LOCUS       NM_001368679            3818 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus dynamin 1 (Dnm1), transcript variant 4, mRNA.
ACCESSION   NM_001368679 XM_006497651
VERSION     NM_001368679.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3818)
  AUTHORS   Hanke-Gogokhia,C., Zapadka,T.E., Finkelstein,S., Klingeborn,M.,
            Maugel,T.K., Singer,J.H., Arshavsky,V.Y. and Demb,J.B.
  TITLE     The Structural and Functional Integrity of Rod Photoreceptor Ribbon
            Synapses Depends on Redundant Actions of Dynamins 1 and 3
  JOURNAL   J Neurosci 44 (25), e1379232024 (2024)
   PUBMED   38641407
  REMARK    GeneRIF: The Structural and Functional Integrity of Rod
            Photoreceptor Ribbon Synapses Depends on Redundant Actions of
            Dynamins 1 and 3.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3818)
  AUTHORS   Jiang,A., Kudo,K., Gormal,R.S., Ellis,S., Guo,S., Wallis,T.P.,
            Longfield,S.F., Robinson,P.J., Johnson,M.E., Joensuu,M. and
            Meunier,F.A.
  TITLE     Dynamin1 long- and short-tail isoforms exploit distinct recruitment
            and spatial patterns to form endocytic nanoclusters
  JOURNAL   Nat Commun 15 (1), 4060 (2024)
   PUBMED   38744819
  REMARK    GeneRIF: Dynamin1 long- and short-tail isoforms exploit distinct
            recruitment and spatial patterns to form endocytic nanoclusters.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3818)
  AUTHORS   Bekku,Y., Zotter,B., You,C., Piehler,J., Leonard,W.J. and
            Salzer,J.L.
  TITLE     Glia trigger endocytic clearance of axonal proteins to promote
            rodent myelination
  JOURNAL   Dev Cell 59 (5), 627-644 (2024)
   PUBMED   38309265
REFERENCE   4  (bases 1 to 3818)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 3818)
  AUTHORS   Boumil,R.M., Letts,V.A., Roberts,M.C., Lenz,C., Mahaffey,C.L.,
            Zhang,Z.W., Moser,T. and Frankel,W.N.
  TITLE     A missense mutation in a highly conserved alternate exon of
            dynamin-1 causes epilepsy in fitful mice
  JOURNAL   PLoS Genet 6 (8), e1001046 (2010)
   PUBMED   20700442
  REMARK    GeneRIF: Missense mutation in conserved alternate exon of dynamin-1
            causes epilepsy in a mouse model.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3818)
  AUTHORS   Di Paolo,G., Sankaranarayanan,S., Wenk,M.R., Daniell,L.,
            Perucco,E., Caldarone,B.J., Flavell,R., Picciotto,M.R., Ryan,T.A.,
            Cremona,O. and De Camilli,P.
  TITLE     Decreased synaptic vesicle recycling efficiency and cognitive
            deficits in amphiphysin 1 knockout mice
  JOURNAL   Neuron 33 (5), 789-804 (2002)
   PUBMED   11879655
REFERENCE   7  (bases 1 to 3818)
  AUTHORS   Yoo,J., Lee,S.S., Jeong,M.J., Lee,K.I., Kwon,B.M., Kim,S.H.,
            Park,Y.M. and Han,M.Y.
  TITLE     Characterization of the mouse dynamin I gene promoter and
            identification of sequences that direct expression in neuronal
            cells
  JOURNAL   Biochem J 351 Pt 3 (Pt 3), 661-668 (2000)
   PUBMED   11042120
REFERENCE   8  (bases 1 to 3818)
  AUTHORS   Noakes,P.G., Chin,D., Kim,S.S., Liang,S. and Phillips,W.D.
  TITLE     Expression and localisation of dynamin and syntaxin during neural
            development and neuromuscular synapse formation
  JOURNAL   J Comp Neurol 410 (4), 531-540 (1999)
   PUBMED   10398046
REFERENCE   9  (bases 1 to 3818)
  AUTHORS   Klocke,R., Augustin,A., Ronsiek,M., Stief,A., van der Putten,H. and
            Jockusch,H.
  TITLE     Dynamin genes Dnm1 and Dnm2 are located on proximal mouse
            chromosomes 2 and 9, respectively
  JOURNAL   Genomics 41 (2), 290-292 (1997)
   PUBMED   9143510
REFERENCE   10 (bases 1 to 3818)
  AUTHORS   Newman-Smith,E.D., Shurland,D.L. and van der Bliek,A.M.
  TITLE     Assignment of the dynamin-1 gene (DNM1) to human chromosome 9q34 by
            fluorescence in situ hybridization and somatic cell hybrid analysis
  JOURNAL   Genomics 41 (2), 286-289 (1997)
   PUBMED   9143509
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL808027.14.
            
            On Feb 14, 2019 this sequence version replaced XM_006497651.2.
            
            Summary: This gene encodes a member of the dynamin subfamily of
            GTP-binding proteins. The encoded protein is a GTPase which is
            required for membrane recycling, including vesicle endocytosis in
            neurons. It may also be involved in cellular fission via
            association with microtubules and actin filaments. Mutations in
            this gene have been shown to cause seizures. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Sep
            2014].
            
            Transcript Variant: This variant (4) contains two alternate exons
            in the mid-coding region and uses an alternate acceptor splice site
            at the 3' terminal exon compared to variant one. The resulting
            isoform (3) is longer than isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164131,
                              SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-281               AL808027.14        206400-206680       c
            282-355             AL808027.14        194184-194257       c
            356-505             AL808027.14        193767-193916       c
            506-709             AL808027.14        193272-193475       c
            710-808             AL808027.14        191352-191450       c
            809-969             AL808027.14        191085-191245       c
            970-1112            AL808027.14        189535-189677       c
            1113-1248           AL808027.14        189289-189424       c
            1249-1316           AL808027.14        189127-189194       c
            1317-1455           AL808027.14        186417-186555       c
            1456-1542           AL808027.14        181312-181398       c
            1543-1613           AL808027.14        177011-177081       c
            1614-1665           AL808027.14        176773-176824       c
            1666-1677           AL808027.14        176530-176541       c
            1678-1791           AL808027.14        173855-173968       c
            1792-1901           AL808027.14        170249-170358       c
            1902-2013           AL808027.14        169150-169261       c
            2014-2025           AL808027.14        168687-168698       c
            2026-2196           AL808027.14        168241-168411       c
            2197-2438           AL808027.14        166035-166276       c
            2439-2654           AL808027.14        165478-165693       c
            2655-3818           AL808027.14        161822-162985       c
FEATURES             Location/Qualifiers
     source          1..3818
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 22.09 cM"
     gene            1..3818
                     /gene="Dnm1"
                     /gene_synonym="Dnm; Ftfl; mKIAA4093"
                     /note="dynamin 1"
                     /db_xref="GeneID:13429"
                     /db_xref="MGI:MGI:107384"
     exon            1..281
                     /gene="Dnm1"
                     /gene_synonym="Dnm; Ftfl; mKIAA4093"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..2724
                     /gene="Dnm1"
                     /gene_synonym="Dnm; Ftfl; mKIAA4093"
                     /EC_number="3.6.5.5"
                     /note="isoform 3 is encoded by transcript variant 4;
                     dynamin I"
                     /codon_start=1
                     /product="dynamin-1 isoform 3"
                     /protein_id="NP_001355608.1"
                     /db_xref="GeneID:13429"
                     /db_xref="MGI:MGI:107384"
                     /translation="MGNRGMEDLIPLVNRLQDAFSAIGQNADLDLPQIAVVGGQSAGK
                     SSVLENFVGRDFLPRGSGIVTRRPLVLQLVNSTTEYAEFLHCKGKKFTDFEEVRLEIE
                     AETDRVTGTNKGISPVPINLRVYSPHVLNLTLVDLPGMTKVPVGDQPPDIEFQIRDML
                     MQFVTKENCLILAVSPANSDLANSDALKIAKEVDPQGQRTIGVITKLDLMDEGTDARD
                     VLENKLLPLRRGYIGVVNRSQKDIDGKKDITAALAAERKFFLSHPSYRHLADRMGTPY
                     LQKVLNQQLTNHIRDTLPGLRNKLQSQLLSIEKEVDEYKNFRPDDPARKTKALLQMVQ
                     QFAVDFEKRIEGSGDQIDTYELSGGARINRIFHERFPFELVKMEFDEKELRREISYAI
                     KNIHGIRTGLFTPDLAFEATVKKQVQKLKEPSIKCVDMVVSELTSTIRKCSEKLQQYP
                     RLREEMERIVTTHIREREGRTKEQVMLLIDIELAYMNTNHEDFIGFANAQQRSNQMNK
                     KKTSGNQDEILVIRKGWLTINNIGIMKGGSKEYWFVLTAENLSWYKDDEEKEKKYMLS
                     VDNLKLRDVEKGFMSSKHIFALFNTEQRNVYKDYRQLELACETQEEVDSWKASFLRAG
                     VYPERVGDKEKASETEENGSDSFMHSMDPQLERQVETIRNLVDSYMAIVNKTVRDLMP
                     KTIMHLMINNTKEFIFSELLANLYSCGDQNTLMEESAEQAQRRDEMLRMYHALKEALS
                     IIGDINTTTVSTPMPPPVDDSWLQVQSVPAGRRSPTSSPTPQRRAPAVPPARPGSRGP
                     APGPPPAGSALGGAPPVPSRPGASPDPFGPPPQVPSRPNRAPPGVPRKGPASPTRPAA
                     PRPTEAPLLDL"
     exon            282..355
                     /gene="Dnm1"
                     /gene_synonym="Dnm; Ftfl; mKIAA4093"
                     /inference="alignment:Splign:2.1.0"
     exon            356..505
                     /gene="Dnm1"
                     /gene_synonym="Dnm; Ftfl; mKIAA4093"
                     /inference="alignment:Splign:2.1.0"
     exon            506..709
                     /gene="Dnm1"
                     /gene_synonym="Dnm; Ftfl; mKIAA4093"
                     /inference="alignment:Splign:2.1.0"
     exon            710..808
                     /gene="Dnm1"
                     /gene_synonym="Dnm; Ftfl; mKIAA4093"
                     /inference="alignment:Splign:2.1.0"
     exon            809..969
                     /gene="Dnm1"
                     /gene_synonym="Dnm; Ftfl; mKIAA4093"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1112
                     /gene="Dnm1"
                     /gene_synonym="Dnm; Ftfl; mKIAA4093"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1248
                     /gene="Dnm1"
                     /gene_synonym="Dnm; Ftfl; mKIAA4093"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1316
                     /gene="Dnm1"
                     /gene_synonym="Dnm; Ftfl; mKIAA4093"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1455
                     /gene="Dnm1"
                     /gene_synonym="Dnm; Ftfl; mKIAA4093"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1542
                     /gene="Dnm1"
                     /gene_synonym="Dnm; Ftfl; mKIAA4093"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1613
                     /gene="Dnm1"
                     /gene_synonym="Dnm; Ftfl; mKIAA4093"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..1665
                     /gene="Dnm1"
                     /gene_synonym="Dnm; Ftfl; mKIAA4093"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..1677
                     /gene="Dnm1"
                     /gene_synonym="Dnm; Ftfl; mKIAA4093"
                     /inference="alignment:Splign:2.1.0"
     exon            1678..1791
                     /gene="Dnm1"
                     /gene_synonym="Dnm; Ftfl; mKIAA4093"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..1901
                     /gene="Dnm1"
                     /gene_synonym="Dnm; Ftfl; mKIAA4093"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..2013
                     /gene="Dnm1"
                     /gene_synonym="Dnm; Ftfl; mKIAA4093"
                     /inference="alignment:Splign:2.1.0"
     exon            2014..2025
                     /gene="Dnm1"
                     /gene_synonym="Dnm; Ftfl; mKIAA4093"
                     /inference="alignment:Splign:2.1.0"
     exon            2026..2196
                     /gene="Dnm1"
                     /gene_synonym="Dnm; Ftfl; mKIAA4093"
                     /inference="alignment:Splign:2.1.0"
     exon            2197..2438
                     /gene="Dnm1"
                     /gene_synonym="Dnm; Ftfl; mKIAA4093"
                     /inference="alignment:Splign:2.1.0"
     exon            2439..2654
                     /gene="Dnm1"
                     /gene_synonym="Dnm; Ftfl; mKIAA4093"
                     /inference="alignment:Splign:2.1.0"
     exon            2655..3818
                     /gene="Dnm1"
                     /gene_synonym="Dnm; Ftfl; mKIAA4093"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3790..3795
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dnm1"
                     /gene_synonym="Dnm; Ftfl; mKIAA4093"
                     /note="hexamer: AATAAA"
     polyA_site      3818
                     /gene="Dnm1"
                     /gene_synonym="Dnm; Ftfl; mKIAA4093"
                     /note="major polyA site"
ORIGIN      
        1 gaggggcggg ggacccgcgg cgcacgcagt cgggatattc ggctgcagcc gcgaagccgg
       61 gggccaagag ccagagcagg agcggcggcc ggatcgcagc ccgccgggcc cgccgcaacc
      121 atgggcaacc gcggcatgga agacctcatc ccgctggtta accggttaca ggacgccttc
      181 tccgccatcg gccagaacgc ggacctcgac ctgccgcaga tcgccgtggt aggcggccag
      241 agcgccggca agagctcggt gctggagaat ttcgtgggca gggacttctt gccccgagga
      301 tctggcatcg tcacccggcg tcccctggtc ctgcagctgg ttaattctac cacagaatat
      361 gccgagttcc tgcactgcaa ggggaagaaa ttcaccgact tcgaggaggt gcgcctggag
      421 atcgaggctg agaccgatcg agtcaccggc accaacaagg gcatttcgcc agtgcccatc
      481 aacctgcggg tctactcgcc ccatgtgctg aacctgactc tagtggacct gccaggaatg
      541 accaaggtcc cagttgggga ccaacctcct gatatcgagt tccagatccg ggacatgctt
      601 atgcagttcg tcactaagga gaactgcctt atcctggctg tgtcccctgc caactcggat
      661 ttggccaact ctgatgccct caagatcgct aaggaggtgg acccccaggg tcagcgcacc
      721 attggggtca tcaccaagtt ggacctgatg gacgagggca cagatgcgcg ggacgtgcta
      781 gagaacaagc tgctcccttt gcgcagaggt tacatcggcg tggtgaaccg gagccagaag
      841 gacatagacg gcaagaagga catcacagcc gccttggctg cagagcgcaa attcttcctc
      901 tctcacccat cctaccgcca cttggctgac cgcatgggca caccctacct gcagaaggtc
      961 ctcaatcagc aattgaccaa ccacatccgg gacacactgc cgggacttcg gaacaagctg
     1021 cagagccagc tgctgtccat tgagaaggag gtggacgagt acaagaactt ccgaccggat
     1081 gacccagcgc gcaagaccaa ggccctgctg cagatggtcc agcagtttgc agtggacttc
     1141 gagaagcgca tcgagggttc tggagaccag attgacactt acgagctgtc aggtggagcc
     1201 cgcattaacc ggatcttcca tgaacgcttc ccctttgagc tggttaagat ggagtttgat
     1261 gagaaggaac tgcgaaggga gatcagctat gctatcaaaa atatccatgg catcaggacg
     1321 ggcctcttca cacctgacct cgcttttgaa gccacagtga aaaagcaggt gcagaagctc
     1381 aaagagccca gtatcaagtg tgtggacatg gtagtcagtg aactcacgtc caccatcaga
     1441 aagtgtagtg aaaagctgca gcaatacccg cgtctgcggg aggagatgga gcgaattgtg
     1501 accacccaca tccgggaacg tgagggccgc accaaggagc aggtcatgct tctcatcgac
     1561 attgagctgg cttacatgaa taccaaccac gaagacttca taggctttgc caatgctcag
     1621 cagagaagca accagatgaa caagaagaag acttcaggga accaggatga gattctggtc
     1681 attcgaaagg ggtggttgac catcaacaac atcggcatca tgaagggagg ctccaaggag
     1741 tactggtttg tgctgactgc tgagaatctg tcctggtaca aggatgatga ggagaaagag
     1801 aagaagtaca tgctgtctgt ggacaatctg aagctgcgtg atgtggagaa gggcttcatg
     1861 tcaagcaagc atatttttgc cctcttcaac acagagcaga ggaatgtcta caaggattac
     1921 cggcagctgg aactggcctg tgagacacag gaggaggtgg acagttggaa ggcttccttc
     1981 ctgagggctg gcgtgtaccc tgagcgtgtt ggggacaaag agaaagccag tgagaccgag
     2041 gagaacggct ctgacagctt catgcactcg atggaccctc agctggagcg ccaggtggag
     2101 accatccgga acctggtaga ctcgtacatg gccattgtca acaagactgt gcgggacctc
     2161 atgcccaaga ccatcatgca cctcatgatc aacaacacca aggagtttat cttctctgag
     2221 ctgctggcca acctgtactc ttgcggggac cagaacacac tgatggaaga atcggccgag
     2281 caggctcagc ggcgcgacga gatgctgcgc atgtaccacg cactgaagga ggcgctcagt
     2341 attatcggcg acatcaacac gaccaccgtc agcacgccca tgcccccgcc cgtggacgac
     2401 tcctggctgc aggtgcagag cgtaccggcc ggacgcagat cgcccacgtc cagccccacg
     2461 ccgcagcgcc gagcccccgc cgtgccccca gcccggcccg gatcgcgggg ccctgctcct
     2521 gggcctccgc ctgctggatc cgccctgggg ggggcgcccc ccgtgccctc caggccgggg
     2581 gcttcccctg acccctttgg cccccctccc caggtgccct cgcgccccaa ccgcgccccg
     2641 cctggggtcc ccaggaaggg cccagcctca cctacgagac ctgcagcccc ccgaccaacg
     2701 gaggctcccc tcttagactt ataagtctgt ggccgcaggc atcggctgcc tgcctcccag
     2761 cctccccagg gtcccctcag aggactcctg actttctgac cacctgaggg gcctccagcg
     2821 ctccctccag ccatcccctt tagcttcaat ctcctggttc aagcacttct ggcctcatgg
     2881 ctgttacatg ggactccctg aggcttgggg tggccctgag ccagtgagat gagagacagt
     2941 gagcaaaaat gagggaggcc ctgtggtgca ttgcctgggt ggtgtgtgag aggccgtgtg
     3001 tgtggcaaga gagggccacc agcctctact cagactacct gctagttacg gcccagcacc
     3061 ccatcttccc tttcattcat caactgtgca tctcttccgg gaaccctgcc cacatccaca
     3121 cctgcctcag cccctgcctc tgctggaggt ggctgctctt gccttaccag ctctccttcc
     3181 ttttctctct tccgttctct ctcggctttc tctccaactg ccagccgatc gggtcaggca
     3241 agtccgtccc gtcctgagag ccccaggccc cccttcgacc tctaaccaga tccctcctac
     3301 tcctcggaga cctcccttac caagcctgcc tggacagctg ttctgtgact tgacagtggc
     3361 tcccccggcc ccaaagcgtc ctattcatca tctgtgactt agtctgttgt agtggtgagc
     3421 tgacacatcc agatgtgatg ttggtgaaaa cttgtgcccc tctgtggtat tgctcctgcg
     3481 acattctata aatatctata aatataccta tatatacata tatatacata tatatggctg
     3541 acacagcctc gcctgtagtg tcagaatcaa ccaccatgct gtccttgtgg agtcttgtgg
     3601 tccaacaagg gaacgctgtc atcctgacaa ccccccctcc agtgtaccac ctccagtgag
     3661 cccccctgtc ctcctggcct gtgaacagcc atccccttgg ccatcccaac cctgcagcaa
     3721 ggggatgctg cagcagcagc agctgtgcag ttctctggta gccaccagtc ttgctgtctc
     3781 ttggctgaga ataaaaccca tttctggatc atggggaa
//
