LOCUS       NM_001370803           14585 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus dynein heavy chain domain 1 (Dnhd1), mRNA.
ACCESSION   NM_001370803 XM_006508382
VERSION     NM_001370803.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 14585)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 14585)
  AUTHORS   Tan,C., Meng,L., Lv,M., He,X., Sha,Y., Tang,D., Tan,Y., Hu,T.,
            He,W., Tu,C., Nie,H., Zhang,H., Du,J., Lu,G., Fan,L.Q., Cao,Y.,
            Lin,G. and Tan,Y.Q.
  TITLE     Bi-allelic variants in DNHD1 cause flagellar axoneme defects and
            asthenoteratozoospermia in humans and mice
  JOURNAL   Am J Hum Genet 109 (1), 157-171 (2022)
   PUBMED   34932939
  REMARK    GeneRIF: Bi-allelic variants in DNHD1 cause flagellar axoneme
            defects and asthenoteratozoospermia in humans and mice.
REFERENCE   3  (bases 1 to 14585)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125227.6 and AC121823.3.
            
            On Jun 3, 2019 this sequence version replaced XM_006508382.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849384,
                              SAMN01164137 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on single protein-coding
                                         transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-166               AC125227.6         162074-162239
            167-366             AC125227.6         162370-162569
            367-1171            AC125227.6         162800-163604
            1172-1333           AC125227.6         166920-167081
            1334-1537           AC125227.6         168185-168388
            1538-1648           AC125227.6         168472-168582
            1649-1805           AC125227.6         179744-179900
            1806-2060           AC125227.6         185088-185342
            2061-2198           AC125227.6         185449-185586
            2199-2250           AC125227.6         185718-185769
            2251-2513           AC125227.6         189092-189354
            2514-2757           AC125227.6         189445-189688
            2758-2915           AC125227.6         194077-194234
            2916-3041           AC125227.6         194931-195056
            3042-3318           AC125227.6         195146-195422
            3319-3446           AC125227.6         197015-197142
            3447-3645           AC125227.6         197239-197437
            3646-3740           AC125227.6         197792-197886
            3741-3948           AC125227.6         198476-198683
            3949-4074           AC125227.6         203940-204065
            4075-4172           AC125227.6         204411-204508
            4173-7050           AC125227.6         204619-207496
            7051-7216           AC125227.6         207696-207861
            7217-7409           AC125227.6         208021-208213
            7410-7698           AC125227.6         208455-208743
            7699-9307           AC121823.3         161922-163530       c
            9308-9516           AC121823.3         161540-161748       c
            9517-9721           AC121823.3         161117-161321       c
            9722-9824           AC121823.3         160942-161044       c
            9825-9974           AC121823.3         157937-158086       c
            9975-10157          AC121823.3         157518-157700       c
            10158-10589         AC121823.3         156976-157407       c
            10590-11052         AC121823.3         156359-156821       c
            11053-11352         AC121823.3         153782-154081       c
            11353-11505         AC121823.3         153432-153584       c
            11506-11684         AC121823.3         153075-153253       c
            11685-12650         AC121823.3         151988-152953       c
            12651-12834         AC121823.3         151591-151774       c
            12835-12948         AC121823.3         151278-151391       c
            12949-13147         AC121823.3         150992-151190       c
            13148-13239         AC121823.3         146605-146696       c
            13240-13389         AC121823.3         146307-146456       c
            13390-14201         AC121823.3         145297-146108       c
            14202-14585         AC121823.3         144768-145151       c
FEATURES             Location/Qualifiers
     source          1..14585
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 55.93 cM"
     gene            1..14585
                     /gene="Dnhd1"
                     /gene_synonym="8030491N06Rik"
                     /note="dynein heavy chain domain 1"
                     /db_xref="GeneID:77505"
                     /db_xref="MGI:MGI:1924755"
     exon            1..166
                     /gene="Dnhd1"
                     /gene_synonym="8030491N06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            167..366
                     /gene="Dnhd1"
                     /gene_synonym="8030491N06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            367..1171
                     /gene="Dnhd1"
                     /gene_synonym="8030491N06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1333
                     /gene="Dnhd1"
                     /gene_synonym="8030491N06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..1537
                     /gene="Dnhd1"
                     /gene_synonym="8030491N06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..1648
                     /gene="Dnhd1"
                     /gene_synonym="8030491N06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..1805
                     /gene="Dnhd1"
                     /gene_synonym="8030491N06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1806..2060
                     /gene="Dnhd1"
                     /gene_synonym="8030491N06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2061..2198
                     /gene="Dnhd1"
                     /gene_synonym="8030491N06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2199..2250
                     /gene="Dnhd1"
                     /gene_synonym="8030491N06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2251..2513
                     /gene="Dnhd1"
                     /gene_synonym="8030491N06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2514..2757
                     /gene="Dnhd1"
                     /gene_synonym="8030491N06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2758..2915
                     /gene="Dnhd1"
                     /gene_synonym="8030491N06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2916..3041
                     /gene="Dnhd1"
                     /gene_synonym="8030491N06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3042..3318
                     /gene="Dnhd1"
                     /gene_synonym="8030491N06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3319..3446
                     /gene="Dnhd1"
                     /gene_synonym="8030491N06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3447..3645
                     /gene="Dnhd1"
                     /gene_synonym="8030491N06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3646..3740
                     /gene="Dnhd1"
                     /gene_synonym="8030491N06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3741..3948
                     /gene="Dnhd1"
                     /gene_synonym="8030491N06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3949..4074
                     /gene="Dnhd1"
                     /gene_synonym="8030491N06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4075..4172
                     /gene="Dnhd1"
                     /gene_synonym="8030491N06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4173..7050
                     /gene="Dnhd1"
                     /gene_synonym="8030491N06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            7051..7216
                     /gene="Dnhd1"
                     /gene_synonym="8030491N06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            7217..7409
                     /gene="Dnhd1"
                     /gene_synonym="8030491N06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            7410..7698
                     /gene="Dnhd1"
                     /gene_synonym="8030491N06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            7699..9307
                     /gene="Dnhd1"
                     /gene_synonym="8030491N06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            9308..9516
                     /gene="Dnhd1"
                     /gene_synonym="8030491N06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            9517..9721
                     /gene="Dnhd1"
                     /gene_synonym="8030491N06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            9722..9824
                     /gene="Dnhd1"
                     /gene_synonym="8030491N06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            9825..9974
                     /gene="Dnhd1"
                     /gene_synonym="8030491N06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            9975..10157
                     /gene="Dnhd1"
                     /gene_synonym="8030491N06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            10158..10589
                     /gene="Dnhd1"
                     /gene_synonym="8030491N06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            10590..11052
                     /gene="Dnhd1"
                     /gene_synonym="8030491N06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            11053..11352
                     /gene="Dnhd1"
                     /gene_synonym="8030491N06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            11353..11505
                     /gene="Dnhd1"
                     /gene_synonym="8030491N06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            11506..11684
                     /gene="Dnhd1"
                     /gene_synonym="8030491N06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            11685..12650
                     /gene="Dnhd1"
                     /gene_synonym="8030491N06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            12651..12834
                     /gene="Dnhd1"
                     /gene_synonym="8030491N06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            12835..12948
                     /gene="Dnhd1"
                     /gene_synonym="8030491N06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            12949..13147
                     /gene="Dnhd1"
                     /gene_synonym="8030491N06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            13148..13239
                     /gene="Dnhd1"
                     /gene_synonym="8030491N06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            13240..13389
                     /gene="Dnhd1"
                     /gene_synonym="8030491N06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            13390..14201
                     /gene="Dnhd1"
                     /gene_synonym="8030491N06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            14202..14585
                     /gene="Dnhd1"
                     /gene_synonym="8030491N06Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      14564..14569
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dnhd1"
                     /gene_synonym="8030491N06Rik"
                     /note="hexamer: AATAAA"
     polyA_site      14585
                     /gene="Dnhd1"
                     /gene_synonym="8030491N06Rik"
                     /note="major polyA site"
ORIGIN      
        1 attctgtaac ggttctaaca gctgggagca ggtggtgcag ctgagtcctc tgctctggct
       61 ctgggatctg ctacccttgc cctcagtggc tcagctcttc cagtgcctag ggaggcccct
      121 cccactggcg caccgggagc tgtcttctgc cacgtctttc cgctaggtgg ttgccagcct
      181 ccactctgaa gttttcctca tgtgaacaca gtttttccaa agattttgca agcgtgtatc
      241 ggtctctgtg ttaagtgact ggaactgagt ctaagttcat tcacgacagg gagcgctccg
      301 caatgaaacc tcattcacag accagtcccc cttcccttcc catgccttct acatcctgca
      361 ggccaggtca gacccagaag ccaaaagcct ggaattggca tttggacccc gagctgtggg
      421 caagatctgt tcgacagcaa ttgaatacct gcctccactt tattctggaa gagaagaaaa
      481 acccatggtt ttataccctt cagtctgggc tcgttggatg tagctgcagc ggacaagaac
      541 actcttggga ctgtcaaatg aaacaggagg atctcaaggc agtggttgaa tcagagcagc
      601 ggacactgct gaagctgctg ctgtctgagc ttcagtctct gttctcagct gtgatgcagg
      661 atggcagttg tgaagcttgg cgctatctgc atgcagtact gggcctgttg cctccatacc
      721 gtgagatgct agctggtcaa ctcgagttgc tgcccttcct ggagcagctg tactgctggg
      781 cacccaaggt ccaagcccgg ctagagctgg acctgctaga tgccatagac aaggcctttc
      841 ccccagacag ttctttgtta catagttctt cccatgttga ctgtggtcta tggatgaaga
      901 ggtttcatcg agggcctcca tgctcagcat gcccttttgt gaaggcccag tgggaccggc
      961 aacaaaaaaa ggaattggcc acgtggctcc gaccattgac actgcctgag ctacagcact
     1021 gtctgggcat tgttggtgct gaggtggccc tagaagagac cccatggctg gacagcctta
     1081 gtcttttgcc cttggcactg gctacagaca tccctgtaca gtatgaaagc agtgatactg
     1141 agcaggcaga aggcgaacct gctgggagaa aacttcaggt tgcctctgaa gctcctgagg
     1201 agaaggccct caagaagaaa agctctagga ctcccgtctt gagaagtcag gtgaaatccc
     1261 ttctggagag agactggacc cagaagaaga tccacttcct ttatctcaat gtggtttctg
     1321 atcgtcactt taacccttac aagctggtgg cagtgccacc agacaaggtg aatcctgagc
     1381 actacatctt ctctcccttt gggatcctgc atatacatcc tgtggagggc agtgaggcaa
     1441 tgacactggg cacttggcac cgagactgtg ctctctggcg tgagctccag cgcatcccat
     1501 tctttaagaa ttgcctcttg cgaaaggcgt tgacctgttg gaagaaaaat gtgaggttgt
     1561 gtgggctgca tcggatccag actttcttga agactcatct gctctcggct attcctcatt
     1621 ttggagctgg gatgctccat attaacaggc ttcttcaaga gtttcgttct gtgtcctggc
     1681 tacccaaaga gccagatagg tcctatgagc tggtggacct gcagaaggca atagccaaag
     1741 agaaccacaa ggctcttcga gtgctctgtc actttctgaa tctctgtaca tccattcttc
     1801 aactgattca tgaagacaca tatcaaatgc aacagggcct gcaggagaga gtgcaaaact
     1861 ggaacaggat caggaaaggc caaggctcca tataccttca gaggacgctg tgcagacatc
     1921 tggagaagaa gctgaagcag gccgaaacat ggttgttgaa gttgggaaag tttgcccgcc
     1981 tgattgacta catgatttgt cagaaccttg tatccatctt agaagatgaa atatcttcct
     2041 ttatagctaa tactctgcaa gccccaaggc aaaacccctt tctcttatca cagctggtct
     2101 ttgatgacaa tggtcagttg tcacctatgc cccgtgttga atctataatc cagggtctca
     2161 ttaagagcct gcagtctatc aagacctctg ccttaaaggt actgcagtct acagatctga
     2221 ggacctccag agatctcctg tattctgaag acaacaaaga ccaggactca aatgcagaat
     2281 tcctgatgcc caagtttcat ggaaaggcca gcgatgctgt tcgcctcttc tgtggcccta
     2341 acgtaggata cgtgtggcct tggaagtctc atgcaattac tgatgtcctg gaagtccgtg
     2401 ggcacaagct acggggtcag tttctgcacc ccaattatga tcatgtgcag gaggacttgg
     2461 acaagaatgc tggaatccaa caggcacttg ctgtacaaca gtcactcttg gaggacatga
     2521 ggcaggaggt gcaggaattc tgcaataaac acaagtgggt agaaggcatc tatgagttcc
     2581 tgaaagcctg gagctctcag aagctagagg acctgagagg ctctcctatt aacaattatg
     2641 taaatctggt aatccaactg aaaaagtggc aggaacgtgt ctccaatatg tctgtcgaat
     2701 tactgacaaa aggcaagttg ctgttcctga gtggccatga tgttcaagaa gagttgggat
     2761 ccaagttaaa taacatgagg aagaacattc ttgaacaggc gcaaaatgaa tgctggagcc
     2821 gtaatcagca gctgatgaca gaactgacag agttcttgcg ggtcttccaa accatcagct
     2881 cagacatcca tgccattgca cagtgctccc agaaactaag tgaagccaat gagcaatact
     2941 gccagctaga ggagcgagtg gaatatgtcc gatcactcca tgacctcatc cgaaaccact
     3001 gtgccctctt cattgctgag aatgagactc tagacattgc gcttctagat ttatgggagg
     3061 catttcaatt tgaaagaagc caggtttcag agttcctgct cagcaagcaa catgccattg
     3121 tgcccaggct gcagcagctg atggcagcag cattggcaga gctggaaggc ctgctagcga
     3181 aggcactgtc tggtcccttt atggatcctt cacaagaaca gaggagcact gagcaacagc
     3241 ttggtgcctt ggagcatcag ttcctgaata tactcaataa cttcaatgcc ctatgcaatg
     3301 cttactgcac cttcactggg tataagaagc ctatgtctcc tcctgcttct gggaaccggc
     3361 ctatagtact gcagcagcgc atctggcggc tttaccggat catctctgaa aacctgggcg
     3421 agtggaaatg cgtggctttt agcaagttca acctttctat ggcccgggag aagaccgatg
     3481 cctggctgac agaggctgta aggctcagca cagccctggg gctgcaaagc cctgtgctac
     3541 aacgctgtat gcgcatgcta gaggagtttc gagcctatct gcctttgctt attaagctgg
     3601 gcaacctcca gctgcaggac cttaatactc aatccctctt gagagcatta gggctgggta
     3661 gtctacgaag cttggacctc cttacactgg gccagatgct caattatcca ctgctggaat
     3721 ttgcagaacg aatcaatcag gtctggcagt acgataagga acggattcat gcccaagaga
     3781 tcctacagca gatgcagcag tactgggagg ggcgccagct gcgcctgctc aacttcatcc
     3841 tgcatgtgcc ctacaagccc ccaacctcag agcgctctaa aaggccagca ctccgaagcc
     3901 cccagtggga gttagtgggc aaagatagtg gcaccttcct cctctcagac tacagcagcc
     3961 tgcaagatgc catccagaac agtctccagg ctctattcaa gatcctagcc atccaaaagt
     4021 caggacagtt gcataaaata gctttagaat gggtagccat catgtatggc ctgggtgccc
     4081 tgctggaggt atgggtggct ttccagcaga agtggatttt tctgaataaa gtgctacatg
     4141 agatgaagat cgagtttcct gctcctgagc tgaatgctcg tttcaaggcc atggatgatc
     4201 agtatcggac tctaatgcgc atctctgtgg ctgacccaat ggttctgtca cttatactgc
     4261 ccaacaccaa gaggagccct tacttccaag gccagcatct acagcaaatg ctgaaagcag
     4321 gatcaggaga gctggaggcc atcatcatgg ctctggagga tgtcctctat ggggtatgtg
     4381 ccaacttccc ccgcctcttc ttcctcagtg acagtgaact ggtggccctg ttggctgccc
     4441 ctctagatac ccgcgaggcc cagctatggg cacagcgttg ttttcctcac attaaagctg
     4501 tgaacttcag gtccaaatca actaaaaaga aaattaacca ggattcaagc tcaagtacag
     4561 agagtgcgga gacaattgct gtgctagcgg caggtggaga ggaagtgaag cttcaggaac
     4621 cccttcctct acatacagat cttcctaagt ggctagcctc tttggagaag tgtctgcggt
     4681 ttataatagt gaacctgctg cagagctgtg tggccacccg ccttgctcaa ggcccatccc
     4741 tcattaaggc tttgaaggca atgcctcaac aaagacagat gcccatgcaa gtgtatgtcc
     4801 agcactggct agatgcagtc caagtttttc catggcagtg tatactggtg gcagaggagg
     4861 tggtgtggcg agctgagatg gaggaggctt tgcttgagtc aaggactatg cacatgcgtt
     4921 ccgtacatgt acacaatctt gaggtactgg tgcaatttat acgctctcag aggagctctc
     4981 aggatgggaa gtctctgcct tctgttcgcc agactagtct attcagtacc ctgctggtca
     5041 aggcagtgac tcatagggat atagcccaac tcctggagaa gaaccaagtc agtgatctga
     5101 cagacttcca ctgggtccgc caacttaagt atcacctggg ttcatctcac ttgaacctca
     5161 aaagccccgt gcagtgtctt acaactattg catctactga gccctctgtg tcacccgctg
     5221 catgctggat agatgtgctc ggccggtcct tcatgtacaa ttatgagtac atggggccca
     5281 aactggggcc tctacctagc ctgatgcatg agcgtcaagt atttattctc ttaatggcct
     5341 tagatgaggt ggcctatggg gccatacttg gcagggatgg tctgggcaag gcagaaactg
     5401 tgaatagcct ggcatggacc ctgggccgcc agctggtaat aatgccctgc ttgccccaga
     5461 tagagttcca atgtctgaga aattatctga atggtgccct tcagagtggt gcctggctgc
     5521 tgttagagaa tgttaaccaa ctaccttcta gcctgctctc tgccctgggc cagcgtctgg
     5581 atgaactgca ctatctttat gccccactat atcagaaagc ttccaaaaac ataagtacca
     5641 taaaccctac taaaccccta ctccttggtg gtggtttctt tgagaagcat caagtgtcta
     5701 tgcgtcttgg ctttggctgt ttcttgacac ttcattccct gggtcctgat atacctgcca
     5761 atctgcatct gctactgcgt cctgtggcat tggcactgcc tgaccttcag agagtggcag
     5821 agctgaacct gctgggagca ggggtacaag atgcctccca aatggcttct cgcctatcta
     5881 aattattttc cctagaacgt gagctggtgt ctgggaactt gccctgccgc ttgccactgc
     5941 tcaagcaggt actggaacac acaatacaga cactaaatac atcccaagaa aagaagtccc
     6001 agcagcccta cgaccccgct gcctctgagg aggctgccct actgcgtgcc ctgttgcatt
     6061 caccactgtt cagcattctc gatggcctcc gtctacaaaa gctccaagaa ctgctctgtg
     6121 ggatttttcc taatgctagc catgtgctgg ctgagcctgt gtcccataga ctgattaaat
     6181 cagtagtggt ggaagaactc cagcagttag gcctatttcc tgcctctaac acggtgacat
     6241 ctctggagca gctgagtcag gccctgagcc gggcctctgg cattctgctc ctgggccctg
     6301 caggcagtgg caagagtact tgttggagga gcttatttaa gattcagaat cggctggcag
     6361 ccatggaaca cacctcaacc aagggtttcc aatctgtgga aattgtccac ctatacccta
     6421 gtgtgctcaa ctccaaagaa tacctagggt ggtcagaagg tccctcctgg cactatggca
     6481 tctttcctaa gctccttcat gctgcccctt attgtaagag tgtgggctca gaagagccgt
     6541 cagagaaatt cacagggatc cagcaatgga taatatgtga tggggcccct aatcatgcat
     6601 ggacagactc tgtcacttgc cttctgaggg accctcctca gctgagtctc ccaaatgggc
     6661 aacagatagc acgaccccta ggtacttttt tcttgataga ggtggcagag gcagcaggca
     6721 tgtctcctac tgtgttaggc cggtgtgctc ttgtctggtg tagtggggaa cagacttggc
     6781 attccatgct tagtgtcttg atggcatctc tgccacatga ataccaccta cagcaagaga
     6841 caatcactga gttcaactac ttagctgaag tgctggtgcc ttcagtgctc cgattcctta
     6901 cccgcatagg tgccagttct cagctacagg tacatgggca tcaagctgtt tgcccgggtg
     6961 tggcagaagt caccagcctg gtccgtatct tgcgtgctct acttgacccc cttctacact
     7021 tattcgagga agagaagtca tacaccaaag aggactttag tggcagtgat cttgtgaccc
     7081 aaaacttcaa atcttcaaaa accagggtcc agtctgaccg tgtcaatgtg aataaaaagc
     7141 agagaagaca tttgctggct atcagcagct ttctttttgc cataatctgg agttttggag
     7201 cccaccttcc ctccagacac tggcctctct ttgatgactt catgaagaag tctattagtt
     7261 ccctgcccaa ctaccctgag ccacctcctt cagccttggt gtttgatcta catgtaaact
     7321 ttgaagatgg gacactggtc cccttcactg gccagtatct gagcacccat gtcaaaggaa
     7381 atctgggttc tttccagccc tcttctcaga ctgaacagct tttgtatgtg gtggacctgc
     7441 ttctgtcaaa tggacagcca gtgctgcttg ctggagagat agcaacggga aagtcagctt
     7501 ttgtggaggt gctggtgaag ccaaattacc ctgtcattca cagtcccatt caccctgcct
     7561 taaattctac tcaccttcgt cacctgctga gcagaggagt ccatggccaa acacaagcca
     7621 gttcaattcc tgggcatcac caggactcca aaggctccat cctttttctg atggaagatc
     7681 tgcacctggc tacttttgat ccagagaaga actgccagcc agtgctggag actctgcggc
     7741 aggcaatgga aggcaccatc tatgcccaca acaccttgga attacagact ctgcagacta
     7801 cagtcaactt ccttgccact gctacagtgc caggctactc tgagcgcccg ctctgtccac
     7861 gtctctaccg actcttcaca gtgctggccc tgaacagcat gactcaggac accctgttga
     7921 gcaggcatgt ccctagtatt caagcctggc ttgagcgctt cccttctgtg gagcgggagc
     7981 acactctggc aagagccctt gtcagggctt cagtggaggc gtgggaggct gtgtgcaagt
     8041 gtttcatgcc ttcacccctc cgcccacact accgcttctc cccacattct gtgagccaca
     8101 ttttgggaag cctgcagctg ctgcctacca gaatgggttc acgaggtttt gcagagactt
     8161 tccatcacca ggagtatctg cgacgggtat ccggcttgcg tggaactcgc ctgactatca
     8221 tgatgtctat gcgtgtcatg gtgcgtcttt ggttgcatga ggcacaaaga acattttgtg
     8281 accggctgga cagcgatagg gaacgttccc attgtgctaa gctgcttcta gaagtagctc
     8341 agaatgtctt ctgtggtggg ccagggtctg agtccttggc caaggactgt gaggaagagg
     8401 aggtggagga ggagaaagtg cctgaagtag aatctgaaga agaaatagcc cagtgggaga
     8461 ccttaagcaa cagtgacagt ggatcagagg aagaggagga tccatatggc cttcaggcca
     8521 ccacaggctc attcctcagt gagaacagtc tagcaccatt ccccagaaag tcagtaaaca
     8581 aggagaacac agaaaatgta agtcagatgg ccgagcagga ggaagatata agggattcta
     8641 gcagtaagct ccagtccaag acacccaagc atgagtggca gatggcaccc cagatggact
     8701 taagtttacc tttgttgcta ccggtgctat tgttctatcc ccaggagagt ccctcagacc
     8761 tggtgttcag tctggagctt acactgggat ctaactttga gagtcccaac ttgtacctgg
     8821 aacggcagtg ggaaaacctt gaaaagcagt tggttgccac agctgttcgg ctgaagatga
     8881 actctggttt ttcccagtgc cctgtgatgg tccagcatgt agctcacctg gtcagagtcc
     8941 tggctaggcc ccagcagcat gctctattgc tctcagaatt ccggggtact gggcgctata
     9001 cagccatcat cctggcttct agcatttgtc aggctcacct tcattattta tcggtcgaat
     9061 cagaggaagc tattttccaa tgtctccgag atgccagctg gcatgctggc ctgttaaacc
     9121 agccagtggc tcttttggtg cctgaaggag tgaatgttgc tatcttttgc cgactattgg
     9181 ccctggcaac ctcaggtagc ttccctgacc agtacacaga agcagatctg gataacatcg
     9241 aagagcactt ccccaaggag aacattgcga acaaacatgc cattaagagg gacacaatac
     9301 tgaataggtt ttaccagcaa gtgtgtaaca acctccacat gttcttcatg gtgggagata
     9361 accaagccca aaatcagctg gcccctaccc ttttcctgaa tctccttcaa ttgaccattg
     9421 ccagtgttga acgctatgaa ccctgggacc aagcttctct ggtcaggatt gctcaattct
     9481 gcctggagaa tgatcacagt ctacctcttg atgatggttc cttgaagtac ccagatttca
     9541 agcacttaat tcctaatgtg gccaacatca tggctcgcat ccatgtttca tctgcctgtt
     9601 accataaaca catgtgccct gcattgccac ttgtcacccc caagaccttc caggacttct
     9661 tggatatgtt cctgcagcaa cagcagcaga tggtcctgca gatgaggatg agggccagtc
     9721 gcattcagac tgccttgaag actctgaggc tgatggttga gaggcacagt acccaaacca
     9781 gcctgctcac tgacttggaa gcacagctaa aaggctccta caaaagtgtt ggtatatgtc
     9841 aaggccaact cgagcaatcc aagatcatgt acaggcagaa gatgatagaa tgccaacatc
     9901 aggagagcct cattgagaat ctggtcaggc agcatgatgc cctaaaggct caacaggagg
     9961 ttttcctgga gcagatgggc aaggcatttg taggtccttt gagccagctg cgggtggctg
    10021 actttgagga gataagaagc tatcgagccc caccagagtc tgtagtcaag gtgacagatg
    10081 cattgtgtga cctgttccac caagagacag gctggtccag tgccaagcag ctgttatgta
    10141 ctgaagactt ttatcaggag ctggtattct tccccaaaga gaagctgacg gactcagagt
    10201 tggtcaagtt aaacgaagct ctaagggctc caggtatgag tgatgcagcc ttgaggtcag
    10261 taagcattcc tgcagcaaac ctggcagtct ggctctgggc ggtcctgcgc tatgggttgg
    10321 cacaacgccg aggattgccc actggcctgc tgctgcggca ggtagatgca acactggctc
    10381 gggagcaggc acgccttggc cagttccagt ttcaggccca tgatctgcta gagcaaactc
    10441 ggtctttgac taaaaagcta gaagatgccc aagtcagcca taaccatgta atggagaccc
    10501 tcaatcaggc acaatgtgga aactttcaga aatggcccat ggagtccgca ctgctcacgc
    10561 ccatgcacat gtggacaaca cagctccaga agttgcagga gcaagccaag actgtgtttg
    10621 gagatgcact cttgtgctca gctgccatca tctatctggg tcccttccca ccacagaggc
    10681 gtcaagaact gctagaaaag tggctatctc tgtgtcaggg ctctgaggaa gccctagacc
    10741 cagatgatgt ggcacgggca ctgaggcaga aatctgttgg ggtaccaaag aaccctctgc
    10801 tgcccacacg tactcccttc agtattttga ccttgctgag ctatggatct gaactgcacc
    10861 agtgggatcg agacctgaag ccccaagcaa agtcagcccg tctgctaggc ctgctgctgc
    10921 gaagccacat ccatttcagc agttcccgtt ggcctttgct aattgacccc agcaaccagg
    10981 ccatcatgtg gttgaatcca ctacctccaa aacagaacag gtcgttggaa ccatctccca
    11041 aagagagcaa agaaaagttc catgtgacaa aacaagacag tggggataat acagaagatg
    11101 aactggaaga tgagaacaat gaagaggaag atgaggccaa tgagcaaaga aaagagcaga
    11161 aagcagagga aaacaagatt cagggagaga acgagcagga agtacaagaa acagaaaaag
    11221 agaatgagcc agagagctca ggctcacact caagtctccc ttctgagact cagtctctgc
    11281 cctcctgcct cactgtgctc tcaggcactg acccagagtt gggtccccag ctcctggagg
    11341 cagctgccaa tggcttgcct gtgctcttga ccaatgtgga gctgagccta gggtgccaag
    11401 aacttcaatg gctgttgtca aagaagaatc tgagtccacc ctccgtgcag cctggcttct
    11461 gtctctttct gagcactacc tttcccatcc atgctttgag ccgagtacta ggttttgaaa
    11521 tgctgaaagg gttgaatgtt ctggatctgg gtctgaacat ggaaatacta gaagaacaaa
    11581 tgctgcatga aatcctgtgc agagagcgcc ctgagcttga aacccgctgg caagatctca
    11641 aaatcagagc agcagatacc tatgaagcta tgaaggctga tgaggaacag ttgctggtga
    11701 cattgctacg tcagaaccaa aagcgtcaga aaccatccaa gtttttgaga aaaatggtga
    11761 ggactcaggc aaagatatgt caactgaatg ctcaaatgga agagctagaa gaccagaagc
    11821 aggaggtggt ggcattgtgg gcaccctacc ggcccgtagc ttatcatgga atggctatgg
    11881 tagaagctct aagccctcta cagaaccttc tgccatcttt ctgtatgacg tcagagaatt
    11941 ggttggcagt catcaggcgg gctatagaca gtatgaagtc atatgacagt tatcgtggag
    12001 aagacttgcc cagccatctg cttcggttga aaatacacct ggcccgccag ctgctgacca
    12061 acactgtggt tgccctaggc ttgatccaaa cacccttggt gggtgccttc ggtgctttgg
    12121 ccatgctgca agtgacaacg aagacaccaa agctagagag attggcatta tggcctggac
    12181 tgtcagcctc tcccagctca ggtcacaaca tgcagatccc tggtgtgatt aggccagcct
    12241 ggctaagttc aaaagcctgg gaagaatgtg gagcattgga actgttgccc ccatttgcag
    12301 ggctgtgtga atccctggca ggtcactctg gtgtgtggca ggattacctg tcactatcat
    12361 ccactgtgct aggtcctgca cctggtccta attctgagcc acttagcctc ttccagaagc
    12421 tgattctgtg gcgggtactg cgaccagatt gcctggcagg tgccctagca gacctcacca
    12481 ccagcctatt aggtcggcca ctagatgaaa acctgggtgc tcctaccatg atctttgaac
    12541 atattcagcc tactcagccc atactgatct tgctgccacc acctggccac cctacagcca
    12601 ccctgcatcc tgtgactgtt atccggaaac tggctgccaa tcacgaaaag cctcagcatc
    12661 tacatgtgat agcactgggc tcggaagact gggatcctgt atcaactgta gtcaacactc
    12721 tatgccaggc tatgctccag gggcactggc tagtgctaga taactgtcat ttgatgccct
    12781 tttggccaag agagctctta cagccattgc agggactgct ggatagagcc agggtggtct
    12841 cagactctga actgctagct gaaccagaga gcaggagtgt ggtcaccgtc catagagatt
    12901 tccgtctttg gctgattgtg cctaccgagg ccagtacttc cttgccaggg atgctgaccc
    12961 agagctccat gcctgttttc tggaatcagt ccttagaact gggccggatc ttgatcgaca
    13021 gtttggattc ccagcaagga ctctgcacac aacctctcac ccagacactg cctttattct
    13081 tcttgcatgg tctcctactt cacagacagc tctatgggtt aaagctgcaa gcacacaggg
    13141 ggcgctggag tcaagtgacc ttgaccaggg ctcttcagat ccaagagcag ctgtgggcta
    13201 gtctcgggaa ccccagtgct gccttgctgg agctgactgc ttcagttctc tacggaggtt
    13261 ctttggggga cctagaggac agagaggccc tggttagcct gacaagaacc tgcctaaatc
    13321 ccagaaacat gaactgggac cagccacata ctccccaata tctcctggcc actctgatgc
    13381 ccagcccaga gctaggggaa ctggatgcca ggacagattg caaggcccag atgcacctac
    13441 tgcccacacc acctgaacct cgtacctgtg gactaaacga agcgccccag gcctggctga
    13501 tgagacgcca aagtcgtgtt ctcctgaatg cgctgcagaa gtgttcatcc acgtgggttc
    13561 ctacagtttg tggaggaatt gcccagcgca aagaaaggca acttcagcaa cgcctggcac
    13621 aagccaagaa gaggctggtg gcacttcagg ctttgctaac caacaaccgt attcgctcag
    13681 gccagtgtgt caccccctgg gcagtgttag gacccaatgc ccggcgacct ctagagggtt
    13741 tcttagagac cgaggtgctg gaactgaagc acctggtggg tacactgctg tgtgaccttg
    13801 actgcctatt gcagcagctg aagggcggga ccccatgcac ttccagtcgc tgcgctaagg
    13861 tagcccaggc tctttgggct ggacacctac ctcagccttg gagatctcat gctcttgctg
    13921 gttcacagct tccctggcta tggctgcggc aactgtcccg ccgtgggcac ctgttgattc
    13981 gctacctgga cagtggcatg agcgaaaatg ccaacaaacc agagcgcata tttcacctgt
    14041 cggctttccg ccaccctggt cgcctgttgc tggcattgcg ttgggaggct gtcctggaga
    14101 actcggtgca caaccccaac cttcctggtc accaagactc tatctctggc agtctcccac
    14161 ctaaatggca ggagttgagc aatcaccctc tgcatatttg ggtggagaat ggtccaaatc
    14221 ccaaagttcc taagatggga ctgctgctga ctgggttaca actccagcat gccgagtggg
    14281 accagacaga tggagccttg caggacagtt tttccagcca accctgcccc ctgcctcctg
    14341 tcagcatcag cacacaagcc cggcgtggca aagatgcacc tgtctcagct ggtctgggca
    14401 tgtactcctg tcctgtatac atgactgggc cctttggcac cactaagctg catagcaaga
    14461 acatcctgat gcacctgcca ctccccacaa ggctcagccc tgacacatgt attcaacgga
    14521 gagtacatgt gtgcagccca actttaacct gagccctgac caaaataaag ctgtagtgat
    14581 gtcaa
//
