LOCUS       NM_007872               9735 bp    mRNA    linear   ROD 02-MAY-2023
DEFINITION  Mus musculus DNA methyltransferase 3A (Dnmt3a), transcript variant
            1, mRNA.
ACCESSION   NM_007872
VERSION     NM_007872.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 9735)
  AUTHORS   Wu H, Li Z, Yang Y, Zhang L, Yuan Y, Wang Y, Li G and Yang X.
  TITLE     Rap1A accelerates homocysteine-induced ANA-1 cells inflammation via
            synergy of FoxO1 and DNMT3a
  JOURNAL   Cell Signal 106, 110627 (2023)
   PUBMED   36791985
  REMARK    GeneRIF: Rap1A accelerates homocysteine-induced ANA-1 cells
            inflammation via synergy of FoxO1 and DNMT3a.
REFERENCE   2  (bases 1 to 9735)
  AUTHORS   Zioni N, Bercovich AA, Chapal-Ilani N, Bacharach T, Rappoport N,
            Solomon A, Avraham R, Kopitman E, Porat Z, Sacma M, Hartmut G,
            Scheller M, Muller-Tidow C, Lipka D, Shlush E, Minden M, Kaushansky
            N and Shlush LI.
  TITLE     Inflammatory signals from fatty bone marrow support DNMT3A driven
            clonal hematopoiesis
  JOURNAL   Nat Commun 14 (1), 2070 (2023)
   PUBMED   37045808
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9735)
  AUTHORS   Sukur G, Uysal F and Cinar O.
  TITLE     High-fat diet induced obesity alters Dnmt1 and Dnmt3a levels and
            global DNA methylation in mouse ovary and testis
  JOURNAL   Histochem Cell Biol 159 (4), 339-352 (2023)
   PUBMED   36624173
  REMARK    GeneRIF: High-fat diet induced obesity alters Dnmt1 and Dnmt3a
            levels and global DNA methylation in mouse ovary and testis.
REFERENCE   4  (bases 1 to 9735)
  AUTHORS   Khazaei S, Chen CCL, Andrade AF, Kabir N, Azarafshar P, Morcos SM,
            Franca JA, Lopes M, Lund PJ, Danieau G, Worme S, Adnani L,
            Nzirorera N, Chen X, Yogarajah G, Russo C, Zeinieh M, Wong CJ,
            Bryant L, Hebert S, Tong B, Sihota TS, Faury D, Puligandla E,
            Jawhar W, Sandy V, Cowan M, Nakada EM, Jerome-Majewska LA, Ellezam
            B, Gomes CC, Denecke J, Lessel D, McDonald MT, Pizoli CE, Taylor K,
            Cocanougher BT, Bhoj EJ, Gingras AC, Garcia BA, Lu C, Campos EI,
            Kleinman CL, Garzia L and Jabado N.
  TITLE     Single substitution in H3.3G34 alters DNMT3A recruitment to cause
            progressive neurodegeneration
  JOURNAL   Cell 186 (6), 1162-1178 (2023)
   PUBMED   36931244
  REMARK    GeneRIF: Single substitution in H3.3G34 alters DNMT3A recruitment
            to cause progressive neurodegeneration.
REFERENCE   5  (bases 1 to 9735)
  AUTHORS   Chen ZX and Riggs AD.
  TITLE     DNA methylation and demethylation in mammals
  JOURNAL   J Biol Chem 286 (21), 18347-18353 (2011)
   PUBMED   21454628
  REMARK    Review article
REFERENCE   6  (bases 1 to 9735)
  AUTHORS   Chen T, Ueda Y, Xie S and Li E.
  TITLE     A novel Dnmt3a isoform produced from an alternative promoter
            localizes to euchromatin and its expression correlates with active
            de novo methylation
  JOURNAL   J Biol Chem 277 (41), 38746-38754 (2002)
   PUBMED   12138111
  REMARK    GeneRIF: These findings suggest that Dnmt3a and Dnmt3a2 may have
            distinct DNA targets and different functions in development.
REFERENCE   7  (bases 1 to 9735)
  AUTHORS   Weisenberger DJ, Velicescu M, Preciado-Lopez MA, Gonzales FA, Tsai
            YC, Liang G and Jones PA.
  TITLE     Identification and characterization of alternatively spliced
            variants of DNA methyltransferase 3a in mammalian cells
  JOURNAL   Gene 298 (1), 91-99 (2002)
   PUBMED   12406579
REFERENCE   8  (bases 1 to 9735)
  AUTHORS   Okano M, Bell DW, Haber DA and Li E.
  TITLE     DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo
            methylation and mammalian development
  JOURNAL   Cell 99 (3), 247-257 (1999)
   PUBMED   10555141
REFERENCE   9  (bases 1 to 9735)
  AUTHORS   Okano M, Takebayashi S, Okumura K and Li E.
  TITLE     Assignment of cytosine-5 DNA methyltransferases Dnmt3a and Dnmt3b
            to mouse chromosome bands 12A2-A3 and 2H1 by in situ hybridization
  JOURNAL   Cytogenet Cell Genet 86 (3-4), 333-334 (1999)
   PUBMED   10575238
REFERENCE   10 (bases 1 to 9735)
  AUTHORS   Okano,M., Xie,S. and Li,E.
  TITLE     Cloning and characterization of a family of novel mammalian DNA
            (cytosine-5) methyltransferases
  JOURNAL   Nat Genet 19 (3), 219-220 (1998)
   PUBMED   9662389
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CJ104461.1, AK147676.1 and
            AC159324.3.
            
            [WARNING] On May 25, 2023 this sequence was replaced by
            NM_007872.5.
            
            On Sep 7, 2006 this sequence version replaced NM_007872.3.
            
            Summary: This is one of two related genes encoding de novo DNA
            methyltransferases, which are responsible for the establishment of
            DNA methylation patterns in embryos. Loss of function of this gene
            causes developmental defects in multiple different organ systems.
            There is a pseudogene for this gene located on chromosome 3.
            Alternatively spliced transcript variants encoding multiple
            isoforms have been observed. [provided by RefSeq, Nov 2012].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1, also known as
            Dnmt3a1). Variants 1 and 3 encode the same isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147676.1, AK090132.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-220               CJ104461.1         1-220
            221-6569            AK147676.1         150-6498
            6570-9735           AC159324.3         166186-169351
FEATURES             Location/Qualifiers
     source          1..9735
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12"
     gene            1..9735
                     /gene="Dnmt3a"
                     /gene_synonym="MmuIIIA"
                     /note="DNA methyltransferase 3A"
                     /db_xref="GeneID:13435"
                     /db_xref="MGI:MGI:1261827"
     exon            1..141
                     /gene="Dnmt3a"
                     /gene_synonym="MmuIIIA"
                     /inference="alignment:Splign:2.1.0"
     exon            142..375
                     /gene="Dnmt3a"
                     /gene_synonym="MmuIIIA"
                     /inference="alignment:Splign:2.1.0"
     CDS             313..3039
                     /gene="Dnmt3a"
                     /gene_synonym="MmuIIIA"
                     /EC_number="2.1.1.37"
                     /note="isoform 1 is encoded by transcript variant 1; DNA
                     (cytosine-5)-methyltransferase 3A; DNA MTase MmuIIIA; DNA
                     methyltransferase MmuIIIA; cysteine methyltransferase
                     DNMT3A"
                     /codon_start=1
                     /product="DNA (cytosine-5)-methyltransferase 3A isoform 1"
                     /protein_id="NP_031898.1"
                     /db_xref="CCDS:CCDS36397.1"
                     /db_xref="GeneID:13435"
                     /db_xref="MGI:MGI:1261827"
                     /translation="MPSSGPGDTSSSSLEREDDRKEGEEQEENRGKEERQEPSATARK
                     VGRPGRKRKHPPVESSDTPKDPAVTTKSQPMAQDSGPSDLLPNGDLEKRSEPQPEEGS
                     PAAGQKGGAPAEGEGTETPPEASRAVENGCCVTKEGRGASAGEGKEQKQTNIESMKME
                     GSRGRLRGGLGWESSLRQRPMPRLTFQAGDPYYISKRKRDEWLARWKREAEKKAKVIA
                     VMNAVEENQASGESQKVEEASPPAVQQPTDPASPTVATTPEPVGGDAGDKNATKAADD
                     EPEYEDGRGFGIGELVWGKLRGFSWWPGRIVSWWMTGRSRAAEGTRWVMWFGDGKFSV
                     VCVEKLMPLSSFCSAFHQATYNKQPMYRKAIYEVLQVASSRAGKLFPACHDSDESDSG
                     KAVEVQNKQMIEWALGGFQPSGPKGLEPPEEEKNPYKEVYTDMWVEPEAAAYAPPPPA
                     KKPRKSTTEKPKVKEIIDERTRERLVYEVRQKCRNIEDICISCGSLNVTLEHPLFIGG
                     MCQNCKNCFLECAYQYDDDGYQSYCTICCGGREVLMCGNNNCCRCFCVECVDLLVGPG
                     AAQAAIKEDPWNCYMCGHKGTYGLLRRREDWPSRLQMFFANNHDQEFDPPKVYPPVPA
                     EKRKPIRVLSLFDGIATGLLVLKDLGIQVDRYIASEVCEDSITVGMVRHQGKIMYVGD
                     VRSVTQKHIQEWGPFDLVIGGSPCNDLSIVNPARKGLYEGTGRLFFEFYRLLHDARPK
                     EGDDRPFFWLFENVVAMGVSDKRDISRFLESNPVMIDAKEVSAAHRARYFWGNLPGMN
                     RPLASTVNDKLELQECLEHGRIAKFSKVRTITTRSNSIKQGKDQHFPVFMNEKEDILW
                     CTEMERVFGFPVHYTDVSNMSRLARQRLLGRSWSVPVIRHLFAPLKEYFACV"
     exon            376..480
                     /gene="Dnmt3a"
                     /gene_synonym="MmuIIIA"
                     /inference="alignment:Splign:2.1.0"
     exon            481..748
                     /gene="Dnmt3a"
                     /gene_synonym="MmuIIIA"
                     /inference="alignment:Splign:2.1.0"
     exon            749..792
                     /gene="Dnmt3a"
                     /gene_synonym="MmuIIIA"
                     /inference="alignment:Splign:2.1.0"
     exon            793..939
                     /gene="Dnmt3a"
                     /gene_synonym="MmuIIIA"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1155
                     /gene="Dnmt3a"
                     /gene_synonym="MmuIIIA"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1314
                     /gene="Dnmt3a"
                     /gene_synonym="MmuIIIA"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1422
                     /gene="Dnmt3a"
                     /gene_synonym="MmuIIIA"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1579
                     /gene="Dnmt3a"
                     /gene_synonym="MmuIIIA"
                     /inference="alignment:Splign:2.1.0"
     exon            1580..1729
                     /gene="Dnmt3a"
                     /gene_synonym="MmuIIIA"
                     /inference="alignment:Splign:2.1.0"
     exon            1730..1774
                     /gene="Dnmt3a"
                     /gene_synonym="MmuIIIA"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..1854
                     /gene="Dnmt3a"
                     /gene_synonym="MmuIIIA"
                     /inference="alignment:Splign:2.1.0"
     exon            1855..1967
                     /gene="Dnmt3a"
                     /gene_synonym="MmuIIIA"
                     /inference="alignment:Splign:2.1.0"
     exon            1968..2151
                     /gene="Dnmt3a"
                     /gene_synonym="MmuIIIA"
                     /inference="alignment:Splign:2.1.0"
     exon            2152..2236
                     /gene="Dnmt3a"
                     /gene_synonym="MmuIIIA"
                     /inference="alignment:Splign:2.1.0"
     exon            2237..2382
                     /gene="Dnmt3a"
                     /gene_synonym="MmuIIIA"
                     /inference="alignment:Splign:2.1.0"
     exon            2383..2473
                     /gene="Dnmt3a"
                     /gene_synonym="MmuIIIA"
                     /inference="alignment:Splign:2.1.0"
     exon            2474..2622
                     /gene="Dnmt3a"
                     /gene_synonym="MmuIIIA"
                     /inference="alignment:Splign:2.1.0"
     exon            2623..2708
                     /gene="Dnmt3a"
                     /gene_synonym="MmuIIIA"
                     /inference="alignment:Splign:2.1.0"
     exon            2709..2778
                     /gene="Dnmt3a"
                     /gene_synonym="MmuIIIA"
                     /inference="alignment:Splign:2.1.0"
     exon            2779..2897
                     /gene="Dnmt3a"
                     /gene_synonym="MmuIIIA"
                     /inference="alignment:Splign:2.1.0"
     exon            2898..9735
                     /gene="Dnmt3a"
                     /gene_synonym="MmuIIIA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9708..9713
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dnmt3a"
                     /gene_synonym="MmuIIIA"
     polyA_site      9733
                     /gene="Dnmt3a"
                     /gene_synonym="MmuIIIA"
                     /note="The 3' most polyA site has not been determined."
ORIGIN      
        1 gacagcgacg gagggaggga gcgcggcagg cagcgggcgg gccgggaggc ggcgcgggcg
       61 gcggcgcgag cagaggacga gccgggacgc ggcgccgcgg cagcagggcg agccgggccg
      121 cccgacccgc cgggccacac ggcagagccg cctgaagccc agcgctgagg ctgcactttt
      181 ccgagggctt gacatcaggg tctatgttta agtcttagct cttgcttaca aagaccacgg
      241 caattccttc tctgaagccc tcgcagcccc acagcgccct cgcagcccca gcctgccgcc
      301 tactgcccag caatgccctc cagcggcccc ggggacacca gcagctcctc tctggagcgg
      361 gaggatgatc gaaaggaagg agaggaacag gaggagaacc gtggcaagga agagcgccag
      421 gagcccagcg ccacggcccg gaaggtgggg aggcctggcc ggaagcgcaa gcacccaccg
      481 gtggaaagca gtgacacccc caaggaccca gcagtgacca ccaagtctca gcccatggcc
      541 caggactctg gcccctcaga tctgctaccc aatggagact tggagaagcg gagtgaaccc
      601 caacctgagg aggggagccc agctgcaggg cagaagggtg gggccccagc tgaaggagag
      661 ggaactgaga ccccaccaga agcctccaga gctgtggaga atggctgctg tgtgaccaag
      721 gaaggccgtg gagcctctgc aggagagggc aaagaacaga agcagaccaa catcgaatcc
      781 atgaaaatgg agggctcccg gggccgactg cgaggtggct tgggctggga gtccagcctc
      841 cgtcagcgac ccatgccaag actcaccttc caggcagggg acccctacta catcagcaaa
      901 cggaaacggg atgagtggct ggcacgttgg aaaagggagg ctgagaagaa agccaaggta
      961 attgcagtaa tgaatgctgt ggaagagaac caggcctctg gagagtctca gaaggtggag
     1021 gaggccagcc ctcctgctgt gcagcagccc acggaccctg cttctccgac tgtggccacc
     1081 acccctgagc cagtaggagg ggatgctggg gacaagaatg ctaccaaagc agccgacgat
     1141 gagcctgagt atgaggatgg ccggggcttt ggcattggag agctggtgtg ggggaaactt
     1201 cggggcttct cctggtggcc aggccgaatt gtgtcttggt ggatgacagg ccggagccga
     1261 gcagctgaag gcactcgctg ggtcatgtgg ttcggagatg gcaagttctc agtggtgtgt
     1321 gtggagaagc tcatgccgct gagctccttc tgcagtgcat tccaccaggc cacctacaac
     1381 aagcagccca tgtaccgcaa agccatctac gaagtcctcc aggtggccag cagccgtgcc
     1441 gggaagctgt ttccagcttg ccatgacagt gatgaaagtg acagtggcaa ggctgtggaa
     1501 gtgcagaaca agcagatgat tgaatgggcc ctcggtggct tccagccctc gggtcctaag
     1561 ggcctggagc caccagaaga agagaagaat ccttacaagg aagtttacac cgacatgtgg
     1621 gtggagcctg aagcagctgc ttacgcccca cccccaccag ccaagaaacc cagaaagagc
     1681 acaacagaga aacctaaggt caaggagatc attgatgagc gcacaaggga gcggctggtg
     1741 tatgaggtgc gccagaagtg cagaaacatc gaggacattt gtatctcatg tgggagcctc
     1801 aatgtcaccc tggagcaccc actcttcatt ggaggcatgt gccagaactg taagaactgc
     1861 ttcttggagt gtgcttacca gtatgacgac gatgggtacc agtcctattg caccatctgc
     1921 tgtggggggc gtgaagtgct catgtgtggg aacaacaact gctgcaggtg cttttgtgtc
     1981 gagtgtgtgg atctcttggt ggggccagga gctgctcagg cagccattaa ggaagacccc
     2041 tggaactgct acatgtgcgg gcataagggc acctatgggc tgctgcgaag acgggaagac
     2101 tggccttctc gactccagat gttctttgcc aataaccatg accaggaatt tgacccccca
     2161 aaggtttacc cacctgtgcc agctgagaag aggaagccca tccgcgtgct gtctctcttt
     2221 gatgggattg ctacagggct cctggtgctg aaggacctgg gcatccaagt ggaccgctac
     2281 attgcctccg aggtgtgtga ggactccatc acggtgggca tggtgcggca ccagggaaag
     2341 atcatgtacg tcggggacgt ccgcagcgtc acacagaagc atatccagga gtggggccca
     2401 ttcgacctgg tgattggagg cagtccctgc aatgacctct ccattgtcaa ccctgcccgc
     2461 aagggacttt atgagggtac tggccgcctc ttctttgagt tctaccgcct cctgcatgat
     2521 gcgcggccca aggagggaga tgatcgcccc ttcttctggc tctttgagaa tgtggtggcc
     2581 atgggcgtta gtgacaagag ggacatctcg cgatttcttg agtctaaccc cgtgatgatt
     2641 gacgccaaag aagtgtctgc tgcacacagg gcccgttact tctggggtaa ccttcctggc
     2701 atgaacaggc ctttggcatc cactgtgaat gataagctgg agctgcaaga gtgtctggag
     2761 cacggcagaa tagccaagtt cagcaaagtg aggaccatta ccaccaggtc aaactctata
     2821 aagcagggca aagaccagca tttccccgtc ttcatgaacg agaaggagga catcctgtgg
     2881 tgcactgaaa tggaaagggt gtttggcttc cccgtccact acacagacgt ctccaacatg
     2941 agccgcttgg cgaggcagag actgctgggc cgatcgtgga gcgtgccggt catccgccac
     3001 ctcttcgctc cgctgaagga atattttgct tgtgtgtaag ggacatgggg gcaaactgaa
     3061 gtagtgatga taaaaaagtt aaacaaacaa acaaacaaaa aacaaaacaa aacaataaaa
     3121 caccaagaac gagaggacgg agaaaagttc agcacccaga agagaaaaag gaatttaaag
     3181 caaaccacag aggaggaaaa cgccggaggg cttggccttg caaaagggtt ggacatcatc
     3241 tcctgagttt tcaatgttaa ccttcagtcc tatctaaaaa gcaaaatagg cccctcccct
     3301 tcttcccctc cggtcctagg aggcgaactt tttgttttct actctttttc agaggggttt
     3361 tctgtttgtt tgggtttttg tttcttgctg tgactgaaac aagagagtta ttgcagcaaa
     3421 atcagtaaca acaaaaagta gaaatgcctt ggagaggaaa gggagagagg gaaaattcta
     3481 taaaaactta aaatattggt tttttttttt ttccttttct atatatctct ttggttgtct
     3541 ctagcctgat cagataggag cacaaacagg aagagaatag agaccctcgg aggcagagtc
     3601 tcctctccca ccccccgagc agtctcaaca gcaccattcc tggtcatgca aaacagaacc
     3661 caactagcag cagggcgctg agagaacacc acaccagaca cttttctaca gtatttcagg
     3721 tgcctaccac acaggaaacc ttgaagaaaa ccagtttcta gaagccgctg ttacctcttg
     3781 tttacagttt atatatatat gatagatatg agatatatat atataaaagg tactgttaac
     3841 tactgtacat cccgacttca taatggtgct ttcaaaacag cgagatgagc aaagacatca
     3901 gcttccgcct ggccctctgt gcaaagggtt tcagcccagg atggggagag gggagcagct
     3961 ggagggggtt ttaacaaact gaaggatgac ccatatcacc ccccacccct gccccatgcc
     4021 tagcttcacc tgccaaaaag gggctcagct gaggtggtcg gaccctgggg aagctgagtg
     4081 tggaatttat ccagactcgc gtgcaataac cttagaatat gaatctaaaa tgactgcctc
     4141 agaaaaatgg cttgagaaaa cattgtccct gattttgaat tcgtcagcca cgttgaaggc
     4201 cccttgtggg atcagaaata ttccagagtg agggaaagtg acccgccatt aaccccacct
     4261 ggagcaaata aaaaaacata caaaatgtac tggtgctttc tgtctaagtt gccttttgtg
     4321 tgttctttta taaggcccca ccatcccctc tgcacatggc agctccggtc ctggaatgtg
     4381 atgtttttgg tcatctctaa agactgcagt ttcatacttg ggaggctgat gacaccttta
     4441 ttataattat tcttatggtt ctggctataa ttgttttaag attttctttc agaaaacaaa
     4501 aacccaacac ccttcccttt aggtttcaaa ccaaggtgcg ggggggtggc aggtgctttt
     4561 ttaaggacca gtggctctgg tgccctggct cccacccctc aggccaggtg agccactggg
     4621 caacaagcta ggcagccagg gagtttgagg cccaccctcc gggccagtca ctcttctctt
     4681 cttcttccct tcctcgtgag tccggtgtgt cagggctgga gggaggccgg ggcagcctcc
     4741 ctccttgtgt gtgtggttgg agtggcgtgt gtttcttttc tagtgtttgc tctgatggct
     4801 gtgctctcac ttgagtcagc ttcacctggg ccatgtgctc gcactttgtt ccgctcccca
     4861 gccagggcag gcagcctggc attggcagcg ggaagggaag gtgtgcttgg ccccagggtg
     4921 agggcttgcc tggatggatg gagtgtagat atgtggcata tagagatata tattttataa
     4981 tgggaggggg gacggcacct cctgggacca gcagagactg ggaggtgtgc tgtcaagcac
     5041 atggtcccaa gaccgcatcc ctagaaagat ggggcctatg ataggcccta tataaataca
     5101 tagatagggt catgtataag aaatatacac agagggggtt ggagggagtg ggctctgtgt
     5161 tgagcctggg tccttcccgc agacagcccc acaaacagta tatcagtcta acacatgcac
     5221 aggaatctat ttctgtctgg atgcacacca gggagccccc agcacacttc tctgcaggat
     5281 caggacgatg gagtcggcta cacagctctc tctcgtacat ctgttgccct gatgacaggt
     5341 agactcgatc ccagaagttg ctaggtgctg aagtcaggaa aaggaggagg tttgatccaa
     5401 gcaggtgctt cctctagcag gtctgtgttg tattcccttt gcctctggtg atgtcagctt
     5461 ctgttagcag cctgtggtta ctgacctgca actctcggca ccagtcaagt cagccctcag
     5521 cccctaccta ttctccccaa ccaaagtcga actgaaatct ctcttggcca tggggcttcc
     5581 attgggaaaa taaaatgtta aaaaaaaaat taaaatggga cagtgaacct cacttttgga
     5641 gtaaagcaaa tcagtaatta gtgctaaaac tagtcagagg ctttggcccc ttgctcactg
     5701 ctcgggacta agcttggctg gtggcttggt acactgcttg ggctgtgtag tcctgcccac
     5761 ctctgctcat tttctctgga tagagtttta agatcgcagc tagtttcccc tgccatggca
     5821 ggtatgacta tggggctgga gcatccagga gagggggatg cttgccctct tggagtccct
     5881 gtactaaatg taacgtcctc ccttgctcca gcagggctcc attctgacct ggagtccacc
     5941 agcaccatgc aggaggactg gaggggagga aggctgcttt aggcagtcca aggtgctccc
     6001 tccccctcta gcaatggcaa ggtcttccca gctcctgtca ggactgtctt caaaggccat
     6061 ctctgcccac cgcatatgtg acgaagctag cctttcccag gagcctagtg ccgcctcagc
     6121 tgggcctggt gctcccgtgc ctggggttag tgtgagggct caggaggagg agttcccaag
     6181 ggactgagta gaggcttcca ggtggctgac cagtactgac ctgacacggt ccctgatgga
     6241 ctcctcatgg ggcgggcatc gggtggcctt ctctagcttt ccttccagcc ccatctgtag
     6301 gcttagtctt accatagtgt gagggcacca ggcgagttag cccccaatat cttttgggga
     6361 ggggtgtctt tgggactgtg ccaatctggc tattcatccg tctctacccc aagtgcggct
     6421 tctagggtca cctctgagga gagctgctgg gatgctgggg tagctgaggg gaggttgtgg
     6481 ggagtttgca gtgcatctag gaactagctc actgcaggtg gggctgaagc tggattcagt
     6541 catgggaggt tccctgtggg ctttcctttc caaagactag gcttgttttc cctagaaact
     6601 aaggtgctgg ggactgggtg acagccacct ctcagcaggt gccgtgtaag tgtgaagatt
     6661 tgtgaagatc tgtggccctt gcccagggga ggtagctggt gctagcacca gggtcacaga
     6721 actaaggcct cctgaggagg cacacatacc agcggggtcc caagctggtg ctaattcctc
     6781 tcataggacc cagtaagccc gggagcctgc agtcggctgt ttctctgctg tggaataccc
     6841 tgttagaaag ctgaggtccc ctaaagagcc tcctggaccg agtcactttt gtggccgggc
     6901 tgagtatggc agcaggtaga aagatccgca ggcataaaga tccctgtggc ttttggcaaa
     6961 tgactgaagt gtggatgcag gagcaatgag tggaggccaa catcaacagc atctaccctc
     7021 cccaatagtg tctctgttct gggggtgctg tggtcctcac ttgctggctt aggattggag
     7081 ttaggctgag ccactttgaa ggagtgtgtt tacaggaaga tacaaattgt tggtttctct
     7141 attctttact gtacagtgtg tccagagagt agaagaaaat tcctgggcct gtctggttgg
     7201 tgcagagctt ttatggcact acaaggtctt caggaactgt cactgtaaga gccctggctg
     7261 tgagctgggg ctacgtgacc actgcagctg agtttccaag caggcctgtg tttggatctg
     7321 agtttgacgc ttggcggctc ccagggcttg ggatgagtgg cagtgctgac ttgttcactt
     7381 ggcagagcca ccctgtgagg aggtggactt agtggccctt tccaattgat cctgtcccat
     7441 ccaggcagta tcagcactag gagcagtgct gggtcagaag tccgaaggaa aggactcggt
     7501 tgatcggggt cattgtgagc ttgtgtatgt ttgtgtagag aaagctgaac tttgggagga
     7561 aaggccttgt ccttgcaggc ttccaagaca ccgctaaggt tagcctttgg ttggagacaa
     7621 gtctctagcc cagacactgg agtaggcgct gagaccaaga ggcaggccaa gatggagatc
     7681 tatggaaggc cctttgctgg tagggattca aagcttctcc aggggacccc agaactctat
     7741 taactggctc ccctaccggg acaagcttcg tttgtgggct catagagtgg ccatagagtg
     7801 ggtttaaccc agcaccaagc ctgagggcat gagcagtggt ctaaagtctc acatagtccc
     7861 attttacaga ctaatttgat tgcccggccg tagaattcta cagaaacaac aatcactgaa
     7921 attccttaga atacgcagag ggaggaggtg actcaacacg gtgctaaaca cattttatta
     7981 aaaatatata ttgttaaatt aagtctgctg tctggacaat gatgttctgt tttgttttct
     8041 tgtagtggag tttaaaagag actattattt tactctgata tattattatt aaaaaggcat
     8101 tttaactttg tacttgaaaa ctaagtgagc gatttcacgt gttttagctg agacatcgaa
     8161 gtagcgggtg cttacttgtg ggaaatcatg tattcatact acaacataaa ctccgtagct
     8221 gatttggtaa taacttttac tgttacagac gaattcgctt tgaccccggt ggcagagcgc
     8281 tttgactcca cattccacgc agctaagtgc aggaccttcc agaaccttcc ccggtccccc
     8341 ctggtcctct ttcggttcct cttcctagct ctctcttttc ctaattcttt tttttaagaa
     8401 ttgtcgtttg tttttcctgg tcccggcttc cttctaccac tgtatttttt gttagggttg
     8461 cttctctatt tattgacagt aataatgtac atttcacagt ctggttctgg gacagccagg
     8521 aggggtgtgg ggggctgcat acagcttgct gcactctccg gtgtcctgtt gtatctctgt
     8581 gtacgtgatg cttgtgacat agctgttgaa gaaatattaa aaggtcaatg cgtacagcag
     8641 gtgtagagag tccgtcagtt ccgcttcatc actttttttt tttttttttg tgcccagaag
     8701 aatataataa agctcctttc taatgtactt gtgctggaga acacttgaat aaatggactg
     8761 tttttgtgca aaaagaaaaa cggaaaaaaa aaaaaaagca ccgtcataat gtccttttgt
     8821 cctgcgactc ctttcccctg atgtggccac tcacagtcct ccagtgggct gaagtgggtg
     8881 cagtttacgt tgggagggtc tgggaaatgg atttctaaag tatctctcat atgggtgtta
     8941 actaggggtt gggacccaag ggcagaggga gtttggttca agatcaaaaa caggttagac
     9001 taaggtgaag ttgtctcgtt tacttcccaa accagcagat tctcgagacc agagcaggca
     9061 acagactggc atcctggtta gctggcagta ggaccagcag ggacttatgg atgccagagt
     9121 ccagaaggaa gaagtcagca aaggagagag gcagctgggg ctgggggaat cctggaagaa
     9181 ccttgcgttt aaaggagata tttgcaaaca cttgacaggt gacccaaggg ctgggatcag
     9241 tggccaatag ggctactgct ggtctgagca taggctgcct ggcagggcct tgcagcctga
     9301 ggagttgtcc accgtgtctc tgccatacct atctagaagg gccgtctgta tgcggggtct
     9361 gtctgtcctg catatctccg ggagtagcca gcaggcttgg ctggggttcc actcctaagg
     9421 actgtccacc cgtttcttcc agcaaacttt ctggacggtt ggatagggag agaccgtgtg
     9481 gcggtccttg agcagactgg gaaagtttgg ctaaacaggt tttctcatgg gcactttttc
     9541 ttgctttttc tttgacaagg ttgtaaatgt gtatttggct tttactctac tttttttctt
     9601 gatgtttttc aatgttgatg tggaatctta ctttcaaatg gctgcatggc attttcttgt
     9661 tgaatgtttg tttatatata ttttattttc gctataaata gagcttcaat aaacatcttt
     9721 atgttttggc ttccc
//
