LOCUS       NP_081385                296 aa            linear   ROD 02-MAY-2024
DEFINITION  deoxyribonuclease-1-like 1 isoform 1 precursor [Mus musculus].
ACCESSION   NP_081385
VERSION     NP_081385.2
DBSOURCE    REFSEQ: accession NM_027109.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 296)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 296)
  AUTHORS   Mohan Kumar,D., Yamaguchi,M., Miura,K., Lin,M., Los,M., Coy,J.F.
            and Rikihisa,Y.
  TITLE     Ehrlichia chaffeensis uses its surface protein EtpE to bind
            GPI-anchored protein DNase X and trigger entry into mammalian cells
  JOURNAL   PLoS Pathog 9 (10), e1003666 (2013)
   PUBMED   24098122
  REMARK    GeneRIF: Yeast two-hybrid screening revealed that DNase X, a
            glycosylphosphatidyl inositol-anchored mammalian cell-surface
            protein binds EtpE-C.
REFERENCE   3  (residues 1 to 296)
  AUTHORS   Shiokawa,D., Shika,Y., Saito,K., Yamazaki,K. and Tanuma,S.
  TITLE     Physical and biochemical properties of mammalian DNase X proteins:
            non-AUG translation initiation of porcine and bovine mRNAs for
            DNase X
  JOURNAL   Biochem J 392 (Pt 3), 511-517 (2005)
   PUBMED   16107205
REFERENCE   4  (residues 1 to 296)
  AUTHORS   Pergolizzi,R., Appierto,V., Bosetti,A., DeBellis,G.L., Rovida,E.
            and Biunno,I.
  TITLE     Cloning of a gene encoding a DNase I-like endonuclease in the human
            Xq28 region
  JOURNAL   Gene 168 (2), 267-270 (1996)
   PUBMED   8654957
REFERENCE   5  (residues 1 to 296)
  AUTHORS   Rivella,S., Tamanini,F., Bione,S., Mancini,M., Herman,G.,
            Chatterjee,A., Maestrini,E. and Toniolo,D.
  TITLE     A comparative transcriptional map of a region of 250 kb on the
            human and mouse X chromosome between the G6PD and the FLN1 genes
  JOURNAL   Genomics 28 (3), 377-382 (1995)
   PUBMED   7490070
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL807376.4.
            
            On Jun 2, 2019 this sequence version replaced NP_081385.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ116784.1, AK009174.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..296
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 37.94 cM"
     Protein         1..296
                     /product="deoxyribonuclease-1-like 1 isoform 1 precursor"
                     /note="deoxyribonuclease I-like 1; DNase X; DNase I-like
                     1"
                     /calculated_mol_wt=31647
     sig_peptide     1..19
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=1954
     Region          9..271
                     /region_name="EEP"
                     /note="Exonuclease-Endonuclease-Phosphatase (EEP) domain
                     superfamily; cl00490"
                     /db_xref="CDD:469791"
     Site            order(26..27,29,33,58,60..62,92..93,95,123,146,149,180,
                     182,187,220,224..225,262..263)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:197337"
     Site            order(26,58,95,146,180,182,225,262..263)
                     /site_type="active"
                     /note="putative catalytic site [active]"
                     /db_xref="CDD:197337"
     Site            order(26,58,262)
                     /site_type="other"
                     /note="putative Mg binding site IVb [ion binding]"
                     /db_xref="CDD:197337"
     Site            order(28,146,180,182,263)
                     /site_type="other"
                     /note="putative phosphate binding site [ion binding]"
                     /db_xref="CDD:197337"
     Site            28
                     /site_type="other"
                     /note="actin binding site [polypeptide binding]"
                     /db_xref="CDD:197337"
     Site            order(29,33,60..62,92..93,95,123,146,149,180,182,187,224,
                     263)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:197337"
     Site            order(116,124)
                     /site_type="other"
                     /note="Ca binding site II [ion binding]"
                     /db_xref="CDD:197337"
     Site            order(180,225,263)
                     /site_type="other"
                     /note="putative Mg binding site IVa [ion binding]"
                     /db_xref="CDD:197337"
     Site            order(184,210)
                     /site_type="metal-binding"
                     /note="metal binding site III [ion binding]"
                     /db_xref="CDD:197337"
     Site            order(213,215)
                     /site_type="other"
                     /note="Ca binding site I [ion binding]"
                     /db_xref="CDD:197337"
     CDS             1..296
                     /gene="Dnase1l1"
                     /gene_synonym="2310005K03Rik; Dnase1ll; Dnasex; Dnl1ll;
                     G4.8"
                     /coded_by="NM_027109.3:273..1163"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS30223.1"
                     /db_xref="GeneID:69537"
                     /db_xref="MGI:MGI:109628"
ORIGIN      
        1 mrglvmapll illvggteaf ricafnahrl tlakltkesv mdtlvqilar cdimvlqevv
       61 dssqntvpfl lqklkssrsy sflnssllgr stykekyvyi yrsdktqvln fyqyndtddi
      121 farepfvahf tlpsktlpsv vlvplhttpk dvekelnaly dvfldvyqrw qnenvillgd
      181 fnadcasltk krlkslllrt kagfhwvipd gedttvrast nctydrivvh gqgcqmllka
      241 aatfdfpkrf qlteeealri sdhypvevel sqatplsipp hylaalllsl lpsqld
//
