKLSHLKDLIAWQIPFLGAGIKIHEKRVSDNLRPFHDRMEECFKNLKM
                     KVEKEYGVREMPDFEDRRVGRPRSMLRSYRQMSVISLASMHSDCSTPSKVPAESFDLE
                     SAPPKTPKVEEEPISPGSTLPEVKLRRSKKRTKRSSVVFADEKAATESDLKRLSRKQE
                     FMSDTNLSEHAAIPARVSILSQMSFASQSMPTIPALTLSVAGVPGLDEANTSPRLSQT
                     FFQVSDGDKKTLKKKKVNQFFKTMLASKSSEESKQIPDFLSTNM"
     exon            126..209
                     /gene="Dock2"
                     /gene_synonym="CED-5; Hch; MBC"
                     /inference="alignment:Splign:2.1.0"
     exon            210..250
                     /gene="Dock2"
                     /gene_synonym="CED-5; Hch; MBC"
                     /inference="alignment:Splign:2.1.0"
     exon            251..306
                     /gene="Dock2"
                     /gene_synonym="CED-5; Hch; MBC"
                     /inference="alignment:Splign:2.1.0"
     exon            307..403
                     /gene="Dock2"
                     /gene_synonym="CED-5; Hch; MBC"
                     /inference="alignment:Splign:2.1.0"
     exon            404..552
                     /gene="Dock2"
                     /gene_synonym="CED-5; Hch; MBC"
                     /inference="alignment:Splign:2.1.0"
     exon            553..688
                     /gene="Dock2"
                     /gene_synonym="CED-5; Hch; MBC"
                     /inference="alignment:Splign:2.1.0"
     exon            689..843
                     /gene="Dock2"
                     /gene_synonym="CED-5; Hch; MBC"
                     /inference="alignment:Splign:2.1.0"
     exon            844..925
                     /gene="Dock2"
                     /gene_synonym="CED-5; Hch; MBC"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1061
                     /gene="Dock2"
                     /gene_synonym="CED-5; Hch; MBC"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1137
                     /gene="Dock2"
                     /gene_synonym="CED-5; Hch; MBC"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1214
                     /gene="Dock2"
                     /gene_synonym="CED-5; Hch; MBC"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1340
                     /gene="Dock2"
                     /gene_synonym="CED-5; Hch; MBC"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1465
                     /gene="Dock2"
                     /gene_synonym="CED-5; Hch; MBC"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1564
                     /gene="Dock2"
                     /gene_synonym="CED-5; Hch; MBC"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1637
                     /gene="Dock2"
                     /gene_synonym="CED-5; Hch; MBC"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..1741
                     /gene="Dock2"
                     /gene_synonym="CED-5; Hch; MBC"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..1925
                     /gene="Dock2"
                     /gene_synonym="CED-5; Hch; MBC"
                     /inference="alignment:Splign:2.1.0"
     exon            1926..2023
                     /gene="Dock2"
                     /gene_synonym="CED-5; Hch; MBC"
                     /inference="alignment:Splign:2.1.0"
     exon            2024..2113
                     /gene="Dock2"
                     /gene_synonym="CED-5; Hch; MBC"
                     /inference="alignment:Splign:2.1.0"
     exon            2114..2214
                     /gene="Dock2"
                     /gene_synonym="CED-5; Hch; MBC"
                     /inference="alignment:Splign:2.1.0"
     exon            2215..2349
                     /gene="Dock2"
                     /gene_synonym="CED-5; Hch; MBC"
                     /inference="alignment:Splign:2.1.0"
     exon            2350..2458
                     /gene="Dock2"
                     /gene_synonym="CED-5; Hch; MBC"
                     /inference="alignment:Splign:2.1.0"
     exon            2459..2529
                     /gene="Dock2"
                     /gene_synonym="CED-5; Hch; MBC"
                     /inference="alignment:Splign:2.1.0"
     exon            2530..2636
                     /gene="Dock2"
                     /gene_synonym="CED-5; Hch; MBC"
                     /inference="alignment:Splign:2.1.0"
     exon            2637..2782
                     /gene="Dock2"
                     /gene_synonym="CED-5; Hch; MBC"
                     /inference="alignment:Splign:2.1.0"
     exon            2783..2878
                     /gene="Dock2"
                     /gene_synonym="CED-5; Hch; MBC"
                     /inference="alignment:Splign:2.1.0"
     exon            2879..2977
                     /gene="Dock2"
                     /gene_synonym="CED-5; Hch; MBC"
                     /inference="alignment:Splign:2.1.0"
     exon            2978..3072
                     /gene="Dock2"
                     /gene_synonym="CED-5; Hch; MBC"
                     /inference="alignment:Splign:2.1.0"
     exon            3073..3151
                     /gene="Dock2"
                     /gene_synonym="CED-5; Hch; MBC"
                     /inference="alignment:Splign:2.1.0"
     exon            3152..3252
                     /gene="Dock2"
                     /gene_synonym="CED-5; Hch; MBC"
                     /inference="alignment:Splign:2.1.0"
     exon            3253..3311
                     /gene="Dock2"
                     /gene_synonym="CED-5; Hch; MBC"
                     /inference="alignment:Splign:2.1.0"
     exon            3312..3460
                     /gene="Dock2"
                     /gene_synonym="CED-5; Hch; MBC"
                     /inference="alignment:Splign:2.1.0"
     exon            3461..3546
                     /gene="Dock2"
                     /gene_synonym="CED-5; Hch; MBC"
                     /inference="alignment:Splign:2.1.0"
     exon            3547..3703
                     /gene="Dock2"
                     /gene_synonym="CED-5; Hch; MBC"
                     /inference="alignment:Splign:2.1.0"
     exon            3704..3744
                     /gene="Dock2"
                     /gene_synonym="CED-5; Hch; MBC"
                     /inference="alignment:Splign:2.1.0"
     exon            3745..3835
                     /gene="Dock2"
                     /gene_synonym="CED-5; Hch; MBC"
                     /inference="alignment:Splign:2.1.0"
     exon            3836..3955
                     /gene="Dock2"
                     /gene_synonym="CED-5; Hch; MBC"
                     /inference="alignment:Splign:2.1.0"
     exon            3956..4045
                     /gene="Dock2"
                     /gene_synonym="CED-5; Hch; MBC"
                     /inference="alignment:Splign:2.1.0"
     exon            4046..4150
                     /gene="Dock2"
                     /gene_synonym="CED-5; Hch; MBC"
                     /inference="alignment:Splign:2.1.0"
     exon            4151..4292
                     /gene="Dock2"
                     /gene_synonym="CED-5; Hch; MBC"
                     /inference="alignment:Splign:2.1.0"
     exon            4293..4374
                     /gene="Dock2"
                     /gene_synonym="CED-5; Hch; MBC"
                     /inference="alignment:Splign:2.1.0"
     exon            4375..4459
                     /gene="Dock2"
                     /gene_synonym="CED-5; Hch; MBC"
                     /inference="alignment:Splign:2.1.0"
     exon            4460..4546
                     /gene="Dock2"
                     /gene_synonym="CED-5; Hch; MBC"
                     /inference="alignment:Splign:2.1.0"
     exon            4547..4723
                     /gene="Dock2"
                     /gene_synonym="CED-5; Hch; MBC"
                     /inference="alignment:Splign:2.1.0"
     exon            4724..4807
                     /gene="Dock2"
                     /gene_synonym="CED-5; Hch; MBC"
                     /inference="alignment:Splign:2.1.0"
     exon            4808..4945
                     /gene="Dock2"
                     /gene_synonym="CED-5; Hch; MBC"
                     /inference="alignment:Splign:2.1.0"
     exon            4946..5073
                     /gene="Dock2"
                     /gene_synonym="CED-5; Hch; MBC"
                     /inference="alignment:Splign:2.1.0"
     exon            5074..5242
                     /gene="Dock2"
                     /gene_synonym="CED-5; Hch; MBC"
                     /inference="alignment:Splign:2.1.0"
     exon            5243..5363
                     /gene="Dock2"
                     /gene_synonym="CED-5; Hch; MBC"
                     /inference="alignment:Splign:2.1.0"
     exon            5364..5506
                     /gene="Dock2"
                     /gene_synonym="CED-5; Hch; MBC"
                     /inference="alignment:Splign:2.1.0"
     exon            5507..6422
                     /gene="Dock2"
                     /gene_synonym="CED-5; Hch; MBC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6016..6021
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dock2"
                     /gene_synonym="CED-5; Hch; MBC"
                     /note="hexamer: ATTAAA"
     polyA_site      6043
                     /gene="Dock2"
                     /gene_synonym="CED-5; Hch; MBC"
                     /note="major polyA site"
ORIGIN      
        1 agtggggccc tgcaaggcgc ctaaccaccc cagccagctt cttcactaga gaacaggagg
       61 ctctcaaggc tccggtcttg ccatggcccc ctggcgcaaa actgacaagg agcgtcacgg
      121 agtggctatc tacaacttcc aaggcagtga agcccagcat ctcacgctac agattggcga
      181 tgtggtacga atacaggaga cctgtggaga ctggtacaga gggtacctca taaagcataa
      241 actgtcacag ggcattttcc ctacatcctt tatccatctc aaggaagtga cagtggagaa
      301 gagaaggaac atagagaaca tcattcctgc agaaatccct ctggcacaag aagtgacaac
      361 cacgctctgg gagtggggaa gcatctggaa gcagctctat gtggccagca aaaaggaacg
      421 cttcctccaa gtgcagtcca tgatgtacga cctgatggaa tggcgctctc agctcctctc
      481 aggaacgcta cccaaggatg agctgaagga actgaagcag aaagtcacat cgaagatcga
      541 ctatggcaac aaaatccttg agctcgatct cattgtcaga gatgaagatg gaaacatact
      601 ggaccctgat aagaccagcg tcatcagctt gttccatgct cacgaggagg caacttacaa
      661 aatcacagag cgcatcaaag aagaaatgtc aaaagaccag ccagattatg gggtttattc
      721 tcggatctcc tcatccccca cccacagcct ctacgtcttt gtgagaaact ttgtgtgccg
      781 aattggggag gatgctgagc tcttcatgtc tctctatgac cctcacaagc aaacggtcat
      841 cagtgagaac tatctggtgc gatggggcag caaaggattc ccaaaggaaa ttgagatgct
      901 caataacctg aaggtagtct tcacggatct tggaaataaa gacctcaaca gggataagat
      961 tttcttgatc tgtcaaatag tccgaattgg gaagatggat cttaaggaca ttaatgccaa
     1021 gaagtgcacc caggggctga ggagaccttt tggggtggca gttatggaca tcaccgacat
     1081 catcaagggc aaggcagaga gcgacgaaga gaagcaacat tttattccat ttcacccggt
     1141 ctcagctgag aacgatttcc ttcacagcct tctgggcaaa gtcatagctt ccaagggaga
     1201 cagtggaggg caaggccttt gggtgaccat gaagatgctg gtgggggaca tcattcagat
     1261 ccgtaaagac tacccacact tggtggacag gaccactgtg gtagcccgaa agctgggctt
     1321 cccagagatc atcatgccag gggatgtcag gaacgacatc tacatcactc tcttacaagg
     1381 tgactttgac aagtacacca agaccacaca gcggaacgtg gaagtgatca tgtgtgtgtg
     1441 cacagaggat ggcaaagtgc tacctaatgc aatttgtgtg ggagcggggg ataaggccat
     1501 gaacgagtac cactcagtcg tctactacca agtcaaacag ccccgatgga tggaaacagt
     1561 caaggtggct gtccctattg aagatatgca gaggatccat ttgaggttca tgtttcgaca
     1621 ccgctcatca ctagaatcta aagataaagg agaaaagaac tttgccatgt cctacgtgaa
     1681 actcatgaaa gaagatggaa ccactctgca tgatggatac cacgagttgg tggttctcaa
     1741 gggagacagc aagaaaatgg aagatgccag cgcttacctg acacttcctt cttatcgaca
     1801 ccccgtggaa aacaagggag ctacgctgag ccggagctcc agcagtgttg ggggcctttc
     1861 tgtcagctcc cgggatgtgt tctccatttc cacgctagtg tgctccacaa agctgaccca
     1921 gaatgtgggt ttgcttggct tgctgaagtg gcgtatgaag ccacaactgc tccaggagaa
     1981 tctagagaag ttgaagattg tggatggcga ggaagtagtg aagttcctcc aggacactct
     2041 ggatgccctc ttcaacatca tgatggaaca ctctcagagt aacgagtatg acatcctcgt
     2101 ctttgatgct ttgatctata taataggact cattgcagac cggaaattcc agcattttaa
     2161 caccgtattg gaggcttaca tccaacagca tttcagtgct accttggcct acaagaaact
     2221 gatgacggtg ctgaagactt acttggatac ctccagcagg ggggagcagt gcgagcccat
     2281 cctcagaacg ctcaaagcct tagaatacgt gttcaagttc attgttcggt cgaggacatt
     2341 attctcacag ctttacgaag gcaaagagca gatggagttt gaagaatcca tgagacggct
     2401 cttcgaatcc atcaacaacc tgatgaaaag tcagtacaag accaccatcc tattgcaggt
     2461 ggcggctttg aaatacatcc cttcagtcct tcacgatgtg gaaacagtct ttgatgccaa
     2521 gttgctcagc cagctactgt atgagttcta cacctgcatc cctcccgtga agctgcagaa
     2581 gcagaaagtt cagtccatga atgagatcgt gcagagcaac ctcttcaaaa agcaagaatg
     2641 ccgggacatt ctgcttcctg tcatcaccaa agagctgaag gagctgctgg agcagaggga
     2701 cgatgggcag caccaggctg agaagaagca ctgtgtggaa cttctcaaca gcatcttgga
     2761 ggtcctcagc tgtcaggatg cggccttcac ttatgaccac atccaagaga tcatggtcca
     2821 gctgcttcgc acagtgaacc ggacagtcat cacgatgggc cgagatcacg ctttgattag
     2881 tcactttgtg gcgtgtatga cagctatctt agaccagatg ggcgaccaac actattcatt
     2941 ttacattgag accttccaga ccagctcaga ccttgtggac ttcttgatgg agacattcat
     3001 catgttcaag gacctcattg ggaagaatgt gtatcctggg gactggatgg ccatgagcat
     3061 ggtccagaac cgggtcttcc tgagagccat caacaagttt gcagaaacca tgaaccagaa
     3121 gtttctggaa cacacaagct ttgagttcca gctgtggaac aactattttc atctggcagt
     3181 tgcctttatc actcaggact ctctgcagct ggagcagttc acacacgcta agtacaacaa
     3241 aatcctgaat aagtacgggg acatgagacg gctcatagga ttctccatcc gtgatatgtg
     3301 gtacaagctt ggccagaaca aaatctgctt catcccgggc atggtgggac ctatattaga
     3361 gatgacactt atccctgagg ctgagctcag gaaagccacc atcccaatct tcttcgacat
     3421 gatgctgtgt gaatatcaaa ggactggggc tttcaaaaag tttgaaaatg aaatcatcct
     3481 gaagctggac catgaggtgg aaggaggccg gggggatgag cagtacatgc aactgctgga
     3541 gtccatcctg atggagtgca cagcggaaca cccaaccatt gccaagtcgg tggagaactt
     3601 tgtgagcttg gtcaaagggc tgctggagaa gttgctagat taccggggcg tgatgacaga
     3661 tgagagcaaa gacaaccgta tgagctgcac agtgaacttg ctgaatttct acaaagataa
     3721 caaccgggaa gagatgtaca taagatacct gtataaactg cgtgaccttc acttggactg
     3781 tgaaaactac acagaggctg cctacacact cctcctccac acctggcttc tcaagtggtc
     3841 agatgagcag tgtgcatccc aggtcatgca gacaggccag cagcaccctc agacccaccg
     3901 gcagctgaag gagacactct atgagaccat tataggctac tttgacaaag gaaagatgtg
     3961 ggaagaggcc atcagcctgt gcaaggaact ggcggaacaa tatgagatgg agatctttga
     4021 ctacgagcta ctcagccaga acctgaccca gcaggccaaa ttctatgaaa acatcatgaa
     4081 aatcctcaga accaaaccag actactttgc tgttggatac tatggccagg gattcccctc
     4141 ctttctgcgg aacaaagtgt tcatctaccg aggcaaggaa tatgagcgaa gagaagactt
     4201 ccagatgcag cttttgagcc agttccccaa cgcagaaaag atgaacacaa cttctgcccc
     4261 aggagacgat gtgaggaatg ccccaggcca gtacatccag tgtttcactg tgcagcctgt
     4321 tctggatgaa caccccaggt tcaagaacaa accggtgcct gaccagatca taaactttta
     4381 caagtctaat tatgtgcaaa agttccacta ctccaggcct gtgcgcaggg gcaaggtaga
     4441 cccagagaac gagtttgctt ccatgtggat cgagaggact tccttcctga cggcctacaa
     4501 gctgcctggc atcctgcgct ggtttgaggt agttcacatg tctcagacca caattagtcc
     4561 tctggagaat gccatcgaga ctatgtccac agtcaacgag aagatcctga tgatgataaa
     4621 ccagtaccag agtgatgaaa gcctccccat caaccctctc tccatgctcc tcaatgggat
     4681 cgtggaccct gctgtcatgg gaggcttcgc caagtatgag aaggccttct tcactgaaga
     4741 gtatagcagg gagcacccgg aggaccagga caagctgagc catctcaagg acctgattgc
     4801 atggcagatc cctttcctgg gagctgggat taagatccac gagaaaaggg tgtcagacaa
     4861 cctgcgcccc ttccatgacc ggatggagga gtgcttcaag aacctgaaaa tgaaggtgga
     4921 aaaggagtat ggtgtccgag agatgcctga cttcgaagac aggagagtgg gccgccccag
     4981 gtccatgctg cgttcctaca ggcagatgtc cgtcatctct ctggcctcca tgcattctga
     5041 ctgcagcact cccagcaaag tccccgcaga aagttttgac ctagagtcag ccccacccaa
     5101 gactcccaaa gtggaggagg agcccatctc cccagggagc actctgccag aggtcaagct
     5161 gcggcggtcc aagaaaagga ccaagaggag cagcgtggtg tttgcagacg agaaggcagc
     5221 aacggagtca gacctgaagc ggctttctag aaagcaagag ttcatgagtg acaccaacct
     5281 ctcagagcat gcagccatcc ctgccagggt gtctatcctc tctcagatga gttttgccag
     5341 ccagtccatg cccaccatcc cagccctcac actctccgtg gcaggcgtgc ctgggttgga
     5401 tgaggccaac acatctcccc gcctgagtca gaccttcttc caagtctcag atggtgacaa
     5461 gaagaccctg aaaaagaaga aagtcaatca attcttcaag accatgctgg ctagcaagtc
     5521 gagtgaagaa agcaagcaga tcccagactt cctgtccacc aacatgtgag gcactgctga
     5581 gccgagcact gtgggaactc gagcgggaat gcatgagtat gaccttggag ttccacaagg
     5641 agacaagtct gtaaaagaga cagatgatct caaggggccc ccagaactca agtgatgact
     5701 agccttgcat ctcctgtggc cactacaaca gtgatggatg actcaacaga caaagaagcc
     5761 ccaccatgga ttgttggacc ccaaggagcc agcaagtgcc caatgaatgt tctccccagc
     5821 atccaaggga cgcatgtcat aactcaaatt cacagctagg aggagctgtc ttctgtttca
     5881 ttcctaagtg tcagcactta aaagaactga tttaaatgtt ctattttccc ttaacatttt
     5941 tgtactttta catttttttt ctaataagcc ccttgctact ccatcatctc cagactgctg
     6001 ctctttctta cccacattaa aaatgaccca tagctcaaat gaaccttgtt gctgagtctc
     6061 ttattgaagg actgaggaga aagatcccag gatgggaggc agcccagggg actacagcaa
     6121 tatgaaaggc ttatgttggc tcatctcaat gccatgtttt ctctccttgc tcaggcaaac
     6181 tcaagaatct tctctgctct aagaaagaag caggaatgag atttcttcta atttctccat
     6241 tgtttagtta ttttgatttg agatacttta ctgatataca agctatttaa actatttggg
     6301 gaaaaaagca atgtttgaga tagctaatat aatggcttct caatggaatg atagcacaat
     6361 ttgaaatgat accaaaaaga ataataaaat gaaccgtttg aggtttgctt aaaaaaaaaa
     6421 aaaaaaaaaa a
//
