LOCUS       NM_175223               2080 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus dynein, axonemal, light intermediate polypeptide 1
            (Dnali1), mRNA.
ACCESSION   NM_175223 XM_990234
VERSION     NM_175223.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2080)
  AUTHORS   Wu,H., Liu,Y., Li,Y., Li,K., Xu,C., Gao,Y., Lv,M., Guo,R., Xu,Y.,
            Zhou,P., Wei,Z., Hua,R., He,X. and Cao,Y.
  TITLE     DNALI1 deficiency causes male infertility with severe
            asthenozoospermia in humans and mice by disrupting the assembly of
            the flagellar inner dynein arms and fibrous sheath
  JOURNAL   Cell Death Dis 14 (2), 127 (2023)
   PUBMED   36792588
  REMARK    GeneRIF: DNALI1 deficiency causes male infertility with severe
            asthenozoospermia in humans and mice by disrupting the assembly of
            the flagellar inner dynein arms and fibrous sheath.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2080)
  AUTHORS   Zhang,D., Liu,C., Li,H. and Jiao,J.
  TITLE     Deficiency of STING Signaling in Embryonic Cerebral Cortex Leads to
            Neurogenic Abnormalities and Autistic-Like Behaviors
  JOURNAL   Adv Sci (Weinh) 7 (23), 2002117 (2020)
   PUBMED   33304758
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2080)
  AUTHORS   Wildung,M., Esser,T.U., Grausam,K.B., Wiedwald,C.,
            Volceanov-Hahn,L., Riedel,D., Beuermann,S., Li,L., Zylla,J.,
            Guenther,A.K., Wienken,M., Ercetin,E., Han,Z., Bremmer,F.,
            Shomroni,O., Andreas,S., Zhao,H. and Lize,M.
  TITLE     Transcription factor TAp73 and microRNA-449 complement each other
            to support multiciliogenesis
  JOURNAL   Cell Death Differ 26 (12), 2740-2757 (2019)
   PUBMED   31068677
REFERENCE   4  (bases 1 to 2080)
  AUTHORS   Mali,G.R., Yeyati,P.L., Mizuno,S., Dodd,D.O., Tennant,P.A.,
            Keighren,M.A., Zur Lage,P., Shoemark,A., Garcia-Munoz,A.,
            Shimada,A., Takeda,H., Edlich,F., Takahashi,S., von Kreigsheim,A.,
            Jarman,A.P. and Mill,P.
  TITLE     ZMYND10 functions in a chaperone relay during axonemal dynein
            assembly
  JOURNAL   Elife 7, e34389 (2018)
   PUBMED   29916806
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2080)
  AUTHORS   Abdelhamed,Z., Vuong,S.M., Hill,L., Shula,C., Timms,A., Beier,D.,
            Campbell,K., Mangano,F.T., Stottmann,R.W. and Goto,J.
  TITLE     A mutation in Ccdc39 causes neonatal hydrocephalus with abnormal
            motile cilia development in mice
  JOURNAL   Development 145 (1) (2018)
   PUBMED   29317443
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2080)
  AUTHORS   Dong,F., Shinohara,K., Botilde,Y., Nabeshima,R., Asai,Y.,
            Fukumoto,A., Hasegawa,T., Matsuo,M., Takeda,H., Shiratori,H.,
            Nakamura,T. and Hamada,H.
  TITLE     Pih1d3 is required for cytoplasmic preassembly of axonemal dynein
            in mouse sperm
  JOURNAL   J Cell Biol 204 (2), 203-213 (2014)
   PUBMED   24421334
REFERENCE   7  (bases 1 to 2080)
  AUTHORS   Tarkar,A., Loges,N.T., Slagle,C.E., Francis,R., Dougherty,G.W.,
            Tamayo,J.V., Shook,B., Cantino,M., Schwartz,D., Jahnke,C.,
            Olbrich,H., Werner,C., Raidt,J., Pennekamp,P., Abouhamed,M.,
            Hjeij,R., Kohler,G., Griese,M., Li,Y., Lemke,K., Klena,N., Liu,X.,
            Gabriel,G., Tobita,K., Jaspers,M., Morgan,L.C., Shapiro,A.J.,
            Letteboer,S.J., Mans,D.A., Carson,J.L., Leigh,M.W., Wolf,W.E.,
            Chen,S., Lucas,J.S., Onoufriadis,A., Plagnol,V., Schmidts,M.,
            Boldt,K., Roepman,R., Zariwala,M.A., Lo,C.W., Mitchison,H.M.,
            Knowles,M.R., Burdine,R.D., Loturco,J.J. and Omran,H.
  CONSRTM   UK10K
  TITLE     DYX1C1 is required for axonemal dynein assembly and ciliary
            motility
  JOURNAL   Nat Genet 45 (9), 995-1003 (2013)
   PUBMED   23872636
REFERENCE   8  (bases 1 to 2080)
  AUTHORS   McClintock,T.S., Glasser,C.E., Bose,S.C. and Bergman,D.A.
  TITLE     Tissue expression patterns identify mouse cilia genes
  JOURNAL   Physiol Genomics 32 (2), 198-206 (2008)
   PUBMED   17971504
  REMARK    GeneRIF: Dnali1 is most abundantly expressed in tissues rich in
            highly ciliated cells, such as olfactory sensory neurons, and is
            predicted to be important to cilia.
REFERENCE   9  (bases 1 to 2080)
  AUTHORS   Rashid,S., Breckle,R., Hupe,M., Geisler,S., Doerwald,N. and
            Neesen,J.
  TITLE     The murine Dnali1 gene encodes a flagellar protein that interacts
            with the cytoplasmic dynein heavy chain 1
  JOURNAL   Mol Reprod Dev 73 (6), 784-794 (2006)
   PUBMED   16496424
  REMARK    GeneRIF: Results describe the gene encoding the dynein axonemal
            light intermediate chain Dnali1, and suggest that the C-terminal
            part of the cytoplasmic dynein heavy chain 1 is a putative
            interacting polypeptide of Dnali1.
REFERENCE   10 (bases 1 to 2080)
  AUTHORS   Geremek,M. and Witt,M.
  TITLE     Primary ciliary dyskinesia: genes, candidate genes and chromosomal
            regions
  JOURNAL   J Appl Genet 45 (3), 347-361 (2004)
   PUBMED   15306728
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL626775.11.
            
            On Jan 23, 2023 this sequence version replaced NM_175223.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK077109.1, BC122552.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-133               AL626775.11        109873-110005       c
            134-279             AL626775.11        109250-109395       c
            280-449             AL626775.11        107908-108077       c
            450-628             AL626775.11        103812-103990       c
            629-793             AL626775.11        103343-103507       c
            794-2080            AL626775.11        99693-100979        c
FEATURES             Location/Qualifiers
     source          1..2080
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 57.99 cM"
     gene            1..2080
                     /gene="Dnali1"
                     /gene_synonym="1700023A09Rik"
                     /note="dynein, axonemal, light intermediate polypeptide 1"
                     /db_xref="GeneID:75563"
                     /db_xref="MGI:MGI:1922813"
     exon            1..133
                     /gene="Dnali1"
                     /gene_synonym="1700023A09Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..829
                     /gene="Dnali1"
                     /gene_synonym="1700023A09Rik"
                     /note="axonemal dynein light chain (hp28) homolog; inner
                     dynein arm light chain, axonemal"
                     /codon_start=1
                     /product="axonemal dynein light intermediate polypeptide
                     1"
                     /protein_id="NP_780432.1"
                     /db_xref="CCDS:CCDS18635.1"
                     /db_xref="GeneID:75563"
                     /db_xref="MGI:MGI:1922813"
                     /translation="MIPPADSLLKYDTPVLVSRNTEKRSPTARPLKVTIQQPGPSSTS
                     PQPPKAKLPSTSCVPDPTKQAEEILNAILPPREWVEDTQLWIQQVSSTPSTRMDVVHL
                     QEQLDLKLQQRQARETGICPVRRELYSQCFDELIREVTINCAERGLLLLRVRDEIHMT
                     IAAYQTLYESSVAFGMRKALQAEQGKSDMERKITELETEKRDLERQVNEQKAKCEATE
                     KRESERRQVEEKKHNEEIQFLKRTNQQLKAQLEGIIAPKK"
     exon            134..279
                     /gene="Dnali1"
                     /gene_synonym="1700023A09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            280..449
                     /gene="Dnali1"
                     /gene_synonym="1700023A09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            450..628
                     /gene="Dnali1"
                     /gene_synonym="1700023A09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            629..793
                     /gene="Dnali1"
                     /gene_synonym="1700023A09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            794..2080
                     /gene="Dnali1"
                     /gene_synonym="1700023A09Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      879..884
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dnali1"
                     /gene_synonym="1700023A09Rik"
                     /note="hexamer: AATAAA"
     polyA_site      903
                     /gene="Dnali1"
                     /gene_synonym="1700023A09Rik"
                     /note="major polyA site"
     regulatory      2062..2067
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dnali1"
                     /gene_synonym="1700023A09Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2080
                     /gene="Dnali1"
                     /gene_synonym="1700023A09Rik"
ORIGIN      
        1 gcaaacaaga ctccacaggg gccgctacgg agttgttacc cctactgcca ccatgatacc
       61 cccagcagac tctctgctca aatatgacac cccggtgttg gtgagccgga atacagagaa
      121 acggagcccc acggctcggc cactgaaagt caccatccag cagcctggac cctctagtac
      181 aagcccacag ccacccaagg ccaagctgcc ctcaacttcc tgtgtcccag atcctaccaa
      241 acaggcagaa gaaatcttaa atgccatcct gcctccaagg gagtgggtgg aagacacaca
      301 gctatggatc cagcaggtgt ccagcacacc cagcaccaga atggatgtgg tgcatctcca
      361 ggagcagctg gacctgaagc tgcagcagag gcaggccagg gagacaggca tctgccctgt
      421 gcgcagggaa ctctactccc agtgttttga cgaactgatc cgggaggtca ccatcaactg
      481 cgcagagaga gggctgctgt tgctgcgtgt ccgggacgag atccacatga ccatcgctgc
      541 ctaccagact ctgtatgaga gcagcgtggc atttggcatg aggaaggcac tgcaggccga
      601 acaggggaag tcagacatgg agaggaaaat tacagaattg gagacagaaa agagggactt
      661 ggagaggcaa gtgaatgaac agaaggcgaa atgcgaggcc accgagaagc gggagagtga
      721 gaggcgacag gtggaggaga agaagcacaa cgaggagatc cagttcctga aacggaccaa
      781 ccagcaactg aaggcccaac tggaaggcat tatcgcaccg aagaagtgat catttccaca
      841 tgggtctcag caggcccctt gccccataag cccattgtaa taaaagccag tttccagagt
      901 gaacaagcca ccccttccct ggtcaccact catgtcattg ttacaactgt tgtcccagag
      961 tcatgaaaca cctaagccag gttcctggct aggcaatgga aggtgggaga acccggtgtc
     1021 catgtgcagc ttaaattggc ctggggcttt gtcatctcac taacttaggg agcaagtgtt
     1081 tcctcaaaga gaccaccttt gcatcaagtt cagtttccag ctcaccttgt accttgggct
     1141 tctctagcct cacccttcca catcacctct ctaatgtaag cttctgcacc tcgtttcgga
     1201 gtttggtttt ggactatagc gtctcattcc cacccgctga gtcagcagga ccctgtcctt
     1261 agtgtcccca gctccaggag gaaaacagca gcagagtcaa agccatgctc actgagaggt
     1321 acaaaagtcc cagtgtcttg agagctgtct gcacccaggt cctccccaca ccatttgaat
     1381 accttctgct ggatagcaaa gcctgactcc acactcccta gatagctata aaggaatagc
     1441 taaggaggta cccacatctc acatgtagtt ctagatgaat tatggactga aggcaaattt
     1501 gtagatcctg aaaactgcag ctctgacctc catcccagtc taagcttact gcaaggccta
     1561 tgaaccccaa cggctgttct gagttgactg tatcccaata ctccgatctt attctacaag
     1621 tcatatcttg gaccctcacc cagtatcctg aggaactagg cctccattag cacaacctgt
     1681 cggtgaagcc atgttcccgt cgtgccacag gctctgtggg cggtgcagga aagcatcggt
     1741 gcctagcagc actcctgcct ccaaaccttg cctgatgtct ctgaagcacg tgtgctttat
     1801 ttatagctct gtagactcct agccccgtgc tactcagtag tgtaagagga acatgcatgt
     1861 ctgtagacac acacaagaca tgctggagga actaagggcc aggtcaggtg tttaaaaaac
     1921 tctggggctg gggacttcct gttgccacag aactggggtg cgccctcacc actaagcttc
     1981 ccaagtgtgc tgtgccttag agatgccaac tgggcacaag aaagcgaaca cagttcctaa
     2041 tggcatattt ttgtataatt taataaacag ctttctcgca
//
