LOCUS       NM_001110831            1930 bp    mRNA    linear   ROD 21-DEC-2022
DEFINITION  Mus musculus aspartyl aminopeptidase (Dnpep), transcript variant 1,
            mRNA.
ACCESSION   NM_001110831
VERSION     NM_001110831.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1930)
  AUTHORS   Kasowitz SD, Ma J, Anderson SJ, Leu NA, Xu Y, Gregory BD, Schultz
            RM and Wang PJ.
  TITLE     Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and
            splicing during mouse oocyte development
  JOURNAL   PLoS Genet 14 (5), e1007412 (2018)
   PUBMED   29799838
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1930)
  AUTHORS   Koumangoye R and Delpire E.
  TITLE     DNPEP is not the only peptidase that produces SPAK fragments in
            kidney
  JOURNAL   Physiol Rep 5 (21) (2017)
   PUBMED   29122955
  REMARK    GeneRIF: Study shows that in the absence of aspartyl aminopeptidase
            (DNPEP), the kidney lysates retain their ability to cleave
            STE20/SPS1-related proline/alanine-rich kinase(SPAK), indicating
            that DNPEP might have been misidentified as the protease behind the
            kidney lysate activity, or that the aspartyl aminopeptidase might
            not be the only protease cleaving SPAK in kidney.
REFERENCE   3  (bases 1 to 1930)
  AUTHORS   Prashar P, Yadav PS, Samarjeet F and Bandyopadhyay A.
  TITLE     Microarray meta-analysis identifies evolutionarily conserved BMP
            signaling targets in developing long bones
  JOURNAL   Dev Biol 389 (2), 192-207 (2014)
   PUBMED   24583261
REFERENCE   4  (bases 1 to 1930)
  AUTHORS   Nakamura Y, Inloes JB, Katagiri T and Kobayashi T.
  TITLE     Chondrocyte-specific microRNA-140 regulates endochondral bone
            development and targets Dnpep to modulate bone morphogenetic
            protein signaling
  JOURNAL   Mol Cell Biol 31 (14), 3019-3028 (2011)
   PUBMED   21576357
  REMARK    GeneRIF: Results demonstrate that Mir140 is essential for normal
            endochondral bone development and suggest that the reduced BMP
            signaling caused by Dnpep upregulation plays a causal role in the
            skeletal defects of Mir140-null mice.
REFERENCE   5  (bases 1 to 1930)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   6  (bases 1 to 1930)
  AUTHORS   Arechaga G, Prieto I, Segarra AB, Alba F, Ruiz-Larrea MB, Ruiz-Sanz
            JI, de Gasparo M and Ramirez M.
  TITLE     Dietary fatty acid composition affects aminopeptidase activities in
            the testes of mice
  JOURNAL   Int J Androl 25 (2), 113-118 (2002)
   PUBMED   11903661
  REMARK    GeneRIF: dietary fatty acids affect activity in mouse testis
REFERENCE   7  (bases 1 to 1930)
  AUTHORS   Wilk S, Wilk E and Magnusson RP.
  TITLE     Purification, characterization, and cloning of a cytosolic aspartyl
            aminopeptidase
  JOURNAL   J Biol Chem 273 (26), 15961-15970 (1998)
   PUBMED   9632644
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK038646.1 and BC092232.1.
            
            [WARNING] On Apr 26, 2023 this sequence was replaced by
            NM_001110831.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK038646.1, AK160084.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1032              AK038646.1         1-1032
            1033-1930           BC092232.1         785-1682
FEATURES             Location/Qualifiers
     source          1..1930
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1"
     gene            1..1930
                     /gene="Dnpep"
                     /note="aspartyl aminopeptidase"
                     /db_xref="GeneID:13437"
                     /db_xref="MGI:MGI:1278328"
     exon            1..303
                     /gene="Dnpep"
                     /inference="alignment:Splign:2.1.0"
     CDS             298..1725
                     /gene="Dnpep"
                     /EC_number="3.4.11.21"
                     /note="isoform a is encoded by transcript variant 1"
                     /codon_start=1
                     /product="aspartyl aminopeptidase isoform a"
                     /protein_id="NP_001104301.1"
                     /db_xref="CCDS:CCDS78623.1"
                     /db_xref="GeneID:13437"
                     /db_xref="MGI:MGI:1278328"
                     /translation="MQMAMNGRARKEAIQATARELLKFVNRSPSPFHVVAECRSRLLQ
                     AGFRELKETEGWDIVPENKYFLTRNSSSIIAFAVGGQYVPGNGFSLIGAHTDSPCLRV
                     KRKSRRSQVGYHQVGVETYGGGIWSTWFDRDLTLAGRVIIKCPTSGRLEQRLVHIERP
                     ILRIPHLAIHLQRNINENFGPNTEIHLVPILATAVQEELEKGTPEPGPLGATDERHHS
                     VLMSLLCTHLGLSPDSIMEMELCLADTQPAVLGGAYEEFIFAPRLDNLHSCFCALQAL
                     IDSCASPASLARDPHVRMVTLYDNEEVGSESAQGAQSLLTELILRRISASPQRLTAFE
                     EAIPKSFMISADMAHAVHPNYSDKHEENHRPLFHKGPVIKVNSKQRYASNAVSESMIR
                     EVAGQVGVPLQDLMVRNDSPCGTTIGPILASRLGLRVLDLGSPQLAMHSIRETACTTG
                     VLQTLTLFKGFFELFPSVSRNLLVD"
     exon            304..397
                     /gene="Dnpep"
                     /inference="alignment:Splign:2.1.0"
     exon            398..486
                     /gene="Dnpep"
                     /inference="alignment:Splign:2.1.0"
     exon            487..600
                     /gene="Dnpep"
                     /inference="alignment:Splign:2.1.0"
     exon            601..726
                     /gene="Dnpep"
                     /inference="alignment:Splign:2.1.0"
     exon            727..857
                     /gene="Dnpep"
                     /inference="alignment:Splign:2.1.0"
     exon            858..933
                     /gene="Dnpep"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1041
                     /gene="Dnpep"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1119
                     /gene="Dnpep"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1203
                     /gene="Dnpep"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1364
                     /gene="Dnpep"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1404
                     /gene="Dnpep"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1506
                     /gene="Dnpep"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1674
                     /gene="Dnpep"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..1819
                     /gene="Dnpep"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagtagtga gggcgggacg cggcctgact ggcacagagc agtcagcgtg tttggaacca
       61 ggcctgacgg gagctgagcg agtagcggga gggggcggaa cccgaccgag gcctgacagg
      121 ggcggagctc gcggagcagc gggggcgggg cgaggcctgg tagaggcgga gtcccggtgc
      181 ggcctgacga gaggcggagc ccacagctcg gcgaaggcga ggcctgatcc gggagggagg
      241 agcggagcgt caggggcggg ccggagtccg gctcctggag cggagtgcgg tggggctatg
      301 cagatggcta tgaacggcag ggctcggaaa gaggccatcc aggccacagc ccgagagctc
      361 ctgaagttcg tgaaccggag tccctctcct ttccacgtcg tggctgagtg ccgcagccgc
      421 ctcctccagg ctggcttccg tgaactcaag gaaacagagg gctgggatat cgtaccagaa
      481 aacaagtact tcttaaccag aaactcctcc tccatcattg cttttgctgt ggggggccag
      541 tatgttcctg gcaatggctt cagcctcatt ggggcccaca cggacagtcc ctgtctcagg
      601 gtgaaacgca aatcgcgccg aagccaggtg ggctaccacc aggtcggtgt tgagacctac
      661 ggcggtggga tctggagcac atggttcgac cgggacctga ccttggctgg acgcgtcatt
      721 atcaagtgcc ctacctcagg ccggctggag cagaggctcg tccatataga acggcccatc
      781 ctgcgcatcc cacatctggc catccatctg cagcgaaata tcaatgagaa ctttgggccc
      841 aacacagaga tccacctagt ccctattctt gccacagcag ttcaggaaga gctggagaaa
      901 gggactcctg aaccagggcc tctcggtgcc actgatgagc ggcaccactc ggtcctcatg
      961 tccctgctct gtacccatct gggcctgagt cctgacagca tcatggagat ggagctctgc
     1021 ctggcagaca cccagcctgc agtcctgggt ggagcctatg aagagttcat cttcgctcct
     1081 cgactggaca atctgcacag ctgcttctgt gccctgcagg cattgattga ttcctgtgca
     1141 tcccctgcct ctctggccag ggatccacat gtgcgcatgg tcacactcta cgacaatgaa
     1201 gaggtggggt cagagagtgc acaaggagca cagtccctgc tgacggagct gatactacgg
     1261 cgcatctcag cctcacctca gcgtctgact gccttcgagg aagccatacc taagtccttc
     1321 atgatcagtg cagacatggc ccatgctgtg cacccaaact actcggacaa gcatgaagaa
     1381 aaccaccggc ctttgttcca taagggtcct gtgatcaagg tgaacagcaa gcagcgctac
     1441 gcctctaatg cagtgtctga gtccatgatt cgagaggtgg ctggccaagt tggggtgccc
     1501 ctgcaggacc tcatggtcag gaatgactcc ccgtgtggta ccaccattgg acctatcttg
     1561 gcttctcgac tggggcttcg ggtgctggac ttaggcagcc cccaactggc tatgcactct
     1621 atccgggaga cagcctgtac cactggagtt ctccagaccc tcaccctttt caagggcttc
     1681 tttgagctgt tcccttctgt aagccggaac ctcttagtgg actgaggcct ctcgccaaga
     1741 gttgtcttcc accccttcaa ttgagagggg aggatctcag tttcgctgat gttggttatt
     1801 aaagtagatt ttcactccaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1861 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1921 aaaaaaaaaa
//
