LOCUS       NM_001411918            1520 bp    mRNA    linear   ROD 08-FEB-2025
DEFINITION  Mus musculus dynein, axonemal, light chain 4 (Dnal4), transcript
            variant 2, mRNA.
ACCESSION   NM_001411918 XM_006521170
VERSION     NM_001411918.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1520)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1520)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC118227.12.
            
            On Sep 9, 2022 this sequence version replaced XM_006521170.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13861889.7156.1,
                                           SRR7652917.1105946.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                AC118227.12        162578-162667       c
            91-157              AC118227.12        154006-154072       c
            158-363             AC118227.12        153035-153240       c
            364-447             AC118227.12        151729-151812       c
            448-1520            AC118227.12        149672-150744       c
FEATURES             Location/Qualifiers
     source          1..1520
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 37.85 cM"
     gene            1..1520
                     /gene="Dnal4"
                     /gene_synonym="D15Ertd424e; Dnalc4"
                     /note="dynein, axonemal, light chain 4"
                     /db_xref="GeneID:54152"
                     /db_xref="MGI:MGI:1859217"
     exon            1..90
                     /gene="Dnal4"
                     /gene_synonym="D15Ertd424e; Dnalc4"
                     /inference="alignment:Splign:2.1.0"
     exon            91..157
                     /gene="Dnal4"
                     /gene_synonym="D15Ertd424e; Dnalc4"
                     /inference="alignment:Splign:2.1.0"
     exon            158..363
                     /gene="Dnal4"
                     /gene_synonym="D15Ertd424e; Dnalc4"
                     /inference="alignment:Splign:2.1.0"
     CDS             295..612
                     /gene="Dnal4"
                     /gene_synonym="D15Ertd424e; Dnalc4"
                     /note="isoform 1 is encoded by transcript variant 2; outer
                     arm dynein light chain 4; dynein light chain 4, axonemal;
                     dynein, axon, light chain 4"
                     /codon_start=1
                     /product="dynein axonemal light chain 4 isoform 1"
                     /protein_id="NP_001398847.1"
                     /db_xref="GeneID:54152"
                     /db_xref="MGI:MGI:1859217"
                     /translation="MGETEGKKEEADYKRLQTFPLVRHSDMPEEMRVETMELCVTACE
                     KFSNNNESAAKMIKETMDKKFGSSWHVVIGEGFGFEITHEVKNLLYLYFGGTLAVCVW
                     KCS"
     exon            364..447
                     /gene="Dnal4"
                     /gene_synonym="D15Ertd424e; Dnalc4"
                     /inference="alignment:Splign:2.1.0"
     exon            448..1520
                     /gene="Dnal4"
                     /gene_synonym="D15Ertd424e; Dnalc4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1499..1504
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dnal4"
                     /gene_synonym="D15Ertd424e; Dnalc4"
                     /note="hexamer: ATTAAA"
     polyA_site      1520
                     /gene="Dnal4"
                     /gene_synonym="D15Ertd424e; Dnalc4"
                     /note="major polyA site"
ORIGIN      
        1 gatggttgct aagacactct ggctcgctcc ttgacaaccc tggcgggggt gcgctggctg
       61 tggcctcggc tccggccccc gcgggagcag gccggaagct catttaagct gcagtccagc
      121 tgactctgaa aagccctgcc tatcatcaga tgcccagcac cccttgggga aagacatttt
      181 ctgctcctgc caagttggca aggcctgctt cccgagcccg tggggcgctg taactgttgg
      241 gcccagcacc tcctgaaagc cctactctcc tcctgagggc acgctgggag gatcatggga
      301 gagactgaag ggaagaaaga ggaggctgac tataaacggc tgcagacctt ccccctggtc
      361 aggcactcgg acatgccaga ggagatgcgc gtggagacca tggagctgtg tgtcacagcc
      421 tgtgagaaat tctccaacaa caatgagagt gctgcaaaga tgatcaagga gacaatggac
      481 aagaagttcg gctcctcctg gcatgtggtg atcggcgagg ggtttgggtt tgagatcacc
      541 cacgaggtga agaacctcct gtacctgtac ttcgggggga ccctggccgt gtgtgtgtgg
      601 aagtgctcct gacccccatc cctgcagctc tcccgcctgt cctctgggct gggggggggc
      661 tccccaggct cccctaggca gagcctggct ctctcaagga gagtcaagtc ttttcttttg
      721 tccttgtgta ccagtttcct gagccgcacc cagagtgtcc acttggtgac ctctccatgc
      781 ccaggctccc cgtggttgtc tccaagctct gagctgtgga caggcatctc tgtgtgcatg
      841 aggggtgggg tgtggcaggt gagagggtga agcacgggat tcttctcctt gaaatggact
      901 ggtcccacct tccatcccag cagcctcaaa gcccttctgc cccaaggact gctgggaagt
      961 atctcctgcc cttgttgtta gtggccatgt ggaatcagcc ggagactcct ctcatgagac
     1021 acagggcaag gctctccttt tcactgggga aggagttccc tctccccttc cccagcctga
     1081 cccgggactg aacagcccac cacatcttac tggaccagcc attcacagcc ctggcattgg
     1141 cccgaggatc acacagtctt cctgtcccct tctcccagct cgggccacat gaacctttca
     1201 caccccttcc accagaactg ctgcgtggcc gaggctggtg cggtggtgta gagcgacttg
     1261 tcaaagtgtt gctgagctcc cggtgagaca cctgggccag gagtgatctc accgtgaggc
     1321 cccgttagca gggaaacctg gcctgccagg gacttcatca gggaccgcat gcgatttgta
     1381 cttcttacct tgctggcttt tctagattct ttttgagtgt gggaagaagg gttttagtag
     1441 aagggtgaat catattttac acagcggtct tatttatata aacgtcttgg tttttacaat
     1501 taaaacgacc aaaaactaaa
//
