LOCUS       NM_001403295            5042 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus dynamin binding protein (Dnmbp), transcript variant 8,
            mRNA.
ACCESSION   NM_001403295 XM_006527352
VERSION     NM_001403295.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5042)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5042)
  AUTHORS   Yoo,D., Park,J., Lee,C., Song,I., Lee,Y.H., Yun,T., Lee,H.,
            Heguy,A., Han,J.Y., Dasen,J.S., Kim,H. and Baek,M.
  TITLE     Little skate genome provides insights into genetic programs
            essential for limb-based locomotion
  JOURNAL   Elife 11, e78345 (2022)
   PUBMED   36288084
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5042)
  AUTHORS   Choquet,H., Melles,R.B., Anand,D., Yin,J., Cuellar-Partida,G.,
            Wang,W., Hoffmann,T.J., Nair,K.S., Hysi,P.G., Lachke,S.A. and
            Jorgenson,E.
  CONSRTM   23andMe Research Team
  TITLE     A large multiethnic GWAS meta-analysis of cataract identifies new
            risk loci and sex-specific effects
  JOURNAL   Nat Commun 12 (1), 3595 (2021)
   PUBMED   34127677
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5042)
  AUTHORS   Sheehan,C.J., McMahon,J.J., Serdar,L.D. and Silver,D.L.
  TITLE     Dosage-dependent requirements of Magoh for cortical interneuron
            generation and survival
  JOURNAL   Development 147 (1) (2020)
   PUBMED   31857347
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5042)
  AUTHORS   Oda,Y., Otani,T., Ikenouchi,J. and Furuse,M.
  TITLE     Tricellulin regulates junctional tension of epithelial cells at
            tricellular contacts through Cdc42
  JOURNAL   J Cell Sci 127 (Pt 19), 4201-4212 (2014)
   PUBMED   25097232
REFERENCE   6  (bases 1 to 5042)
  AUTHORS   Rajabian,T., Gavicherla,B., Heisig,M., Muller-Altrock,S.,
            Goebel,W., Gray-Owen,S.D. and Ireton,K.
  TITLE     The bacterial virulence factor InlC perturbs apical cell junctions
            and promotes cell-to-cell spread of Listeria
  JOURNAL   Nat Cell Biol 11 (10), 1212-1218 (2009)
   PUBMED   19767742
REFERENCE   7  (bases 1 to 5042)
  AUTHORS   Kovacs,E.M., Makar,R.S. and Gertler,F.B.
  TITLE     Tuba stimulates intracellular N-WASP-dependent actin assembly
  JOURNAL   J Cell Sci 119 (Pt 13), 2715-2726 (2006)
   PUBMED   16757518
  REMARK    GeneRIF: Tuba-stimulated dorsal ruffling might represent a novel
            mechanism for the coordination of N-WASP-dependent cytoskeletal
            rearrangements, and Tuba function is implicated in motility
            processes.
REFERENCE   8  (bases 1 to 5042)
  AUTHORS   Dike,S., Balija,V.S., Nascimento,L.U., Xuan,Z., Ou,J., Zutavern,T.,
            Palmer,L.E., Hannon,G., Zhang,M.Q. and McCombie,W.R.
  TITLE     The mouse genome: experimental examination of gene predictions and
            transcriptional start sites
  JOURNAL   Genome Res 14 (12), 2424-2429 (2004)
   PUBMED   15574821
REFERENCE   9  (bases 1 to 5042)
  AUTHORS   Salazar,M.A., Kwiatkowski,A.V., Pellegrini,L., Cestra,G.,
            Butler,M.H., Rossman,K.L., Serna,D.M., Sondek,J., Gertler,F.B. and
            De Camilli,P.
  TITLE     Tuba, a novel protein containing bin/amphiphysin/Rvs and Dbl
            homology domains, links dynamin to regulation of the actin
            cytoskeleton
  JOURNAL   J Biol Chem 278 (49), 49031-49043 (2003)
   PUBMED   14506234
REFERENCE   10 (bases 1 to 5042)
  AUTHORS   Yoshizawa,M., Sone,M., Matsuo,N., Nagase,T., Ohara,O., Nabeshima,Y.
            and Hoshino,M.
  TITLE     Dynamic and coordinated expression profile of dbl-family guanine
            nucleotide exchange factors in the developing mouse brain
  JOURNAL   Gene Expr Patterns 3 (3), 375-381 (2003)
   PUBMED   12799088
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132251.3.
            
            On Mar 29, 2022 this sequence version replaced XM_006527352.5.
            
            Summary: This gene encodes a member of the DBL family of guanine
            nucleotide exchange factors. The encoded protein has been proposed
            to regulate the actin cytoskeleton by specifically activating the
            Rho-family GTPase Cdc42. An interaction between the encoded protein
            and a Listeria protein has been shown to mediate Listeria
            infection. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Apr 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253013.2499646.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1295              AC132251.3         70120-71414
            1296-1489           AC132251.3         85704-85897
            1490-1589           AC132251.3         86467-86566
            1590-1737           AC132251.3         90415-90562
            1738-1755           AC132251.3         91118-91135
            1756-1955           AC132251.3         91720-91919
            1956-2086           AC132251.3         93067-93197
            2087-2191           AC132251.3         94031-94135
            2192-2320           AC132251.3         104094-104222
            2321-2653           AC132251.3         105595-105927
            2654-2833           AC132251.3         106412-106591
            2834-3032           AC132251.3         108302-108500
            3033-3583           AC132251.3         110398-110948
            3584-5042           AC132251.3         112446-113904
FEATURES             Location/Qualifiers
     source          1..5042
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 36.67 cM"
     gene            1..5042
                     /gene="Dnmbp"
                     /gene_synonym="2410003L07Rik; 2410003M15Rik; TUBA"
                     /note="dynamin binding protein"
                     /db_xref="GeneID:71972"
                     /db_xref="MGI:MGI:1917352"
     exon            1..1295
                     /gene="Dnmbp"
                     /gene_synonym="2410003L07Rik; 2410003M15Rik; TUBA"
                     /inference="alignment:Splign:2.1.0"
     CDS             380..3769
                     /gene="Dnmbp"
                     /gene_synonym="2410003L07Rik; 2410003M15Rik; TUBA"
                     /note="isoform 7 is encoded by transcript variant 8;
                     scaffold protein Tuba"
                     /codon_start=1
                     /product="dynamin-binding protein isoform 7"
                     /protein_id="NP_001390224.1"
                     /db_xref="GeneID:71972"
                     /db_xref="MGI:MGI:1917352"
                     /translation="MDSGETNRSGKEGLFPAGSAASRNGEDIECVNLGPGTERRSLAG
                     SPAGILEAGGCGTVNGCVECKDPIYNPNDLQKAKHRNGYRDLGDSLENLYQPQNWCMG
                     LRNFNYSLEDYKGINLDYRDHTSSCHVPGPYTNGESLERPDLNGVTGGEEFLRYYEED
                     RKVCQSNRIYPKAKADCPVDLATFVVENKGYDGTSSTNSESHRYRQVSSLHRGEDLEY
                     DDIDRLGVRAPRGRGAISENLPQHPGSEQGEYHFGIAGAPTLESPWHPGEMRALPGSE
                     PWGRNSCFRRTAPSTLRHSEFVQRRKKPQDMTLLSSQSSSLAAPFGSVSTENPEQRML
                     EKRAKVVAELLQTERDYIRDLEMCIERVMVPLQQAQVPNVDFEGLFGNMQTVIKVSKQ
                     LLAALEISDAVGPVFLDHRDELEGTYRVYCQNHDEAISLLEMYEKDEKTQKHLQDYLA
                     DLKSLYHEWGCTNYINLGSFLIKPVQRIMRYPLLLMELLNSTPESHPDKVPLTNAVLA
                     VKEINVNINEYKRRKDLVLKYRKGDEDSLMEKISKLNIHSIIKKSSRVSSHLKHLTGF
                     APQLKDEVFEETEKNFRMQERLIKSFIRDLSLYLQHIRESACVKVVAAMSIWDLCMER
                     GHHDLEQFEKVHRYISDQLFTRFKERTERLVINPLNQLLNMFTGPYKLVQKRFDKLLD
                     FYNCTERAEKLKDKKTLEELQSARNNYEALNSQLLDELPKFQQYAQSLFTNCIHGYAE
                     AHCDFVQQALEQLQPLLSLLKATDREGNLIAIFLEEHSRVLQQLQVFTFFPESLPAPR
                     KPFERKTTDRQSSRKTLLGMPSYMLQSEELRSSLLARYPPEKLFHVQRNFNAAQDLDV
                     SLLEGDLVGVIKKKDPMGSQNRWLVDNGVTKGFVYSSFLKPYNPRCSHSDASVASHSS
                     TESEHSGSSPGCHRQNSHSALTFNSNNMTVSFTSGLALTQPQDASPLKDCAHETLAVS
                     WNTGHPETGPSTCSSDPGFSCQRRLGNPADGARDISQPASTLRGCQRGSPHSEVVGYS
                     VPGQNDQGSDSIKGSARVCQAPEDRDRGVGSSETEGNQVYFAIYTFKARNPNELSVLA
                     NQRLRIHEFKDVTGNTEWWLAEVNGRKGYVPSNYIRKTEYT"
     exon            1296..1489
                     /gene="Dnmbp"
                     /gene_synonym="2410003L07Rik; 2410003M15Rik; TUBA"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1589
                     /gene="Dnmbp"
                     /gene_synonym="2410003L07Rik; 2410003M15Rik; TUBA"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1737
                     /gene="Dnmbp"
                     /gene_synonym="2410003L07Rik; 2410003M15Rik; TUBA"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..1755
                     /gene="Dnmbp"
                     /gene_synonym="2410003L07Rik; 2410003M15Rik; TUBA"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..1955
                     /gene="Dnmbp"
                     /gene_synonym="2410003L07Rik; 2410003M15Rik; TUBA"
                     /inference="alignment:Splign:2.1.0"
     exon            1956..2086
                     /gene="Dnmbp"
                     /gene_synonym="2410003L07Rik; 2410003M15Rik; TUBA"
                     /inference="alignment:Splign:2.1.0"
     exon            2087..2191
                     /gene="Dnmbp"
                     /gene_synonym="2410003L07Rik; 2410003M15Rik; TUBA"
                     /inference="alignment:Splign:2.1.0"
     exon            2192..2320
                     /gene="Dnmbp"
                     /gene_synonym="2410003L07Rik; 2410003M15Rik; TUBA"
                     /inference="alignment:Splign:2.1.0"
     exon            2321..2653
                     /gene="Dnmbp"
                     /gene_synonym="2410003L07Rik; 2410003M15Rik; TUBA"
                     /inference="alignment:Splign:2.1.0"
     exon            2654..2833
                     /gene="Dnmbp"
                     /gene_synonym="2410003L07Rik; 2410003M15Rik; TUBA"
                     /inference="alignment:Splign:2.1.0"
     exon            2834..3032
                     /gene="Dnmbp"
                     /gene_synonym="2410003L07Rik; 2410003M15Rik; TUBA"
                     /inference="alignment:Splign:2.1.0"
     exon            3033..3583
                     /gene="Dnmbp"
                     /gene_synonym="2410003L07Rik; 2410003M15Rik; TUBA"
                     /inference="alignment:Splign:2.1.0"
     exon            3584..5042
                     /gene="Dnmbp"
                     /gene_synonym="2410003L07Rik; 2410003M15Rik; TUBA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5022..5027
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dnmbp"
                     /gene_synonym="2410003L07Rik; 2410003M15Rik; TUBA"
                     /note="hexamer: AATAAA"
     polyA_site      5042
                     /gene="Dnmbp"
                     /gene_synonym="2410003L07Rik; 2410003M15Rik; TUBA"
                     /note="major polyA site"
ORIGIN      
        1 agccagagca acaggaagac tccagtgctg tgggagacat tttaaggaca gagccagcct
       61 taggctagac tgcacctgtt cgagtttcac cccaaccccg agctcatgga acagagaagc
      121 aaagtccgag ttcctactga acatgagtga gacacgcgag attgggaggg aaagggtcgc
      181 tgagctttct gcggggcctc ggggctccag ttgggagtat gaagactgca ggagcctccg
      241 gaaaagaagc cttacggacc caggtgggct ccacccagaa aatggcctgg acgctacgtg
      301 ccgggccaaa aggcggaatc ggccctacag aaaaagggat tgtgggtact gggattttga
      361 gcagagtgaa ccagattata tggactcggg agaaacaaat cggagtggaa aggagggtct
      421 cttcccagca ggctctgctg cttccaggaa tggagaagac atagagtgtg tgaatctcgg
      481 gcctgggaca gagaggcgtt cacttgcggg aagcccggct gggatcctgg aggctggagg
      541 atgtgggacg gtgaatggct gtgtagagtg taaggatccg atttataatc ccaacgatct
      601 gcaaaaagcc aaacacagga atggctacag ggatttgggc gactctttgg agaatttata
      661 tcaacctcag aactggtgca tgggcctgag gaattttaat tacagtcttg aggattataa
      721 aggaattaac ttagattata gagatcacac aagttcgtgc cacgttcctg ggccttatac
      781 caacggcgag tctctggagc gtccagattt gaatggggtc acgggaggtg aagaatttct
      841 tagatactat gaagaagaca ggaaggtttg ccaaagtaac cgaatctacc ccaaagcaaa
      901 ggccgactgt cccgtggatc tggctacttt tgttgtagaa aataaaggct atgatggtac
      961 ctcctctaca aactcagagt ctcatcgtta tagacaagtt tcttctctcc atcgaggaga
     1021 ggatttggag tatgacgaca ttgacagact gggagtgagg gcccccagag gcagaggagc
     1081 catctctgaa aatctgccgc agcatcctgg gagtgagcaa ggagaatatc actttgggat
     1141 tgcaggggcc cctacactag aaagtccctg gcacccgggg gagatgagag cgttacctgg
     1201 ttcagagccg tggggaagga atagctgctt ccgccgcacg gctcccagca ccctgagaca
     1261 ctcggagttt gtgcagagaa ggaagaagcc tcaagacatg acgctcctct cttcccagtc
     1321 ttcatccctg gcggccccct ttgggtctgt gtccactgaa aacccagagc agaggatgct
     1381 ggagaagaga gccaaggtgg tggcggagct tttgcagacg gagagagact acatccggga
     1441 tctggagatg tgcattgaga gggtcatggt gcccctgcag caggcacagg taccaaacgt
     1501 tgattttgaa ggactttttg gaaatatgca aacagtgatt aaagtctcaa agcaattgtt
     1561 ggcggccttg gaaatcagcg atgctgtagg acccgtgttt cttgaccacc gagacgagct
     1621 tgagggaacg tacagggttt actgccagaa ccacgatgaa gccatctccc tgctggaaat
     1681 gtatgagaag gacgagaaga cccagaagca ccttcaggac tacctggcag atctcaagag
     1741 cctgtaccac gaatggggat gcaccaatta catcaacctg ggctccttcc tcatcaagcc
     1801 cgtacagaga ataatgcgtt acccgctgct gctgatggag ttgctgaatt ccaccccaga
     1861 atcccacccg gataaagtgc ctttaaccaa cgcggtcctc gccgtcaagg agatcaatgt
     1921 taacattaat gagtacaagc gtcggaagga tctggtgctt aagtaccgca aaggggatga
     1981 agatagcctg atggaaaaga tctccaagct gaacatacac tccatcatca agaagtccag
     2041 ccgcgttagc agccacctca aacacctcac tggcttcgct ccgcagctaa aagatgaagt
     2101 atttgaagag acagaaaaga acttccggat gcaggagaga ttgattaaat cttttatccg
     2161 agacctgtcc ctctacctcc agcatatacg ggaatctgca tgtgtgaagg tggtggcagc
     2221 catgagcata tgggatctgt gcatggagag gggacatcat gacctggagc agttcgagaa
     2281 ggtgcatcgc tacatcagtg accagctctt cacacggttt aaagagagga ccgagcggct
     2341 cgtcatcaat cccttaaacc agttgttgaa catgttcacg gggccctaca agctggtgca
     2401 gaagcggttc gacaagctcc tggacttcta caactgcact gagcgagcgg agaagctgaa
     2461 ggacaagaag actctggagg agctgcagtc agcccgaaac aactacgagg ccctgaactc
     2521 gcagctgctg gacgagctgc ccaagttcca gcagtacgcc cagagcctct tcaccaactg
     2581 catccacggc tatgccgaag cccactgtga cttcgtgcag caagccctgg agcagctgca
     2641 gccgctgctg tcgttactga aagccaccga ccgagaaggc aacttgatcg ccatcttcct
     2701 tgaggagcac agccgggtgc tacagcagct ccaggtcttc acattcttcc ccgagtccct
     2761 cccagcgccc aggaagccct ttgagaggaa aaccacagac cgccagtcat cccggaagac
     2821 ccttctgggc atgccaagct acatgctgca gtcggaagag ctgcggagct ccctgctggc
     2881 gaggtacccg ccggaaaagc tcttccacgt ccagcggaac ttcaacgctg cgcaggactt
     2941 ggatgtctcc cttttggaag gcgacctggt gggcgtgatc aaaaagaaag accccatggg
     3001 cagccagaac cgctggctcg tggacaacgg agtcaccaaa ggctttgtct acagctcctt
     3061 cctgaagcct tacaatcctc gctgcagcca ttcggatgcc tccgtggcca gccactcctc
     3121 cacggagtca gagcacagtg gctcctcccc cgggtgccat cgacagaaca gccacagtgc
     3181 cttgaccttc aactccaaca acatgactgt gtccttcacc tcaggacttg ccctaacgca
     3241 gcctcaggat gcatctccac tgaaggactg tgcccacgaa actctcgctg tgtcctggaa
     3301 cacagggcat ccagagactg gaccttccac gtgctcttcc gacccaggct tttcctgcca
     3361 gcgcaggctg gggaaccctg cagatggtgc cagagacatc agccaacctg cttcaacctt
     3421 gaggggctgc cagcgaggct ccccgcattc agaagtggtc ggttactctg tgccagggca
     3481 aaatgaccaa ggcagtgact ctataaaagg ctctgcaaga gtctgtcagg ctccagaaga
     3541 cagagacaga ggggtcggga gcagcgagac agagggcaac caggtctatt ttgccattta
     3601 tactttcaag gcacgaaacc caaatgaact gagtgtgtta gccaatcaga gactcaggat
     3661 ccatgagttt aaagacgtca caggcaatac agagtggtgg ttggctgaag ttaacggaag
     3721 gaagggctac gtcccatcca actatatccg gaaaaccgag tacacctgag ccaagttgcc
     3781 tcccgccctg ccttgctgcc gctttcagtc cgacggaagg tcctggaggg cttcgggctc
     3841 ctgctcccga gcagggaccc accacactgc ctatccataa ctcggagcgc aagataagct
     3901 ttgttctgat tgggttgtac actttgatgc tcgctagaat ttgaagtggg tggaccccaa
     3961 atgtttgcca gtgattccgt gtccacaaga agcaggccaa gtgccggtgt cagctttggg
     4021 aaatgagacg ttcccaatca gagaagcagt attgtacgcg ggaagctgtg ccagcatcag
     4081 cggatgctgg cattggttgc cgcactccat ggtcgactga gcagtcacgg ggtgaggagg
     4141 agtgggctcc gagagctcct cctttatgcc cccatccacg gtcttgtcac aatcacacca
     4201 aacctggtgt gtcagagtgt tcgagacacc ccggtgcccg gcagccttct ctctgacact
     4261 tgcccctcct agttcttaac atgctaacct ttcactgctt ccccgttgaa tgtttacagt
     4321 ctaactttta ttctgaccgt gtgtctgaaa ggttccctta ccttgtcgaa cacggtcagc
     4381 tgcctcttcc ctgacactca tttcaacttt atttgatctc tatgatgtct cctaaccttt
     4441 ctcccagtac gcgataacta acggacttcc ctagactagg ggggctcggg gctcggcact
     4501 ccgcccagcc actgaacgta gtcattcatt ctgccggtgg aaacgggacg cctgcccctc
     4561 ccctttccac ccttgcactt ggctgcctct agtcacctcc acgcgtgctc aagacaacca
     4621 cgtggcttat tcaaagtagg taggatcagt ggccccagaa gcttgtctta gagtcggaga
     4681 taagtatttt ccttctcacc acctactgcc atacttcaga gacaatattc aaagtcagac
     4741 agatgctaaa gtgcctaatg agacctcaaa cccaaggctg gaaggtggcc gctaaaccct
     4801 catgtgagga aatggcccga gagacttgtc tcagcgtggg tcttagactc caggtcttcc
     4861 ccatccttcc agccgctgct cttctagctg cacatttggc cttaaagtcc tgatgagtca
     4921 ggacttgcct gtggacaccc atccacggct gcaccactgg tcagagcctc gtatgaagtg
     4981 tttatattta gaaatgttta tatttaagta gctattttat aaataaaagc atttctattg
     5041 ac
//
