LOCUS       NM_001314011            5235 bp    mRNA    linear   ROD 03-SEP-2024
DEFINITION  Mus musculus DNA methyltransferase 1 (Dnmt1), transcript variant 5,
            mRNA.
ACCESSION   NM_001314011 XM_006509987
VERSION     NM_001314011.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5235)
  AUTHORS   Tan,J., Li,Y., Li,X., Zhu,X., Liu,L., Huang,H., Wei,J., Wang,H.,
            Tian,Y., Wang,Z., Zhang,Z. and Zhu,B.
  TITLE     Pramel15 facilitates zygotic nuclear DNMT1 degradation and DNA
            demethylation
  JOURNAL   Nat Commun 15 (1), 7310 (2024)
   PUBMED   39181896
  REMARK    GeneRIF: Pramel15 facilitates zygotic nuclear DNMT1 degradation and
            DNA demethylation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5235)
  AUTHORS   Song,J., Rechkoblit,O., Bestor,T.H. and Patel,D.J.
  TITLE     Structure of DNMT1-DNA complex reveals a role for autoinhibition in
            maintenance DNA methylation
  JOURNAL   Science 331 (6020), 1036-1040 (2011)
   PUBMED   21163962
  REMARK    GeneRIF: structure of DNMT1 composed of CXXC, tandem bromo-adjacent
            homology (BAH1/2), and methyltransferase domains bound to
            DNA-containing unmethylated CpG sites; studies identify an
            autoinhibitory mechanism of DNA methylation
REFERENCE   3  (bases 1 to 5235)
  AUTHORS   Damelin,M. and Bestor,T.H.
  TITLE     Biological functions of DNA methyltransferase 1 require its
            methyltransferase activity
  JOURNAL   Mol Cell Biol 27 (11), 3891-3899 (2007)
   PUBMED   17371843
  REMARK    GeneRIF: Data suggest that the biological functions of DNA
            methyltransferase 1 are exerted through the methylation of DNA.
REFERENCE   4  (bases 1 to 5235)
  AUTHORS   Ko,Y.G., Nishino,K., Hattori,N., Arai,Y., Tanaka,S. and Shiota,K.
  TITLE     Stage-by-stage change in DNA methylation status of Dnmt1 locus
            during mouse early development
  JOURNAL   J Biol Chem 280 (10), 9627-9634 (2005)
   PUBMED   15634679
  REMARK    GeneRIF: This enzyme is a target of DNA methylation in
            embryogenesis.
REFERENCE   5  (bases 1 to 5235)
  AUTHORS   Fatemi,M., Hermann,A., Pradhan,S. and Jeltsch,A.
  TITLE     The activity of the murine DNA methyltransferase Dnmt1 is
            controlled by interaction of the catalytic domain with the
            N-terminal part of the enzyme leading to an allosteric activation
            of the enzyme after binding to methylated DNA
  JOURNAL   J Mol Biol 309 (5), 1189-1199 (2001)
   PUBMED   11399088
REFERENCE   6  (bases 1 to 5235)
  AUTHORS   Margot,J.B., Aguirre-Arteta,A.M., Di Giacco,B.V., Pradhan,S.,
            Roberts,R.J., Cardoso,M.C. and Leonhardt,H.
  TITLE     Structure and function of the mouse DNA methyltransferase gene:
            Dnmt1 shows a tripartite structure
  JOURNAL   J Mol Biol 297 (2), 293-300 (2000)
   PUBMED   10715201
REFERENCE   7  (bases 1 to 5235)
  AUTHORS   Fuks,F., Burgers,W.A., Brehm,A., Hughes-Davies,L. and Kouzarides,T.
  TITLE     DNA methyltransferase Dnmt1 associates with histone deacetylase
            activity
  JOURNAL   Nat Genet 24 (1), 88-91 (2000)
   PUBMED   10615135
REFERENCE   8  (bases 1 to 5235)
  AUTHORS   Gaudet,F., Talbot,D., Leonhardt,H. and Jaenisch,R.
  TITLE     A short DNA methyltransferase isoform restores methylation in vivo
  JOURNAL   J Biol Chem 273 (49), 32725-32729 (1998)
   PUBMED   9830015
REFERENCE   9  (bases 1 to 5235)
  AUTHORS   Mertineit,C., Yoder,J.A., Taketo,T., Laird,D.W., Trasler,J.M. and
            Bestor,T.H.
  TITLE     Sex-specific exons control DNA methyltransferase in mammalian germ
            cells
  JOURNAL   Development 125 (5), 889-897 (1998)
   PUBMED   9449671
REFERENCE   10 (bases 1 to 5235)
  AUTHORS   Bestor,T., Laudano,A., Mattaliano,R. and Ingram,V.
  TITLE     Cloning and sequencing of a cDNA encoding DNA methyltransferase of
            mouse cells. The carboxyl-terminal domain of the mammalian enzymes
            is related to bacterial restriction methyltransferases
  JOURNAL   J Mol Biol 203 (4), 971-983 (1988)
   PUBMED   3210246
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC170598.2.
            
            On Apr 21, 2022 this sequence version replaced NM_001314011.1.
            
            Summary: This gene encodes a methyltransferase that preferentially
            methylates cytosines of CpG residues in hemimethylated DNA to
            generate fully methylated CpG base pairs during DNA replication.
            This enzyme plays roles in diverse cellular processes including
            cell cycle regulation, DNA repair, and telomere maintenance. The
            encoded protein is composed of an N-terminal domain with a nuclear
            localization sequence and replication fork-targeting domain, a
            DNA-binding CXXC domain, two bromo-adjacent homology domains, and a
            C-terminal catalytic domain. Mouse embryonic stem cells mutant for
            this gene are viable, but when introduced into the germ line, cause
            a recessive lethal phenotype with mutant embryos displaying stunted
            growth and developmental defects. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (5) uses an alternate in-frame
            splice site in the 5' coding region compared to variant 1. It
            encodes isoform 5, which is longer than isoform 1. This variant has
            two upstream in-frame AUGs but N-terminal sequencing and western
            analysis from PMID: 9830015 (Table I and Figure 2) support the use
            of the third in-frame AUG.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053047.1, SRR13948564.1684555.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: experimental evidence
                                                (PMID:9830015)
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-119               AC170598.2         180291-180409       c
            120-156             AC170598.2         170166-170202       c
            157-264             AC170598.2         169282-169389       c
            265-496             AC170598.2         168935-169166       c
            497-575             AC170598.2         168059-168137       c
            576-651             AC170598.2         165654-165729       c
            652-683             AC170598.2         164745-164776       c
            684-762             AC170598.2         164126-164204       c
            763-803             AC170598.2         162102-162142       c
            804-888             AC170598.2         159698-159782       c
            889-929             AC170598.2         157708-157748       c
            930-1011            AC170598.2         156631-156712       c
            1012-1076           AC170598.2         154690-154754       c
            1077-1119           AC170598.2         154389-154431       c
            1120-1200           AC170598.2         154214-154294       c
            1201-1310           AC170598.2         154028-154137       c
            1311-1429           AC170598.2         151606-151724       c
            1430-1522           AC170598.2         151285-151377       c
            1523-1674           AC170598.2         150349-150500       c
            1675-1862           AC170598.2         149877-150064       c
            1863-2040           AC170598.2         149606-149783       c
            2041-2138           AC170598.2         147692-147789       c
            2139-2286           AC170598.2         147423-147570       c
            2287-2402           AC170598.2         146018-146133       c
            2403-2607           AC170598.2         145699-145903       c
            2608-2744           AC170598.2         145489-145625       c
            2745-2918           AC170598.2         144880-145053       c
            2919-3137           AC170598.2         143305-143523       c
            3138-3330           AC170598.2         141480-141672       c
            3331-3415           AC170598.2         140155-140239       c
            3416-3544           AC170598.2         139763-139891       c
            3545-3827           AC170598.2         139316-139598       c
            3828-3969           AC170598.2         139000-139141       c
            3970-4136           AC170598.2         137723-137889       c
            4137-4314           AC170598.2         137276-137453       c
            4315-4510           AC170598.2         136673-136868       c
            4511-4791           AC170598.2         136055-136335       c
            4792-4882           AC170598.2         135454-135544       c
            4883-5235           AC170598.2         134792-135144       c
FEATURES             Location/Qualifiers
     source          1..5235
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 7.66 cM"
     gene            1..5235
                     /gene="Dnmt1"
                     /gene_synonym="Cxxc9; Dnmt; Dnmt1o; m.MmuI; MCMT; Met-1;
                     Met1; MommeD2; MTase"
                     /note="DNA methyltransferase 1"
                     /db_xref="GeneID:13433"
                     /db_xref="MGI:MGI:94912"
     exon            1..119
                     /gene="Dnmt1"
                     /gene_synonym="Cxxc9; Dnmt; Dnmt1o; m.MmuI; MCMT; Met-1;
                     Met1; MommeD2; MTase"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..4923
                     /gene="Dnmt1"
                     /gene_synonym="Cxxc9; Dnmt; Dnmt1o; m.MmuI; MCMT; Met-1;
                     Met1; MommeD2; MTase"
                     /EC_number="2.1.1.37"
                     /note="isoform 5 is encoded by transcript variant 5; DNA
                     (cytosine-5)-methyltransferase 1; DNA MTase MmuI; DNA
                     methyltransferase MmuI; DNA methyltransferase (cytosine-5)
                     1"
                     /codon_start=1
                     /product="DNA (cytosine-5)-methyltransferase 1 isoform 5"
                     /protein_id="NP_001300940.1"
                     /db_xref="GeneID:13433"
                     /db_xref="MGI:MGI:94912"
                     /translation="MPARTAPARVPALASPAGSLPDHVRRRLKDLERDGLTEKECVRE
                     KLNLLHEFLQTEIKSQLCDLETKLHKEELSEEGYLAKVKSLLNKDLSLENGTHTLTQK
                     ANGCPANGSRPTWRAEMADSNRSPRSRPKPRGPRRSKSDSDTLCKDTRHTAVETSPSS
                     VATRRTTRQTTITAHFTKGPTKRKPKEESEEGNSAESAAEERDQDKKRRVVDTESGAA
                     AAVEKLEEVTAGTQLGPEEPCEQEDDNRSLRRHTRELSLRRKSKEDPDREARPETHLD
                     EDEDGKKDKRSSRPRSQPRDPAAKRRPKEAEPEQVAPETPEDRDEDEREEKRRKTTRK
                     KLESHTVPVQSRSERKAAQSKSVIPKINSPKCPECGQHLDDPNLKYQQHPEDAVDEPQ
                     MLTSEKLSIYDSTSTWFDTYEDSPMHRFTSFSVYCSRGHLCPVDTGLIEKNVELYFSG
                     CAKAIHDENPSMEGGINGKNLGPINQWWLSGFDGGEKVLIGFSTAFAEYILMEPSKEY
                     EPIFGLMQEKIYISKIVVEFLQNNPDAVYEDLINKIETTVPPSTINVNRFTEDSLLRH
                     AQFVVSQVESYDEAKDDDETPIFLSPCMRALIHLAGVSLGQRRATRRVMGATKEKDKA
                     PTKATTTKLVYQIFDTFFSEQIEKYDKEDKENAMKRRRCGVCEVCQQPECGKCKACKD
                     MVKFGGTGRSKQACLKRRCPNLAVKEADDDEEADDDVSEMPSPKKLHQGKKKKQNKDR
                     ISWLGQPMKIEENRTYYQKVSIDEEMLEVGDCVSVIPDDSSKPLYLARVTALWEDKNG
                     QMMFHAHWFCAGTDTVLGATSDPLELFLVGECENMQLSYIHSKVKVIYKAPSENWAME
                     GGTDPETTLPGAEDGKTYFFQLWYNQEYARFESPPKTQPTEDNKHKFCLSCIRLAELR
                     QKEMPKVLEQIEEVDGRVYCSSITKNGVVYRLGDSVYLPPEAFTFNIKVASPVKRPKK
                     DPVNETLYPEHYRKYSDYIKGSNLDAPEPYRIGRIKEIHCGKKKGKVNEADIKLRLYK
                     FYRPENTHRSYNGSYHTDINMLYWSDEEAVVNFSDVQGRCTVEYGEDLLESIQDYSQG
                     GPDRFYFLEAYNSKTKNFEDPPNHARSPGNKGKGKGKGKGKGKHQVSEPKEPEAAIKL
                     PKLRTLDVFSGCGGLSEGFHQAGISETLWAIEMWDPAAQAFRLNNPGTTVFTEDCNVL
                     LKLVMAGEVTNSLGQRLPQKGDVEMLCGGPPCQGFSGMNRFNSRTYSKFKNSLVVSFL
                     SYCDYYRPRFFLLENVRNFVSYRRSMVLKLTLRCLVRMGYQCTFGVLQAGQYGVAQTR
                     RRAIILAAAPGEKLPLFPEPLHVFAPRACQLSVVVDDKKFVSNITRLSSGPFRTITVR
                     DTMSDLPEIQNGASNSEIPYNGEPLSWFQRQLRGSHYQPILRDHICKDMSPLVAARMR
                     HIPLFPGSDWRDLPNIQVRLGDGVIAHKLQYTFHDVKNGYSSTGALRGVCSCAEGKAC
                     DPESRQFSTLIPWCLPHTGNRHNHWAGLYGRLEWDGFFSTTVTNPEPMGKQGRVLHPE
                     QHRVVSVRECARSQGFPDSYRFFGNILDRHRQVGNAVPPPLAKAIGLEIKLCLLSSAR
                     ESASAAVKAKEEAATKD"
     exon            120..156
                     /gene="Dnmt1"
                     /gene_synonym="Cxxc9; Dnmt; Dnmt1o; m.MmuI; MCMT; Met-1;
                     Met1; MommeD2; MTase"
                     /inference="alignment:Splign:2.1.0"
     exon            157..264
                     /gene="Dnmt1"
                     /gene_synonym="Cxxc9; Dnmt; Dnmt1o; m.MmuI; MCMT; Met-1;
                     Met1; MommeD2; MTase"
                     /inference="alignment:Splign:2.1.0"
     exon            265..496
                     /gene="Dnmt1"
                     /gene_synonym="Cxxc9; Dnmt; Dnmt1o; m.MmuI; MCMT; Met-1;
                     Met1; MommeD2; MTase"
                     /inference="alignment:Splign:2.1.0"
     exon            497..575
                     /gene="Dnmt1"
                     /gene_synonym="Cxxc9; Dnmt; Dnmt1o; m.MmuI; MCMT; Met-1;
                     Met1; MommeD2; MTase"
                     /inference="alignment:Splign:2.1.0"
     exon            576..651
                     /gene="Dnmt1"
                     /gene_synonym="Cxxc9; Dnmt; Dnmt1o; m.MmuI; MCMT; Met-1;
                     Met1; MommeD2; MTase"
                     /inference="alignment:Splign:2.1.0"
     exon            652..683
                     /gene="Dnmt1"
                     /gene_synonym="Cxxc9; Dnmt; Dnmt1o; m.MmuI; MCMT; Met-1;
                     Met1; MommeD2; MTase"
                     /inference="alignment:Splign:2.1.0"
     exon            684..762
                     /gene="Dnmt1"
                     /gene_synonym="Cxxc9; Dnmt; Dnmt1o; m.MmuI; MCMT; Met-1;
                     Met1; MommeD2; MTase"
                     /inference="alignment:Splign:2.1.0"
     exon            763..803
                     /gene="Dnmt1"
                     /gene_synonym="Cxxc9; Dnmt; Dnmt1o; m.MmuI; MCMT; Met-1;
                     Met1; MommeD2; MTase"
                     /inference="alignment:Splign:2.1.0"
     exon            804..888
                     /gene="Dnmt1"
                     /gene_synonym="Cxxc9; Dnmt; Dnmt1o; m.MmuI; MCMT; Met-1;
                     Met1; MommeD2; MTase"
                     /inference="alignment:Splign:2.1.0"
     exon            889..929
                     /gene="Dnmt1"
                     /gene_synonym="Cxxc9; Dnmt; Dnmt1o; m.MmuI; MCMT; Met-1;
                     Met1; MommeD2; MTase"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1011
                     /gene="Dnmt1"
                     /gene_synonym="Cxxc9; Dnmt; Dnmt1o; m.MmuI; MCMT; Met-1;
                     Met1; MommeD2; MTase"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1076
                     /gene="Dnmt1"
                     /gene_synonym="Cxxc9; Dnmt; Dnmt1o; m.MmuI; MCMT; Met-1;
                     Met1; MommeD2; MTase"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1119
                     /gene="Dnmt1"
                     /gene_synonym="Cxxc9; Dnmt; Dnmt1o; m.MmuI; MCMT; Met-1;
                     Met1; MommeD2; MTase"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1200
                     /gene="Dnmt1"
                     /gene_synonym="Cxxc9; Dnmt; Dnmt1o; m.MmuI; MCMT; Met-1;
                     Met1; MommeD2; MTase"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1310
                     /gene="Dnmt1"
                     /gene_synonym="Cxxc9; Dnmt; Dnmt1o; m.MmuI; MCMT; Met-1;
                     Met1; MommeD2; MTase"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1429
                     /gene="Dnmt1"
                     /gene_synonym="Cxxc9; Dnmt; Dnmt1o; m.MmuI; MCMT; Met-1;
                     Met1; MommeD2; MTase"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1522
                     /gene="Dnmt1"
                     /gene_synonym="Cxxc9; Dnmt; Dnmt1o; m.MmuI; MCMT; Met-1;
                     Met1; MommeD2; MTase"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..1674
                     /gene="Dnmt1"
                     /gene_synonym="Cxxc9; Dnmt; Dnmt1o; m.MmuI; MCMT; Met-1;
                     Met1; MommeD2; MTase"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..1862
                     /gene="Dnmt1"
                     /gene_synonym="Cxxc9; Dnmt; Dnmt1o; m.MmuI; MCMT; Met-1;
                     Met1; MommeD2; MTase"
                     /inference="alignment:Splign:2.1.0"
     exon            1863..2040
                     /gene="Dnmt1"
                     /gene_synonym="Cxxc9; Dnmt; Dnmt1o; m.MmuI; MCMT; Met-1;
                     Met1; MommeD2; MTase"
                     /inference="alignment:Splign:2.1.0"
     exon            2041..2138
                     /gene="Dnmt1"
                     /gene_synonym="Cxxc9; Dnmt; Dnmt1o; m.MmuI; MCMT; Met-1;
                     Met1; MommeD2; MTase"
                     /inference="alignment:Splign:2.1.0"
     exon            2139..2286
                     /gene="Dnmt1"
                     /gene_synonym="Cxxc9; Dnmt; Dnmt1o; m.MmuI; MCMT; Met-1;
                     Met1; MommeD2; MTase"
                     /inference="alignment:Splign:2.1.0"
     exon            2287..2402
                     /gene="Dnmt1"
                     /gene_synonym="Cxxc9; Dnmt; Dnmt1o; m.MmuI; MCMT; Met-1;
                     Met1; MommeD2; MTase"
                     /inference="alignment:Splign:2.1.0"
     exon            2403..2607
                     /gene="Dnmt1"
                     /gene_synonym="Cxxc9; Dnmt; Dnmt1o; m.MmuI; MCMT; Met-1;
                     Met1; MommeD2; MTase"
                     /inference="alignment:Splign:2.1.0"
     exon            2608..2744
                     /gene="Dnmt1"
                     /gene_synonym="Cxxc9; Dnmt; Dnmt1o; m.MmuI; MCMT; Met-1;
                     Met1; MommeD2; MTase"
                     /inference="alignment:Splign:2.1.0"
     exon            2745..2918
                     /gene="Dnmt1"
                     /gene_synonym="Cxxc9; Dnmt; Dnmt1o; m.MmuI; MCMT; Met-1;
                     Met1; MommeD2; MTase"
                     /inference="alignment:Splign:2.1.0"
     exon            2919..3137
                     /gene="Dnmt1"
                     /gene_synonym="Cxxc9; Dnmt; Dnmt1o; m.MmuI; MCMT; Met-1;
                     Met1; MommeD2; MTase"
                     /inference="alignment:Splign:2.1.0"
     exon            3138..3330
                     /gene="Dnmt1"
                     /gene_synonym="Cxxc9; Dnmt; Dnmt1o; m.MmuI; MCMT; Met-1;
                     Met1; MommeD2; MTase"
                     /inference="alignment:Splign:2.1.0"
     exon            3331..3415
                     /gene="Dnmt1"
                     /gene_synonym="Cxxc9; Dnmt; Dnmt1o; m.MmuI; MCMT; Met-1;
                     Met1; MommeD2; MTase"
                     /inference="alignment:Splign:2.1.0"
     exon            3416..3544
                     /gene="Dnmt1"
                     /gene_synonym="Cxxc9; Dnmt; Dnmt1o; m.MmuI; MCMT; Met-1;
                     Met1; MommeD2; MTase"
                     /inference="alignment:Splign:2.1.0"
     exon            3545..3827
                     /gene="Dnmt1"
                     /gene_synonym="Cxxc9; Dnmt; Dnmt1o; m.MmuI; MCMT; Met-1;
                     Met1; MommeD2; MTase"
                     /inference="alignment:Splign:2.1.0"
     exon            3828..3969
                     /gene="Dnmt1"
                     /gene_synonym="Cxxc9; Dnmt; Dnmt1o; m.MmuI; MCMT; Met-1;
                     Met1; MommeD2; MTase"
                     /inference="alignment:Splign:2.1.0"
     exon            3970..4136
                     /gene="Dnmt1"
                     /gene_synonym="Cxxc9; Dnmt; Dnmt1o; m.MmuI; MCMT; Met-1;
                     Met1; MommeD2; MTase"
                     /inference="alignment:Splign:2.1.0"
     exon            4137..4314
                     /gene="Dnmt1"
                     /gene_synonym="Cxxc9; Dnmt; Dnmt1o; m.MmuI; MCMT; Met-1;
                     Met1; MommeD2; MTase"
                     /inference="alignment:Splign:2.1.0"
     exon            4315..4510
                     /gene="Dnmt1"
                     /gene_synonym="Cxxc9; Dnmt; Dnmt1o; m.MmuI; MCMT; Met-1;
                     Met1; MommeD2; MTase"
                     /inference="alignment:Splign:2.1.0"
     exon            4511..4791
                     /gene="Dnmt1"
                     /gene_synonym="Cxxc9; Dnmt; Dnmt1o; m.MmuI; MCMT; Met-1;
                     Met1; MommeD2; MTase"
                     /inference="alignment:Splign:2.1.0"
     exon            4792..4882
                     /gene="Dnmt1"
                     /gene_synonym="Cxxc9; Dnmt; Dnmt1o; m.MmuI; MCMT; Met-1;
                     Met1; MommeD2; MTase"
                     /inference="alignment:Splign:2.1.0"
     exon            4883..5235
                     /gene="Dnmt1"
                     /gene_synonym="Cxxc9; Dnmt; Dnmt1o; m.MmuI; MCMT; Met-1;
                     Met1; MommeD2; MTase"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5214..5219
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dnmt1"
                     /gene_synonym="Cxxc9; Dnmt; Dnmt1o; m.MmuI; MCMT; Met-1;
                     Met1; MommeD2; MTase"
                     /note="hexamer: AATAAA"
     polyA_site      5235
                     /gene="Dnmt1"
                     /gene_synonym="Cxxc9; Dnmt; Dnmt1o; m.MmuI; MCMT; Met-1;
                     Met1; MommeD2; MTase"
                     /note="major polyA site"
ORIGIN      
        1 gtctcgttca gagctgttct gtcgtctgca acctgcaaga tgccagcgcg aacagctcca
       61 gcccgagtgc ctgcgcttgc ctccccggca ggctcgctcc cggaccatgt ccgcaggcgg
      121 ctcaaagact tggaaagaga tggcttaaca gaaaaggagt gtgtgaggga gaaattaaac
      181 ttactgcatg aattcctgca aacagaaata aaaagccagt tgtgtgactt ggaaaccaaa
      241 ttacataaag aggaattatc tgaggaaggc tacctggcta aagtcaagtc cctcttaaat
      301 aaggatttgt ccttggagaa cggaacacac actctcactc aaaaagccaa cggttgtccc
      361 gccaacggga gccggccaac ctggagagca gaaatggcag actcaaatag atccccaaga
      421 tccaggccca agcctcgggg acccaggaga agcaagtcgg acagtgacac cctttgtaag
      481 gacacgagac atactgcagt tgaaacttca cctagttccg tggctacgag gagaaccacc
      541 aggcagacca ccatcacggc tcacttcacg aagggcccca ctaaacggaa acccaaggaa
      601 gagtcggaag aggggaactc ggctgagtcg gctgcagagg agagagacca ggataagaaa
      661 cgcagagttg tagacacaga gagtggtgct gcagctgctg tggagaaact ggaagaggta
      721 acagcgggaa cccagctggg tccggaagag ccatgtgaac aggaagatga caacaggagt
      781 cttcgacgtc acaccagaga gctatcattg aggcggaaat caaaggagga tccagacaga
      841 gaagcaagac cggaaactca cttggacgag gacgaggacg gaaaaaagga taaaagaagt
      901 tccagaccca ggagccagcc cagagatcca gctgccaaac ggagacccaa ggaagcagag
      961 ccagagcagg tagctccaga gactcccgag gacagagacg aggatgagag ggaggagaag
     1021 agacgaaaaa cgacacgtaa aaaactggag tcacacaccg ttcccgttca gagcagatcg
     1081 gagagaaaag ccgctcaaag caaaagtgtg atcccgaaga tcaactcacc aaagtgcccc
     1141 gagtgtggcc agcacctaga cgaccctaac ctgaagtacc agcagcaccc tgaggatgct
     1201 gtggatgaac cccagatgtt gaccagtgag aaactgtcca tctacgactc cacctcgacc
     1261 tggtttgata cttatgaaga ttctcccatg cataggttca cttccttcag tgtgtactgc
     1321 agtcgcgggc acctgtgtcc tgtcgacacc ggtctcattg agaagaatgt agagctctac
     1381 ttttctgggt gtgccaaagc aattcatgac gagaatccat ctatggaagg tggtattaat
     1441 ggcaaaaacc tcgggccaat caatcagtgg tggctcagtg gctttgatgg tggcgagaag
     1501 gtgctcattg gcttctccac tgcatttgct gaatacattt tgatggagcc cagcaaagag
     1561 tatgagccaa tatttgggct gatgcaggag aaaatttaca tcagcaagat tgttgttgag
     1621 ttcctgcaaa acaatcctga tgctgtatat gaagacctga tcaataagat tgagaccact
     1681 gttcctcctt ctaccattaa tgtgaaccgg ttcacagagg actccctctt acgccacgcc
     1741 cagtttgtag tgagccaggt agagagttac gacgaagcca aggacgatga tgagaccccc
     1801 atcttcttgt ctccctgtat gagagccctg atccatttgg ctggtgtctc cctgggacag
     1861 aggcgagcaa caaggcgcgt catgggtgct accaaggaga aggacaaagc acccacgaaa
     1921 gccaccacca ccaagctggt ctatcagatc tttgacactt tcttctcaga gcagattgag
     1981 aagtatgata aggaggacaa ggagaatgcc atgaagcgcc gccgctgtgg tgtctgtgag
     2041 gtctgtcagc agcctgagtg tgggaagtgc aaggcgtgca aagatatggt gaagtttggt
     2101 ggcactggac ggagtaagca ggcttgcctc aagaggaggt gtcctaactt ggcggtgaag
     2161 gaggcagacg acgatgaaga ggctgatgat gatgtgtcag agatgccatc acccaaaaag
     2221 ctgcatcagg ggaagaagaa gaagcagaac aaggaccgca tctcctggct tgggcagcct
     2281 atgaagattg aagagaatag aacttactat cagaaggtga gcatcgatga ggagatgcta
     2341 gaggtgggcg actgcgtctc ggtcattcca gatgattcct ccaaaccact ctatctagcc
     2401 agggtcacag ctctgtggga agacaaaaat ggtcagatga tgttccatgc gcactggttc
     2461 tgcgctggga cagacacagt cctgggagcc acctccgacc ccctggaact gttcctggtg
     2521 ggcgagtgcg aaaacatgca gctttcctac atccacagca aggtcaaggt catctacaaa
     2581 gccccttctg aaaactgggc catggaggga ggcacagacc ctgagaccac actgcctggg
     2641 gctgaggatg gcaagactta cttcttccag ctctggtaca accaggagta cgcaaggttt
     2701 gaatccccac ccaagaccca gccgaccgag gacaacaagc acaagttctg cctatcttgt
     2761 atccggctgg ctgagctgag acaaaaagaa atgcccaagg tcctggaaca aattgaggag
     2821 gtggatggcc gggtctactg cagttccatc accaagaatg gtgttgtcta ccgactgggt
     2881 gacagtgtgt accttcctcc cgaggccttt actttcaaca tcaaagtggc tagccccgtg
     2941 aaacgcccaa agaaggatcc tgtgaacgag accctgtacc ctgagcacta ccgcaagtat
     3001 tctgactaca tcaaggggag caacctggat gctccagagc cctatcgcat cggtcggata
     3061 aaagagatcc actgtggcaa gaagaaaggc aaggtcaacg aggcagacat caagctgagg
     3121 ctctacaagt tctacaggcc tgagaatacc cacaggtcct acaacggatc ctatcacact
     3181 gacatcaaca tgctttactg gagcgacgag gaagctgtgg tgaacttcag cgacgtgcag
     3241 ggccgctgta ccgtggagta cggggaagac ctacttgaga gcatccagga ttattcacaa
     3301 gggggccctg accgcttcta cttcctcgag gcctacaatt caaagaccaa gaactttgaa
     3361 gacccaccaa accatgcccg cagccctggg aacaaaggga aagggaaggg gaaagggaag
     3421 gggaagggga agcatcaggt gtcagagccc aaagagcctg aggcagccat caaactgccc
     3481 aagctccgga ccctggatgt gttttccggc tgtggagggt tatcggaagg attccaccaa
     3541 gcaggcatct cggaaacgct gtgggccatc gagatgtggg acccggcagc ccaggcattt
     3601 cggctgaaca accccggcac cacagtgttc acagaggact gcaacgtgct tcttaagctg
     3661 gtcatggctg gggaggtgac caactctctg ggccaaaggc tgccacagaa gggcgatgtg
     3721 gagatgctgt gtggtgggcc accctgccag ggcttcagtg gcatgaaccg cttcaactcc
     3781 cgcacttact ccaagttcaa aaactcccta gtggtctcct tcctcagcta ctgtgactac
     3841 taccggcctc ggttcttcct tctggagaac gtcaggaact tcgtgtccta cagacgctcc
     3901 atggtgctga agctcacact gcgctgcctg gtccgcatgg gctaccagtg cacctttggt
     3961 gtgctccagg ctggacagta tggcgtggcc cagacacgaa ggagggccat catcttggct
     4021 gcagccccag gagaaaagct gcctctgttc ccagagcctc tgcatgtgtt tgcgccccgt
     4081 gcctgccagc tgagcgttgt ggtggatgac aagaagtttg ttagcaacat aacgaggctg
     4141 agctcggggc ccttccgaac catcaccgtg cgagacacca tgtctgacct ccccgagatc
     4201 cagaatggag cctcgaattc tgagatcccc tacaatggag agccactgtc ctggttccag
     4261 aggcagctgc gaggatcaca ctaccagccc atcctcaggg accatatctg caaggacatg
     4321 agcccactgg tggctgcccg catgcggcac atcccactgt tcccaggatc agattggcgt
     4381 gacctgccca acatacaggt gcggctggga gatggcgtca tagcccataa gctacagtac
     4441 acctttcatg atgtgaaaaa tggctacagc agcaccggtg ccctgcgtgg agtctgttcc
     4501 tgtgcagaag gcaaggcctg cgaccctgag tccaggcaat tcagcaccct catcccctgg
     4561 tgcctgccgc acactgggaa ccggcacaac cactgggctg gcctctacgg gcgtctggag
     4621 tgggatggct tcttcagcac cactgtcacc aaccctgagc ccatgggcaa gcagggtcgg
     4681 gtgctccacc cggagcagca ccgggtcgtg agtgttcggg aatgtgcccg ctcccagggc
     4741 tttccagata gctaccggtt cttcggcaac atcctggaca gacaccggca ggtgggtaat
     4801 gctgtgccac cacccctggc caaagccatt ggcctggaga ttaagctctg cctgctgtcc
     4861 agtgctcggg agagcgcatc agctgcagtt aaagcaaaag aggaggctgc taccaaggac
     4921 tagtgctctc acccagagcc ccacgtgcac tgatgttttt aaccctttga gccccatcat
     4981 ttgaagtctt gtgctcagtg tctgtggcca tggctgacac taagctgttt gtatgaggtt
     5041 tgttttgtga ccaagctgtg tagtactttg tgcattctga attttaaggt tttttttttt
     5101 gtttggtttg gtttggtttg gtttttttct tatcctgtat tctatcagat ctgccactgt
     5161 gcaggtggca agtgagactt gatgtagttt tatatgttgt aatatttctt caaaataaag
     5221 cgcttctgtc aagca
//
