LOCUS       NM_001038619            7538 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus dynamin 3 (Dnm3), transcript variant 1, mRNA.
ACCESSION   NM_001038619
VERSION     NM_001038619.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7538)
  AUTHORS   Hanke-Gogokhia,C., Zapadka,T.E., Finkelstein,S., Klingeborn,M.,
            Maugel,T.K., Singer,J.H., Arshavsky,V.Y. and Demb,J.B.
  TITLE     The Structural and Functional Integrity of Rod Photoreceptor Ribbon
            Synapses Depends on Redundant Actions of Dynamins 1 and 3
  JOURNAL   J Neurosci 44 (25), e1379232024 (2024)
   PUBMED   38641407
  REMARK    GeneRIF: The Structural and Functional Integrity of Rod
            Photoreceptor Ribbon Synapses Depends on Redundant Actions of
            Dynamins 1 and 3.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7538)
  AUTHORS   Wu,J., Moriwaki,K., Asuka,T., Nakai,R., Kanda,S., Taniguchi,M.,
            Sugiyama,T., Yoshimura,S.I., Kunii,M., Nagasawa,T., Hosen,N.,
            Miyoshi,E. and Harada,A.
  TITLE     EHBP1L1, an apicobasal polarity regulator, is critical for nuclear
            polarization during enucleation of erythroblasts
  JOURNAL   Blood Adv 7 (14), 3382-3394 (2023)
   PUBMED   37042948
  REMARK    Erratum:[Blood Adv. 2024 Mar 12;8(5):1151. doi:
            10.1182/bloodadvances.2023011838.. PMID: 38421726]
REFERENCE   3  (bases 1 to 7538)
  AUTHORS   Imoto,Y., Raychaudhuri,S., Ma,Y., Fenske,P., Sandoval,E., Itoh,K.,
            Blumrich,E.M., Matsubayashi,H.T., Mamer,L., Zarebidaki,F.,
            Sohl-Kielczynski,B., Trimbuch,T., Nayak,S., Iwasa,J.H., Liu,J.,
            Wu,B., Ha,T., Inoue,T., Jorgensen,E.M., Cousin,M.A., Rosenmund,C.
            and Watanabe,S.
  TITLE     Dynamin is primed at endocytic sites for ultrafast endocytosis
  JOURNAL   Neuron 110 (17), 2815-2835 (2022)
   PUBMED   35809574
REFERENCE   4  (bases 1 to 7538)
  AUTHORS   Yang,S., Park,D., Manning,L., Hill,S.E., Cao,M., Xuan,Z.,
            Gonzalez,I., Dong,Y., Clark,B., Shao,L., Okeke,I.,
            Almoril-Porras,A., Bai,J., De Camilli,P. and Colon-Ramos,D.A.
  TITLE     Presynaptic autophagy is coupled to the synaptic vesicle cycle via
            ATG-9
  JOURNAL   Neuron 110 (5), 824-840 (2022)
   PUBMED   35065714
REFERENCE   5  (bases 1 to 7538)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7538)
  AUTHORS   Medrihan,L., Rohlmann,A., Fairless,R., Andrae,J., Doring,M.,
            Missler,M., Zhang,W. and Kilimann,M.W.
  TITLE     Neurobeachin, a protein implicated in membrane protein traffic and
            autism, is required for the formation and functioning of central
            synapses
  JOURNAL   J Physiol 587 (Pt 21), 5095-5106 (2009)
   PUBMED   19723784
REFERENCE   7  (bases 1 to 7538)
  AUTHORS   Reems,J.A., Wang,W., Tsubata,K., Abdurrahman,N., Sundell,B.,
            Tijssen,M.R., van der Schoot,E., Di Summa,F., Patel-Hett,S.,
            Italiano,J. Jr. and Gilligan,D.M.
  TITLE     Dynamin 3 participates in the growth and development of
            megakaryocytes
  JOURNAL   Exp Hematol 36 (12), 1714-1727 (2008)
   PUBMED   19007685
  REMARK    GeneRIF: Dynamin 3 participates in the growth and development of
            megakaryocytes.
REFERENCE   8  (bases 1 to 7538)
  AUTHORS   Watanabe,T., Sato,T., Amano,T., Kawamura,Y., Kawamura,N.,
            Kawaguchi,H., Yamashita,N., Kurihara,H. and Nakaoka,T.
  TITLE     Dnm3os, a non-coding RNA, is required for normal growth and
            skeletal development in mice
  JOURNAL   Dev Dyn 237 (12), 3738-3748 (2008)
   PUBMED   18985749
REFERENCE   9  (bases 1 to 7538)
  AUTHORS   Loebel,D.A., Tsoi,B., Wong,N. and Tam,P.P.
  TITLE     A conserved noncoding intronic transcript at the mouse Dnm3 locus
  JOURNAL   Genomics 85 (6), 782-789 (2005)
   PUBMED   15885504
REFERENCE   10 (bases 1 to 7538)
  AUTHORS   Noakes,P.G., Chin,D., Kim,S.S., Liang,S. and Phillips,W.D.
  TITLE     Expression and localisation of dynamin and syntaxin during neural
            development and neuromuscular synapse formation
  JOURNAL   J Comp Neurol 410 (4), 531-540 (1999)
   PUBMED   10398046
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK049724.1, AK147678.1, AK046124.1 and AW047427.1.
            
            On Feb 7, 2018 this sequence version replaced NM_001038619.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147678.1, BC141144.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-627               AK049724.1         2-628
            628-3058            AK147678.1         568-2998
            3059-4602           AK049724.1         3048-4591
            4603-6497           AK046124.1         135-2029
            6498-7521           AK147678.1         6437-7460
            7522-7538           AW047427.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..7538
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 69.95 cM"
     gene            1..7538
                     /gene="Dnm3"
                     /gene_synonym="9630020E24Rik; B230343F03Rik; C530045C17;
                     Dyna III; mKIAA0820"
                     /note="dynamin 3"
                     /db_xref="GeneID:103967"
                     /db_xref="MGI:MGI:1341299"
     exon            1..372
                     /gene="Dnm3"
                     /gene_synonym="9630020E24Rik; B230343F03Rik; C530045C17;
                     Dyna III; mKIAA0820"
                     /inference="alignment:Splign:2.1.0"
     CDS             212..2803
                     /gene="Dnm3"
                     /gene_synonym="9630020E24Rik; B230343F03Rik; C530045C17;
                     Dyna III; mKIAA0820"
                     /EC_number="3.6.5.5"
                     /note="isoform 1 is encoded by transcript variant 1;
                     t-dynamin; testicular dynamin; dynamin III"
                     /codon_start=1
                     /product="dynamin-3 isoform 1"
                     /protein_id="NP_001033708.1"
                     /db_xref="GeneID:103967"
                     /db_xref="MGI:MGI:1341299"
                     /translation="MGNREMEELIPLVNRLQDAFSALGQSCLLELPQIAVVGGQSAGK
                     SSVLENFVGRDFLPRGSGIVTRRPLVLQLVTSKAEYAEFLHCKGKKFTDFDEVRHEIE
                     AETDRVTGMNKGISSIPINLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIRDMI
                     MQFITRENCLILAVTPANTDLANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARD
                     VLENKLLPLRRGYVGVVNRSQKDIDGKKDIKAAMLAERKFFLSHPAYRHIADRMGTPH
                     LQKVLNQQLTNHIRDTLPNFRNKLQGQLLSIEHEVEAFKNFKPEDPTRKTKALLQMVQ
                     QFAVDFEKRIEGSGDQVDTLELSGGAKINRIFHERFPFEIVKMEFNEKELRREISYAI
                     KNIHGIRTGLFTPDMAFEAIVKKQIVKLKGPSLKSVDLVMQELINTVKKCTKRLANFP
                     RLCEETERIVANHIREREGKTKDQVLLLIDIQVSYINTNHEDFIGFANAQQRSSQVHK
                     KSTIGNQVIRKGWLTVSNIGIMKGGSKGYWFVLTAESLSWYKDDEEKEKKYMLPLDNL
                     KVRDVEKGFMSSKHVFALFNTEQRNVYKDYRFLELACDSQEDVDSWKASLLRAGVYPD
                     KSVGSNKTENDENGQAENFSMDPQLERQVETIRNLVDSYMSIINKCIRDLIPKTIMHL
                     MINNVKDFINSELLAQLYSSEDQNTLMEESAEQAQRRDEMLRMYQALKEALAIIGDIN
                     TATVSTPAPPPVDDSWLQHSRRSPPPSPTTQRRLTISAPLPRPTSGRGPAPAIPSPGP
                     HSGAPPVPFRPGPLPPFPNSSDSFGAPPQVPSRPTRAPPSVPSRRPPPSPTRPTIIRP
                     LESSLLD"
     exon            373..446
                     /gene="Dnm3"
                     /gene_synonym="9630020E24Rik; B230343F03Rik; C530045C17;
                     Dyna III; mKIAA0820"
                     /inference="alignment:Splign:2.1.0"
     exon            447..596
                     /gene="Dnm3"
                     /gene_synonym="9630020E24Rik; B230343F03Rik; C530045C17;
                     Dyna III; mKIAA0820"
                     /inference="alignment:Splign:2.1.0"
     exon            597..800
                     /gene="Dnm3"
                     /gene_synonym="9630020E24Rik; B230343F03Rik; C530045C17;
                     Dyna III; mKIAA0820"
                     /inference="alignment:Splign:2.1.0"
     exon            801..899
                     /gene="Dnm3"
                     /gene_synonym="9630020E24Rik; B230343F03Rik; C530045C17;
                     Dyna III; mKIAA0820"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1060
                     /gene="Dnm3"
                     /gene_synonym="9630020E24Rik; B230343F03Rik; C530045C17;
                     Dyna III; mKIAA0820"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1203
                     /gene="Dnm3"
                     /gene_synonym="9630020E24Rik; B230343F03Rik; C530045C17;
                     Dyna III; mKIAA0820"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1339
                     /gene="Dnm3"
                     /gene_synonym="9630020E24Rik; B230343F03Rik; C530045C17;
                     Dyna III; mKIAA0820"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1407
                     /gene="Dnm3"
                     /gene_synonym="9630020E24Rik; B230343F03Rik; C530045C17;
                     Dyna III; mKIAA0820"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1546
                     /gene="Dnm3"
                     /gene_synonym="9630020E24Rik; B230343F03Rik; C530045C17;
                     Dyna III; mKIAA0820"
                     /inference="alignment:Splign:2.1.0"
     exon            1547..1633
                     /gene="Dnm3"
                     /gene_synonym="9630020E24Rik; B230343F03Rik; C530045C17;
                     Dyna III; mKIAA0820"
                     /inference="alignment:Splign:2.1.0"
     exon            1634..1704
                     /gene="Dnm3"
                     /gene_synonym="9630020E24Rik; B230343F03Rik; C530045C17;
                     Dyna III; mKIAA0820"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..1756
                     /gene="Dnm3"
                     /gene_synonym="9630020E24Rik; B230343F03Rik; C530045C17;
                     Dyna III; mKIAA0820"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..1870
                     /gene="Dnm3"
                     /gene_synonym="9630020E24Rik; B230343F03Rik; C530045C17;
                     Dyna III; mKIAA0820"
                     /inference="alignment:Splign:2.1.0"
     exon            1871..1980
                     /gene="Dnm3"
                     /gene_synonym="9630020E24Rik; B230343F03Rik; C530045C17;
                     Dyna III; mKIAA0820"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..2092
                     /gene="Dnm3"
                     /gene_synonym="9630020E24Rik; B230343F03Rik; C530045C17;
                     Dyna III; mKIAA0820"
                     /inference="alignment:Splign:2.1.0"
     exon            2093..2104
                     /gene="Dnm3"
                     /gene_synonym="9630020E24Rik; B230343F03Rik; C530045C17;
                     Dyna III; mKIAA0820"
                     /inference="alignment:Splign:2.1.0"
     exon            2105..2269
                     /gene="Dnm3"
                     /gene_synonym="9630020E24Rik; B230343F03Rik; C530045C17;
                     Dyna III; mKIAA0820"
                     /inference="alignment:Splign:2.1.0"
     exon            2270..2496
                     /gene="Dnm3"
                     /gene_synonym="9630020E24Rik; B230343F03Rik; C530045C17;
                     Dyna III; mKIAA0820"
                     /inference="alignment:Splign:2.1.0"
     exon            2497..2733
                     /gene="Dnm3"
                     /gene_synonym="9630020E24Rik; B230343F03Rik; C530045C17;
                     Dyna III; mKIAA0820"
                     /inference="alignment:Splign:2.1.0"
     exon            2734..7523
                     /gene="Dnm3"
                     /gene_synonym="9630020E24Rik; B230343F03Rik; C530045C17;
                     Dyna III; mKIAA0820"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7500..7505
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dnm3"
                     /gene_synonym="9630020E24Rik; B230343F03Rik; C530045C17;
                     Dyna III; mKIAA0820"
                     /note="hexamer: AATAAA"
     polyA_site      7523
                     /gene="Dnm3"
                     /gene_synonym="9630020E24Rik; B230343F03Rik; C530045C17;
                     Dyna III; mKIAA0820"
                     /note="major polyA site"
ORIGIN      
        1 ctccttcgcc tctctgggct gcgcaagcgc gtcgtgggct gtgagctgtc aggatcctag
       61 cagtgggagg cagggatcgg acatcggtgc agggactccg ccgtgtgagc cccgcacagc
      121 gacaaccggg acaagtgctt cgaggcctgg gctgcctgcc aggtcacaca gtcgaacagg
      181 gacctgtggg gcagttggcc gcacaggcaa gatggggaac cgggagatgg aagagctgat
      241 ccctctggtg aaccgtctgc aggacgcttt ctcggctctg ggacagagct gtctgctaga
      301 gctgccacag atcgccgtgg tgggcggcca gagcgccggc aagagctcag tgctcgagaa
      361 tttcgtgggc agggactttc ttcctcgagg ctcaggcatt gtaaccagac ggcctcttgt
      421 actccagctt gtcacctcta aagcagaata tgccgagttt ctacattgca aaggaaaaaa
      481 atttacagat tttgatgaag ttcgacatga gatcgaagca gaaacagacc gcgtaacagg
      541 aatgaataaa ggcatctctt ctatacccat taacctccga gtctactctc cccacgtgtt
      601 aaatctaacg ctaatcgacc tacctggaat aacgaaagtg cccgtgggag accagccgcc
      661 agatatcgag tatcagatca gagatatgat tatgcagttc atcacgaggg agaactgtct
      721 gattttggct gtcacgccag ccaacaccga tcttgcgaac tcggatgcac tgaagctagc
      781 caaagaagtt gatcctcaag gtctgaggac cattggcgtg atcaccaagc tggatctcat
      841 ggatgaagga acagatgcca gggatgtgct ggagaacaag ctgctgcctc ttcgcagggg
      901 ctacgtgggg gtggtcaaca gaagccagaa ggacatagat ggaaagaaag acattaaggc
      961 agccatgttg gcagaaagga aattttttct ttctcacccg gcgtacagac acattgctga
     1021 tcgtatgggg accccacacc tccagaaggt cctgaatcag caacttacca accatattcg
     1081 agatactctg cccaacttca ggaacaagct acaggggcag ctgctctcca tagaacatga
     1141 agtggaagcc ttcaaaaact tcaaaccgga agaccccaca aggaagacca aagccctgct
     1201 gcagatggtc caacagtttg ctgtggactt tgagaagaga atcgaagggt caggagatca
     1261 agtagacacc ttagagctct ctggcggtgc taagatcaac cgcattttcc acgaacgctt
     1321 tccttttgag atagtgaaga tggagttcaa tgagaaagaa ctgagaagag aaataagcta
     1381 cgcaatcaaa aacatacatg ggatcaggac agggttgttt actccagaca tggcgtttga
     1441 ggcaatagtt aaaaagcaga tagtaaaact gaaagggcct tccttgaaga gtgtggacct
     1501 ggtaatgcag gagctgatca acaccgtgaa gaagtgtacc aagaggctgg caaacttccc
     1561 cagactctgt gaagaaacag aaaggattgt tgctaaccac atccgtgaga gagaagggaa
     1621 gacaaaggac caggtcctgc tactgattga cattcaagtc tcttacatta acaccaacca
     1681 tgaggacttc atcggctttg caaatgctca gcagaggagc agtcaggttc acaagaaaag
     1741 cacaattgga aatcaggtga ttcgtaaggg ctggctgacc gtcagcaaca ttggcatcat
     1801 gaaagggggc tcgaagggct actggtttgt cctcactgca gaaagcctgt cctggtataa
     1861 agacgatgag gagaaagaaa agaaatatat gcttcccctg gacaacctga aggtccggga
     1921 tgtggagaag ggcttcatgt ccagcaagca cgtcttcgca ctcttcaaca ccgagcaaag
     1981 gaatgtatac aaagactatc gcttcctgga gctggcctgt gattcccagg aagatgtgga
     2041 cagctggaag gcgtctctgc tcagagccgg ggtctaccca gataaatctg tagggagcaa
     2101 caaaactgaa aatgatgaaa atggacaagc agaaaacttt tccatggacc cacagttgga
     2161 gaggcaagtg gagaccatac gcaacctagt agactcctac atgtcaataa tcaacaaatg
     2221 catccgagac ttaattccaa aaacaataat gcatcttatg atcaataacg ttaaagactt
     2281 catcaactct gaactcctag cacagctcta ctcttctgag gaccagaaca ctctgatgga
     2341 agagtccgcg gagcaggctc agcgccgaga tgagatgctc cgaatgtacc aagccctgaa
     2401 agaagctctc gcaatcattg gtgacatcaa cacggccacg gtgtccaccc cagccccacc
     2461 tccagtcgat gactcctggc tccaacactc caggaggtca cctcctccga gccccaccac
     2521 ccaacgaagg ctgacgataa gtgctcccct cccaaggccc acatctggcc gtgggccagc
     2581 tcccgctatc ccctctccag gcccccactc cggagctccc ccagttccat tccgtcctgg
     2641 cccattacct ccttttccca acagcagtga ctcctttgga gcccctccgc aagttccgtc
     2701 caggcccacc agggcacccc ccagtgttcc aagccggagg ccacccccat caccaactcg
     2761 ccccactata atccgtccac tagaatcctc actgttagac taaacgaagt gtccggcatg
     2821 gcaattaacc actaatgatt tatgcaaacg cagcacattc ggtaaccttt gcagctcaac
     2881 catgagtagt cgcatgtatg gacctctata ggcaagtagc cagtcttact aatgtgttca
     2941 ccaactcatc ttcattgctc atggtatgtc agacctttgg ggtttgactc cgaaaacctg
     3001 ctaacctgta gagaggctta aatatgttgt attgaccaag gtagttttat acagcagccc
     3061 tatactttgg taccatttgt ctacccaaca tatatcagaa gttgctttgg aagagctttc
     3121 taagctgtct acagagaagc ttatgacgac tcttaacaga tacaagagtg tgagcttgga
     3181 accataccga ccttccgcac attctgttta gggcagcaga aactctgcct tctgatgtta
     3241 acgccaccat tcagtccgca attgcttatt taggcttctt ccccccaccc cccttatttc
     3301 ataggactgc tttaaaaaaa aaaaaaagca aggttcttaa atcagcattg ctgaagatga
     3361 aagcttttca ggagcccgag gcagtctgca aagggcaagt gcccagggct tgccctggag
     3421 agcctctcct ggggcttgtg tgctgtgctt tgtgctagag gcacaagcac catccaggca
     3481 aagcgtgagg ggtactggca atcagttgat agatttggct cctttcagag ttcaaagaag
     3541 aagcaaaaac taattgccat tctaaaagtg tctgagaaga tagaatttat tatcttatta
     3601 tttacctctt tgtgagctat gatgaaggaa ggctgacact gcaagtgttt aattttccag
     3661 ttgattggac agcatgggta actaactccg tttagttatt gtgactatta ttttggctgg
     3721 aaaaaagtta aatgtatgct agcacatgat ttctatggtt tatatataaa tgattataca
     3781 agaatccttt ttaaaaaacg actttagtgt ctccacccat tccagactcc cttaaatctt
     3841 acagcctact ctgacacaat tgcatggcaa gtatggaacc tggtatggga aggtgatcca
     3901 tcagcgatgc catggtttaa gagcacggcc cacgtgtttc cagcttgctc ctgaaaaaca
     3961 acatcctggc catactgagc tgcagaacaa gtctgtagcc tctcagatct ctaaacttta
     4021 catgagcagc ctagcctaga ggttattagt tcaacctcga ggctacgttt tgaactacct
     4081 atgaccagat ggttagcaca taggaaccag ctagaagcca aatggaattc tgtctgctaa
     4141 ccgcacccag acggcagagc gggcgggctt tcaccgaatt gtagcgtccc cagacattat
     4201 tccataatca caaaggtaaa tcaggtttta ctaactgcaa catctccttt tgaaggcagt
     4261 caacatgatt tgtatgcaaa cttcacttta atttcctgtg cagtttctac ccgaagcaag
     4321 tggctataaa atatgatgta aaaactttta accattattt taaaaagttt ttttttccaa
     4381 gtgaaatgcc actgcattga acttattcta atgggttaga tcccactttt aattggcaaa
     4441 aattagagaa catgcaacat acaaaggggt atttttcaac ctttaagtga catagaagag
     4501 ctctaatgtc tctaaatttt tttccctgtt gaaaaaaaaa ccgtgaatgg aactcgtata
     4561 agacatgcac attgtctttg aaaacagtgt cccaactaaa tgaaaaaaaa aaacatacat
     4621 taagcaaatg tttataatca aacaactcgt gggcaatgag gtctccccac aaatccctcc
     4681 tttcagcgcc ccctttgctt cttcctctga attctctaaa acaggcagct aaggaaatag
     4741 atacttcagg gtttggcttt gtccctcctc tgcttgtaca tcttgctata tttcaaaccc
     4801 ttccttctgt tggaagaaac taactcagaa aaccactggt gtgttcttga atcagcacaa
     4861 accaatgtca aggaaaactg gggatttgtc tctccacatt tcttcccatt gatcccagac
     4921 ggtcgtgagc aacggaatgg cacttgtcat ccttagctct tgcttcttga tccacagatt
     4981 ccttgtccca aatgtctccc tgtgtcagga cagttttgtt ctctttgcta ccgagctata
     5041 atcccttact ccaccacccc ctccccagaa gttcaacact ggcaccccag aatattttca
     5101 gattgctgca gttcagaggg tttgcactct gctaacagca gacaccaaca tgaacgaagc
     5161 ctgaggtttc actggcgtgt gcggagtgca cgtcaggcct caggacggga atgtaagctt
     5221 gaaggacctt cgcttcgcac tcagtttcta atctctcagt caacctcctg gttgaggaca
     5281 ccaaggttgt cagcgcaata gatgtagttt tatcttgtct agcataataa taactttaaa
     5341 aagtgttttt aggatttgaa aaggtacatg gttgataagt aaaagccagc tttcctgtca
     5401 catgctaact tacgcatgca gattggctag ctggaatagc caaccatttg tggatggact
     5461 atgaaacagg atcgatttag cacagatata tttccaaaaa tcatctacca agaatacctt
     5521 cttggatatt gcctttaggt gtgttttata acatagaaga gcagtggggt ctatttactg
     5581 gcaatttctc tgtttctgca gatacatacc cattctatcc aaaagtgtaa ccaaacagtt
     5641 cctgtgatat aagcattcta aatttagaat taagagatag ccacatagat tcacttgtga
     5701 ttgttagacc gtatccatac tctaaaccat gagatgggac ctgacaccag tccgtgacaa
     5761 ctgttgtttt ctgtgcactc gttttctctg catgtctcta ggaatacact atgtacatag
     5821 tgaccacgta ttttgtgtcc ttttgagtaa gtaggttcaa aagcaattac taaaacccca
     5881 ttaagcatga atgtgatttt atgtgcatca tatatataca tatgaatata aatatcagtg
     5941 taagcctgtg ctcagtatgt aagagtatga atatattttc aactgtgtta atatatatgt
     6001 tgggaagacc tgccataata tgattatggt agttcatttc tcataacata catgagaaac
     6061 acaggatctc ctaacctatt ctgtatatat tctgaggggc acaaagctta tgataaccat
     6121 gatgaccacc ataactataa ccatgacaaa gtagcgtgat gtctatggtc ctttgcattg
     6181 aaacccacag cactgctacc taggaaggca ttactttttg ggtgagactt tggtttttaa
     6241 aaaatgtaag aaagatttgg aagctttctc cagggtccct agttagtatt gtgttctctg
     6301 gggattgttg agctgactct tacaaagagc taagttaatc tgtgttgtcc tgagttctct
     6361 tcagtaaagt taaaagaatg cgaagtcagc aacacaatga aagtaatagg cctttctgag
     6421 caaacctgtt aaaacacgtg ggggacagga tactcaattc ctcgaaggta tgttatctac
     6481 tctgacaggt aaacctttga cattcgggaa actgtgcaat cactttaaat tgatgggaat
     6541 ctctgcagga tgagtaacaa atcctaaaca gacatcctag ctgtcttaac tcagtgagag
     6601 atgtctgtgt ttaagaagga agcatgagtt tgtaatttca cccagcacta gtagctgtga
     6661 gctcagagtt cctgcgaaag aagccaactt tagagaaata atggatagtt caccaggtcc
     6721 tttagtcttt tctaaagaac tcagtttgtc ttctagataa taataggctg tctgtctagc
     6781 tgatgtgttt aaaattgtgt ggtgctttgt atgtgaaact ttaacaatat ttttgaagta
     6841 tatatagtat atgcattgct agttgtgtat atatacatac atgtagtagt atctgtatgt
     6901 gtggagagca agagacagga gcctcaaaga atctcctgct taagatgtgt tagtactggt
     6961 atactggtga gactcctcat tccactgctc aagggcttca catgtggctc agctcaaggc
     7021 attcatttca ttctaatctt taccattaca tcccttaaac attactcata atgttttcaa
     7081 ttcatacaaa aactactcca gtgtcttgta ctgactgctg ccaatctgtg aaaatgactt
     7141 ctcccaaacc agaaacccta ccactgtcac cttgtgtgtt tgatttcatg tgcacactgc
     7201 ttttgtttca tgggcttgta tgtattcctc ttctctcccc gttctgaatc aaacttcact
     7261 tcaccttttg tgtgaatggt tgagtacaca gaagtcaaat cttgttttct ctgttgattc
     7321 tttaacatga gccagaatac tccccattgt cgtttttaac cactttgggg atttcttaat
     7381 gttggattaa tatggattct gtgaatggga tttttgaagc aaattcctaa agcctgtatc
     7441 attcttggag gtcatgtacc tattgtgaaa aaaatgtgaa actgtatttc tgaacctgaa
     7501 ataaatgatt acatttgaag gaaaaaaaaa aaaaaaaa
//
