LOCUS       NM_007870               3702 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus deoxyribonuclease 1-like 3 (Dnase1l3), mRNA.
ACCESSION   NM_007870
VERSION     NM_007870.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3702)
  AUTHORS   Stabach,P.R., Sims,D., Gomez-Banuelos,E., Zehentmeier,S.,
            Dammen-Brower,K., Bernhisel,A., Kujawski,S., Lopez,S.G., Petri,M.,
            Goldman,D.W., Lester,E.R., Le,Q., Ishaq,T., Kim,H., Srivastava,S.,
            Kumar,D., Pereira,J.P., Yarema,K.J., Koumpouras,F., Andrade,F. and
            Braddock,D.T.
  TITLE     A dual-acting DNASE1/DNASE1L3 biologic prevents autoimmunity and
            death in genetic and induced lupus models
  JOURNAL   JCI Insight 9 (14), e177003 (2024)
   PUBMED   38888971
  REMARK    GeneRIF: A dual-acting DNASE1/DNASE1L3 biologic prevents
            autoimmunity and death in genetic and induced lupus models.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3702)
  AUTHORS   Garreau,A., Santa,P., Dubois,M., Brisou,D., Levionnois,E.,
            Laurent,P., Ferriere,A., Roubertie,A., Loizon,S., Duluc,D.,
            Blanco,P., Contin-Bordes,C., Truchetet,M.E. and Sisirak,V.
  TITLE     The deficiency of DNASE1L3 does not affect systemic sclerosis
            pathogenesis in two inducible murine models of the disease
  JOURNAL   Eur J Immunol 54 (6), e2350903 (2024)
   PUBMED   38576111
  REMARK    GeneRIF: The deficiency of DNASE1L3 does not affect systemic
            sclerosis pathogenesis in two inducible murine models of the
            disease.
REFERENCE   3  (bases 1 to 3702)
  AUTHORS   Montorsi,L., Pitcher,M.J., Zhao,Y., Dionisi,C., Demonti,A.,
            Tull,T.J., Dhami,P., Ellis,R.J., Bishop,C., Sanderson,J.D.,
            Jain,S., D'Cruz,D., Gibbons,D.L., Winkler,T.H., Bemark,M.,
            Ciccarelli,F.D. and Spencer,J.
  TITLE     Double-negative B cells and DNASE1L3 colocalise with microbiota in
            gut-associated lymphoid tissue
  JOURNAL   Nat Commun 15 (1), 4051 (2024)
   PUBMED   38744839
  REMARK    GeneRIF: Double-negative B cells and DNASE1L3 colocalise with
            microbiota in gut-associated lymphoid tissue.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3702)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 3702)
  AUTHORS   Elrod,J., Heuer,A., Knopf,J., Schoen,J., Schonfeld,L.,
            Trochimiuk,M., Stiel,C., Appl,B., Raluy,L.P., Saygi,C., Zlatar,L.,
            Hosari,S., Royzman,D., Winkler,T.H., Lochnit,G., Leppkes,M.,
            Grutzmann,R., Schett,G., Tomuschat,C., Reinshagen,K., Herrmann,M.,
            Fuchs,T.A. and Boettcher,M.
  TITLE     Neutrophil extracellular traps and DNases orchestrate formation of
            peritoneal adhesions
  JOURNAL   iScience 26 (12), 108289 (2023)
   PUBMED   38034352
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3702)
  AUTHORS   Napirei,M., Ludwig,S., Mezrhab,J., Klockl,T. and Mannherz,H.G.
  TITLE     Murine serum nucleases--contrasting effects of plasmin and heparin
            on the activities of DNase1 and DNase1-like 3 (DNase1l3)
  JOURNAL   FEBS J 276 (4), 1059-1073 (2009)
   PUBMED   19154352
  REMARK    GeneRIF: serum contains two nucleases, DNase1 and DNase1l3, which
            may substitute or cooperate with each other during DNA degradation,
            providing effective clearance after exposure or release from dying
            cells.
REFERENCE   7  (bases 1 to 3702)
  AUTHORS   Shiokawa,D., Shika,Y., Araki,S., Sunaga,S., Mizuta,R., Kitamura,D.
            and Tanuma,S.
  TITLE     Stage-specific expression of DNasegamma during B-cell development
            and its role in B-cell receptor-mediated apoptosis in WEHI-231
            cells
  JOURNAL   Cell Death Differ 14 (5), 992-1000 (2007)
   PUBMED   17218958
  REMARK    GeneRIF: These results suggest that DNasegamma provides an
            alternative mechanism for inducing nuclear changes when the working
            apoptotic cascade is unsuitable for caspase-activated DNase
            activation.
REFERENCE   8  (bases 1 to 3702)
  AUTHORS   Napirei,M., Wulf,S., Eulitz,D., Mannherz,H.G. and Kloeckl,T.
  TITLE     Comparative characterization of rat deoxyribonuclease 1 (Dnase1)
            and murine deoxyribonuclease 1-like 3 (Dnase1l3)
  JOURNAL   Biochem J 389 (Pt 2), 355-364 (2005)
   PUBMED   15796714
  REMARK    GeneRIF: A comparison of the expression and transport of DNAse1
            from rats and DNAse1L3 from mice is reported.
REFERENCE   9  (bases 1 to 3702)
  AUTHORS   Shiokawa,D., Kobayashi,T. and Tanuma,S.
  TITLE     Involvement of DNase gamma in apoptosis associated with myogenic
            differentiation of C2C12 cells
  JOURNAL   J Biol Chem 277 (34), 31031-31037 (2002)
   PUBMED   12050166
REFERENCE   10 (bases 1 to 3702)
  AUTHORS   Baron,W.F., Pan,C.Q., Spencer,S.A., Ryan,A.M., Lazarus,R.A. and
            Baker,K.P.
  TITLE     Cloning and characterization of an actin-resistant DNase I-like
            endonuclease secreted by macrophages
  JOURNAL   Gene 215 (2), 291-301 (1998)
   PUBMED   9714828
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC139029.10, AF047355.1 and U76110.1.
            
            On Jan 6, 2006 this sequence version replaced NM_007870.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK156109.1, AK172254.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                AC139029.10        97554-97588         c
            36-191              AF047355.1         11-166
            192-1131            U76110.1           1-940
            1132-3702           AC139029.10        68593-71163         c
FEATURES             Location/Qualifiers
     source          1..3702
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 4.67 cM"
     gene            1..3702
                     /gene="Dnase1l3"
                     /gene_synonym="Dhp2; DNasegamma; Lsd"
                     /note="deoxyribonuclease 1-like 3"
                     /db_xref="GeneID:13421"
                     /db_xref="MGI:MGI:1314633"
     exon            1..353
                     /gene="Dnase1l3"
                     /gene_synonym="Dhp2; DNasegamma; Lsd"
                     /inference="alignment:Splign:2.1.0"
     CDS             198..1130
                     /gene="Dnase1l3"
                     /gene_synonym="Dhp2; DNasegamma; Lsd"
                     /note="liver and spleen DNase; deoxyribonuclease gamma;
                     LS-DNase; macrophage specific DNase I; DNase gamma; DNase
                     I-like 3; deoxyribonuclease I-like 3; DNase I homolog
                     protein DHP2"
                     /codon_start=1
                     /product="deoxyribonuclease gamma precursor"
                     /protein_id="NP_031896.3"
                     /db_xref="CCDS:CCDS26807.1"
                     /db_xref="GeneID:13421"
                     /db_xref="MGI:MGI:1314633"
                     /translation="MSLHPASPRLASLLLFILALHDTLALRLCSFNVRSFGASKKENH
                     EAMDIIVKIIKRCDLILLMEIKDSSNNICPMLMEKLNGNSRRSTTYNYVISSRLGRNT
                     YKEQYAFVYKEKLVSVKTKYHYHDYQDGDTDVFSREPFVVWFHSPFTAVKDFVIVPLH
                     TTPETSVKEIDELVDVYTDVRSQWKTENFIFMGDFNAGCSYVPKKAWQNIRLRTDPKF
                     VWLIGDQEDTTVKKSTSCAYDRIVLCGQEIVNSVVPRSSGVFDFQKAYDLSEEEALDV
                     SDHFPVEFKLQSSRAFTNNRKSVSLKKRKKGNRS"
     exon            354..442
                     /gene="Dnase1l3"
                     /gene_synonym="Dhp2; DNasegamma; Lsd"
                     /inference="alignment:Splign:2.1.0"
     exon            443..532
                     /gene="Dnase1l3"
                     /gene_synonym="Dhp2; DNasegamma; Lsd"
                     /inference="alignment:Splign:2.1.0"
     exon            533..645
                     /gene="Dnase1l3"
                     /gene_synonym="Dhp2; DNasegamma; Lsd"
                     /inference="alignment:Splign:2.1.0"
     exon            646..758
                     /gene="Dnase1l3"
                     /gene_synonym="Dhp2; DNasegamma; Lsd"
                     /inference="alignment:Splign:2.1.0"
     exon            759..916
                     /gene="Dnase1l3"
                     /gene_synonym="Dhp2; DNasegamma; Lsd"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1013
                     /gene="Dnase1l3"
                     /gene_synonym="Dhp2; DNasegamma; Lsd"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..3702
                     /gene="Dnase1l3"
                     /gene_synonym="Dhp2; DNasegamma; Lsd"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2128..2133
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dnase1l3"
                     /gene_synonym="Dhp2; DNasegamma; Lsd"
                     /note="hexamer: AATACA"
     polyA_site      2151
                     /gene="Dnase1l3"
                     /gene_synonym="Dhp2; DNasegamma; Lsd"
                     /note="major polyA site"
     regulatory      3676..3681
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dnase1l3"
                     /gene_synonym="Dhp2; DNasegamma; Lsd"
                     /note="hexamer: AATAAA"
     polyA_site      3702
                     /gene="Dnase1l3"
                     /gene_synonym="Dhp2; DNasegamma; Lsd"
ORIGIN      
        1 ggacaagaaa accagaggcc tctctaatgg ctaacccatt accttcattt ccttggggat
       61 tgaaacgcgt gatggtgagt tcctcagaga agtgaaagtg acctagaggg atccagtaat
      121 tcctgttatc agcctgcttt ataagtcagt gagccaggca ctgtcttcat ccagcctgaa
      181 gtcccaggag tgcaaagatg tccctgcacc cagcttcccc acgcctggcc tccctgctgc
      241 tcttcatcct tgccctccat gacaccctgg ccctaaggct ctgctccttc aatgtgaggt
      301 cctttggagc gagcaagaag gaaaaccatg aagccatgga tatcattgtg aagatcatca
      361 aacgctgtga ccttatactg ttgatggaaa tcaaggacag cagcaacaac atctgtccca
      421 tgctgatgga gaagctgaat ggaaattcac gaagaagcac aacatacaac tatgtgatta
      481 gttctcgact tggaagaaac acgtacaaag agcagtatgc cttcgtctac aaggagaagc
      541 tggtgtctgt gaagacaaaa taccactacc atgactatca ggatggagac acagacgtgt
      601 tttccaggga gccctttgtg gtttggttcc attccccctt tactgctgtc aaggacttcg
      661 tgattgtccc cttgcacaca actcccgaga cctccgttaa agagatagat gagctggtcg
      721 atgtctacac ggatgtgaga agccagtgga agacagagaa tttcatcttc atgggtgatt
      781 tcaacgccgg ctgtagctat gtccccaaga aggcctggca gaacattcgt ttgaggacgg
      841 accccaagtt tgtttggctg attggggacc aagaggacac tacggtcaag aagagtacca
      901 gctgtgccta tgacaggatt gtgctttgtg gacaagagat agtcaactcc gtggttcccc
      961 gttccagtgg cgtctttgac tttcagaaag cttatgactt gtctgaggag gaggccctgg
     1021 atgtcagtga tcactttcca gttgagttta agctacagtc ttcaagggcc ttcaccaaca
     1081 acagaaaatc tgtttctctc aaaaagagaa aaaaaggcaa tcgctcctag gtatcacgct
     1141 gccttttttt tttttttttt ttttttttgc cactccttgc aaatggctct cataggtcta
     1201 agctatctgc atgctcagga attaagactg gccaagctgc tttcattgtc cacttgagtt
     1261 aattttgcct ggaaccaagc tgggaggaga gtcttctgtt acatcacctt gatccccaat
     1321 atcatcactg gtaccctgcg aaacattgcc actatttagg caacaggaca gatttggcat
     1381 ggtatgatac tttatgatgg aggcaatgaa actcagttgc ctggggtcat gcgtggaaga
     1441 agagtgaagg acacttccac tgtgctgtcc tgcccgtccc tactcacagc ccacccctac
     1501 ccacacctca ctcctatcca cacctcactc ctatccacac ctcaccccta gctacagccc
     1561 acctgtgctc acagcgctgt gcttaagcca tcagcatgtc ctgagctcag tcttcggata
     1621 tatgaaggtt ttcattatct gacagccagc ctcactttgg atgcatgctc caacagtgtc
     1681 ttccctccct ttctcccttc ctcttcctcc tgtgcccctc cctgaaaggg ctcaaccttg
     1741 catgcctgtc ctgttctaac tgtccccagt cacatatccc atgtgcaaca ctgaccacac
     1801 agtgtctgtc accacggcca gcactgcagc tcgccccagc acaagccccc ctggctggct
     1861 tggacctgag tgtttgctcc cttcctgcca ctcctggaat ctgcaatgtg gcgccatctt
     1921 gcttgtatgc agggcacccg tttttgtgca tttcgctttg ttttcctgga tattctttac
     1981 tcttgcacat gagcacctgt acttaggaac agtggagaac agtgacccgt ctggcccgac
     2041 tcccagtctc agaagcaacc cctccacaca gctgtgggct ccccaaaggc gtctgcacac
     2101 aagcaagcac catgtgtaac ctgaagaaat acaaagtcta ttacactgta actatggggt
     2161 cgagttgttc cttaacacac tgggaactgt gtgactttga tgtgagaaag aagactgtga
     2221 gtctttgtgc tcgtcagctc cgtcatcctg acatgttctg agatcatcct cctcctaaca
     2281 gacatcccag atcatcttaa aaggaggggc tgggttttga cttgtgcttc cagaagtttc
     2341 aatttatggc ccttgactct gttgtttctg ggtcagtgaa aaagagtgtg tggtagaaca
     2401 cacacacaca cacacacaca cacacacaca cacacacaca cacgcaccac atgcacatga
     2461 ggtgggctct tctggcctcc acaggccaat atacaaggaa gaaaggcact catacacatt
     2521 aaataaagag acatggggtt ggggaggcat aaacccagtt tctgttccag aacacagtct
     2581 ctcccatgac ctccaaccaa gctccacctc ttacaagtgt tccatctccc aacagcatcc
     2641 tgatctggta tatcagcaag tcttttctat gtgaaccttt agaaaccact acagttccaa
     2701 atggtggagc taataggtag gattatatac catcttgcca agggaataaa atcaaaagtg
     2761 cccggttaag ttggaggaga taatgcccgg ctcatctctt actgagattc tattgtctgg
     2821 cgatgacgta gtctttcggg gaagatggca aagctgttga gactttggag gagttcacca
     2881 tacctagaaa ccttacagtc cccaaatggt aaagtatgct actcatatat gagacagttc
     2941 tggagagatg ggtcctctga cctctgcacc caagcaccaa aatttccctg gctgatgtgg
     3001 ctaggagagg aaccccaggt cccaggcaat gggcttggga ctcactaaca gggagatggg
     3061 gaggaggtgg actggacatc aaaaggccct ttccatgcct ctggcttggg agtcaacggg
     3121 tccagacacc ctgaagtttc gacccatact aatgctcttc tgcctctgcc cagtggcagg
     3181 ttagagatac aaatgagggt ctctgcaagc tgtcactctg ccaaactcag acagacagag
     3241 gagttatttt cactcttcct gactgagtgt tgtacaaact cctgctttta tgtccccctc
     3301 ccttccttct ctcctttctg aggatgacct tgaactctga ccctcctgtt tccaccttcc
     3361 cactggatga gtgccagcct tatagatgcc agccaccact cagcgtttca tgcagtgctc
     3421 agacaggact aagcaagcac tttgtgtgtg ctacacaagc actctacttg ctgggcccca
     3481 gccccagcct ctaggctgtg ccctaaaaat gtgttgcctg ggcagtggga tggctcagag
     3541 ggtaaagacc ttcgctgaca actctggcaa cttgaatttg atctccagaa tgggcacgat
     3601 ggaaggaaag ggtcaagtcc atcacgccat tctcagatct ctccacatgt aaacatgccc
     3661 ccaataaata aatgtaataa aattagaata tcgatgtaaa aa
//
