LOCUS       NM_027109               1515 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus deoxyribonuclease 1-like 1 (Dnase1l1), transcript
            variant 1, mRNA.
ACCESSION   NM_027109
VERSION     NM_027109.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1515)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1515)
  AUTHORS   Mohan Kumar,D., Yamaguchi,M., Miura,K., Lin,M., Los,M., Coy,J.F.
            and Rikihisa,Y.
  TITLE     Ehrlichia chaffeensis uses its surface protein EtpE to bind
            GPI-anchored protein DNase X and trigger entry into mammalian cells
  JOURNAL   PLoS Pathog 9 (10), e1003666 (2013)
   PUBMED   24098122
  REMARK    GeneRIF: Yeast two-hybrid screening revealed that DNase X, a
            glycosylphosphatidyl inositol-anchored mammalian cell-surface
            protein binds EtpE-C.
REFERENCE   3  (bases 1 to 1515)
  AUTHORS   Shiokawa,D., Shika,Y., Saito,K., Yamazaki,K. and Tanuma,S.
  TITLE     Physical and biochemical properties of mammalian DNase X proteins:
            non-AUG translation initiation of porcine and bovine mRNAs for
            DNase X
  JOURNAL   Biochem J 392 (Pt 3), 511-517 (2005)
   PUBMED   16107205
REFERENCE   4  (bases 1 to 1515)
  AUTHORS   Pergolizzi,R., Appierto,V., Bosetti,A., DeBellis,G.L., Rovida,E.
            and Biunno,I.
  TITLE     Cloning of a gene encoding a DNase I-like endonuclease in the human
            Xq28 region
  JOURNAL   Gene 168 (2), 267-270 (1996)
   PUBMED   8654957
REFERENCE   5  (bases 1 to 1515)
  AUTHORS   Rivella,S., Tamanini,F., Bione,S., Mancini,M., Herman,G.,
            Chatterjee,A., Maestrini,E. and Toniolo,D.
  TITLE     A comparative transcriptional map of a region of 250 kb on the
            human and mouse X chromosome between the G6PD and the FLN1 genes
  JOURNAL   Genomics 28 (3), 377-382 (1995)
   PUBMED   7490070
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL807376.4.
            
            On Jun 2, 2019 this sequence version replaced NM_027109.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ116784.1, AK009174.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-106               AL807376.4         63907-64012         c
            107-410             AL807376.4         59425-59728         c
            411-499             AL807376.4         59032-59120         c
            500-577             AL807376.4         58865-58942         c
            578-678             AL807376.4         56754-56854         c
            679-791             AL807376.4         56492-56604         c
            792-1040            AL807376.4         56164-56412         c
            1041-1515           AL807376.4         55603-56077         c
FEATURES             Location/Qualifiers
     source          1..1515
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 37.94 cM"
     gene            1..1515
                     /gene="Dnase1l1"
                     /gene_synonym="2310005K03Rik; Dnase1ll; Dnasex; Dnl1ll;
                     G4.8"
                     /note="deoxyribonuclease 1-like 1"
                     /db_xref="GeneID:69537"
                     /db_xref="MGI:MGI:109628"
     exon            1..106
                     /gene="Dnase1l1"
                     /gene_synonym="2310005K03Rik; Dnase1ll; Dnasex; Dnl1ll;
                     G4.8"
                     /inference="alignment:Splign:2.1.0"
     exon            107..410
                     /gene="Dnase1l1"
                     /gene_synonym="2310005K03Rik; Dnase1ll; Dnasex; Dnl1ll;
                     G4.8"
                     /inference="alignment:Splign:2.1.0"
     CDS             273..1163
                     /gene="Dnase1l1"
                     /gene_synonym="2310005K03Rik; Dnase1ll; Dnasex; Dnl1ll;
                     G4.8"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; deoxyribonuclease I-like 1; DNase X; DNase
                     I-like 1"
                     /codon_start=1
                     /product="deoxyribonuclease-1-like 1 isoform 1 precursor"
                     /protein_id="NP_081385.2"
                     /db_xref="CCDS:CCDS30223.1"
                     /db_xref="GeneID:69537"
                     /db_xref="MGI:MGI:109628"
                     /translation="MRGLVMAPLLILLVGGTEAFRICAFNAHRLTLAKLTKESVMDTL
                     VQILARCDIMVLQEVVDSSQNTVPFLLQKLKSSRSYSFLNSSLLGRSTYKEKYVYIYR
                     SDKTQVLNFYQYNDTDDIFAREPFVAHFTLPSKTLPSVVLVPLHTTPKDVEKELNALY
                     DVFLDVYQRWQNENVILLGDFNADCASLTKKRLKSLLLRTKAGFHWVIPDGEDTTVRA
                     STNCTYDRIVVHGQGCQMLLKAAATFDFPKRFQLTEEEALRISDHYPVEVELSQATPL
                     SIPPHYLAALLLSLLPSQLD"
     exon            411..499
                     /gene="Dnase1l1"
                     /gene_synonym="2310005K03Rik; Dnase1ll; Dnasex; Dnl1ll;
                     G4.8"
                     /inference="alignment:Splign:2.1.0"
     exon            500..577
                     /gene="Dnase1l1"
                     /gene_synonym="2310005K03Rik; Dnase1ll; Dnasex; Dnl1ll;
                     G4.8"
                     /inference="alignment:Splign:2.1.0"
     exon            578..678
                     /gene="Dnase1l1"
                     /gene_synonym="2310005K03Rik; Dnase1ll; Dnasex; Dnl1ll;
                     G4.8"
                     /inference="alignment:Splign:2.1.0"
     exon            679..791
                     /gene="Dnase1l1"
                     /gene_synonym="2310005K03Rik; Dnase1ll; Dnasex; Dnl1ll;
                     G4.8"
                     /inference="alignment:Splign:2.1.0"
     exon            792..1040
                     /gene="Dnase1l1"
                     /gene_synonym="2310005K03Rik; Dnase1ll; Dnasex; Dnl1ll;
                     G4.8"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1515
                     /gene="Dnase1l1"
                     /gene_synonym="2310005K03Rik; Dnase1ll; Dnasex; Dnl1ll;
                     G4.8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1494..1499
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dnase1l1"
                     /gene_synonym="2310005K03Rik; Dnase1ll; Dnasex; Dnl1ll;
                     G4.8"
                     /note="hexamer: AATAAA"
     polyA_site      1514
                     /gene="Dnase1l1"
                     /gene_synonym="2310005K03Rik; Dnase1ll; Dnasex; Dnl1ll;
                     G4.8"
                     /note="major polyA site"
ORIGIN      
        1 aactgcgcgt ccttacccgc cttggctgga gctgcgattc tgtggagtgg aatgttttat
       61 tcggttcaac gctgaggcag gcgtggggcc gacttgggct gtggaggtgg tcaagctctg
      121 tgtacagaag ttgaaatacg ttccaggaag agattcaaga aatgttcagg gccaacagca
      181 gggagaatac taattagctg agatcagctg cagtgccaat gccctttgga caacctggat
      241 tcctttggag ggttcctgat gcacacatag caatgcgtgg ccttgttatg gctcccctgc
      301 tcattctcct ggttggtggg actgaagcct ttcgtatctg tgccttcaat gcccacagac
      361 tgacactggc caagctaacc aaggagtcag tgatggatac cttagttcag atcctagccc
      421 gatgtgatat catggtgctt caggaggtag tagattcttc ccagaatact gtcccctttc
      481 tgcttcaaaa acttaaaagt tccaggagtt acagcttcct aaacagctca ttgctggggc
      541 gcagcacata caaggaaaag tatgtgtata tctacaggtc tgacaagaca caggtcctaa
      601 atttctacca atacaacgac acagatgata tttttgcccg agaaccattt gtggcccatt
      661 tcactctccc tagcaaaact cttccaagtg tggtgctggt tcctctccac accactccca
      721 aggatgttga gaaggagctg aatgccctct atgatgtgtt tctggatgtc taccagcgct
      781 ggcagaatga gaatgtgatt ctgcttggag acttcaatgc agactgtgca tcgctgacaa
      841 aaaaacgtct gaaaagcctg ctactccgga ctaaggcagg cttccactgg gtgattcctg
      901 atggggagga tactacagtg cgggccagta ctaactgtac ctatgaccga attgtggtgc
      961 atggacaggg ctgccaaatg ctgctgaagg ctgcagctac ctttgacttt cccaagaggt
     1021 ttcagctgac tgaggaagag gctctccgca tcagtgacca ttatcctgta gaagtggaac
     1081 tgagccaggc cactccactg agtatcccac cccactactt agccgctcta ctgctgtcac
     1141 tcctgccatc tcagctggac tagatagcca ttgacttgac cagggcactg gtagtctcag
     1201 atgtgaaagt caatgacagc ttttttaaat agctgcttgc tattctgaga aagctagggc
     1261 tgggagtata actcagcaac aagtgccttg ggcttgaatc ctgttgggta gacaggactt
     1321 cacctgaggt agttaggaac aaagctccag tagaaatggg ctcagatcat acctaagatt
     1381 tctgcaactg atacaaatga gctcatactg gaaaaacctt aggtctaagt aatcttgctt
     1441 ctccatgcac tatactacat ggctctgcca gtgttgtcag gtttaaaata ttcaataaaa
     1501 tcattttaac ctttt
//
