LOCUS       NM_025718               1236 bp    mRNA    linear   ROD 11-NOV-2023
DEFINITION  Mus musculus deoxyribonuclease 1-like 2 (Dnase1l2), mRNA.
ACCESSION   NM_025718 XM_914479
VERSION     NM_025718.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1236)
  AUTHORS   Verhulsdonk L, Mannherz HG and Napirei M.
  TITLE     Comparison of the secretory murine DNase1 family members expressed
            in Pichia pastoris
  JOURNAL   PLoS One 16 (7), e0253476 (2021)
   PUBMED   34329318
  REMARK    GeneRIF: Comparison of the secretory murine DNase1 family members
            expressed in Pichia pastoris.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1236)
  AUTHORS   Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J,
            Buniello A, Martelletti E, Preite L, Lam CC, Weiss FD, Powis Z,
            Suwannarat P, Lelliott CJ, Dawson SJ, White JK and Steel KP.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1236)
  AUTHORS   Manils J, Fischer H, Climent J, Casas E, Garcia-Martinez C, Bas J,
            Sukseree S, Vavouri T, Ciruela F, de Anta JM, Tschachler E, Eckhart
            L and Soler C.
  TITLE     Double deficiency of Trex2 and DNase1L2 nucleases leads to
            accumulation of DNA in lingual cornifying keratinocytes without
            activating inflammatory responses
  JOURNAL   Sci Rep 7 (1), 11902 (2017)
   PUBMED   28928425
  REMARK    GeneRIF: This study reports that lack of Trex2 results in the
            accumulation of DNA fragments in the cytoplasm of cornifying
            lingual keratinocytes and co-deletion of DNase1L2 and Trex2 causes
            massive accumulation of DNA fragments throughout the cornified
            layers of the tongue epithelium.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1236)
  AUTHORS   Fischer H, Buchberger M, Napirei M, Tschachler E and Eckhart L.
  TITLE     Inactivation of DNase1L2 and DNase2 in keratinocytes suppresses DNA
            degradation during epidermal cornification and results in
            constitutive parakeratosis
  JOURNAL   Sci Rep 7 (1), 6433 (2017)
   PUBMED   28743926
  REMARK    GeneRIF: DNase1L2 participate in the degradation of DNA during
            cornification in the interfollicular epidermis of
            mice.Cornification of epidermal keratinocytes depends on the
            cooperation of DNase1L2 and DNase2.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1236)
  AUTHORS   Sundberg JP, Dadras SS, Silva KA, Kennedy VE, Garland G, Murray SA,
            Sundberg BA, Schofield PN and Pratt CH.
  TITLE     Systematic screening for skin, hair, and nail abnormalities in a
            large-scale knockout mouse program
  JOURNAL   PLoS One 12 (7), e0180682 (2017)
   PUBMED   28700664
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1236)
  AUTHORS   Fischer H, Fumicz J, Rossiter H, Napirei M, Buchberger M,
            Tschachler E and Eckhart L.
  TITLE     Holocrine Secretion of Sebum Is a Unique DNase2-Dependent Mode of
            Programmed Cell Death
  JOURNAL   J Invest Dermatol 137 (3), 587-594 (2017)
   PUBMED   27771328
REFERENCE   7  (bases 1 to 1236)
  AUTHORS   Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK,
            Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L,
            Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre
            JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A,
            Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ,
            Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall
            S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA,
            Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR,
            Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana
            S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, MacArthur DG,
            Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC,
            Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL,
            de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown
            SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bucan M and Murray
            SA.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. PMID: 29144450]
REFERENCE   8  (bases 1 to 1236)
  AUTHORS   Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H,
            Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T,
            Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P,
            Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ,
            Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD,
            Flicek P, Skarnes WC, Mallon AM and Parkinson H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   9  (bases 1 to 1236)
  AUTHORS   White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN,
            Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J,
            Bottomley JR, Melvin DG, Sunter D, Adams NC, Tannahill D, Logan DW,
            Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM,
            Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A and
            Steel KP.
  CONSRTM   Sanger Institute Mouse Genetics Project
  TITLE     Genome-wide generation and systematic phenotyping of knockout mice
            reveals new roles for many genes
  JOURNAL   Cell 154 (2), 452-464 (2013)
   PUBMED   23870131
REFERENCE   10 (bases 1 to 1236)
  AUTHORS   Fischer H, Szabo S, Scherz J, Jaeger K, Rossiter H, Buchberger M,
            Ghannadan M, Hermann M, Theussl HC, Tobin DJ, Wagner EF, Tschachler
            E and Eckhart L.
  TITLE     Essential role of the keratinocyte-specific endonuclease DNase1L2
            in the removal of nuclear DNA from hair and nails
  JOURNAL   J Invest Dermatol 131 (6), 1208-1215 (2011)
   PUBMED   21307874
  REMARK    GeneRIF: DNase1L2 as an essential and specific regulator of
            programmed cell death in skin appendages, and demonstrate that the
            breakdown of nuclear DNA is crucial for establishing the full
            mechanical stability of hair.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK003619.1.
            
            [WARNING] On Jan 9, 2024 this sequence was replaced by NM_025718.4.
            
            On Jun 3, 2007 this sequence version replaced NM_025718.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK003619.1, BC106188.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1236              AK003619.1         2-1237
FEATURES             Location/Qualifiers
     source          1..1236
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 12.39 cM"
     gene            1..1236
                     /gene="Dnase1l2"
                     /gene_synonym="4733401H14Rik"
                     /note="deoxyribonuclease 1-like 2"
                     /db_xref="GeneID:66705"
                     /db_xref="MGI:MGI:1913955"
     exon            1..95
                     /gene="Dnase1l2"
                     /gene_synonym="4733401H14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            96..255
                     /gene="Dnase1l2"
                     /gene_synonym="4733401H14Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..948
                     /gene="Dnase1l2"
                     /gene_synonym="4733401H14Rik"
                     /EC_number="3.1.21.1"
                     /note="DNase I-like 2; deoxyribonuclease I-like 2"
                     /codon_start=1
                     /product="deoxyribonuclease-1-like 2 precursor"
                     /protein_id="NP_079994.2"
                     /db_xref="CCDS:CCDS37489.1"
                     /db_xref="GeneID:66705"
                     /db_xref="MGI:MGI:1913955"
                     /translation="MGWPWAPLTAVWALGVMGATALRIGAFNVQSFGDNKVSDPDCGS
                     VIAQILAGYDIALVQEVRDPDLSAVSLLMEQINRVSKHEYGFVSSKPLGRDQYKEMYL
                     FVYRKDVASVVSTYQYPDPEDAFSREPFVVKFSVPSCATKELVLIPLHAAPHQAVAEI
                     DALYDVYLDVIDKWNTDDMLFLGDFNADCKYVKAHDWPSIRLRSSEVFKWLIPDSADT
                     TVGNSDCAYDRIVVSGAHLRRSLKPHSASVHNFQEEFDLDQTQALAISDHFPVEVTFK
                     TH"
     exon            256..344
                     /gene="Dnase1l2"
                     /gene_synonym="4733401H14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            345..428
                     /gene="Dnase1l2"
                     /gene_synonym="4733401H14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            429..529
                     /gene="Dnase1l2"
                     /gene_synonym="4733401H14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            530..642
                     /gene="Dnase1l2"
                     /gene_synonym="4733401H14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            643..894
                     /gene="Dnase1l2"
                     /gene_synonym="4733401H14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1236
                     /gene="Dnase1l2"
                     /gene_synonym="4733401H14Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attgtgggtc caagactgca gttcatcttg agccatctta ggccctcagt ctggactgaa
       61 tctcactgac ttgggatatt ttattcacag cccaggtttt ctgcttttgt catgggttgg
      121 ccctgggccc cgctgacagc agtttgggca ctgggggtca tgggagccac agcgctgcgg
      181 attggagcct tcaatgttca gagctttgga gacaacaaag tgtcagatcc agactgtggc
      241 agtgtcatag cacagatcct ggccggctat gatatcgccc tggtgcaaga ggtacgagac
      301 ccagacctaa gtgcagtgtc cttgctcatg gagcaaatta acagagtgtc caagcacgag
      361 tacggctttg tgagcagcaa gccactcgga cgtgaccagt acaaggaaat gtacctgttt
      421 gtttacagga aagatgtagc gtcagtggtg agcacgtacc agtatccaga cccagaggac
      481 gctttcagcc gggagccttt tgtggtcaaa ttctcagttc ctagctgtgc caccaaggag
      541 ctggtgctga tccccctcca tgcagcacca caccaggcgg tggcagagat cgacgcgctc
      601 tacgatgtgt accttgatgt cattgacaag tggaacactg atgacatgct gtttctgggt
      661 gactttaatg ccgattgcaa gtacgtgaag gcgcatgact ggccatcgat ccgccttcga
      721 agcagtgagg tgtttaaatg gctcatccca gacagtgcgg acaccacagt gggcaactca
      781 gactgtgcct atgaccggat tgtagtgagt ggcgcccatc tgcgcaggag cctgaagccc
      841 cactcagcct cagttcacaa ctttcaggag gaatttgacc tagatcagac ccaggctctt
      901 gccatcagtg accattttcc tgtggaagtg actttcaaga ctcactgaga gccaaggcct
      961 caggatatgc cacctgcaga ctattaccac aaggactggc accacagtga atcattcagg
     1021 tggcaggcca cccacccact gaggacacag ggtcggacca gctggtgtgg acaatggctg
     1081 tgaacacatt tacaggactc cttaaagctc ccatttcctc atctgcaagg tgaactaaca
     1141 tcacctacct catcgggctg ctgtgaggag aaccgagcag cgccaggcac atagctgcat
     1201 gcttaataaa caagccgctc ttggccagga ctaccc
//
