LOCUS       NM_019448               1685 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus DNA methyltransferase 3-like (Dnmt3l), transcript
            variant 1, mRNA.
ACCESSION   NM_019448 XM_359253
VERSION     NM_019448.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1685)
  AUTHORS   Wen,Y., Zhou,S., Gui,Y., Li,Z., Yin,L., Xu,W., Feng,S., Ma,X.,
            Gan,S., Xiong,M., Dong,J., Cheng,K., Wang,X. and Yuan,S.
  TITLE     hnRNPU is required for spermatogonial stem cell pool establishment
            in mice
  JOURNAL   Cell Rep 43 (4), 114113 (2024)
   PUBMED   38625792
REFERENCE   2  (bases 1 to 1685)
  AUTHORS   Kubo,N., Uehara,R., Uemura,S., Ohishi,H., Shirane,K. and Sasaki,H.
  TITLE     Combined and differential roles of ADD domains of DNMT3A and DNMT3L
            on DNA methylation landscapes in mouse germ cells
  JOURNAL   Nat Commun 15 (1), 3266 (2024)
   PUBMED   38627502
  REMARK    GeneRIF: Combined and differential roles of ADD domains of DNMT3A
            and DNMT3L on DNA methylation landscapes in mouse germ cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1685)
  AUTHORS   Zoch,A., Konieczny,G., Auchynnikava,T., Stallmeyer,B., Rotte,N.,
            Heep,M., Berrens,R.V., Schito,M., Kabayama,Y., Schopp,T.,
            Kliesch,S., Houston,B., Nagirnaja,L., O'Bryan,M.K., Aston,K.I.,
            Conrad,D.F., Rappsilber,J., Allshire,R.C., Cook,A.G., Tuttelmann,F.
            and O'Carroll,D.
  TITLE     C19ORF84 connects piRNA and DNA methylation machineries to defend
            the mammalian germ line
  JOURNAL   Mol Cell 84 (6), 1021-1035 (2024)
   PUBMED   38359823
REFERENCE   4  (bases 1 to 1685)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 1685)
  AUTHORS   Shovlin,T.C., Bourc'his,D., La Salle,S., O'Doherty,A.,
            Trasler,J.M., Bestor,T.H. and Walsh,C.P.
  TITLE     Sex-specific promoters regulate Dnmt3L expression in mouse germ
            cells
  JOURNAL   Hum Reprod 22 (2), 457-467 (2007)
   PUBMED   17060371
  REMARK    GeneRIF: Sex-specific promoters control Dnmt3L expression in the
            mouse germ line, mirroring the situation at the Dnmt1 and Dnmt3A
            loci.
REFERENCE   6  (bases 1 to 1685)
  AUTHORS   Bourc'his,D., Xu,G.L., Lin,C.S., Bollman,B. and Bestor,T.H.
  TITLE     Dnmt3L and the establishment of maternal genomic imprints
  JOURNAL   Science 294 (5551), 2536-2539 (2001)
   PUBMED   11719692
  REMARK    GeneRIF: likely to function not directly as a DNA methyltransferase
            but as a regulator of methylation at imprinted loci
REFERENCE   7  (bases 1 to 1685)
  AUTHORS   Aapola,U., Lyle,R., Krohn,K., Antonarakis,S.E. and Peterson,P.
  TITLE     Isolation and initial characterization of the mouse Dnmt3l gene
  JOURNAL   Cytogenet Cell Genet 92 (1-2), 122-126 (2001)
   PUBMED   11306809
REFERENCE   8  (bases 1 to 1685)
  AUTHORS   Aapola,U., Kawasaki,K., Scott,H.S., Ollila,J., Vihinen,M.,
            Heino,M., Shintani,A., Kawasaki,K., Minoshima,S., Krohn,K.,
            Antonarakis,S.E., Shimizu,N., Kudoh,J. and Peterson,P.
  TITLE     Isolation and initial characterization of a novel zinc finger gene,
            DNMT3L, on 21q22.3, related to the cytosine-5-methyltransferase 3
            gene family
  JOURNAL   Genomics 65 (3), 293-298 (2000)
   PUBMED   10857753
REFERENCE   9  (bases 1 to 1685)
  AUTHORS   Gerlai,R.
  TITLE     Targeting genes and proteins in the analysis of learning and
            memory: caveats and future directions
  JOURNAL   Rev Neurosci 11 (1), 15-26 (2000)
   PUBMED   10716651
  REMARK    Review article
REFERENCE   10 (bases 1 to 1685)
  AUTHORS   Blechschmidt,K., Schweiger,M., Wertz,K., Poulson,R.,
            Christensen,H.M., Rosenthal,A., Lehrach,H. and Yaspo,M.L.
  TITLE     The mouse Aire gene: comparative genomic sequencing, gene
            organization, and expression
  JOURNAL   Genome Res 9 (2), 158-166 (1999)
   PUBMED   10022980
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK010434.1 and AV511576.1.
            
            On Sep 26, 2013 this sequence version replaced NM_019448.3.
            
            Summary: CpG methylation is an epigenetic modification that is
            important for embryonic development, imprinting, and X-chromosome
            inactivation. Studies in mice have demonstrated that DNA
            methylation is required for mammalian development. This gene
            encodes a nuclear protein that is a catalytically inactive
            regulatory factor of DNA methyltransferases. Alternatively spliced
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (1) is expressed in
            prospermatogonia (PMID: 17060371). It encodes the longer isoform
            (1). Variants 1, 2 and 3 encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK010434.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1669              AK010434.1         2-1670
            1670-1685           AV511576.1         246-261
FEATURES             Location/Qualifiers
     source          1..1685
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..1685
                     /gene="Dnmt3l"
                     /gene_synonym="D6Ertd14e; ecat7"
                     /note="DNA methyltransferase 3-like"
                     /db_xref="GeneID:54427"
                     /db_xref="MGI:MGI:1859287"
     exon            1..70
                     /gene="Dnmt3l"
                     /gene_synonym="D6Ertd14e; ecat7"
                     /inference="alignment:Splign:2.1.0"
     exon            71..258
                     /gene="Dnmt3l"
                     /gene_synonym="D6Ertd14e; ecat7"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..1403
                     /gene="Dnmt3l"
                     /gene_synonym="D6Ertd14e; ecat7"
                     /note="isoform 1 is encoded by transcript variant 1; DNA
                     (cytosine-5-)-methyltransferase 3-like"
                     /codon_start=1
                     /product="DNA (cytosine-5)-methyltransferase 3-like
                     isoform 1"
                     /protein_id="NP_062321.1"
                     /db_xref="CCDS:CCDS23962.1"
                     /db_xref="GeneID:54427"
                     /db_xref="MGI:MGI:1859287"
                     /translation="MGSRETPSSCSKTLETLDLETSDSSSPDADSPLEEQWLKSSPAL
                     KEDSVDVVLEDCKEPLSPSSPPTGREMIRYEVKVNRRSIEDICLCCGTLQVYTRHPLF
                     EGGLCAPCKDKFLESLFLYDDDGHQSYCTICCSGGTLFICESPDCTRCYCFECVDILV
                     GPGTSERINAMACWVCFLCLPFSRSGLLQRRKRWRHQLKAFHDQEGAGPMEIYKTVSA
                     WKRQPVRVLSLFRNIDKVLKSLGFLESGSGSGGGTLKYVEDVTNVVRRDVEKWGPFDL
                     VYGSTQPLGSSCDRCPGWYMFQFHRILQYALPRQESQRPFFWIFMDNLLLTEDDQETT
                     TRFLQTEAVTLQDVRGRDYQNAMRVWSNIPGLKSKHAPLTPKEEEYLQAQVRSRSKLD
                     APKVDLLVKNCLLPLREYFKYFSQNSLPL"
     exon            259..345
                     /gene="Dnmt3l"
                     /gene_synonym="D6Ertd14e; ecat7"
                     /inference="alignment:Splign:2.1.0"
     exon            346..390
                     /gene="Dnmt3l"
                     /gene_synonym="D6Ertd14e; ecat7"
                     /inference="alignment:Splign:2.1.0"
     exon            391..470
                     /gene="Dnmt3l"
                     /gene_synonym="D6Ertd14e; ecat7"
                     /inference="alignment:Splign:2.1.0"
     exon            471..583
                     /gene="Dnmt3l"
                     /gene_synonym="D6Ertd14e; ecat7"
                     /inference="alignment:Splign:2.1.0"
     exon            584..755
                     /gene="Dnmt3l"
                     /gene_synonym="D6Ertd14e; ecat7"
                     /inference="alignment:Splign:2.1.0"
     exon            756..843
                     /gene="Dnmt3l"
                     /gene_synonym="D6Ertd14e; ecat7"
                     /inference="alignment:Splign:2.1.0"
     exon            844..938
                     /gene="Dnmt3l"
                     /gene_synonym="D6Ertd14e; ecat7"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1014
                     /gene="Dnmt3l"
                     /gene_synonym="D6Ertd14e; ecat7"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1154
                     /gene="Dnmt3l"
                     /gene_synonym="D6Ertd14e; ecat7"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1240
                     /gene="Dnmt3l"
                     /gene_synonym="D6Ertd14e; ecat7"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1676
                     /gene="Dnmt3l"
                     /gene_synonym="D6Ertd14e; ecat7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1651..1656
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dnmt3l"
                     /gene_synonym="D6Ertd14e; ecat7"
                     /note="hexamer: AATATA"
     polyA_site      1670
                     /gene="Dnmt3l"
                     /gene_synonym="D6Ertd14e; ecat7"
                     /note="major polyA site"
ORIGIN      
        1 acaccctcaa ccccatcatc ccaggccctc ataggctcca tccagcatta cgtcctcatc
       61 cctacctacg ggttctgacg accctgctgt cacacccgcc atcccttgga cgcagaccct
      121 tctagccgat tacatcaatg ggttcccggg agacaccttc ttcttgctct aagacccttg
      181 aaaccttgga cctggagact tccgacagct ctagccctga tgctgacagt cctctggaag
      241 agcaatggct gaaatcctcc ccagccctga aggaggacag tgtggatgtg gtactggaag
      301 actgcaaaga gcctctgtcc ccctcctcgc ctccgacagg cagagagatg atcaggtacg
      361 aagtcaaagt gaaccgacgg agcattgaag acatctgcct ctgctgtgga actctccagg
      421 tgtacactcg gcaccccttg tttgagggag ggttatgtgc cccatgtaag gataagttcc
      481 tggagtccct cttcctgtat gatgatgatg gacaccagag ttactgcacc atctgctgtt
      541 ccgggggtac cctgttcatc tgtgagagcc ccgactgtac cagatgctac tgtttcgagt
      601 gtgtggacat cctggtgggc cccgggacct cagagaggat caatgccatg gcctgctggg
      661 tttgcttcct gtgcctgccc ttctcacgga gtggactgct gcagaggcgc aagaggtggc
      721 ggcaccagct gaaggccttc catgatcaag agggagcggg ccctatggag atatacaaga
      781 cagtgtctgc atggaagaga cagccagtgc gggtactgag cctttttaga aatattgata
      841 aagtactaaa gagtttgggc tttttggaaa gcggttctgg ttctggggga ggaacgctga
      901 agtacgtgga agatgtcaca aatgtcgtga ggagagacgt ggagaaatgg ggcccctttg
      961 acctggtgta cggctcgacg cagcccctag gcagctcttg tgatcgctgt cccggctggt
     1021 acatgttcca gttccaccgg atcctgcagt atgcgctgcc tcgccaggag agtcagcggc
     1081 ccttcttctg gatattcatg gacaatctgc tgctgactga ggatgaccaa gagacaacta
     1141 cccgcttcct tcagacagag gctgtgaccc tccaggatgt ccgtggcaga gactaccaga
     1201 atgctatgcg ggtgtggagc aacattccag ggctgaagag caagcatgcg cccctgaccc
     1261 caaaggaaga agagtatctg caagcccaag tcagaagcag gagcaagctg gacgccccga
     1321 aagttgacct cctggtgaag aactgccttc tcccgctgag agagtacttc aagtattttt
     1381 ctcaaaactc acttcctctt tagaaatgaa tcaccataag atgaaagtct ttcctagaac
     1441 cagggcagat ttcttcctaa ggtctcttcc ctccacagtt ttctctggtt tgctttcagg
     1501 ccttcgggtt tctctcctgt ttgattgcca ggatgcctct gtgcagctca ctttgcgggg
     1561 tgggaggtgc ctacggctct gcacaagttc ccggtgggat aacctgccat gtttctctga
     1621 aactgtgtgt acctgttgtg aagtttttca aatatatcat aggattgtta ctggtaaaaa
     1681 aaaaa
//
