LOCUS       NM_001360007            4152 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus dynamin 1-like (Dnm1l), transcript variant 6, mRNA.
ACCESSION   NM_001360007
VERSION     NM_001360007.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4152)
  AUTHORS   Yadav,S., Ganta,V.C., Varadarajan,S., Ong,V., Shi,Y., Das,A.,
            Ash,D., Nagarkoti,S., McMenamin,M., Kelley,S., Fukai,T. and
            Ushio-Fukai,M.
  TITLE     Myeloid DRP1 deficiency limits revascularization in ischemic
            muscles via inflammatory macrophage polarization and metabolic
            reprogramming
  JOURNAL   JCI Insight 10 (1), e177334 (2025)
   PUBMED   39589842
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4152)
  AUTHORS   Zhang,J., Wang,S., Zhang,H., Yang,X., Ren,X., Wang,L., Yang,Y.,
            Yang,Y. and Wen,Y.
  TITLE     Drp1 acetylation mediated by CDK5-AMPK-GCN5L1 axis promotes
            cerebral ischemic injury via facilitating mitochondrial fission
  JOURNAL   Mol Med 30 (1), 173 (2024)
   PUBMED   39390372
  REMARK    GeneRIF: Drp1 acetylation mediated by CDK5-AMPK-GCN5L1 axis
            promotes cerebral ischemic injury via facilitating mitochondrial
            fission.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4152)
  AUTHORS   Li,X., Pham,K., Ysaguirre,J., Mahmud,I., Tan,L., Wei,B., Shao,L.J.,
            Elizondo,M., Habib,R., Elizondo,F., Sesaki,H., Lorenzi,P.L. and
            Sun,K.
  TITLE     Mechanistic insights into metabolic function of dynamin-related
            protein 1
  JOURNAL   J Lipid Res 65 (9), 100633 (2024)
   PUBMED   39182608
  REMARK    GeneRIF: Mechanistic insights into metabolic function of
            dynamin-related protein 1.
REFERENCE   4  (bases 1 to 4152)
  AUTHORS   Tang,S., Fuss,A., Fattahi,Z. and Culmsee,C.
  TITLE     Drp1 depletion protects against ferroptotic cell death by
            preserving mitochondrial integrity and redox homeostasis
  JOURNAL   Cell Death Dis 15 (8), 626 (2024)
   PUBMED   39191736
  REMARK    GeneRIF: Drp1 depletion protects against ferroptotic cell death by
            preserving mitochondrial integrity and redox homeostasis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4152)
  AUTHORS   Du,Y., He,J., Xu,Y., Wu,X., Cheng,H., Yu,J., Wang,X., An,Y., Wu,Y.
            and Guo,W.
  TITLE     SIRT6 prevent chronic cerebral hypoperfusion induced cognitive
            impairment by remodeling mitochondrial dynamics in a
            STAT5-PGAM5-Drp1 dependent manner
  JOURNAL   J Transl Med 22 (1), 788 (2024)
   PUBMED   39183280
  REMARK    GeneRIF: SIRT6 prevent chronic cerebral hypoperfusion induced
            cognitive impairment by remodeling mitochondrial dynamics in a
            STAT5-PGAM5-Drp1 dependent manner.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4152)
  AUTHORS   Brooks,C., Wei,Q., Cho,S.G. and Dong,Z.
  TITLE     Regulation of mitochondrial dynamics in acute kidney injury in cell
            culture and rodent models
  JOURNAL   J Clin Invest 119 (5), 1275-1285 (2009)
   PUBMED   19349686
  REMARK    GeneRIF: Mitochondrial fragmentation in acute kidney injury
            involves the activation of mitochondrial fission via Drp1.
REFERENCE   7  (bases 1 to 4152)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   8  (bases 1 to 4152)
  AUTHORS   Honda,S. and Hirose,S.
  TITLE     Stage-specific enhanced expression of mitochondrial fusion and
            fission factors during spermatogenesis in rat testis
  JOURNAL   Biochem Biophys Res Commun 311 (2), 424-432 (2003)
   PUBMED   14592431
REFERENCE   9  (bases 1 to 4152)
  AUTHORS   VanBuren,V., Piao,Y., Dudekula,D.B., Qian,Y., Carter,M.G.,
            Martin,P.R., Stagg,C.A., Bassey,U.C., Aiba,K., Hamatani,T.,
            Kargul,G.J., Luo,A.G., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Assembly, verification, and initial annotation of the NIA mouse
            7.4K cDNA clone set
  JOURNAL   Genome Res 12 (12), 1999-2003 (2002)
   PUBMED   12466305
REFERENCE   10 (bases 1 to 4152)
  AUTHORS   Kamimoto,T., Nagai,Y., Onogi,H., Muro,Y., Wakabayashi,T. and
            Hagiwara,M.
  TITLE     Dymple, a novel dynamin-like high molecular weight GTPase lacking a
            proline-rich carboxyl-terminal domain in mammalian cells
  JOURNAL   J Biol Chem 273 (2), 1044-1051 (1998)
   PUBMED   9422767
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC112943.12.
            
            On Apr 21, 2022 this sequence version replaced NM_001360007.1.
            
            Summary: This gene encodes a member of the dynamin family. The
            encoded protein is localized to the cytoplasm and mitochondrial
            membrane, is involved in mitochondrial and peroxisomal division,
            and is essential for mitochondrial fission. Alternative splicing
            results in multiple transcript variants. A related pseudogene has
            been identified on chromosome 2. [provided by RefSeq, Feb 2013].
            
            Transcript Variant: This variant (6) represents the longest
            transcript and encodes the longest isoform (e).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.83048.1,
                                           SRR1660819.17040.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-236               AC112943.12        216778-217013       c
            237-402             AC112943.12        203994-204159       c
            403-441             AC112943.12        200711-200749       c
            442-488             AC112943.12        199436-199482       c
            489-560             AC112943.12        199010-199081       c
            561-647             AC112943.12        196607-196693       c
            648-810             AC112943.12        194867-195029       c
            811-931             AC112943.12        191843-191963       c
            932-1063            AC112943.12        190015-190146       c
            1064-1270           AC112943.12        187817-188023       c
            1271-1391           AC112943.12        181989-182109       c
            1392-1547           AC112943.12        181636-181791       c
            1548-1637           AC112943.12        181344-181433       c
            1638-1730           AC112943.12        179598-179690       c
            1731-1787           AC112943.12        177466-177522       c
            1788-1865           AC112943.12        176778-176855       c
            1866-1898           AC112943.12        176459-176491       c
            1899-2075           AC112943.12        174616-174792       c
            2076-2185           AC112943.12        174348-174457       c
            2186-2345           AC112943.12        172278-172437       c
            2346-4152           AC112943.12        170251-172057       c
FEATURES             Location/Qualifiers
     source          1..4152
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 10.12 cM"
     gene            1..4152
                     /gene="Dnm1l"
                     /gene_synonym="6330417M19Rik; Dlp1; Dnmlp1; Drp1; python"
                     /note="dynamin 1-like"
                     /db_xref="GeneID:74006"
                     /db_xref="MGI:MGI:1921256"
     exon            1..236
                     /gene="Dnm1l"
                     /gene_synonym="6330417M19Rik; Dlp1; Dnmlp1; Drp1; python"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..2402
                     /gene="Dnm1l"
                     /gene_synonym="6330417M19Rik; Dlp1; Dnmlp1; Drp1; python"
                     /EC_number="3.6.5.5"
                     /note="isoform e is encoded by transcript variant 6;
                     dymple; dynamin-1-like protein; dynamin-related protein 1;
                     dynamin family member proline-rich carboxyl-terminal
                     domain less"
                     /codon_start=1
                     /product="dynamin-1-like protein isoform e"
                     /protein_id="NP_001346936.1"
                     /db_xref="GeneID:74006"
                     /db_xref="MGI:MGI:1921256"
                     /translation="MEALIPVINKLQDVFNTVGADIIQLPQIVVVGTQSSGKSSVLES
                     LVGRDLLPRGTGVVTRRPLILQLVHVSPEDKRKTTGEENGKFQSWNPATWKNSRHLSK
                     GVEAEEWGKFLHTKNKLYTDFDEIRQEIENETERISGNNKGVSPEPIHLKVFSPNVVN
                     LTLVDLPGMTKVPVGDQPKDIELQIRELILRFISNPNSIILAVTAANTDMATSEALKI
                     SREVDPDGRRTLAVITKLDLMDAGTDAMDVLMGRVIPVKLGIIGVVNRSQLDINNKKS
                     VTDSIRDEYAFLQKKYPSLANRNGTKYLARTLNRLLMHHIRDCLPELKTRINVLAAQY
                     QSLLNSYGEPVDDKSATLLQLITKFATEYCNTIEGTAKYIETSELCGGARICYIFHET
                     FGRTLESVDPLGGLNTIDILTAIRNATGPRPALFVPEVSFELLVKRQIKRLEEPSLRC
                     VELVHEEMQRIIQHCSNYSTQELLRFPKLHDAIVEVVTCLLRKRLPVTNEMVHNLVAI
                     ELAYINTKHPDFADACGLMNNNIEEQRRNRLARELPSAGSRDKSSKVPSALAPASQEP
                     PPAASAEADGKLIQDNRRETKNVPSAGGGIGDGGQEPTTGNWRGMLKTSKAEELLAEE
                     KSKPIPIMPASPQKGHAVNLLDVPVPVARKLSAREQRDCEVIERLIKSYFLIVRKNIQ
                     DSVPKAVMHFLVNHVKDTLQSELVGQLYKSSLLDDLLTESEDMAQRRKEAADMLKALQ
                     GASQIIAEIRETHLW"
     exon            237..402
                     /gene="Dnm1l"
                     /gene_synonym="6330417M19Rik; Dlp1; Dnmlp1; Drp1; python"
                     /inference="alignment:Splign:2.1.0"
     exon            403..441
                     /gene="Dnm1l"
                     /gene_synonym="6330417M19Rik; Dlp1; Dnmlp1; Drp1; python"
                     /inference="alignment:Splign:2.1.0"
     exon            442..488
                     /gene="Dnm1l"
                     /gene_synonym="6330417M19Rik; Dlp1; Dnmlp1; Drp1; python"
                     /inference="alignment:Splign:2.1.0"
     exon            489..560
                     /gene="Dnm1l"
                     /gene_synonym="6330417M19Rik; Dlp1; Dnmlp1; Drp1; python"
                     /inference="alignment:Splign:2.1.0"
     exon            561..647
                     /gene="Dnm1l"
                     /gene_synonym="6330417M19Rik; Dlp1; Dnmlp1; Drp1; python"
                     /inference="alignment:Splign:2.1.0"
     exon            648..810
                     /gene="Dnm1l"
                     /gene_synonym="6330417M19Rik; Dlp1; Dnmlp1; Drp1; python"
                     /inference="alignment:Splign:2.1.0"
     exon            811..931
                     /gene="Dnm1l"
                     /gene_synonym="6330417M19Rik; Dlp1; Dnmlp1; Drp1; python"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1063
                     /gene="Dnm1l"
                     /gene_synonym="6330417M19Rik; Dlp1; Dnmlp1; Drp1; python"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1270
                     /gene="Dnm1l"
                     /gene_synonym="6330417M19Rik; Dlp1; Dnmlp1; Drp1; python"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1391
                     /gene="Dnm1l"
                     /gene_synonym="6330417M19Rik; Dlp1; Dnmlp1; Drp1; python"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1547
                     /gene="Dnm1l"
                     /gene_synonym="6330417M19Rik; Dlp1; Dnmlp1; Drp1; python"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1637
                     /gene="Dnm1l"
                     /gene_synonym="6330417M19Rik; Dlp1; Dnmlp1; Drp1; python"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..1730
                     /gene="Dnm1l"
                     /gene_synonym="6330417M19Rik; Dlp1; Dnmlp1; Drp1; python"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..1787
                     /gene="Dnm1l"
                     /gene_synonym="6330417M19Rik; Dlp1; Dnmlp1; Drp1; python"
                     /inference="alignment:Splign:2.1.0"
     exon            1788..1865
                     /gene="Dnm1l"
                     /gene_synonym="6330417M19Rik; Dlp1; Dnmlp1; Drp1; python"
                     /inference="alignment:Splign:2.1.0"
     exon            1866..1898
                     /gene="Dnm1l"
                     /gene_synonym="6330417M19Rik; Dlp1; Dnmlp1; Drp1; python"
                     /inference="alignment:Splign:2.1.0"
     exon            1899..2075
                     /gene="Dnm1l"
                     /gene_synonym="6330417M19Rik; Dlp1; Dnmlp1; Drp1; python"
                     /inference="alignment:Splign:2.1.0"
     exon            2076..2185
                     /gene="Dnm1l"
                     /gene_synonym="6330417M19Rik; Dlp1; Dnmlp1; Drp1; python"
                     /inference="alignment:Splign:2.1.0"
     exon            2186..2345
                     /gene="Dnm1l"
                     /gene_synonym="6330417M19Rik; Dlp1; Dnmlp1; Drp1; python"
                     /inference="alignment:Splign:2.1.0"
     exon            2346..4152
                     /gene="Dnm1l"
                     /gene_synonym="6330417M19Rik; Dlp1; Dnmlp1; Drp1; python"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2981..2986
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dnm1l"
                     /gene_synonym="6330417M19Rik; Dlp1; Dnmlp1; Drp1; python"
                     /note="hexamer: ATTAAA"
     polyA_site      3006
                     /gene="Dnm1l"
                     /gene_synonym="6330417M19Rik; Dlp1; Dnmlp1; Drp1; python"
                     /note="major polyA site"
     regulatory      4126..4131
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dnm1l"
                     /gene_synonym="6330417M19Rik; Dlp1; Dnmlp1; Drp1; python"
                     /note="hexamer: AATAAA"
     polyA_site      4152
                     /gene="Dnm1l"
                     /gene_synonym="6330417M19Rik; Dlp1; Dnmlp1; Drp1; python"
                     /note="major polyA site"
ORIGIN      
        1 gggtgctggc ccggcccaat gggtgcgggc tcccgaggaa agggcggagg agaagaggaa
       61 gcaagcgggc tgtgggtcga gtccccattc attgcagtgg cctgctgggt tgggggtcca
      121 gtgtttcggg ggtcatggag gcgctgatcc cggtcatcaa taagctgcag gacgtcttca
      181 acacagtggg tgcggacatc atccagctgc ctcagatcgt cgtagtggga acgcagagca
      241 gtgggaagag ctcagtgctg gaaagcctag tgggcaggga ccttcttccc agaggaactg
      301 gtgtggtcac ccggagacct ctcattctgc agctagtcca cgtttcacca gaagataaaa
      361 gaaaaacaac aggagaagaa aatggtaaat ttcagagctg gaaccctgcc acatggaaaa
      421 actcaagaca cctttccaaa ggagttgaag cagaagaatg gggtaaattt cttcacacca
      481 aaaacaagct ttacacagat tttgatgaaa ttcgacaaga aattgaaaat gaaactgaaa
      541 gaatttcagg aaataataag ggggtaagcc ctgagccaat ccatctcaag gttttctcgc
      601 ccaacgttgt caacctgaca cttgtggatt taccgggaat gaccaaagta cctgtaggcg
      661 atcagcccaa ggacatcgag cttcagatca gagaacttat tcttcggttc atcagtaatc
      721 ccaattccat tatcctcgcc gtcactgctg caaatacaga tatggcaaca tcagaagcac
      781 tcaagatttc cagagaggta gatccagatg ggcgcagaac tctagctgta atcactaaac
      841 ttgatctcat ggatgcgggt actgatgcca tggatgtatt gatgggaagg gttattccag
      901 tcaagcttgg aataattgga gtagttaaca gaagccaact ggatattaac aataagaaga
      961 gtgtaactga ttcaatccgt gatgagtatg cttttcttca aaagaagtac ccatctctgg
     1021 ccaacagaaa tggaacaaag tatcttgcta ggaccctgaa taggttactt atgcatcata
     1081 tcagagattg tttaccagag ctgaaaacaa gaataaatgt cttagctgct cagtatcagt
     1141 ctcttctaaa tagctatggt gaaccggtgg atgataaaag tgctacttta ctccagctta
     1201 ttaccaaatt tgccacagag tattgtaaca cgattgaagg aaccgcaaag tacattgaaa
     1261 cttctgagct atgcggtggt gctaggattt gttatatttt ccatgagact ttcgggcgaa
     1321 ccttagaatc tgtggaccca ctaggtggcc ttaacactat tgacatcctg actgccatca
     1381 gaaatgctac tggcccccgt cctgctttat ttgtgcctga agtttcattt gagttactgg
     1441 tcaaacgtca gattaagcgt ctagaagagc ccagcctacg gtgtgtggag ctggtccatg
     1501 aggagatgca gaggatcatt cagcattgta gcaattacag cacacaggaa ttgttacggt
     1561 tccctaaact tcacgatgcc atagttgaag tagtgacctg tcttcttcgt aaaaggttgc
     1621 ccgtgacaaa tgaaatggtg cataacttag tggcaattga gctagcgtat atcaacacaa
     1681 aacaccccga ctttgctgat gcctgtgggc taatgaacaa taatatagag gaacaaagaa
     1741 gaaacaggct agcaagagag ctgccttcag ctggatcacg ggacaagtct tctaaagttc
     1801 caagtgcttt ggcacctgcc tcccaggagc ccccccctgc tgcttctgct gaggctgatg
     1861 gcaagttaat tcaggacaac agaagagaaa ctaaaaatgt cccatctgca ggtggtggga
     1921 ttggagacgg tggtcaggaa ccaacaacag gcaactggag aggaatgctg aaaacttcaa
     1981 aagctgaaga attacttgct gaagaaaaat caaaaccaat tccaattatg ccagcaagtc
     2041 cacagaaagg ccatgctgtc aatttgctag atgtgccagt tccagttgca agaaaactgt
     2101 ctgcccgaga acagcgagat tgtgaggtta ttgaaagact tatcaaatca tattttctaa
     2161 ttgtcagaaa gaatattcaa gacagtgtcc caaaggcagt aatgcatttt ttggttaatc
     2221 atgtgaaaga tactcttcag agtgaactgg tagggcagct gtataagtca tccttattag
     2281 atgaccttct gactgaatcc gaggacatgg cccaacgaag aaaagaagca gcggatatgc
     2341 tgaaggcatt acaaggagcc agtcaaatta ttgctgaaat ccgagagact catctttggt
     2401 gaacagaact gtttgatatc cacactttgc tgacttgaac ctgctgctgc ctacctgagt
     2461 agaagtttat gaacttttgt gtattgcagt gtatgaattt gctcgtgtga agactggcta
     2521 taagctgaaa agtatattat tcgttacaaa acaaatcaca tgtttaattc acatttttca
     2581 agtttcctat gacgtatatc aagtctgtcc gtttcagtcg aacttacaag agcaattgat
     2641 attctagttg tacaaagcag tttgcctgtg catatgaccc atgtaacttt cttagtctca
     2701 aagctgcagc tgtagtcctc agaaaggaag ctccaggaca tttcatgact ataatgcatg
     2761 cactatttat atagactgac ctggctttaa aagatggagc ctggcaagtt cctcacataa
     2821 tcaatgtatc cacctatcct tcatttttat agtcttaaaa aacaaacaaa actcttttgc
     2881 agtttcaaga aatatataag atcttaaaga ctcatcaaga tgtaggaaca gactgtgtaa
     2941 ttaatggctc ctgagtctac actgccctgg tgcattagaa attaaaaata ctttgattct
     3001 aaaaaagcct gaaaatttaa tgacttcctg cattaaaaac aactattggg aactgttagt
     3061 aacaatggct agtcctatta gtctctaaat gatccaatga taacctaaat ttctcttatt
     3121 tacaaataca gcaattgcaa tccagataca cccttaaaat ggggcactta aattgggctc
     3181 caagactcac agttaaatgg aacctaaaat tccactcttt atccactggt aatagctact
     3241 ttagttccac gccaacagaa tacattagac taatggtatg aaaacactag tggaccttta
     3301 ttaaagaaaa acatctggac acacacatac atacacctaa aagcttatgg acttcattca
     3361 gggggttagg gtaatgttta caacctattt tgtgaaaact gcctgtacaa atcgtctttt
     3421 aaactaagca ttgaaaagtt ttctcaccta gctgggcagt ggtggtgcaa gcctttaatc
     3481 ccagcacttg ggaggcagac gtgggtggag gatctctgag ttcaaggcca ccgtggttcc
     3541 agacaactag aactacagag aaaccttgtc ttgaaaaacc caaaaaattg aaacctaagt
     3601 agaaatcctt gatgtatcta gttgtctctg accaaatgat acattcgttt tataaatact
     3661 aaaattcttt tcaggttatg gtcaggcatc ttatgaaata ctattagcaa ggaaaacaag
     3721 aacatgttat ctttagttta tgatgcccac tgagcaatct caaaatcata aaagcagttt
     3781 gatacagtac cggcttgaca gtgagtacac actgcctaaa tgtgttagca tactttaaaa
     3841 aaataccctc ttatccaact attaggtatc agtgacttaa ttttttaaga aagatgacca
     3901 ccactgtagc ctttttgaat ttgtaaggac aaagaaatgc acctttatcc aacatttcaa
     3961 ataaatttta aatggaagat gtttagcact acacactttg tacaaaggaa aacaagcaag
     4021 aaacagggaa aggggaagct tcctttgtgt gcttttacac tgatgtgttc tgaaacatgg
     4081 agataatttc tggcatattt ataagacgac tgtatgttct atgtaaataa aaatgctggt
     4141 gtgcaattgc ca
//
