LOCUS       NM_001301737            3295 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus dynamin 1 (Dnm1), transcript variant 2, mRNA.
ACCESSION   NM_001301737 XM_006497657
VERSION     NM_001301737.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3295)
  AUTHORS   Hanke-Gogokhia,C., Zapadka,T.E., Finkelstein,S., Klingeborn,M.,
            Maugel,T.K., Singer,J.H., Arshavsky,V.Y. and Demb,J.B.
  TITLE     The Structural and Functional Integrity of Rod Photoreceptor Ribbon
            Synapses Depends on Redundant Actions of Dynamins 1 and 3
  JOURNAL   J Neurosci 44 (25), e1379232024 (2024)
   PUBMED   38641407
  REMARK    GeneRIF: The Structural and Functional Integrity of Rod
            Photoreceptor Ribbon Synapses Depends on Redundant Actions of
            Dynamins 1 and 3.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3295)
  AUTHORS   Jiang,A., Kudo,K., Gormal,R.S., Ellis,S., Guo,S., Wallis,T.P.,
            Longfield,S.F., Robinson,P.J., Johnson,M.E., Joensuu,M. and
            Meunier,F.A.
  TITLE     Dynamin1 long- and short-tail isoforms exploit distinct recruitment
            and spatial patterns to form endocytic nanoclusters
  JOURNAL   Nat Commun 15 (1), 4060 (2024)
   PUBMED   38744819
  REMARK    GeneRIF: Dynamin1 long- and short-tail isoforms exploit distinct
            recruitment and spatial patterns to form endocytic nanoclusters.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3295)
  AUTHORS   Bekku,Y., Zotter,B., You,C., Piehler,J., Leonard,W.J. and
            Salzer,J.L.
  TITLE     Glia trigger endocytic clearance of axonal proteins to promote
            rodent myelination
  JOURNAL   Dev Cell 59 (5), 627-644 (2024)
   PUBMED   38309265
REFERENCE   4  (bases 1 to 3295)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 3295)
  AUTHORS   Boumil,R.M., Letts,V.A., Roberts,M.C., Lenz,C., Mahaffey,C.L.,
            Zhang,Z.W., Moser,T. and Frankel,W.N.
  TITLE     A missense mutation in a highly conserved alternate exon of
            dynamin-1 causes epilepsy in fitful mice
  JOURNAL   PLoS Genet 6 (8), e1001046 (2010)
   PUBMED   20700442
  REMARK    GeneRIF: Missense mutation in conserved alternate exon of dynamin-1
            causes epilepsy in a mouse model.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3295)
  AUTHORS   Di Paolo,G., Sankaranarayanan,S., Wenk,M.R., Daniell,L.,
            Perucco,E., Caldarone,B.J., Flavell,R., Picciotto,M.R., Ryan,T.A.,
            Cremona,O. and De Camilli,P.
  TITLE     Decreased synaptic vesicle recycling efficiency and cognitive
            deficits in amphiphysin 1 knockout mice
  JOURNAL   Neuron 33 (5), 789-804 (2002)
   PUBMED   11879655
REFERENCE   7  (bases 1 to 3295)
  AUTHORS   Yoo,J., Lee,S.S., Jeong,M.J., Lee,K.I., Kwon,B.M., Kim,S.H.,
            Park,Y.M. and Han,M.Y.
  TITLE     Characterization of the mouse dynamin I gene promoter and
            identification of sequences that direct expression in neuronal
            cells
  JOURNAL   Biochem J 351 Pt 3 (Pt 3), 661-668 (2000)
   PUBMED   11042120
REFERENCE   8  (bases 1 to 3295)
  AUTHORS   Noakes,P.G., Chin,D., Kim,S.S., Liang,S. and Phillips,W.D.
  TITLE     Expression and localisation of dynamin and syntaxin during neural
            development and neuromuscular synapse formation
  JOURNAL   J Comp Neurol 410 (4), 531-540 (1999)
   PUBMED   10398046
REFERENCE   9  (bases 1 to 3295)
  AUTHORS   Klocke,R., Augustin,A., Ronsiek,M., Stief,A., van der Putten,H. and
            Jockusch,H.
  TITLE     Dynamin genes Dnm1 and Dnm2 are located on proximal mouse
            chromosomes 2 and 9, respectively
  JOURNAL   Genomics 41 (2), 290-292 (1997)
   PUBMED   9143510
REFERENCE   10 (bases 1 to 3295)
  AUTHORS   Newman-Smith,E.D., Shurland,D.L. and van der Bliek,A.M.
  TITLE     Assignment of the dynamin-1 gene (DNM1) to human chromosome 9q34 by
            fluorescence in situ hybridization and somatic cell hybrid analysis
  JOURNAL   Genomics 41 (2), 286-289 (1997)
   PUBMED   9143509
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY297150.1, AK011651.1,
            CA328097.1, BQ179370.1, CO425806.1, BC034679.1 and AL808027.14.
            
            On Sep 12, 2014 this sequence version replaced XM_006497657.1.
            
            Summary: This gene encodes a member of the dynamin subfamily of
            GTP-binding proteins. The encoded protein is a GTPase which is
            required for membrane recycling, including vesicle endocytosis in
            neurons. It may also be involved in cellular fission via
            association with microtubules and actin filaments. Mutations in
            this gene have been shown to cause seizures. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Sep
            2014].
            
            Transcript Variant: This variant (2) has multiple differences in
            the coding region, one of which results in a frameshift, compared
            to variant 1. The resulting protein (isoform 2) has a distinct
            C-terminus and is shorter than isoform 1. This variant contains the
            alternate 'a' exon in the central coding region and the 'b'
            splicing pattern in the 3' coding region (PMID:10398046,
            PMID:20700442).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK220483.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                BY297150.1         1-33
            34-390              AK011651.1         1-357
            391-1076            CA328097.1         17-702
            1077-1792           BQ179370.1         2-717
            1793-2393           CO425806.1         112-712
            2394-2654           BC034679.1         2348-2608
            2655-2691           AL808027.14        163802-163838       c
            2692-3295           BC034679.1         2744-3347
FEATURES             Location/Qualifiers
     source          1..3295
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 22.09 cM"
     gene            1..3295
                     /gene="Dnm1"
                     /gene_synonym="Dnm; Ftfl; mKIAA4093"
                     /note="dynamin 1"
                     /db_xref="GeneID:13429"
                     /db_xref="MGI:MGI:107384"
     exon            1..281
                     /gene="Dnm1"
                     /gene_synonym="Dnm; Ftfl; mKIAA4093"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..2676
                     /gene="Dnm1"
                     /gene_synonym="Dnm; Ftfl; mKIAA4093"
                     /EC_number="3.6.5.5"
                     /note="isoform 2 is encoded by transcript variant 2;
                     dynamin I"
                     /codon_start=1
                     /product="dynamin-1 isoform 2"
                     /protein_id="NP_001288666.1"
                     /db_xref="CCDS:CCDS79772.1"
                     /db_xref="GeneID:13429"
                     /db_xref="MGI:MGI:107384"
                     /translation="MGNRGMEDLIPLVNRLQDAFSAIGQNADLDLPQIAVVGGQSAGK
                     SSVLENFVGRDFLPRGSGIVTRRPLVLQLVNSTTEYAEFLHCKGKKFTDFEEVRLEIE
                     AETDRVTGTNKGISPVPINLRVYSPHVLNLTLVDLPGMTKVPVGDQPPDIEFQIRDML
                     MQFVTKENCLILAVSPANSDLANSDALKIAKEVDPQGQRTIGVITKLDLMDEGTDARD
                     VLENKLLPLRRGYIGVVNRSQKDIDGKKDITAALAAERKFFLSHPSYRHLADRMGTPY
                     LQKVLNQQLTNHIRDTLPGLRNKLQSQLLSIEKEVDEYKNFRPDDPARKTKALLQMVQ
                     QFAVDFEKRIEGSGDQIDTYELSGGARINRIFHERFPFELVKMEFDEKELRREISYAI
                     KNIHGIRTGLFTPDLAFEATVKKQVQKLKEPSIKCVDMVVSELTSTIRKCSEKLQQYP
                     RLREEMERIVTTHIREREGRTKEQVMLLIDIELAYMNTNHEDFIGFANAQQRSNQMNK
                     KKTSGNQDEILVIRKGWLTINNIGIMKGGSKEYWFVLTAENLSWYKDDEEKEKKYMLS
                     VDNLKLRDVEKGFMSSKHIFALFNTEQRNVYKDYRQLELACETQEEVDSWKASFLRAG
                     VYPERVGDKEKASETEENGSDSFMHSMDPQLERQVETIRNLVDSYMAIVNKTVRDLMP
                     KTIMHLMINNTKEFIFSELLANLYSCGDQNTLMEESAEQAQRRDEMLRMYHALKEALS
                     IIGDINTTTVSTPMPPPVDDSWLQVQSVPAGRRSPTSSPTPQRRAPAVPPARPGSRGP
                     APGPPPAGSALGGAPPVPSRPGASPDPFGPPPQVPSRPNRAPPGVPRITISDP"
     exon            282..355
                     /gene="Dnm1"
                     /gene_synonym="Dnm; Ftfl; mKIAA4093"
                     /inference="alignment:Splign:2.1.0"
     exon            356..505
                     /gene="Dnm1"
                     /gene_synonym="Dnm; Ftfl; mKIAA4093"
                     /inference="alignment:Splign:2.1.0"
     exon            506..709
                     /gene="Dnm1"
                     /gene_synonym="Dnm; Ftfl; mKIAA4093"
                     /inference="alignment:Splign:2.1.0"
     exon            710..808
                     /gene="Dnm1"
                     /gene_synonym="Dnm; Ftfl; mKIAA4093"
                     /inference="alignment:Splign:2.1.0"
     exon            809..969
                     /gene="Dnm1"
                     /gene_synonym="Dnm; Ftfl; mKIAA4093"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1112
                     /gene="Dnm1"
                     /gene_synonym="Dnm; Ftfl; mKIAA4093"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1248
                     /gene="Dnm1"
                     /gene_synonym="Dnm; Ftfl; mKIAA4093"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1316
                     /gene="Dnm1"
                     /gene_synonym="Dnm; Ftfl; mKIAA4093"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1455
                     /gene="Dnm1"
                     /gene_synonym="Dnm; Ftfl; mKIAA4093"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1542
                     /gene="Dnm1"
                     /gene_synonym="Dnm; Ftfl; mKIAA4093"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1613
                     /gene="Dnm1"
                     /gene_synonym="Dnm; Ftfl; mKIAA4093"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..1665
                     /gene="Dnm1"
                     /gene_synonym="Dnm; Ftfl; mKIAA4093"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..1677
                     /gene="Dnm1"
                     /gene_synonym="Dnm; Ftfl; mKIAA4093"
                     /inference="alignment:Splign:2.1.0"
     exon            1678..1791
                     /gene="Dnm1"
                     /gene_synonym="Dnm; Ftfl; mKIAA4093"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..1901
                     /gene="Dnm1"
                     /gene_synonym="Dnm; Ftfl; mKIAA4093"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..2013
                     /gene="Dnm1"
                     /gene_synonym="Dnm; Ftfl; mKIAA4093"
                     /inference="alignment:Splign:2.1.0"
     exon            2014..2025
                     /gene="Dnm1"
                     /gene_synonym="Dnm; Ftfl; mKIAA4093"
                     /inference="alignment:Splign:2.1.0"
     exon            2026..2196
                     /gene="Dnm1"
                     /gene_synonym="Dnm; Ftfl; mKIAA4093"
                     /inference="alignment:Splign:2.1.0"
     exon            2197..2438
                     /gene="Dnm1"
                     /gene_synonym="Dnm; Ftfl; mKIAA4093"
                     /inference="alignment:Splign:2.1.0"
     exon            2439..2654
                     /gene="Dnm1"
                     /gene_synonym="Dnm; Ftfl; mKIAA4093"
                     /inference="alignment:Splign:2.1.0"
     exon            2655..2691
                     /gene="Dnm1"
                     /gene_synonym="Dnm; Ftfl; mKIAA4093"
                     /inference="alignment:Splign:2.1.0"
     exon            2692..3285
                     /gene="Dnm1"
                     /gene_synonym="Dnm; Ftfl; mKIAA4093"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3257..3262
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dnm1"
                     /gene_synonym="Dnm; Ftfl; mKIAA4093"
                     /note="hexamer: AATAAA"
     polyA_site      3285
                     /gene="Dnm1"
                     /gene_synonym="Dnm; Ftfl; mKIAA4093"
                     /note="major polyA site"
ORIGIN      
        1 gaggggcggg ggacccgcgg cgcacgcagt cgggatattc ggctgcagcc gcgaagccgg
       61 gggccaagag ccagagcagg agcggcggcc ggatcgcagc ccgccgggcc cgccgcaacc
      121 atgggcaacc gcggcatgga agacctcatc ccgctggtta accggttaca ggacgccttc
      181 tccgccatcg gccagaacgc ggacctcgac ctgccgcaga tcgccgtggt aggcggccag
      241 agcgccggca agagctcggt gctggagaat ttcgtgggca gggacttctt gccccgagga
      301 tctggcatcg tcacccggcg tcccctggtc ctgcagctgg ttaattctac cacagaatat
      361 gccgagttcc tgcactgcaa ggggaagaaa ttcaccgact tcgaggaggt gcgcctggag
      421 atcgaggctg agaccgatcg agtcaccggc accaacaagg gcatttcgcc agtgcccatc
      481 aacctgcggg tctactcgcc ccatgtgctg aacctgactc tagtggacct gccaggaatg
      541 accaaggtcc cagttgggga ccaacctcct gatatcgagt tccagatccg ggacatgctt
      601 atgcagttcg tcactaagga gaactgcctt atcctggctg tgtcccctgc caactcggat
      661 ttggccaact ctgatgccct caagatcgct aaggaggtgg acccccaggg tcagcgcacc
      721 attggggtca tcaccaagtt ggacctgatg gacgagggca cagatgcgcg ggacgtgcta
      781 gagaacaagc tgctcccttt gcgcagaggt tacatcggcg tggtgaaccg gagccagaag
      841 gacatagacg gcaagaagga catcacagcc gccttggctg cagagcgcaa attcttcctc
      901 tctcacccat cctaccgcca cttggctgac cgcatgggca caccctacct gcagaaggtc
      961 ctcaatcagc aattgaccaa ccacatccgg gacacactgc cgggacttcg gaacaagctg
     1021 cagagccagc tgctgtccat tgagaaggag gtggacgagt acaagaactt ccgaccggat
     1081 gacccagcgc gcaagaccaa ggccctgctg cagatggtcc agcagtttgc agtggacttc
     1141 gagaagcgca tcgagggttc tggagaccag attgacactt acgagctgtc aggtggagcc
     1201 cgcattaacc ggatcttcca tgaacgcttc ccctttgagc tggttaagat ggagtttgat
     1261 gagaaggaac tgcgaaggga gatcagctat gctatcaaaa atatccatgg catcaggacg
     1321 ggcctcttca cacctgacct cgcttttgaa gccacagtga aaaagcaggt gcagaagctc
     1381 aaagagccca gtatcaagtg tgtggacatg gtagtcagtg aactcacgtc caccatcaga
     1441 aagtgtagtg aaaagctgca gcaatacccg cgtctgcggg aggagatgga gcgaattgtg
     1501 accacccaca tccgggaacg tgagggccgc accaaggagc aggtcatgct tctcatcgac
     1561 attgagctgg cttacatgaa taccaaccac gaagacttca taggctttgc caatgctcag
     1621 cagagaagca accagatgaa caagaagaag acttcaggga accaggatga gattctggtc
     1681 attcgaaagg ggtggttgac catcaacaac atcggcatca tgaagggagg ctccaaggag
     1741 tactggtttg tgctgactgc tgagaatctg tcctggtaca aggatgatga ggagaaagag
     1801 aagaagtaca tgctgtctgt ggacaatctg aagctgcgtg atgtggagaa gggcttcatg
     1861 tcaagcaagc atatttttgc cctcttcaac acagagcaga ggaatgtcta caaggattac
     1921 cggcagctgg aactggcctg tgagacacag gaggaggtgg acagttggaa ggcttccttc
     1981 ctgagggctg gcgtgtaccc tgagcgtgtt ggggacaaag agaaagccag tgagaccgag
     2041 gagaacggct ctgacagctt catgcactcg atggaccctc agctggagcg ccaggtggag
     2101 accatccgga acctggtaga ctcgtacatg gccattgtca acaagactgt gcgggacctc
     2161 atgcccaaga ccatcatgca cctcatgatc aacaacacca aggagtttat cttctctgag
     2221 ctgctggcca acctgtactc ttgcggggac cagaacacac tgatggaaga atcggccgag
     2281 caggctcagc ggcgcgacga gatgctgcgc atgtaccacg cactgaagga ggcgctcagt
     2341 attatcggcg acatcaacac gaccaccgtc agcacgccca tgcccccgcc cgtggacgac
     2401 tcctggctgc aggtgcagag cgtaccggcc ggacgcagat cgcccacgtc cagccccacg
     2461 ccgcagcgcc gagcccccgc cgtgccccca gcccggcccg gatcgcgggg ccctgctcct
     2521 gggcctccgc ctgctggatc cgccctgggg ggggcgcccc ccgtgccctc caggccgggg
     2581 gcttcccctg acccctttgg cccccctccc caggtgccct cgcgccccaa ccgcgccccg
     2641 cctggggtcc ccagaatcac tatcagtgac ccctgaggag tgtcagctac gccgatcggg
     2701 tcaggcaagt ccgtcccgtc ctgagagccc caggcccccc ttcgacctct aaccagatcc
     2761 ctcctactcc tcggagacct cccttaccaa gcctgcctgg acagctgttc tgtgacttga
     2821 cagtggctcc cccggcccca aagcgtccta ttcatcatct gtgacttagt ctgttgtagt
     2881 ggtgagctga cacatccaga tgtgatgttg gtgaaaactt gtgcccctct gtggtattgc
     2941 tcctgcgaca ttctataaat atctataaat atacctatat atacatatat atacatatat
     3001 atggctgaca cagcctcgcc tgtagtgtca gaatcaacca ccatgctgtc cttgtggagt
     3061 cttgtggtcc aacaagggaa cgctgtcatc ctgacaaccc cccctccagt gtaccacctc
     3121 cagtgagccc ccctgtcctc ctggcctgtg aacagccatc cccttggcca tcccaaccct
     3181 gcagcaaggg gatgctgcag cagcagcagc tgtgcagttc tctggtagcc accagtcttg
     3241 ctgtctcttg gctgagaata aaacccattt ctggatcatg gggaaaaaaa aaaaa
//
