LOCUS       NM_152915               3664 bp    mRNA    linear   ROD 13-MAY-2024
DEFINITION  Mus musculus delta/notch-like EGF repeat containing (Dner), mRNA.
ACCESSION   NM_152915
VERSION     NM_152915.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3664)
  AUTHORS   Li,J., Huang,Y., Yang,X., Cai,Y., Wang,Y., Dai,W., Jiang,L.,
            Wang,C. and Wen,Z.
  TITLE     Tyrosine-phosphorylated DNER sensitizes insulin signaling in
            hepatic gluconeogenesis by inducing proteasomal degradation of TRB3
  JOURNAL   Mol Metab 83, 101927 (2024)
   PUBMED   38553003
  REMARK    GeneRIF: Tyrosine-phosphorylated DNER sensitizes insulin signaling
            in hepatic gluconeogenesis by inducing proteasomal degradation of
            TRB3.
REFERENCE   2  (bases 1 to 3664)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3664)
  AUTHORS   Ruiz-Otero,N. and Kuruvilla,R.
  TITLE     Role of Delta/Notch-like EGF-related receptor in blood glucose
            homeostasis
  JOURNAL   Front Endocrinol (Lausanne) 14, 1161085 (2023)
   PUBMED   37223028
  REMARK    GeneRIF: Role of Delta/Notch-like EGF-related receptor in blood
            glucose homeostasis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3664)
  AUTHORS   Shue,Y.T., Drainas,A.P., Li,N.Y., Pearsall,S.M., Morgan,D.,
            Sinnott-Armstrong,N., Hipkins,S.Q., Coles,G.L., Lim,J.S., Oro,A.E.,
            Simpson,K.L., Dive,C. and Sage,J.
  TITLE     A conserved YAP/Notch/REST network controls the neuroendocrine cell
            fate in the lungs
  JOURNAL   Nat Commun 13 (1), 2690 (2022)
   PUBMED   35577801
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3664)
  AUTHORS   Hoffner O'Connor,M., Berglind,A., Kennedy Ng,M.M., Keith,B.P.,
            Lynch,Z.J., Schaner,M.R., Steinbach,E.C., Herzog,J., Trad,O.K.,
            Jeck,W.R., Arthur,J.C., Simon,J.M., Sartor,R.B., Furey,T.S. and
            Sheikh,S.Z.
  TITLE     BET Protein Inhibition Regulates Macrophage Chromatin Accessibility
            and Microbiota-Dependent Colitis
  JOURNAL   Front Immunol 13, 856966 (2022)
   PUBMED   35401533
  REMARK    GeneRIF: BET Protein Inhibition Regulates Macrophage Chromatin
            Accessibility and Microbiota-Dependent Colitis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3664)
  AUTHORS   Tohgo,A., Eiraku,M., Miyazaki,T., Miura,E., Kawaguchi,S.Y.,
            Nishi,M., Watanabe,M., Hirano,T., Kengaku,M. and Takeshima,H.
  TITLE     Impaired cerebellar functions in mutant mice lacking DNER
  JOURNAL   Mol Cell Neurosci 31 (2), 326-333 (2006)
   PUBMED   16298139
REFERENCE   7  (bases 1 to 3664)
  AUTHORS   Nakagawa,T., Guichard,A., Castro,C.P., Xiao,Y., Rizen,M.,
            Zhang,H.Z., Hu,D., Bang,A., Helms,J., Bier,E. and Derynck,R.
  TITLE     Characterization of a human rhomboid homolog, p100hRho/RHBDF1,
            which interacts with TGF-alpha family ligands
  JOURNAL   Dev Dyn 233 (4), 1315-1331 (2005)
   PUBMED   15965977
REFERENCE   8  (bases 1 to 3664)
  AUTHORS   Eiraku,M., Tohgo,A., Ono,K., Kaneko,M., Fujishima,K., Hirano,T. and
            Kengaku,M.
  TITLE     DNER acts as a neuron-specific Notch ligand during Bergmann glial
            development
  JOURNAL   Nat Neurosci 8 (7), 873-880 (2005)
   PUBMED   15965470
  REMARK    GeneRIF: DNER mediates neuron-glia interaction and promotes
            morphological differentiation of Bergmann glia through
            Deltex-dependent Notch signaling.
REFERENCE   9  (bases 1 to 3664)
  AUTHORS   Eiraku,M., Hirata,Y., Takeshima,H., Hirano,T. and Kengaku,M.
  TITLE     Delta/notch-like epidermal growth factor (EGF)-related receptor, a
            novel EGF-like repeat-containing protein targeted to dendrites of
            developing and adult central nervous system neurons
  JOURNAL   J Biol Chem 277 (28), 25400-25407 (2002)
   PUBMED   11950833
  REMARK    GeneRIF: expression in developing and mature central nervous system
REFERENCE   10 (bases 1 to 3664)
  AUTHORS   Nishizumi,H., Komiyama,T., Miyabayashi,T., Sakano,S. and Sakano,H.
  TITLE     BET, a novel neuronal transmembrane protein with multiple EGF-like
            motifs
  JOURNAL   Neuroreport 13 (6), 909-915 (2002)
   PUBMED   11997712
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC034634.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC034634.1, AK044597.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3664
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 43.4 cM"
     gene            1..3664
                     /gene="Dner"
                     /gene_synonym="A930026D19Rik; BET; Bret"
                     /note="delta/notch-like EGF repeat containing"
                     /db_xref="GeneID:227325"
                     /db_xref="MGI:MGI:2152889"
     exon            1..769
                     /gene="Dner"
                     /gene_synonym="A930026D19Rik; BET; Bret"
                     /inference="alignment:Splign:2.1.0"
     CDS             494..2707
                     /gene="Dner"
                     /gene_synonym="A930026D19Rik; BET; Bret"
                     /note="delta and Notch-like epidermal growth
                     factor-related receptor; brain EGF repeat-containing
                     transmembrane protein; transmembrane protein Bet;
                     delta/notch-like EGF-related receptor"
                     /codon_start=1
                     /product="delta and Notch-like epidermal growth
                     factor-related receptor precursor"
                     /protein_id="NP_690879.1"
                     /db_xref="CCDS:CCDS15105.1"
                     /db_xref="GeneID:227325"
                     /db_xref="MGI:MGI:2152889"
                     /translation="MPPRRAQAPGAPLLPVLALLPLLLGAGPQSGCLASPVSAAPLPA
                     PGPCASQPCRNGGVCTPRSVTDQEHPAADAEPRYSCTCPAGVSGTYCQFVADPCASNP
                     CHHGNCSSSSSSSSDSYLCICNDGYEGLNCEQPLPSIPTSGWTESTAPRQLQPVPATQ
                     EPDIILPRSQATVTLPTWQPKTGQKVVEMKWDQVEVVPDVACGNASSNNSAGGRLVSF
                     EVPQNTSVKIRQDANSLLILLWKVTATGFQQCSLIDGRSVTPLQAPGGLVLLEEMLAL
                     GPNHFIGFVNDSVAKSIVALRLTLVVKASNCVPGDSHSNDLECSGKGKCATKPSEATF
                     SCTCQDQYIGTFCEEFDACQRKPCQNEASCIDANEKQDGSNFTCLCLPGYTGELCQSK
                     IDYCVLDPCRNGATCVSSLSGFTCQCLEGYFGSACEEKVDPCMSSPCQNNGTCYVDGV
                     HFTCSCSPGFTGPTCAQLVDFCALSPCAHGMCRSVGTSYKCLCDPGYHGLYCEEEYNE
                     CLSAPCLNAATCRDLINGYECVCLAEYKGTHCELYKDPCANISCLNGGTCDSEGLNGT
                     CICAPGFTGEECDIDINECDSNPCHHAGTCLDQPNGYTCHCPHGWVGANCEIHLQWKS
                     GHMAESLTNMPRHSLYIIIGALCVAFILMLIILIVGICRISRIEYQGSSRPAYEEFYN
                     CRSIDSEFSNAIASIRHARFGKKSRPAMYDVTPIAYEDYSPDDKPLVTLIKTKDL"
     exon            770..1078
                     /gene="Dner"
                     /gene_synonym="A930026D19Rik; BET; Bret"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1173
                     /gene="Dner"
                     /gene_synonym="A930026D19Rik; BET; Bret"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1340
                     /gene="Dner"
                     /gene_synonym="A930026D19Rik; BET; Bret"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1486
                     /gene="Dner"
                     /gene_synonym="A930026D19Rik; BET; Bret"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..1640
                     /gene="Dner"
                     /gene_synonym="A930026D19Rik; BET; Bret"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..1754
                     /gene="Dner"
                     /gene_synonym="A930026D19Rik; BET; Bret"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..1979
                     /gene="Dner"
                     /gene_synonym="A930026D19Rik; BET; Bret"
                     /inference="alignment:Splign:2.1.0"
     exon            1980..2102
                     /gene="Dner"
                     /gene_synonym="A930026D19Rik; BET; Bret"
                     /inference="alignment:Splign:2.1.0"
     exon            2103..2216
                     /gene="Dner"
                     /gene_synonym="A930026D19Rik; BET; Bret"
                     /inference="alignment:Splign:2.1.0"
     exon            2217..2348
                     /gene="Dner"
                     /gene_synonym="A930026D19Rik; BET; Bret"
                     /inference="alignment:Splign:2.1.0"
     exon            2349..2595
                     /gene="Dner"
                     /gene_synonym="A930026D19Rik; BET; Bret"
                     /inference="alignment:Splign:2.1.0"
     exon            2596..3632
                     /gene="Dner"
                     /gene_synonym="A930026D19Rik; BET; Bret"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3609..3614
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dner"
                     /gene_synonym="A930026D19Rik; BET; Bret"
                     /note="hexamer: AATAAA"
     polyA_site      3631
                     /gene="Dner"
                     /gene_synonym="A930026D19Rik; BET; Bret"
                     /note="major polyA site"
ORIGIN      
        1 gtcaggccgg tcccgctgcg gtttcacaga ttctgcgcca agaggtcgcg agtggcagct
       61 gcgagccatc tgaagcgatc tcttcaggct gccggggcct ctccattcac tttctacccc
      121 agcatcacct ctctctcctc tctcagccga cggctcccac ctctgtgcca tcctgccttc
      181 ctttggacac acccacgact ctgacccctt aaggctgggg accgaagaca gccttcttgc
      241 aacttgctga gacgcggagc agaagggttc ccatcccggg tcctccagcc gggagcccag
      301 cctccgtggg ccccgccccc ggccccgccc gcggttgccc ggggaaccac gggctcccgc
      361 agctgcagga ggcgtccggt cccgctgagc agcactagcc gctggcgccg ctgccaccgc
      421 catctccgcc gctagcagcg ccgccgtcac cgcgcccagc tcctctccag cttctgcgtt
      481 ctctccgctc gctatgcctc cccgccgcgc ccaggcgccc ggtgccccgc tgctgcccgt
      541 gctggccctg ctgcccctgc tgctgggtgc tgggccccaa agcggctgct tggctagccc
      601 ggtgtccgcc gcgcccctgc ctgctccggg accgtgcgcc tcccagccct gtcggaacgg
      661 gggcgtgtgc actccgcgtt cggtgaccga ccaagagcac cctgcggccg atgctgagcc
      721 ccgctacagc tgcacctgtc ccgctggggt ctctggcacc tattgtcagt ttgttgcaga
      781 tccttgtgcc agcaaccctt gtcaccatgg taactgcagc agcagcagca gcagcagcag
      841 cgacagctac ctctgcattt gcaacgacgg ctatgaaggt cttaactgtg aacaaccact
      901 tcccagtatt ccaacctctg gctggacaga gtccacggca cccagacagc ttcagcctgt
      961 ccccgccacc caggagcctg acataatcct gccccgctct caggcaaccg tgacactgcc
     1021 aacttggcag ccaaaaacag ggcagaaagt tgtagaaatg aaatgggatc aagtagaggt
     1081 ggtccctgat gttgcctgtg ggaatgccag ttccaacaac tctgcgggtg gccgcctagt
     1141 gtcttttgaa gtgccacaga acacctctgt aaagattcgg caggatgcca attctttgct
     1201 gatcttgctg tggaaggtca cagccacagg ctttcaacag tgttccctca tagatggtcg
     1261 aagtgtgaca cccctccagg ctccaggggg ccttgtcctg ctagaggaga tgctggcctt
     1321 gggacccaac cacttcattg gttttgtgaa tgactctgtt gctaaatcca ttgtggcttt
     1381 gcgtttaaca cttgtggtga aggctagcaa ctgtgttccg ggggacagcc actcaaatga
     1441 cttagagtgt tcgggaaaag gaaaatgtgc cacgaagcca tcagaggcaa ccttttcctg
     1501 cacctgccag gaccagtaca ttggcacctt ctgtgaagaa tttgatgcct gccagaggaa
     1561 accctgccag aatgaggcga gctgtattga tgcaaatgag aagcaggatg ggagcaattt
     1621 cacttgcctt tgtcttccag gttatactgg agagctttgc cagtccaaga ttgattactg
     1681 tgtcctagac ccatgcagaa atggagccac atgtgtgtcc agcctcagcg ggttcacctg
     1741 ccagtgtctg gaagggtact tcggctccgc ttgtgaagag aaggtggacc cttgcatgtc
     1801 ctctccatgc cagaacaatg gcacttgcta cgtggatggc gtgcatttca cctgcagctg
     1861 cagcccaggc ttcacagggc ctacgtgtgc ccagctggtg gacttctgcg ccctcagtcc
     1921 gtgtgctcat ggcatgtgcc gtagcgtggg caccagctac aagtgcctct gcgatccagg
     1981 ttaccatggc ctctactgtg aggaggaata caatgagtgc ctgtcggccc cttgcctgaa
     2041 tgccgccacc tgccgggacc tcatcaatgg ctatgagtgt gtgtgcctgg cagaatataa
     2101 aggaacacac tgcgaactgt acaaggaccc ctgtgctaac atcagctgtc tgaatggagg
     2161 tacctgtgac agcgaggggc tgaatggcac gtgcatctgt gcacccgggt tcacaggtga
     2221 agagtgtgac attgacatca atgaatgtga tagtaaccca tgtcatcatg ctggaacctg
     2281 cttggaccag cccaatggtt acacctgcca ctgtcctcat ggctgggtgg gagcaaactg
     2341 tgaaatccac ctgcagtgga agtctgggca catggccgag agcctcacca acatgcctcg
     2401 gcactccctc tacatcatca tcggagccct ctgcgtcgcc ttcatcctca tgctcatcat
     2461 cctgattgtg ggcatctgcc gcatcagccg catcgagtac cagggctcct cccggccagc
     2521 ctatgaggag ttctacaact gccgcagcat tgacagtgag ttcagcaatg ccatcgcatc
     2581 catccggcat gccaggtttg ggaagaagtc tcggcctgcc atgtacgacg tgactcccat
     2641 tgcctacgag gattacagtc ccgatgacaa acccttggtc acactgatta aaacaaaaga
     2701 tttgtaatct tttttggatt atttttcaaa aacatatgag atattaagat cgtttaaata
     2761 tttttaagaa aattaaaaag cttaagagat gtaaaatgtt agctgctcaa gagttttcag
     2821 tagactatcg aggaactaat tttctgcagc ttttagttta aaaaaacagt attttaaaaa
     2881 aaaccagaat ttgtgaaatc cgtagaccat gttttaatgt actttcagct ctcaacactg
     2941 tatacttcaa caaggatggg cttttttgac agtagaccca tcataaaacc cagatggact
     3001 tctgtggttg ttacagaata aaccttatgt aggaagagtt tcttttgatg tgtgatgccg
     3061 gctttctgag tagagttagg aaaataaata gagtatgatg cataattcag tataatcgtt
     3121 acttaatatg acgtggcgtc cgagatgttt gttttgtgaa aaaagaaaac tagttaaatt
     3181 tattattcct agcctgaatg gaattagcct ctttcttatt ctgtgcatgg gtaacttatt
     3241 ttctgcactg ttctgttgaa ctctgaggaa atgtcgttcc ttccagtttg tttgagtcat
     3301 tttttttgta tcagtccttg aacttgacct tgtaaacata aacaaggaaa gagtctaggg
     3361 aggcaaatag cgatcagttt caacctacag tttttccttt aaaagtcaag catttttctt
     3421 tttaattgtg agtggactaa attatgttgc aggtgtttct tgctaagagg tagtgacatg
     3481 taagaggtgc cagtcccttc tgtagtgttt cttagagtgc acatttattt atacccaaga
     3541 caattttttg tggctgtatt tgattgatat gtgcttctta tgattcttgc taatttcaaa
     3601 gaatattgaa taaacgttag caggtcgagg acaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     3661 aaaa
//
