LOCUS       NM_007873               5068 bp    mRNA    linear   ROD 17-JUN-2024
DEFINITION  Mus musculus double C2, beta (Doc2b), mRNA.
ACCESSION   NM_007873
VERSION     NM_007873.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5068)
  AUTHORS   Guiberson,N.G.L., Black,L.S., Haller,J.E., Brukner,A., Abramov,D.,
            Ahmad,S., Xie,Y.X., Sharma,M. and Burre,J.
  TITLE     Disease-linked mutations in Munc18-1 deplete synaptic Doc2
  JOURNAL   Brain 147 (6), 2185-2202 (2024)
   PUBMED   38242640
  REMARK    GeneRIF: Disease-linked mutations in Munc18-1 deplete synaptic
            Doc2.
REFERENCE   2  (bases 1 to 5068)
  AUTHORS   Adiga,D., Bhat,S., Chakrabarty,S. and Kabekkodu,S.P.
  TITLE     DOC2B is a negative regulator of Wnt/beta-catenin signaling pathway
            in cervical cancer
  JOURNAL   Pharmacol Res 180, 106239 (2022)
   PUBMED   35500882
  REMARK    GeneRIF: DOC2B is a negative regulator of Wnt/beta-catenin
            signaling pathway in cervical cancer.
REFERENCE   3  (bases 1 to 5068)
  AUTHORS   Bhat,S., Adiga,D., Shukla,V., Guruprasad,K.P., Kabekkodu,S.P. and
            Satyamoorthy,K.
  TITLE     Metastatic suppression by DOC2B is mediated by inhibition of
            epithelial-mesenchymal transition and induction of senescence
  JOURNAL   Cell Biol Toxicol 38 (2), 237-258 (2022)
   PUBMED   33758996
  REMARK    GeneRIF: Metastatic suppression by DOC2B is mediated by inhibition
            of epithelial-mesenchymal transition and induction of senescence.
REFERENCE   4  (bases 1 to 5068)
  AUTHORS   Bourgeois-Jaarsma,Q., Miaja Hernandez,P. and Groffen,A.J.
  TITLE     Ca2+ sensor proteins in spontaneous release and synaptic
            plasticity: Limited contribution of Doc2c, rabphilin-3a and
            synaptotagmin 7 in hippocampal glutamatergic neurons
  JOURNAL   Mol Cell Neurosci 112, 103613 (2021)
   PUBMED   33753311
REFERENCE   5  (bases 1 to 5068)
  AUTHORS   Wu,H., Petitpre,C., Fontanet,P., Sharma,A., Bellardita,C.,
            Quadros,R.M., Jannig,P.R., Wang,Y., Heimel,J.A., Cheung,K.K.Y.,
            Wanderoy,S., Xuan,Y., Meletis,K., Ruas,J., Gurumurthy,C.B.,
            Kiehn,O., Hadjab,S. and Lallemend,F.
  TITLE     Distinct subtypes of proprioceptive dorsal root ganglion neurons
            regulate adaptive proprioception in mice
  JOURNAL   Nat Commun 12 (1), 1026 (2021)
   PUBMED   33589589
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5068)
  AUTHORS   Groffen,A.J., Friedrich,R., Brian,E.C., Ashery,U. and Verhage,M.
  TITLE     DOC2A and DOC2B are sensors for neuronal activity with unique
            calcium-dependent and kinetic properties
  JOURNAL   J Neurochem 97 (3), 818-833 (2006)
   PUBMED   16515538
REFERENCE   7  (bases 1 to 5068)
  AUTHORS   Chen,B., Schaevitz,L.R. and McConnell,S.K.
  TITLE     Fezl regulates the differentiation and axon targeting of layer 5
            subcortical projection neurons in cerebral cortex
  JOURNAL   Proc Natl Acad Sci U S A 102 (47), 17184-17189 (2005)
   PUBMED   16284245
REFERENCE   8  (bases 1 to 5068)
  AUTHORS   Toonen,R.F., de Vries,K.J., Zalm,R., Sudhof,T.C. and Verhage,M.
  TITLE     Munc18-1 stabilizes syntaxin 1, but is not essential for syntaxin 1
            targeting and SNARE complex formation
  JOURNAL   J Neurochem 93 (6), 1393-1400 (2005)
   PUBMED   15935055
REFERENCE   9  (bases 1 to 5068)
  AUTHORS   Bouwman,J., Maia,A.S., Camoletto,P.G., Posthuma,G., Roubos,E.W.,
            Oorschot,V.M., Klumperman,J. and Verhage,M.
  TITLE     Quantification of synapse formation and maintenance in vivo in the
            absence of synaptic release
  JOURNAL   Neuroscience 126 (1), 115-126 (2004)
   PUBMED   15145078
REFERENCE   10 (bases 1 to 5068)
  AUTHORS   Kojima,T., Fukuda,M., Aruga,J. and Mikoshiba,K.
  TITLE     Calcium-dependent phospholipid binding to the C2A domain of a
            ubiquitous form of double C2 protein (Doc2 beta)
  JOURNAL   J Biochem 120 (3), 671-676 (1996)
   PUBMED   8902635
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BB624126.1, BC067030.1 and
            AL669897.15.
            
            On Sep 11, 2015 this sequence version replaced NM_007873.2.
            
            Summary: The protein encoded by this gene is a calcium sensor
            involved in glucose-stimulated insulin secretion, spontaneous
            neurotransmitter release, and enhanced SNARE-dependent vesicle
            fusion. [provided by RefSeq, Sep 2015].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC067030.1, D85037.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 BB624126.1         1-3
            4-4248              BC067030.1         1-4245
            4249-5068           AL669897.15        54173-54992         c
FEATURES             Location/Qualifiers
     source          1..5068
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 45.92 cM"
     gene            1..5068
                     /gene="Doc2b"
                     /note="double C2, beta"
                     /db_xref="GeneID:13447"
                     /db_xref="MGI:MGI:1100497"
     exon            1..540
                     /gene="Doc2b"
                     /inference="alignment:Splign:2.1.0"
     exon            541..620
                     /gene="Doc2b"
                     /inference="alignment:Splign:2.1.0"
     exon            621..695
                     /gene="Doc2b"
                     /inference="alignment:Splign:2.1.0"
     exon            696..805
                     /gene="Doc2b"
                     /inference="alignment:Splign:2.1.0"
     exon            806..932
                     /gene="Doc2b"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1090
                     /gene="Doc2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1172
                     /gene="Doc2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1269
                     /gene="Doc2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..5068
                     /gene="Doc2b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4226..4231
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Doc2b"
                     /note="hexamer: AGTAAA"
     polyA_site      4248
                     /gene="Doc2b"
     polyA_site      4372
                     /gene="Doc2b"
                     /note="major polyA site"
     regulatory      4897..4902
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Doc2b"
                     /note="hexamer: AATAAA"
     polyA_site      4917
                     /gene="Doc2b"
     regulatory      5041..5046
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Doc2b"
                     /note="hexamer: AATAAA"
     polyA_site      5061
                     /gene="Doc2b"
ORIGIN      
        1 tcactcgcac cggccgccgc cgagcaggca gcagccgcgt cagggccgtc cgggggccac
       61 gctggcgatg accgcagccc ccgcagcgcc ccgcgggacc cgctgacttg cccccgggcc
      121 ggggtcacac cgggccgggc cgggccgcgc gccgcggcgc tgcctgcatg accctccggc
      181 ggcgcgggga gaaggcgacc atcagcatcc aggagcatat ggccatcgac gtgtgtcccg
      241 gccccattcg gcctatcaag cagatctccg attattttcc ccgcttcccg cggggcctcc
      301 cccctaccgc cgcgccccgc gcccccgcgc ccccggacgc ccccgcgcgc tctcccgcag
      361 ccagcgccag cccccgcagc ccctccgacg gcgcccgcga cgacgacgaa gatgtggacc
      421 agctcttcgg agcctacgga gccagcccag gccccagccc cggccccagc cccgcgaggc
      481 cgcccgccaa gccccccgag gacgagccgg acgtcgacgg ctacgagtca gacgactgca
      541 ccgccctggg tacgctggac ttcagtctgc tctatgacca ggagaacaac gcactgcact
      601 gcaccatcag caaggccaag ggcctgaagc cgatggacca caatggactg gctgatccct
      661 acgtcaaact acacctgctg cctggagcca gcaaggcaaa taagctcaga acaaaaactc
      721 ttcggaacac cctgaacccc tcgtggaacg agaccctcac ttattacgga atcacggatg
      781 aggacatggt ccgaaagacc ctgaggatct ccgtgtgtga tgaggacaaa ttccgccaca
      841 atgagttcat tggagagact cgggtgcccc tgaagaagct gaagcccaat cacaccaaga
      901 cattcagcat ctgcctggag aagcagctgc cggtggacaa ggcagaggac aagtctctgg
      961 aagagcgagg ccgcatcctc atctccctca agtacagctc acagaagcag ggcctgctgg
     1021 tgggcatcgt gcgctgtgca cacctggctg ccatggatgc taatggctac tcggacccct
     1081 atgtgaaaac atatctgaag ccagatgtag acaagaaatc caagcataag acagcagtga
     1141 agaagaaaac actaaaccca gaattcaatg aggaattctg ttacgagatc aagcatggag
     1201 acctggccaa aaagactctg gaggtcactg tctgggatta tgacattgga aaatccaatg
     1261 atttcatcgg tggtgtggtt ctgggcatca acgccaaggg cgagcgcctg aagcactggt
     1321 ttgactgctt gaagaacaag gacaagagga ttgagcgttg gcacacgctc accaatgagc
     1381 tcccaggggc tgtactcagc gactgactgt cccatctgct gccacccacc cttgccaccc
     1441 ggcccacaca ggtccaaccc tgggctttct cagctgccgc caagggcaag atccaagttg
     1501 tctgctcgga catagacagt gcagcccctg ctaggaggcc aagagcaccc agcctccctc
     1561 agagggacag gaaaacacaa catgatacct gttccagctc cctgggcatc caagctggcc
     1621 agagctgggg gaatcctcag cctcagctcc atccagagga agggctatct acagtgagga
     1681 cctattggag gtgaggggtg gagccctgct gcaagcccag aaatgggggt actctggctg
     1741 cctggagact acagggagga caatgggcag gcagagccca ggactccagg acagacaatg
     1801 tagccagcca gagcttccaa cttgcttgtg cattgatggg cagatagact ccgtgagcct
     1861 ctgggacggg gattcccact ctagcagggc atctgggtgc acatattgct acaaaggggt
     1921 gcagcatacc agaaccagcc agttgtctgc aggggctgtg ggtactgctg actgctgaag
     1981 ggtggagggc aaggaaggca tcccatgaga gtcagggctc agcacagtct tgaaaaccca
     2041 gctgtggctt gaaagctagg agaaaaccaa atacagaaaa gaggaggcct gaaagagggt
     2101 accaggggac agggagccat gggggcctag ggttgcgcta gggcagcatt gggcttttag
     2161 gcaggagcta ggcttaggga tgtgtacaag cacttgggaa acaatgttca aacccaagct
     2221 ctcccatttg atcttgctcc caaggggtct caatgcacac tgctcctgtt ctcagcgtaa
     2281 attcccagtc agcttcaggg gaatgagaaa gggatcctac taatgtggaa agaagcaagc
     2341 atccctcctg cccacctgtc cctcccttct tcatcccctc agctcaagct ggtgttaggt
     2401 ccttcacggc tacctatggc atcctggccc tatcaagaca gtcaggacca gcagtggaaa
     2461 atagaaagcc ttgtttgggg gaaggtggag ggatgggggt tctgccctca ggagctgaga
     2521 actctggcct cagtttctag gaaagggtag gacactggtc agtcttgaag ctcccaactg
     2581 cctcctgcca actgggattc aggagcacag ggggaacagg gaaccaagga gttccaccat
     2641 catctcagag ccccattttc ctcaatccat cactgagtga taagacactg gggtcctgcc
     2701 ctaagcctag aaccctccta cagctgaaat aagaactcgg ggtcccagaa catgattcca
     2761 atccacagtg ctcaccagcc ttccctagtt ggcagggaaa ataggtctct agctctccac
     2821 agcaccaagc cacctgttgc ttgtaagaga ctgggtttcc ctctttaaaa ggtgtcgcct
     2881 gttactgaat tggcaaacgc cttcttattg aatcttcacc atcctgtgtg gtgggaggca
     2941 tggtcaaccc attttataaa tgagatggct ccagagttgt tgataaactt ccagggccac
     3001 cacggtgtga agggctgaag caaaaactcc aagccttttg actatctgag gacaaggact
     3061 ctcaggtccc tctctccgga gttaatgggg cttagtgagg tctcttacag agaagtcttg
     3121 ttattgtcag ccacctcacc ctctagctgg ctttgaaatc atttgtgcca tttaggattt
     3181 gccaaaggct acagccaagc cctggaactc agctgtccca cccccagcct gaggtcaagg
     3241 aacttggggg accggcctga tgttttcccc atacagctag aaacaggagc agatatttaa
     3301 gtgcacctgg ttgagctctg agtaactcag attttgcctt ttggggtgct ttgttcagag
     3361 aggagtttag aaaccccccg acgatacaga aatgtttatt atacctaaat gtttattata
     3421 cctgaggtga ctgaagctca tcaaaagaac aggtggctca ggtggacaag aaacctggat
     3481 ccctgttgca ccaggcagta agtgggtttg ggactcaatg atgatccttg ccaatcccag
     3541 ggacaggcag ggtgggaagc agggcttcta gccacctaaa aagtgatggc cactaaaaag
     3601 tgatggaact ttcccggatc ctggaacgtt tctaaatccc cagtacatta catctctact
     3661 aaagggaaaa ggtcctttga gaagtttcag aatcagttca gtctttcatt ccaaacgagt
     3721 atcttccttc tggctcatca gcgttgcaaa gaggaaattt gataccaaaa acaaaggtca
     3781 ttccaaagta ctgtcagtaa ccagggcctc tcttgatgcc catcatccac ctcgcgtcct
     3841 ggtctctgcc ccgccctcca ccaccgttag ccaatccctg aacagtcccg tcttccaacc
     3901 cagagtcagt gacctcctga cctctagtgg caaaaatgag gaactgcacc tccgtggccc
     3961 gcccgcccgc ccgcccgccc gccgagctcg ggccaagcgt cctgccctcc gtccttctcc
     4021 agccaagtga atctcccgat gcatggactc tggctgtcct cgacacggac tcgtgcactg
     4081 cttacagttt tgctgccacg tgacgactgc agaatacatc ctcaaactgc agcgccacga
     4141 aacaattttt gtaatcttgt ctgaccttcc caaaggtgtc ctttttaagt cttatttgtt
     4201 aatatttata acgatatata atcaaagtaa atgagaacgt cgtactgagg tcgcactagc
     4261 ttgggaaact ccttggaaga tctgggggga acaagcgaaa gacaactggg gcttatatgt
     4321 ggcgtttact tttgtttttt gaaatgcatt tgtaaaccag tctagcatcc aacttgtgat
     4381 gatcctcctg cctctcattt acaactctcc atttgaaaca ggctcctagg ttacttatgg
     4441 aaaaacaggc tcagaagttt gaatatgtga ggctgatcag atgcacctgc cacacaagcc
     4501 tcaggattaa gcgtgatccc tggaagacaa aaaggcaaga ctttctggtg tggcccacac
     4561 ctttataatc ccagcacttg ggagacagag gcagaccgag gccagcctgg tctacatacc
     4621 cagttccagg acagccaaca aacaaaaaat tcaggatatg caggtggtgg aggccaaggc
     4681 cataagttcc agcactcaag agacaggcag atctgagttt gaaaccagcc tggtctacaa
     4741 gttgaacagc caaggctacg caaaccattt caaacacaca cccacacaca cccaaatcag
     4801 gatgtgatgt gacattaata atcccagcaa tcccagggac catatgggaa gtggggattg
     4861 gggagttgcc cagagccttc ctgccaacta acctagaata aacacccaaa aataagatcg
     4921 tccctgtatc aagctttaag gtgtaaagtt atcctctgac ctccacacaa ttgaaccagc
     4981 ttgcacgctc agtatctcaa cctccctcta tttccctccc tgtccctcac ttatacacac
     5041 aataaaatgt taaaataatg agttaaaa
//
