LOCUS       NM_001253893            3582 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus dynamin 2 (Dnm2), transcript variant 1, mRNA.
ACCESSION   NM_001253893
VERSION     NM_001253893.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3582)
  AUTHORS   Wang,L., Yang,Z., Satoshi,F., Prasanna,X., Yan,Z., Vihinen,H.,
            Chen,Y., Zhao,Y., He,X., Bu,Q., Li,H., Zhao,Y., Jiang,L., Qin,F.,
            Dai,Y., Zhang,N., Qin,M., Kuang,W., Zhao,Y., Jokitalo,E.,
            Vattulainen,I., Kajander,T., Zhao,H. and Cen,X.
  TITLE     Membrane remodeling by FAM92A1 during brain development regulates
            neuronal morphology, synaptic function, and cognition
  JOURNAL   Nat Commun 15 (1), 6209 (2024)
   PUBMED   39043703
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3582)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3582)
  AUTHORS   Arriagada-Diaz,J., Flores-Munoz,C., Gomez-Soto,B.,
            Labrana-Allende,M., Mattar-Araos,M., Prado-Vega,L., Hinostroza,F.,
            Gajardo,I., Guerra-Fernandez,M.J., Bevilacqua,J.A., Cardenas,A.M.,
            Bitoun,M., Ardiles,A.O. and Gonzalez-Jamett,A.M.
  TITLE     A centronuclear myopathy-causing mutation in dynamin-2 disrupts
            neuronal morphology and excitatory synaptic transmission in a
            murine model of the disease
  JOURNAL   Neuropathol Appl Neurobiol 49 (4), e12918 (2023)
   PUBMED   37317811
  REMARK    GeneRIF: A centronuclear myopathy-causing mutation in dynamin-2
            disrupts neuronal morphology and excitatory synaptic transmission
            in a murine model of the disease.
REFERENCE   4  (bases 1 to 3582)
  AUTHORS   Wu,J., Moriwaki,K., Asuka,T., Nakai,R., Kanda,S., Taniguchi,M.,
            Sugiyama,T., Yoshimura,S.I., Kunii,M., Nagasawa,T., Hosen,N.,
            Miyoshi,E. and Harada,A.
  TITLE     EHBP1L1, an apicobasal polarity regulator, is critical for nuclear
            polarization during enucleation of erythroblasts
  JOURNAL   Blood Adv 7 (14), 3382-3394 (2023)
   PUBMED   37042948
  REMARK    Erratum:[Blood Adv. 2024 Mar 12;8(5):1151. doi:
            10.1182/bloodadvances.2023011838.. PMID: 38421726]
REFERENCE   5  (bases 1 to 3582)
  AUTHORS   Perdreau-Dahl,H., Lipsett,D.B., Frisk,M., Kermani,F., Carlson,C.R.,
            Brech,A., Shen,X., Bergan-Dahl,A., Hou,Y., Tuomainen,T., Tavi,P.,
            Jones,P.P., Lunde,M., Wasserstrom,J.A., Laporte,J., Ullrich,N.D.,
            Christensen,G., Morth,J.P. and Louch,W.E.
  TITLE     BIN1, Myotubularin, and Dynamin-2 Coordinate T-Tubule Growth in
            Cardiomyocytes
  JOURNAL   Circ Res 132 (11), e188-e205 (2023)
   PUBMED   37139790
  REMARK    GeneRIF: BIN1, Myotubularin, and Dynamin-2 Coordinate T-Tubule
            Growth in Cardiomyocytes.
REFERENCE   6  (bases 1 to 3582)
  AUTHORS   Wan,K.F., Sambi,B.S., Frame,M., Tate,R. and Pyne,N.J.
  TITLE     The inhibitory gamma subunit of the type 6 retinal cyclic guanosine
            monophosphate phosphodiesterase is a novel intermediate regulating
            p42/p44 mitogen-activated protein kinase signaling in human
            embryonic kidney 293 cells
  JOURNAL   J Biol Chem 276 (41), 37802-37808 (2001)
   PUBMED   11502744
REFERENCE   7  (bases 1 to 3582)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   8  (bases 1 to 3582)
  AUTHORS   McNiven,M.A., Kim,L., Krueger,E.W., Orth,J.D., Cao,H. and Wong,T.W.
  TITLE     Regulated interactions between dynamin and the actin-binding
            protein cortactin modulate cell shape
  JOURNAL   J Cell Biol 151 (1), 187-198 (2000)
   PUBMED   11018064
REFERENCE   9  (bases 1 to 3582)
  AUTHORS   Noakes,P.G., Chin,D., Kim,S.S., Liang,S. and Phillips,W.D.
  TITLE     Expression and localisation of dynamin and syntaxin during neural
            development and neuromuscular synapse formation
  JOURNAL   J Comp Neurol 410 (4), 531-540 (1999)
   PUBMED   10398046
REFERENCE   10 (bases 1 to 3582)
  AUTHORS   Klocke,R., Augustin,A., Ronsiek,M., Stief,A., van der Putten,H. and
            Jockusch,H.
  TITLE     Dynamin genes Dnm1 and Dnm2 are located on proximal mouse
            chromosomes 2 and 9, respectively
  JOURNAL   Genomics 41 (2), 290-292 (1997)
   PUBMED   9143510
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY275016.1, AK150046.1, AK005012.2, BY549643.1, AK157844.1 and
            AA221527.1.
            
            Transcript Variant: This variant (1) represents the longest variant
            and it encodes the longest protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849374,
                              SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                BY275016.1         2-42
            42-822              AK150046.1         5-785
            823-2731            AK005012.2         799-2707
            2732-2916           BY549643.1         57-241
            2917-3523           AK157844.1         2883-3489
            3524-3582           AA221527.1         281-339
FEATURES             Location/Qualifiers
     source          1..3582
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 7.79 cM"
     gene            1..3582
                     /gene="Dnm2"
                     /gene_synonym="b2b2159Clo; Dyn2; Udnm"
                     /note="dynamin 2"
                     /db_xref="GeneID:13430"
                     /db_xref="MGI:MGI:109547"
     exon            1..349
                     /gene="Dnm2"
                     /gene_synonym="b2b2159Clo; Dyn2; Udnm"
                     /inference="alignment:Splign:2.1.0"
     CDS             189..2801
                     /gene="Dnm2"
                     /gene_synonym="b2b2159Clo; Dyn2; Udnm"
                     /EC_number="3.6.5.5"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="dynamin-2 isoform 1"
                     /protein_id="NP_001240822.1"
                     /db_xref="CCDS:CCDS57657.1"
                     /db_xref="GeneID:13430"
                     /db_xref="MGI:MGI:109547"
                     /translation="MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGK
                     SSVLENFVGRDFLPRGSGIVTRRPLILQLIFSKTEYAEFLHCKSKKFTDFDEVRQEIE
                     AETDRVTGTNKGISPVPINLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMI
                     LQFISRESSLILAVTPANMDLANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARD
                     VLENKLLPLRRGYIGVVNRSQKDIEGKKDIRAALAAERKFFLSHPAYRHMADRMGTPH
                     LQKTLNQQLTNHIRESLPTLRSKLQSQLLSLEKEVEEYKNFRPDDPTRKTKALLQMVQ
                     QFGVDFEKRIEGSGDQVDTLELSGGARINRIFHERFPFELVKMEFDEKDLRREISYAI
                     KNIHGVRTGLFTPDLAFEAIVKKQVVKLKEPCLKCVDLVIQELISTVRQCTSKLSSYP
                     RLREETERIVTTYIREREGRTKDQILLLIDIEQSYINTNHEDFIGFANAQQRSTQLNK
                     KRAIPNQGEILVIRRGWLTINNISLMKGGSKEYWFVLTAESLSWYKDEEEKEKKYMLP
                     LDNLKIRDVEKGFMSNKHVFAIFNTEQRNVYKDLRQIELACDSQEDVDSWKASFLRAG
                     VYPEKDQAENEDGAQENTFSMDPQLERQVETIRNLVDSYVAIINKSIRDLMPKTIMHL
                     MINNTKAFIHHELLAYLYSSADQSSLMEESAEQAQRRDDMLRMYHALKEALNIIGDIS
                     TSTVSTPVPPPVDDTWLQNTSGHSPTPQRRPVSSVHPPGRPPAVRGPTPGPPLIPMPV
                     GATSSFSAPPIPSRPGPQSVFANNDPFSAPPQIPSRPARIPPGIPPGVPSRRAPAAPS
                     RPTIIRPAEPSLLD"
     exon            350..423
                     /gene="Dnm2"
                     /gene_synonym="b2b2159Clo; Dyn2; Udnm"
                     /inference="alignment:Splign:2.1.0"
     exon            424..573
                     /gene="Dnm2"
                     /gene_synonym="b2b2159Clo; Dyn2; Udnm"
                     /inference="alignment:Splign:2.1.0"
     exon            574..777
                     /gene="Dnm2"
                     /gene_synonym="b2b2159Clo; Dyn2; Udnm"
                     /inference="alignment:Splign:2.1.0"
     exon            778..876
                     /gene="Dnm2"
                     /gene_synonym="b2b2159Clo; Dyn2; Udnm"
                     /inference="alignment:Splign:2.1.0"
     exon            877..1037
                     /gene="Dnm2"
                     /gene_synonym="b2b2159Clo; Dyn2; Udnm"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1180
                     /gene="Dnm2"
                     /gene_synonym="b2b2159Clo; Dyn2; Udnm"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1316
                     /gene="Dnm2"
                     /gene_synonym="b2b2159Clo; Dyn2; Udnm"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1384
                     /gene="Dnm2"
                     /gene_synonym="b2b2159Clo; Dyn2; Udnm"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1523
                     /gene="Dnm2"
                     /gene_synonym="b2b2159Clo; Dyn2; Udnm"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1610
                     /gene="Dnm2"
                     /gene_synonym="b2b2159Clo; Dyn2; Udnm"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..1681
                     /gene="Dnm2"
                     /gene_synonym="b2b2159Clo; Dyn2; Udnm"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1733
                     /gene="Dnm2"
                     /gene_synonym="b2b2159Clo; Dyn2; Udnm"
                     /inference="alignment:Splign:2.1.0"
     exon            1734..1745
                     /gene="Dnm2"
                     /gene_synonym="b2b2159Clo; Dyn2; Udnm"
                     /inference="alignment:Splign:2.1.0"
     exon            1746..1859
                     /gene="Dnm2"
                     /gene_synonym="b2b2159Clo; Dyn2; Udnm"
                     /inference="alignment:Splign:2.1.0"
     exon            1860..1969
                     /gene="Dnm2"
                     /gene_synonym="b2b2159Clo; Dyn2; Udnm"
                     /inference="alignment:Splign:2.1.0"
     exon            1970..2081
                     /gene="Dnm2"
                     /gene_synonym="b2b2159Clo; Dyn2; Udnm"
                     /inference="alignment:Splign:2.1.0"
     exon            2082..2246
                     /gene="Dnm2"
                     /gene_synonym="b2b2159Clo; Dyn2; Udnm"
                     /inference="alignment:Splign:2.1.0"
     exon            2247..2479
                     /gene="Dnm2"
                     /gene_synonym="b2b2159Clo; Dyn2; Udnm"
                     /inference="alignment:Splign:2.1.0"
     exon            2480..2731
                     /gene="Dnm2"
                     /gene_synonym="b2b2159Clo; Dyn2; Udnm"
                     /inference="alignment:Splign:2.1.0"
     exon            2732..3545
                     /gene="Dnm2"
                     /gene_synonym="b2b2159Clo; Dyn2; Udnm"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3515..3520
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dnm2"
                     /gene_synonym="b2b2159Clo; Dyn2; Udnm"
                     /note="hexamer: AATAAA"
     polyA_site      3541
                     /gene="Dnm2"
                     /gene_synonym="b2b2159Clo; Dyn2; Udnm"
                     /note="major polyA site"
ORIGIN      
        1 gttcgctcgg gtcgggtgtc gcctgagaac cggatgaggc ggcgactctg aggccgagcc
       61 gggagcgggc gtcgcggcga aggggagacc gggcgggccg gcagagcaga gcaggaggaa
      121 gcaacggcca cagacacatc ggaaccgaga gtcttagtcg ggggatccgc gcggcggagg
      181 cggacaccat gggcaaccgc gggatggaag agctcatccc gctggttaac aagctgcagg
      241 acgccttcag ctccatcggt cagagctgcc acctggacct gccgcagatc gccgtggtgg
      301 gcggccagag cgccggcaaa agttcggtgc tcgagaactt cgtgggccgg gacttccttc
      361 cacgaggatc aggaattgtc acccggaggc ctctcattct gcagctcatc ttttccaaaa
      421 cagaatatgc ggaatttttg cactgcaagt ccaaaaaatt tacagacttt gatgaagtcc
      481 ggcaggagat cgaagcagag actgaccggg tcacaggcac caacaaaggc atctcccctg
      541 tgcccatcaa ccttcgggtc tactcaccac acgtgttgaa cttgaccctc atcgacctcc
      601 caggcatcac taaggtgccg gtgggggacc agccgccaga catcgagtac cagatcaagg
      661 acatgatcct gcagttcatc agccgcgaga gcagcctcat tcttgccgtc acacctgcca
      721 acatggactt ggccaactca gacgccctca agctggccaa ggaggtggac ccccaaggcc
      781 tacggaccat cggtgtcatc accaagctag acttgatgga tgaaggcaca gacgccaggg
      841 atgtcctgga aaacaagcta ctgcccttga gaagaggcta tatcggcgtg gttaaccgaa
      901 gccagaaaga catcgagggc aaaaaggaca tccgggctgc tctggcagcc gagaggaaat
      961 tcttcctctc ccacccagcc taccggcaca tggctgaccg catgggcacc ccacacttgc
     1021 agaaaaccct gaaccagcaa ctgaccaacc acatccgaga gtcactgccg acccttcgca
     1081 gcaagctgca gagccaactg ctgtccctgg agaaggaagt ggaagagtac aagaatttcc
     1141 ggcctgatga ccccacgcgc aagaccaaag ccctgctgca gatggttcag cagtttggag
     1201 tggactttga gaagcgaatt gaaggctcgg gagatcaagt agacacacta gagttgtctg
     1261 gtggagcccg catcaatcgt atctttcatg agcgctttcc ctttgaactg gtaaagatgg
     1321 agtttgatga gaaagatcta cgaagagaga tcagctatgc tattaagaac atccacggag
     1381 tcagaactgg gctcttcacg ccggatttgg cgttcgaggc cattgtgaaa aagcaggtgg
     1441 tcaagctgaa agagccctgt ctgaaatgcg tggacctggt tatccaggag ctaatcagta
     1501 cagttaggca gtgcaccagc aagctgagtt cctacccccg gctgcgagag gagaccgagc
     1561 gaattgtcac cacctacatc agggagcgag aagggagaac caaggaccag attcttcttc
     1621 tgattgacat tgagcagtcg tacatcaaca caaaccatga agacttcatt ggatttgcca
     1681 atgcccagca gaggagcacg cagctgaaca agaagagggc catacccaat cagggggaga
     1741 tcttggtgat ccgcaggggc tggttgacca tcaacaatat cagcttgatg aagggtggct
     1801 ccaaggagta ctggttcgtg ctgacagctg agtcattgtc ttggtacaag gatgaggagg
     1861 agaaagaaaa gaagtacatg ctgccactgg acaacctcaa gatccgggac gtggaaaagg
     1921 gcttcatgtc caacaagcac gtgtttgcca tcttcaacac agagcagagg aatgtctaca
     1981 aggaccttcg acagattgaa ctggcttgtg actcccagga agatgtggac agctggaagg
     2041 cttcgttcct gcgcgctggg gtctacccag agaaggacca ggcagagaat gaggatggag
     2101 cacaagagaa caccttctcc atggacccgc agctggagcg acaggtggag accatccgta
     2161 acctggtgga ctcctacgtg gccatcatca acaagtccat ccgtgacctt atgccaaaga
     2221 ccatcatgca cctcatgatc aacaacacaa aggccttcat ccaccatgag ctgctggctt
     2281 acctgtattc atcagcagac cagagcagcc tcatggaaga gtcagccgag caggctcagc
     2341 ggcgggacga catgctgcgc atgtaccacg cactgaagga ggccctcaac attattgggg
     2401 acatcagcac cagcaccgtg tccacacccg tgcccccacc ggtcgatgac acgtggctcc
     2461 aaaacaccag cggccacagc cccactccac agcgccgacc tgtgtccagt gtgcacccac
     2521 caggccggcc acctgcagtg cggggtccta caccggggcc tcccctgatt cctatgcctg
     2581 tgggggccac atcctccttc tcagcacctc ccatcccatc ccggcctgga ccacagagtg
     2641 tgtttgccaa caacgacccc ttctctgcgc cacctcagat accatctcgg ccagcacgga
     2701 ttccccctgg tatccctcca ggagtgccca gcagaagagc gcccgctgcg cccagccggc
     2761 ccaccattat ccgcccagcc gagccgtccc tgctcgacta ggctgcaggg ggcaatgttc
     2821 tgggggggtc ctcgtgcacc cacagtgtag gacagttttg gtggtctggg ccctgctact
     2881 tgccctccat gctgggacca ggctccccgt gggcaagccc tgccctttcc ctcctcgccc
     2941 tagtggacat gacaatgaag ggtgaggagg cccacagcac agcacatggg ggctttgcac
     3001 tttgggatga ggaggagctc tggctagcag aacaggaact gcatccttgg gaccatcagg
     3061 aaaaaaaggt ccaggctagt gtggggggac tcttctggag ctcctccaga gcctttgttc
     3121 tttctggggt ccaggaactg cccacctttc ctaaggactc ctcaggagtg agccaggccc
     3181 agcaggtcca gtgctgaccc acctggctca agttgtatat atagagctcc tttggccata
     3241 ttaaccacac aagctgagcc cagcccaggc tccgcaccca gaggtgcctt tgtgccttcc
     3301 tcaggcctgg agggcctcag ctctggccac cctcactctc ctcagccccg gttgtggttt
     3361 gggctgtatg aactggggag acatcagagg cctcttggct cccaaccaga tgtccccaca
     3421 gggtgggccc tgggtgcctc tgcagcctcg gctcccaccg cctggattga ccactgttaa
     3481 gtgcctgcct ctgtatatcc tattaataaa ctaaaataaa gggaagccct actggtggct
     3541 acgtgaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa
//
