LOCUS       NM_025489                947 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus DnaJ heat shock protein family (Hsp40) member C5 beta
            (Dnajc5b), transcript variant 2, mRNA.
ACCESSION   NM_025489
VERSION     NM_025489.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 947)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. PMID: 29144450]
REFERENCE   2  (bases 1 to 947)
  AUTHORS   Rodriguez-de la Rosa,L., Sanchez-Calderon,H., Contreras,J.,
            Murillo-Cuesta,S., Falagan,S., Avendano,C., Dopazo,J.,
            Varela-Nieto,I. and Milo,M.
  TITLE     Comparative gene expression study of the vestibular organ of the
            Igf1 deficient mouse using whole-transcript arrays
  JOURNAL   Hear Res 330 (Pt A), 62-77 (2015)
   PUBMED   26341476
REFERENCE   3  (bases 1 to 947)
  AUTHORS   Gundersen,C.B., Kohan,S.A., Souda,P., Whitelegge,J.P. and
            Umbach,J.A.
  TITLE     Cysteine string protein beta is prominently associated with nerve
            terminals and secretory organelles in mouse brain
  JOURNAL   Brain Res 1332, 1-11 (2010)
   PUBMED   20338151
  REMARK    GeneRIF: the enrichment of CSP-beta in synaptosomes and the
            association of CSP-beta with synaptic vesicles suggest that
            CSP-beta, like CSP-alpha, may be an important component of the
            regulated secretory machinery in mouse brain
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY085815.1, AK005725.1 and CA463124.1.
            
            [WARNING] On Apr 4, 2024 this sequence was replaced by NM_025489.4.
            
            On Jul 23, 2009 this sequence version replaced NM_025489.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. All three variants encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC049579.1, AK005749.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                BY085815.1         2-21
            21-813              AK005725.1         1-793
            814-947             CA463124.1         528-661
FEATURES             Location/Qualifiers
     source          1..947
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 5.55 cM"
     gene            1..947
                     /gene="Dnajc5b"
                     /gene_synonym="1700008A05Rik"
                     /note="DnaJ heat shock protein family (Hsp40) member C5
                     beta"
                     /db_xref="GeneID:66326"
                     /db_xref="MGI:MGI:1913576"
     exon            1..112
                     /gene="Dnajc5b"
                     /gene_synonym="1700008A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            113..239
                     /gene="Dnajc5b"
                     /gene_synonym="1700008A05Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..720
                     /gene="Dnajc5b"
                     /gene_synonym="1700008A05Rik"
                     /note="beta-CSP; beta cysteine string protein; CSP-beta;
                     cysteine string protein beta; DnaJ (Hsp40) homolog,
                     subfamily C, member 5 beta"
                     /codon_start=1
                     /product="dnaJ homolog subfamily C member 5B"
                     /protein_id="NP_079765.3"
                     /db_xref="CCDS:CCDS17257.1"
                     /db_xref="GeneID:66326"
                     /db_xref="MGI:MGI:1913576"
                     /translation="MACNAPNQRQRTLSTSGESLYEILGLHKGASCEEIKKTYRKLAL
                     RHHPDKNPDDPSAAEKFKEINNAHTILTDTSKRNIYDKYGSLGLYVAEQFGDENVNTY
                     FMLSSWWAKTLFIIIGLLTGCYFCCCLCCCCNCCCGHCRPKSSTPEEEFYVSPEDLEE
                     QIRTDMEKDMDFPVVLQPTNTNEKTQLIREGSRSYCTDS"
     exon            240..453
                     /gene="Dnajc5b"
                     /gene_synonym="1700008A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            454..625
                     /gene="Dnajc5b"
                     /gene_synonym="1700008A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            626..943
                     /gene="Dnajc5b"
                     /gene_synonym="1700008A05Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcatctgag aaggaaaagc aacggaggct cagttattga cagagcaggg gaagaacact
       61 cgtggaagga cccagaagga tcagccagcc atgcctccag ttcaggtaca agattgagaa
      121 atggcatgta acgcacccaa ccaaagacag cggactttgt caacatcagg agaaagtcta
      181 tatgaaattc ttggtctgca taagggagca tcatgtgaag aaattaagaa aacctacaga
      241 aaattagccc tgcgacacca tccagacaag aatccagatg acccatctgc tgctgagaag
      301 tttaaagaaa tcaacaacgc ccacacaatc ctcaccgaca cctcaaagag aaacatatat
      361 gacaagtatg gatcgctggg actctacgtg gctgaacaat ttggagatga aaacgttaac
      421 acatacttca tgttgtcaag ctggtgggca aagaccctgt tcatcatcat tggcctcttg
      481 accggctgct atttttgttg ctgcctttgc tgctgctgca actgttgttg tggacattgt
      541 cggcccaaat catcgacacc agaagaggag ttctatgtgt caccagagga ccttgaggag
      601 cagatcagaa ctgacatgga gaaagatatg gactttccag ttgttctcca gcctacaaat
      661 acaaatgaga aaacacagct aatcagagaa ggatctcgaa gttactgcac agactcttaa
      721 tgttggcccg tggagggtcc acagctcctc tttttggttc agccatgtct ctgggtggtc
      781 atcggggaag tgcaaacatg aaatgctgtg aacatattca catttgtatt ttatttttag
      841 gttaagggga agatgattgc tacataattt tctcagactt tctctttgag tagaatccta
      901 atcaaaagca ttcagtttga tgaataaagg cctgaagagt tgaaaaa
//
