LOCUS       NM_172400               1410 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus DnaJ heat shock protein family (Hsp40) member C8
            (Dnajc8), mRNA.
ACCESSION   NM_172400
VERSION     NM_172400.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1410)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1410)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1410)
  AUTHORS   Perez-Garcia,V., Fineberg,E., Wilson,R., Murray,A., Mazzeo,C.I.,
            Tudor,C., Sienerth,A., White,J.K., Tuck,E., Ryder,E.J., Gleeson,D.,
            Siragher,E., Wardle-Jones,H., Staudt,N., Wali,N., Collins,J.,
            Geyer,S., Busch-Nentwich,E.M., Galli,A., Smith,J.C., Robertson,E.,
            Adams,D.J., Weninger,W.J., Mohun,T. and Hemberger,M.
  TITLE     Placentation defects are highly prevalent in embryonic lethal mouse
            mutants
  JOURNAL   Nature 555 (7697), 463-468 (2018)
   PUBMED   29539633
REFERENCE   4  (bases 1 to 1410)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (bases 1 to 1410)
  AUTHORS   Liu,X., Jiao,Y., Cao,Y., Deng,N., Ma,Y., Hasty,K.A., Kang,A.,
            Chen,H., Stuart,J.M. and Gu,W.
  TITLE     Decreased expression levels of Ifi genes is associated to the
            increased resistance to spontaneous arthritis disease in mice
            deficiency of IL-1RA
  JOURNAL   BMC Immunol 17 (1), 25 (2016)
   PUBMED   27480124
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1410)
  AUTHORS   Gineste,C., De Winter,J.M., Kohl,C., Witt,C.C., Giannesini,B.,
            Brohm,K., Le Fur,Y., Gretz,N., Vilmen,C., Pecchi,E., Jubeau,M.,
            Cozzone,P.J., Stienen,G.J., Granzier,H., Labeit,S.,
            Ottenheijm,C.A., Bendahan,D. and Gondin,J.
  TITLE     In vivo and in vitro investigations of heterozygous nebulin
            knock-out mice disclose a mild skeletal muscle phenotype
  JOURNAL   Neuromuscul Disord 23 (4), 357-369 (2013)
   PUBMED   23375831
REFERENCE   7  (bases 1 to 1410)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   8  (bases 1 to 1410)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY754536.1, AK168645.1 and BC064732.1.
            
            On Oct 6, 2007 this sequence version replaced NM_172400.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC064732.1, AK088325.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                BY754536.1         5-21
            18-1385             AK168645.1         2-1369
            1386-1410           BC064732.1         1365-1389
FEATURES             Location/Qualifiers
     source          1..1410
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 65.52 cM"
     gene            1..1410
                     /gene="Dnajc8"
                     /gene_synonym="1110021D09Rik; 2010009J04Rik"
                     /note="DnaJ heat shock protein family (Hsp40) member C8"
                     /db_xref="GeneID:68598"
                     /db_xref="MGI:MGI:1915848"
     exon            1..105
                     /gene="Dnajc8"
                     /gene_synonym="1110021D09Rik; 2010009J04Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..789
                     /gene="Dnajc8"
                     /gene_synonym="1110021D09Rik; 2010009J04Rik"
                     /note="DnaJ (Hsp40) homolog, subfamily C, member 8"
                     /codon_start=1
                     /product="dnaJ homolog subfamily C member 8"
                     /protein_id="NP_765988.2"
                     /db_xref="CCDS:CCDS51319.1"
                     /db_xref="GeneID:68598"
                     /db_xref="MGI:MGI:1915848"
                     /translation="MAASGESGASGGGGSTEEAFMTFYSEVKQIEKRDSVLTSKNQIE
                     RLTRPGSSYFNLNPFEVLQIDPEVTDEEIKKRFRQLSILVHPDKNQDDADRAQKAFEA
                     VDKAYKLLLDQEQKKRALDVIQAGKEYVEHTVKERKKQLKKEGKPTNVEEDDPELFKQ
                     AVYKQTMKLFAELEIKRKEREAKEMHERKRQREEEIEAQEKAKREREWQKNFEESRDG
                     RVDSWRNFQANTKGKKEKKNRTFLRPPKVKMEQRE"
     exon            106..207
                     /gene="Dnajc8"
                     /gene_synonym="1110021D09Rik; 2010009J04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            208..264
                     /gene="Dnajc8"
                     /gene_synonym="1110021D09Rik; 2010009J04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            265..331
                     /gene="Dnajc8"
                     /gene_synonym="1110021D09Rik; 2010009J04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            332..426
                     /gene="Dnajc8"
                     /gene_synonym="1110021D09Rik; 2010009J04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            427..498
                     /gene="Dnajc8"
                     /gene_synonym="1110021D09Rik; 2010009J04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            499..590
                     /gene="Dnajc8"
                     /gene_synonym="1110021D09Rik; 2010009J04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            591..666
                     /gene="Dnajc8"
                     /gene_synonym="1110021D09Rik; 2010009J04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            667..1392
                     /gene="Dnajc8"
                     /gene_synonym="1110021D09Rik; 2010009J04Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1369..1374
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dnajc8"
                     /gene_synonym="1110021D09Rik; 2010009J04Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1387
                     /gene="Dnajc8"
                     /gene_synonym="1110021D09Rik; 2010009J04Rik"
                     /note="major polyA site"
ORIGIN      
        1 acggtcacgt ggtggttagc cgggaaaatg gcggcttcgg gagagagtgg tgcttcgggt
       61 ggcggaggca gcacagagga ggcatttatg accttctaca gtgaggtgaa acaaatagag
      121 aagagagatt cagttctaac atccaaaaat caaattgaaa gattgactcg tcctggttcc
      181 tcttacttta atctgaaccc atttgaggtt cttcagatag atcctgaagt gacagatgaa
      241 gaaataaaaa agaggtttcg tcagttgtcc atcctggtgc atcctgacaa aaaccaggac
      301 gatgctgaca gagcacagaa ggcttttgaa gctgtggaca aagcttacaa gttgctactg
      361 gatcaggaac aaaagaagag ggccctggat gtaattcagg caggaaaaga atacgtggaa
      421 cacactgtta aagagcgaaa aaaacaactg aagaaggaag gaaagcctac aaatgtggag
      481 gaagatgatc ccgaactgtt caaacaggca gtctacaaac agaccatgaa gctgtttgct
      541 gagctggaga ttaaaaggaa agagagagaa gccaaagaaa tgcatgagag gaagcgacag
      601 agagaagagg agatcgaagc ccaggaaaaa gccaagcgag aaagagagtg gcagaaaaac
      661 tttgaggaaa gtcgggatgg tcgagtggac agttggcgaa atttccaggc aaatacaaag
      721 gggaagaagg agaagaagaa tcggaccttc ctgcggccac cgaaagtcaa gatggagcag
      781 cgggagtgag cagcaggacc agagcctccc cgctgctcct cctgcttcac ggactcattc
      841 tctctccacc tccaccccac cagagagtag cgattgcttt ttagtctatt ttgttgtcaa
      901 tacaatttaa tatcaatcag agtaatcctt tgtacattga gaggaggggc ttggtttcac
      961 catccccgtc ctttccccac ggatccacca ggattgaagg agcttcggac ccatgccgcc
     1021 ttcttttccc acgcctctaa cttaatgttt tatatttgaa ttgtgtggct caagggtcat
     1081 gtatagtttg tggaattttt ccaattaaat gtcttgctta cagtggtgtt gccccgactc
     1141 cagatcagcc tgggccacct tgggaagcca tccttgaggc ccttgctcca ataggagagg
     1201 tattgtggat tcacacggca gtcacttgtt gccctcatgc cctgtggtgt ttggcacgag
     1261 gctcccagcc acttaaacct gttcactttc caaagaattc atcttccagc cagtcccgtt
     1321 gtgtccttgc ttgtctgcat ttattagtgg taatattctt ttacgtataa taaattttta
     1381 tacccaagcc ttaaaaaaaa aaaaaaaaaa
//
