LOCUS       NM_010062               1754 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Mus musculus deoxyribonuclease II alpha (Dnase2a), transcript
            variant 1, mRNA.
ACCESSION   NM_010062
VERSION     NM_010062.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1754)
  AUTHORS   Li,L.J., Sun,X.Y., Huang,Y.R., Lu,S., Xu,Y.M., Yang,J., Xie,X.X.,
            Zhu,J., Niu,X.Y., Wang,D., Liang,S.Y., Du,X.Y., Hou,S.J., Yu,X.L.
            and Liu,R.T.
  TITLE     Neuronal double-stranded DNA accumulation induced by DNase II
            deficiency drives tau phosphorylation and neurodegeneration
  JOURNAL   Transl Neurodegener 13 (1), 39 (2024)
   PUBMED   39095921
  REMARK    GeneRIF: Neuronal double-stranded DNA accumulation induced by DNase
            II deficiency drives tau phosphorylation and neurodegeneration.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1754)
  AUTHORS   Nakayama,E., Kato,F., Tajima,S., Ogawa,S., Yan,K., Takahashi,K.,
            Sato,Y., Suzuki,T., Kawai,Y., Inagaki,T., Taniguchi,S., Le,T.T.,
            Tang,B., Prow,N.A., Uda,A., Maeki,T., Lim,C.K., Khromykh,A.A.,
            Suhrbier,A. and Saijo,M.
  TITLE     Neuroinvasiveness of the MR766 strain of Zika virus in IFNAR-/-
            mice maps to prM residues conserved amongst African genotype
            viruses
  JOURNAL   PLoS Pathog 17 (7), e1009788 (2021)
   PUBMED   34310650
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1754)
  AUTHORS   Yamashita,Y., Suzuki,C., Uchiyama,Y. and Nagata,S.
  TITLE     Infertility Caused by Inefficient Apoptotic Germ Cell Clearance in
            Xkr8-Deficient Male Mice
  JOURNAL   Mol Cell Biol 40 (3), e00402-19 (2020)
   PUBMED   31712393
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1754)
  AUTHORS   Yoshikawa,R., Sakabe,S., Urata,S. and Yasuda,J.
  TITLE     Species-Specific Pathogenicity of Severe Fever with
            Thrombocytopenia Syndrome Virus Is Determined by Anti-STAT2
            Activity of NSs
  JOURNAL   J Virol 93 (10), e02226-18 (2019)
   PUBMED   30814285
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1754)
  AUTHORS   Lan,Y.Y., Heather,J.M., Eisenhaure,T., Garris,C.S., Lieb,D.,
            Raychowdhury,R. and Hacohen,N.
  TITLE     Extranuclear DNA accumulates in aged cells and contributes to
            senescence and inflammation
  JOURNAL   Aging Cell 18 (2), e12901 (2019)
   PUBMED   30706626
REFERENCE   6  (bases 1 to 1754)
  AUTHORS   Hackney,J.A., Charbord,P., Brunk,B.P., Stoeckert,C.J.,
            Lemischka,I.R. and Moore,K.A.
  TITLE     A molecular profile of a hematopoietic stem cell niche
  JOURNAL   Proc Natl Acad Sci U S A 99 (20), 13061-13066 (2002)
   PUBMED   12226475
REFERENCE   7  (bases 1 to 1754)
  AUTHORS   Krieser,R.J., MacLea,K.S., Longnecker,D.S., Fields,J.L., Fiering,S.
            and Eastman,A.
  TITLE     Deoxyribonuclease IIalpha is required during the phagocytic phase
            of apoptosis and its loss causes perinatal lethality
  JOURNAL   Cell Death Differ 9 (9), 956-962 (2002)
   PUBMED   12181746
REFERENCE   8  (bases 1 to 1754)
  AUTHORS   Kawane,K., Fukuyama,H., Kondoh,G., Takeda,J., Ohsawa,Y.,
            Uchiyama,Y. and Nagata,S.
  TITLE     Requirement of DNase II for definitive erythropoiesis in the mouse
            fetal liver
  JOURNAL   Science 292 (5521), 1546-1549 (2001)
   PUBMED   11375492
REFERENCE   9  (bases 1 to 1754)
  AUTHORS   Krieser,R.J. and Eastman,A.
  TITLE     Deoxyribonuclease II: structure and chromosomal localization of the
            murine gene, and comparison with the genomic structure of the human
            and three C. elegans homologs
  JOURNAL   Gene 252 (1-2), 155-162 (2000)
   PUBMED   10903447
REFERENCE   10 (bases 1 to 1754)
  AUTHORS   Baker,K.P., Baron,W.F., Henzel,W.J. and Spencer,S.A.
  TITLE     Molecular cloning and characterization of human and murine DNase II
  JOURNAL   Gene 215 (2), 281-289 (1998)
   PUBMED   9714827
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161765.5.
            
            On Feb 5, 2019 this sequence version replaced NM_010062.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058609.1, SRR5189682.157947.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-116               AC161765.5         176121-176236
            117-294             AC161765.5         176351-176528
            295-373             AC161765.5         176623-176701
            374-538             AC161765.5         176892-177056
            539-736             AC161765.5         177138-177335
            737-1754            AC161765.5         178052-179069
FEATURES             Location/Qualifiers
     source          1..1754
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 41.31 cM"
     gene            1..1754
                     /gene="Dnase2a"
                     /gene_synonym="Dnase2"
                     /note="deoxyribonuclease II alpha"
                     /db_xref="GeneID:13423"
                     /db_xref="MGI:MGI:1329019"
     exon            1..116
                     /gene="Dnase2a"
                     /gene_synonym="Dnase2"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..1083
                     /gene="Dnase2a"
                     /gene_synonym="Dnase2"
                     /EC_number="3.1.22.1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; deoxyribonuclease-2-alpha; acid DNase; DNase II
                     alpha; lysosomal DNase II"
                     /codon_start=1
                     /product="deoxyribonuclease-2-alpha isoform 1 precursor"
                     /protein_id="NP_034192.1"
                     /db_xref="CCDS:CCDS22484.1"
                     /db_xref="GeneID:13423"
                     /db_xref="MGI:MGI:1329019"
                     /translation="MATLRSLLLAALLWVPAEALSCYGDSGQPVDWFVVYKLPAHSGS
                     RDTPKGLTYKYMDQNSDGWQDGVGYINSSEGAVGRSLQPLYRKNSSQLAFLLYNDQPP
                     KSSSARDSTGHGHTKGVLLLDQEGGFWLVHSVPRFPPPASSGAYTWPPNAQTFGQTLL
                     CVSLPFTQFARIGKQLTYTYPLVYDHKLEGFFAQKLPDLETVIKNQHVLHEPWNSSVI
                     LTSQAGATFQSFAKFGKFGDDLYSGWLAEALGTNLQVQFWQNSPGILPSNCSGAYQVL
                     DVTQTGFPGPSRLTFSATEDHSKWCVAPQGPWACVGDMNRNKAETHRGGGTVCTQLPS
                     FWKAFQSLVKDWKPCIEGS"
     exon            117..294
                     /gene="Dnase2a"
                     /gene_synonym="Dnase2"
                     /inference="alignment:Splign:2.1.0"
     exon            295..373
                     /gene="Dnase2a"
                     /gene_synonym="Dnase2"
                     /inference="alignment:Splign:2.1.0"
     exon            374..538
                     /gene="Dnase2a"
                     /gene_synonym="Dnase2"
                     /inference="alignment:Splign:2.1.0"
     exon            539..736
                     /gene="Dnase2a"
                     /gene_synonym="Dnase2"
                     /inference="alignment:Splign:2.1.0"
     exon            737..1754
                     /gene="Dnase2a"
                     /gene_synonym="Dnase2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1501..1506
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dnase2a"
                     /gene_synonym="Dnase2"
                     /note="hexamer: AAGAAA"
     polyA_site      1533
                     /gene="Dnase2a"
                     /gene_synonym="Dnase2"
                     /note="major polyA site"
ORIGIN      
        1 agagtccatt gctgtcgcct catggcaaca ctgagatcgc tgctgctggc tgcgctgctg
       61 tgggtccctg ccgaagccct gagctgctat ggggactccg ggcagcctgt ggattggttc
      121 gtggtataca agctgccggc tcacagcggg tctagggata ctccaaaggg actgacgtat
      181 aaatacatgg accagaactc cgacggttgg caagacggtg tagggtacat caacagctcg
      241 gagggagccg tgggccgcag cttgcagcca ttgtaccgaa agaactccag ccagctggcc
      301 tttctactct acaacgacca acctcctaaa tccagctcag ctcgggactc taccggccat
      361 gggcatacga agggtgtcct gctcctggac caagaagggg gcttctggct ggtccacagt
      421 gtgcctcgct tcccaccccc tgcgtcctct ggtgcataca cctggcctcc taatgctcaa
      481 accttcggcc agaccctact ctgtgtgtcc ctcccgttca ctcagtttgc aaggattggc
      541 aagcagctaa cctacaccta tccccttgtc tatgaccaca agctggaagg cttcttcgct
      601 cagaaattac ctgacctaga gacggtgatc aagaaccaac atgtcctcca tgagccctgg
      661 aatagcagtg taatactcac ttcccaagct ggggccacct tccagagctt tgccaaattt
      721 ggaaaatttg gagatgacct gtactccgga tggttggcag aagcccttgg caccaaccta
      781 caggtccagt tctggcaaaa ttctccaggc atcctgccct ccaactgctc tggagcctat
      841 caggttctgg atgtgacaca gacaggattc cctggcccat ctagactaac tttcagtgcc
      901 acagaggacc actccaaatg gtgtgtggcc cctcaagggc cctgggcctg tgtgggtgac
      961 atgaatagga acaaagcaga gacacaccga ggtggcggca cagtatgcac ccaactgcct
     1021 tccttttgga aggccttcca gtccctggtg aaagactgga aaccctgtat agaggggagc
     1081 tgactgaagc ccatcggagc aaaggactaa gactccgcag tctaaccagg tgggggccgg
     1141 actagccttt accccagcac ttgggaggca gaggcaggtg gatcgattct ctctctctct
     1201 ctggtttttc gagacagggt ttctctgtgt agccttggct gtcctggaac tcactctgta
     1261 gaccaggctg gcctcgaact cagaaatctg cttgcctctg cctctgtctc tttctcccaa
     1321 gtgctgggat taaaggcatg cgccaccact gcccggctca ggtggatctc ttgagttcca
     1381 ggccagcctg gtctacagag agttccagga gagccagggc aacacagaga acccttgtct
     1441 caaagaaaag aagaagaaga aaaaaaaaga aaaacaagaa aaagagaaaa gaaagaaaga
     1501 aagaaaagac tcagagacta gttttgactt gaatttgttt gtgtgtctgt tggtgggtta
     1561 aacccagggc ttaccacatg ggacacaagt acagtgctgc tgagccacac tccctgtccc
     1621 agctatgaat ctgaatacca gttcagtccc ttcctaactg gagaccttaa cagtgcctta
     1681 acctctagct gtctgttgca aaatgggcat cacagcatgt ctctaagagg ttgttaatac
     1741 aaccaactct gtgc
//
