LOCUS       NM_028821               5792 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus dynein, axonemal, light chain 1 (Dnal1), transcript
            variant 1, mRNA.
ACCESSION   NM_028821 XM_356594
VERSION     NM_028821.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5792)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5792)
  AUTHORS   Horvath,J., Fliegauf,M., Olbrich,H., Kispert,A., King,S.M.,
            Mitchison,H., Zariwala,M.A., Knowles,M.R., Sudbrak,R., Fekete,G.,
            Neesen,J., Reinhardt,R. and Omran,H.
  TITLE     Identification and analysis of axonemal dynein light chain 1 in
            primary ciliary dyskinesia patients
  JOURNAL   Am J Respir Cell Mol Biol 33 (1), 41-47 (2005)
   PUBMED   15845866
  REMARK    GeneRIF: analysis of the human (DNAL1) and murine (Dnal1) orthologs
            of the Chlamydomonas LC1-gene
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY126068.1, BC070454.1 and AC125071.3.
            
            On Jan 11, 2008 this sequence version replaced NM_028821.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070454.1, BG916281.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                BY126068.1         2-44
            44-1313             BC070454.1         1-1270
            1314-5645           AC125071.3         51253-55584         c
            5646-5792           BC070454.1         4192-4338
FEATURES             Location/Qualifiers
     source          1..5792
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 39.05 cM"
     gene            1..5792
                     /gene="Dnal1"
                     /gene_synonym="1700010H15Rik; Dnalc1; E330027P08Rik"
                     /note="dynein, axonemal, light chain 1"
                     /db_xref="GeneID:105000"
                     /db_xref="MGI:MGI:1921462"
     exon            1..72
                     /gene="Dnal1"
                     /gene_synonym="1700010H15Rik; Dnalc1; E330027P08Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..642
                     /gene="Dnal1"
                     /gene_synonym="1700010H15Rik; Dnalc1; E330027P08Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     dynein light chain 1, axonemal"
                     /codon_start=1
                     /product="dynein axonemal light chain 1 isoform 1"
                     /protein_id="NP_083097.2"
                     /db_xref="CCDS:CCDS26039.2"
                     /db_xref="GeneID:105000"
                     /db_xref="MGI:MGI:1921462"
                     /translation="MAKATTIKEALSRWEEKTGQKPSDAKEIKLYAQIPPIEKMDASL
                     STLGNCEKLSLSTNCIEKIANLNGLKNLRILSLGRNNIKNLNGLEAVGETLEELWISY
                     NFIEKLKGIHVMKKLKILYMSNNLVKDWAEFLKLAELPCLEDLVFVGNPLEEKHSAEG
                     NWIDEATKRVPKLKKLDGTPVIKEDEEEES"
     exon            73..111
                     /gene="Dnal1"
                     /gene_synonym="1700010H15Rik; Dnalc1; E330027P08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            112..221
                     /gene="Dnal1"
                     /gene_synonym="1700010H15Rik; Dnalc1; E330027P08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            222..277
                     /gene="Dnal1"
                     /gene_synonym="1700010H15Rik; Dnalc1; E330027P08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            278..333
                     /gene="Dnal1"
                     /gene_synonym="1700010H15Rik; Dnalc1; E330027P08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            334..460
                     /gene="Dnal1"
                     /gene_synonym="1700010H15Rik; Dnalc1; E330027P08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            461..601
                     /gene="Dnal1"
                     /gene_synonym="1700010H15Rik; Dnalc1; E330027P08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            602..5765
                     /gene="Dnal1"
                     /gene_synonym="1700010H15Rik; Dnalc1; E330027P08Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      690..695
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dnal1"
                     /gene_synonym="1700010H15Rik; Dnalc1; E330027P08Rik"
                     /note="hexamer: AATAGA"
     polyA_site      723
                     /gene="Dnal1"
                     /gene_synonym="1700010H15Rik; Dnalc1; E330027P08Rik"
                     /note="major polyA site"
     polyA_site      754
                     /gene="Dnal1"
                     /gene_synonym="1700010H15Rik; Dnalc1; E330027P08Rik"
     regulatory      5674..5679
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dnal1"
                     /gene_synonym="1700010H15Rik; Dnalc1; E330027P08Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      5696
                     /gene="Dnal1"
                     /gene_synonym="1700010H15Rik; Dnalc1; E330027P08Rik"
                     /note="major polyA site"
ORIGIN      
        1 agaggcgcgc ctgcgcactg accccggcgg gccctagcaa ccagagcagt gacggtagca
       61 accgccggaa tggcaaaagc aacaacgatc aaagaagccc tgtccagatg ggaagaaaag
      121 actggtcaga agccatctga tgccaaagaa atcaagctgt atgcccagat tccccccata
      181 gagaagatgg acgcatctct atccacactt ggtaactgcg agaagctttc cctgtctaca
      241 aactgcattg aaaaaattgc caacctgaat ggcctaaaaa acttgaggat tttgtcctta
      301 ggaagaaaca acataaagaa cctaaatgga ctggaagcag taggagaaac actggaagaa
      361 ctgtggatct cctacaattt tattgagaag ttgaaaggaa tccatgtaat gaagaaactg
      421 aagattctct acatgtctaa taacctggta aaagactggg ctgagttcct gaagctggcc
      481 gagctgccgt gcctggagga cctggtgttc gtcggtaatc ccctggagga gaaacactct
      541 gccgagggca actggatcga tgaagcaacc aagagagtgc ccaagctgaa aaagctggat
      601 ggtactccag taattaagga ggatgaagaa gaggaaagct aaggctgtac ttttcatttt
      661 gtgttaattt atttaaatgt tatgagaaaa atagataagt tttgtataat tgtctatttt
      721 aaagattttg tggagcagag ttcttaagat aaaacacatc tctcacttcc atcctttaaa
      781 aaaaaacata ttcagtgttt atcccacaaa ccagtagcac caattgtagt caagtccagc
      841 cttgggaact acagatgtcc tggtcttgtc cagttatgta tgtcacctgt ctcccagtat
      901 ttatagacca gtcattttta ataggaaagg acttattatg tgtactcagt tgcttagtat
      961 ttcttagccc aggcatttta aagatagacg actttgccat ccatagaagg ttcaggccct
     1021 tacaagtcag aagcacaaat gcagcacgca ttgcttcaga ggcagcgtgg tgagaggaca
     1081 cactcccctt agagcacagc ggtatctgga cgcaggagcc cagcgtctag ttggaaacac
     1141 tgctcagaaa aggaagaatg gctgccgtgg aggcttcttg gctcatggtc tattttcttc
     1201 cttttccaaa aatgtgtgca ctgtcaactg gagtgtaggt tgtgcaccat ggatgccgct
     1261 taagtcatca tgtacagcca gacaccccat ggtccccatc agtggctaac gcaactggca
     1321 ggatcactcc ttggtagtac tgcgactaca tcaactcttg taaccttgct ttatgtagat
     1381 tttaagaaat aatttctcat gtgtttaaag cagtagtcaa tagtcctaag tatcgaccac
     1441 tgagattttg aaaaccttca ccctcatgat ttacccagat gccctttgct ttacagttat
     1501 gagtagacac ttaaagactg aatttggtac ctatagataa gtgagacagt atttcaagat
     1561 atatttttga gaaaatctaa atgaaacagc ttttaaagtg tatcatgtaa gtgctgtgga
     1621 ggaaacagtg aggtgttttg ggcaaatggc aatatgttgt agattgtcac tataggtgtc
     1681 ttaacctcag acctgcaaag caatagttaa gtgtgaacag tataatttat catgtaagaa
     1741 aaatattctg aaacctgtaa aatggcatca gcaccagatg aagtctccag tgggtcaaga
     1801 tagaattatt gactgattgt ggagtagtca ggaaccgctg ccaacctgtg cctaaagtct
     1861 cagccagagg ctgccgattc ttgtccctgt ctccacgtgg ttctccctga aagtcaccac
     1921 agtgaagggg gcagagtctt ttgtttctgt ttttaattat tatataagta gtcttggttt
     1981 gagaacttat aactatcatt tcagtaaaaa tgactcaatt tctgtaagag tcacgctggt
     2041 cagaagggac cactgctttg acaatcaact ctaaatccat acaagaatgt ctggttgtgg
     2101 gctggtgaga cagctcagag gtaagagtac ctgttgctca ggacctgagc ttgcttccca
     2161 gtaccatgag gaggctcaca gccctctgga cctccagggg ctctgatgtc cttttctgga
     2221 cctccagggg ctctgatgtc cttttctgga cctccaggga ctctcatgtc cttttctggc
     2281 ctcccacaca catgttgcac agacagacat ggaggtgaga cactaaatgc ataatcaatt
     2341 tttaaaaaga atacctagtc taataccttt ttagcttttc tgatggggag aaactttacc
     2401 ctgactggct taaacgttca aaaccattgg catttctctt ctgagcaaca gtggtgagac
     2461 ttcttggtgg tgcagaaggc ctataagctt aggagacact gttgtggttg cttgtagttt
     2521 acacaggcaa gccctgttcc cgctgatgct gtgcttcctg cgacacacct ggagtgaggg
     2581 caggaagggg atggcttcag actggctctg tgaagtgact tacagatgtg tgtttgtttc
     2641 caaattctgt agttgggaaa cacccctccc ctatttctca atgtctttta ttcactgatg
     2701 gttctcagag atgtgcacgg tgcttttctg tgtccatttc tctctctctc tccctctctc
     2761 tctttctctc tctccctccc tctctctctc cctccctccc tctctctctc cctcccccct
     2821 ccctccctcc ctccctccct cccctcccct ccccccccca cacaaacatt ttcggctcct
     2881 catcacaaat attggaatga ctttgatgcg gctctgttcc tggaattaaa gccaaaatgc
     2941 attcaatttg aaagtggaag gccagcctgg tctacagagt gagttccaga acagccaggg
     3001 ctacacagag aaaccctgtc ttaaaaaaca aaaccaaaaa aaacggaagg aaggaaggaa
     3061 agaaggaagg agggagggag ggagggaggg aggaaggaag gaaggaagga aggaaggaag
     3121 gaaggaagga aggaaggagg gagggaagga gggaaggaag aagggaagga aggaaggaag
     3181 aaaggaagga aggaaggaaa tggaaggctg ggtacctgag agaattaagg ctgtcctcgc
     3241 tgtccttgtc ctcctcatcc tccctgccca ctctgatcag tcctgatgtc ttcttttact
     3301 ggaaaaaaaa atgtagttga ggaaggtggg acttatgcca ttcagattgg agatggaacc
     3361 aacttggaat agatgttctc tgtgatcatt tgaacttcta gtattataaa taatggtagg
     3421 gtgcaggaac acccagtatt ttaatttttc accgtcaata tgatattggt atattggagt
     3481 tgtacttcct atgtctcctg atcctgagct aatgaccata ttatctagct aggccttgga
     3541 gggctttcct acctgtgctt acggcaccag agatgctcag tgtggcgctg tttacattta
     3601 ggctgtatga ctcactcttg tgggccgtgc actgtgtgca ggttagctgc agccctgtcc
     3661 tttactccct acatgccagg agctcctctc cagttatggt aacaaaagat ggctgcaagc
     3721 gttgcccact gagccctgga gcaggtggga cagccaaatt ctctagatag gagccagtgt
     3781 ttcctgtccc agcattcctc tgtgcaggct ggtcagcttc agtctgtagt ctgtgccact
     3841 agcattattg taagagaagg tgacatttta ccatcatggc tggacctgat caggtctgtt
     3901 gcccttttat gcaatgctca gtttcatgtt ccccacacag ccttagaagc tcaggcctag
     3961 aagctgaaac ttctgcctgt aggatttcaa cttgagtttc ttgtcccctg ctcatgttag
     4021 gacaatggtt gaccagttaa tctacctctg tcactgtcaa caaaatctag cttttatgat
     4081 agattttgtt ctgtctctaa agcttaatat ttgtattaca ctttagaaaa tgtatcaccc
     4141 tgcacagact cttttgcagg gtgtgtcagt cattaagtct agactgtgtt gtattgagtt
     4201 gctcgtgccc agaagttagc tgatgcagat gtccagtgca actgaccaga agggtgctgt
     4261 ccctcaccgc tcagttactt ggaatgcttc ctggggctga cctaaatgtg gctctggaat
     4321 ggaagtttct ggttgaatag gtgtttgttg ttgaataggt gtttgtcagg ggtctgaaaa
     4381 cgagggagca ttggaaataa atctgtcatt ggctcagagt tggtgacaga gaaagcaggg
     4441 agtcttttac ctgggttttt cttgaggtca aaacaaacaa acaaacaaag cagttagccg
     4501 gcctagacag tttgcatgta atcattcact ttgaaaaatg gttgaggagt tcttgtctct
     4561 gactgaggta gctgttccga gttcactgag acggtaaaca gtaacggcaa ggggagaaaa
     4621 cctgtccttc ccacagtcag tctcagatat ccatgtcctt tgtgtgggcc gagaatgagt
     4681 ctgtgactaa tgaagcaaca gccgggcagc agagtcgggt tgtgtgtggc agccgacgag
     4741 gtcatggccc tttacccttc cttacccagt gtgaacagct gcatcagtga tcactcagcc
     4801 ttccgagttc catgtctgtg tccatcacta actgtaagca aggaagcaga caggaaaaac
     4861 tatagacttt tagcctgata gaacacagga gaagtcctaa tcagattctc attgatttcc
     4921 catattgggc agattagagg acccagacaa ccaattatga tctgacaatt ttaacaagaa
     4981 ggaagagaga ataaactatt tttaaaatag atttgcactt taaaattatg agtgtggctc
     5041 ataggaacgc acacaggagt ccggactcag acttcaacct ttgtccacac acgcccgtct
     5101 tcatactcac ttaggatttt ctgcctttct gatttgggtt gtatccgagg tcatccctct
     5161 gggagggtgt aaatagcttt tctatttaga atagaaactt tggtttggtt tagtttggtt
     5221 ttggttgttc aagacagggt ttcccaggca gtcttgggac ttactctgta tgtagaccag
     5281 gctagcatca aacacagaga tccacctgtc tctgcctccc tagtgctgga gttaaagaca
     5341 tgtaccacta ccgcctggcc catatctaga tttaaaattt tctttttagt gttgtctaca
     5401 ttacatggta tgtctccagt cagtgggaga ccctgcctat gacgctgttg ccaagtggga
     5461 ccactcctgc caatggccag tggagagcag aaggtaccca gtccacctgc ttctctcagg
     5521 ttgtcgttca tggccaggag catcattcgc aaagctttga cttctagatc catgttcatt
     5581 ctgaagaacg ttttaacatc tgttaatgct ttggtaataa tcttttctac acaggacttt
     5641 tgtagcatga ctttatgact aaacttattg tgcattaaat tatttagtaa tattgagttt
     5701 ctgaatgtta ttttgtgaaa cttgttttaa aatagtaata aatcatgtta ttttataaaa
     5761 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa
//
