LOCUS       NM_016775               4325 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus DnaJ heat shock protein family (Hsp40) member C5
            (Dnajc5), transcript variant 3, mRNA.
ACCESSION   NM_016775 XM_990872
VERSION     NM_016775.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4325)
  AUTHORS   Wang,N., Zhu,B., Allnutt,M.A., Grijalva,R.M., Zhao,H. and
            Chandra,S.S.
  TITLE     Decoding transcriptomic signatures of cysteine string protein
            alpha-mediated synapse maintenance
  JOURNAL   Proc Natl Acad Sci U S A 121 (24), e2320064121 (2024)
   PUBMED   38833477
REFERENCE   2  (bases 1 to 4325)
  AUTHORS   Dash,S., Lamb,M.C., Lange,J.J., McKinney,M.C., Tsuchiya,D., Guo,F.,
            Zhao,X., Corbin,T.J., Kirkman,M., Delventhal,K., Moore,E.L.,
            McKinney,S., Shiang,R. and Trainor,P.A.
  TITLE     rRNA transcription is integral to phase separation and maintenance
            of nucleolar structure
  JOURNAL   PLoS Genet 19 (8), e1010854 (2023)
   PUBMED   37639467
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4325)
  AUTHORS   Naseri,N.N., Ergel,B., Kharel,P., Na,Y., Huang,Q., Huang,R.,
            Dolzhanskaya,N., Burre,J., Velinov,M.T. and Sharma,M.
  TITLE     Aggregation of mutant cysteine string protein-alpha via Fe-S
            cluster binding is mitigated by iron chelators
  JOURNAL   Nat Struct Mol Biol 27 (2), 192-201 (2020)
   PUBMED   32042150
  REMARK    GeneRIF: Point mutations in cysteine string protein-alpha (CSP
            alpha) cause dominantly inherited adult-onset neuronal ceroid
            lipofuscinosis (ANCL). Normally palmitoylated cysteine string
            region of cysteine string protein alpha loses palmitoylation in
            ANCL mutants.
REFERENCE   4  (bases 1 to 4325)
  AUTHORS   Nieto-Gonzalez,J.L., Gomez-Sanchez,L., Mavillard,F.,
            Linares-Clemente,P., Rivero,M.C., Valenzuela-Villatoro,M.,
            Munoz-Bravo,J.L., Pardal,R. and Fernandez-Chacon,R.
  TITLE     Loss of postnatal quiescence of neural stem cells through mTOR
            activation upon genetic removal of cysteine string protein-alpha
  JOURNAL   Proc Natl Acad Sci U S A 116 (16), 8000-8009 (2019)
   PUBMED   30926666
  REMARK    GeneRIF: Studied role of the synaptic co-chaperone cysteine string
            protein-alpha in postnatal quiescence of mouse hippocampal radial
            glia-like (RGL) neural stem cells through mechanistic target of
            rapamycin kinase (mTOR) activation.
REFERENCE   5  (bases 1 to 4325)
  AUTHORS   Deng,J., Koutras,C., Donnelier,J., Alshehri,M., Fotouhi,M.,
            Girard,M., Casha,S., McPherson,P.S., Robbins,S.M. and Braun,J.E.A.
  TITLE     Neurons Export Extracellular Vesicles Enriched in Cysteine String
            Protein and Misfolded Protein Cargo
  JOURNAL   Sci Rep 7 (1), 956 (2017)
   PUBMED   28424476
  REMARK    GeneRIF: Results indicate that by assisting local
            lysosome/proteasome processes, CSPalpha-mediated removal of toxic
            proteins via extracellular vesicles plays a central role in
            synaptic proteostasis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4325)
  AUTHORS   Ohtsuka,K. and Hata,M.
  TITLE     Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a
            proposal for their classification and nomenclature
  JOURNAL   Cell Stress Chaperones 5 (2), 98-112 (2000)
   PUBMED   11147971
REFERENCE   7  (bases 1 to 4325)
  AUTHORS   Lambert,J., Bergeron,D., Kozak,C.A. and Rassart,E.
  TITLE     Identification of a common site of provirus integration in
            radiation leukemia virus-induced T-cell lymphomas in mice
  JOURNAL   Virology 264 (1), 181-186 (1999)
   PUBMED   10544143
REFERENCE   8  (bases 1 to 4325)
  AUTHORS   Lyu,M.S., Rhee,S.G., Chae,H.Z., Lee,T.H., Adamson,M.C., Kang,S.W.,
            Jin,D.Y., Jeang,K.T. and Kozak,C.A.
  TITLE     Genetic mapping of six mouse peroxiredoxin genes and fourteen
            peroxiredoxin related sequences
  JOURNAL   Mamm Genome 10 (10), 1017-1019 (1999)
   PUBMED   10501973
REFERENCE   9  (bases 1 to 4325)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   10 (bases 1 to 4325)
  AUTHORS   Chin,H., Lyu,M.S., Kwon,O.J. and Kozak,C.A.
  TITLE     Genetic mapping of the gene encoding cysteine string protein
  JOURNAL   Mamm Genome 8 (6), 456-457 (1997)
   PUBMED   9257949
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY333630.1, AK029006.1 and AK035288.1.
            
            On Oct 19, 2012 this sequence version replaced NM_016775.2.
            
            Transcript Variant: This variant (3) lacks an exon in the 5' UTR
            compared to variant 1. Variants 1, 2, and 3 all encode the same
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.65720.1,
                                           SRR1660813.83900.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-310               BY333630.1         1-310
            311-3146            AK029006.1         249-3084
            3147-4325           AK035288.1         562-1740
FEATURES             Location/Qualifiers
     source          1..4325
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 103.63 cM"
     gene            1..4325
                     /gene="Dnajc5"
                     /gene_synonym="2610314I24Rik; Csp"
                     /note="DnaJ heat shock protein family (Hsp40) member C5"
                     /db_xref="GeneID:13002"
                     /db_xref="MGI:MGI:892995"
     exon            1..213
                     /gene="Dnajc5"
                     /gene_synonym="2610314I24Rik; Csp"
                     /inference="alignment:Splign:2.1.0"
     exon            214..331
                     /gene="Dnajc5"
                     /gene_synonym="2610314I24Rik; Csp"
                     /inference="alignment:Splign:2.1.0"
     CDS             225..821
                     /gene="Dnajc5"
                     /gene_synonym="2610314I24Rik; Csp"
                     /note="cysteine string protein; DnaJ (Hsp40) homolog,
                     subfamily C, member 5"
                     /codon_start=1
                     /product="dnaJ homolog subfamily C member 5"
                     /protein_id="NP_058055.1"
                     /db_xref="CCDS:CCDS17215.1"
                     /db_xref="GeneID:13002"
                     /db_xref="MGI:MGI:892995"
                     /translation="MADQRQRSLSTSGESLYHVLGLDKNATSDDIKKSYRKLALKYHP
                     DKNPDNPEAADKFKEINNAHAILTDATKRNIYDKYGSLGLYVAEQFGEENVNTYFVLS
                     SWWAKALFVVCGLLTCCYCCCCLCCCFNCCCGKCKPKAPEGEETEFYVSPEDLEAQLQ
                     SDEREATDTPIVIQPASATETTQLTADSHPSYHTDGFN"
     exon            332..545
                     /gene="Dnajc5"
                     /gene_synonym="2610314I24Rik; Csp"
                     /inference="alignment:Splign:2.1.0"
     exon            546..717
                     /gene="Dnajc5"
                     /gene_synonym="2610314I24Rik; Csp"
                     /inference="alignment:Splign:2.1.0"
     exon            718..4325
                     /gene="Dnajc5"
                     /gene_synonym="2610314I24Rik; Csp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaacacacg tctttttccg ggggcgcgcg tgccagtgag tgagcgtgcg cgttcttgct
       61 gccgccagtg ttgcttccgc cgtcctctgc cgctgctacg gctgtcgccg cccgggatcc
      121 tcaggccgag cagtaggccg gccggctgcc caccactgcc ccgggacgga aagcggagcc
      181 gcggaaccgg tggaccggcg ggcgtgccga cagactaacc taacatggcc gaccagaggc
      241 agcgctcact ctctacttcc ggggaatcat tataccatgt tcttggactg gacaagaatg
      301 caacctcaga tgacattaaa aagtcctatc ggaagctggc cctgaagtat caccctgaca
      361 agaaccctga taacccagag gctgcagaca agtttaagga gattaacaac gcacacgcca
      421 tcctgacaga cgccacgaaa agaaacattt atgacaagta tggctcgctg gggctctatg
      481 tggcggagca gtttggggag gagaacgtca acacctactt cgtactctcc agctggtggg
      541 ccaaggcgct gtttgttgtt tgtggcctcc tcacctgctg ctactgctgc tgctgtttgt
      601 gctgttgctt taactgctgc tgtgggaaat gcaagcccaa ggcacctgag ggtgaggaga
      661 cagaattcta cgtatcccct gaagacttgg aggcacagct gcagtctgat gaaagggagg
      721 ctacagacac accgatcgtc atacagccag catctgccac agagaccacc cagctgacag
      781 ctgactccca ccccagctat cacaccgacg ggttcaacta aattcaggag aggctgtgat
      841 tagaggatga atcagcatct ggccactgca accttagaat catgaactgt agtcactgag
      901 atgggaaggc agccgtcaac ctgacctgct ctggctggtc agggccactc ccacctcctc
      961 taagtccacc catctgtcaa tccttgatac atgaagtgcg tagcatgcag tatttaaagc
     1021 agtgtagcta cggtcttctt ctgttttatc ctttttttaa tagcatgtat gggttatgtt
     1081 caatgtctgt gttgtggacg tgctgcagct gggctgaatt aactggatgg tagtgcttat
     1141 tttgggtttt cagccaagcg ggtccagtga aggttcagct gtctccttgt gcttacagga
     1201 gtcaggtaag cacctggagc tacatctcct tgttggcctc tgtgtcctgt gatatggtct
     1261 agtccatggc tctgatctca tcctcaaggc tgcagacagg gctctgatat cacctgcaaa
     1321 ggagggaact gggccccgtc ttccaggcac caccagcatc agtcgtttgc acggtgttcg
     1381 tgttgggaag ctttcatagg gtctctgcat catctcactc ggcctcgtga cagttttcct
     1441 gttagatctg ctatggagag tgcaggtatg ccccttctga aagtgggagc acactctgtg
     1501 taatgtcact atcttgggtc tcctggcctt gtggactgaa atcctatcat tggaggcatg
     1561 tctcttgctg gtgtgtggga aatcatttgt ctctgttctg cacctttcca ggtcaaaagc
     1621 tggattgacg gggccacagc ctccttccct cattcctggg tcatcttcca cattccttca
     1681 agccaacctt ttaatctttt ttggactttt aagaaccaca aatggcagca cctgccactt
     1741 agtcatagtc agaaagtctc ttgagtccag ttgtgggtgg catgcaactg cttatgcaga
     1801 gtctgagtgc ccaggctcca gaacctcctc cctgtgcttg ccagtgcccc accccctgct
     1861 tgccttcgct tccacctgtc actatcaatg cctctggcag ctggagtgtt gggttcctgg
     1921 agcaggtggc tggaccctgg tgctcctggc tcagaagggt tggcttctag ggaagctatg
     1981 gtagtagtca ctcaacctgg gaggccagct cccggccaca ggattccttt gtgaacctct
     2041 ctccagtcag tattccagtc ttggttctag ggtaccatgg tgggtggagt tgaaaaatgt
     2101 ggttaccagt gatatggagc catcctaccc ttttacagtt agctagatag ttgtaccaga
     2161 cttcaatgag ccaggttcct ccagaacctt cccgttggct gctgctgccc atctgcattt
     2221 ccagaacaga tgaagaagga gaaggctcat gtggtggctc tgtggcccag acaaaccatc
     2281 atgtgtttct gaagcccacc ccgcccacct cctggcccca gctcaccagg gccttcagga
     2341 ccagatcagg ttgtcaggaa gttacaagaa gaggcagcac tgtgaggaca aacatggcag
     2401 tgatcaaggg aacccatcca ggtcctggga gacactgatg ccaagttccc agttgaccct
     2461 acaacagaac tacatgagcc aagatcctcc catggatttg ttagtttcgt tctttaaagg
     2521 attttaggga tatccactaa catagtcagt taaaagtaat ttgtaaacat cagacctgtg
     2581 tctagatgta gtgggatacg cctataatcc cagcactagg gaggctgagg taggaggacc
     2641 ttgagttgta gaccagtctg ggcttacaca gtaagaccct aactcaaata aaacaaccta
     2701 aaagaagaat gagaaatcta ttaattggcc catatttggg acaaaggaaa aagaagtcac
     2761 tggtcaacct ggggtgctgg gcctcttttc ctacagtgac caggaaccag gtccagactt
     2821 gtagatgatc agttgcagtc tggtagcaca cccctcctgc atgtagctct gtggcccttt
     2881 ccctcacatc ctaacgagct agatcctgaa ctgggacttg tggtgctgtc aggatgagaa
     2941 catggaagtt ttgaacctag tgtcttttgg aattcgtaaa gctaaataaa tgatgttgaa
     3001 cttgaaaccc tccatatgta gatcagtttc aaagtgataa tagtgattgc cacggccagt
     3061 aagtaccctg acctgtccct gtgcagactc ccttgcaggg ttttactatg ttgatctaag
     3121 gtctccttga tttcatttgt cctaagctaa gaactggtga gtctcaggat cagtctgact
     3181 gttcttgtcc aaatataaat attaaataga gaaacacaca cactccccta actcctatac
     3241 tggcaggcag tgtagatggt gctgtgctgt gttgcccaga gagtgctgga atctgtgcat
     3301 gcaagctcat cctgtgcagt ggagaccact tctgacctac agaaagtagt cgggagagac
     3361 cctgggggac ccgtctacca aggctgctgg agtgtaggtt tctgtttgtg cccagtgatg
     3421 tctttccttg tcttcctttt gactgtattt taagattact ttagatgatt ctgtgcaatg
     3481 tttatgacct ttcctaccct tctaatgttc agttaacaca gccagtaccc aatggggaaa
     3541 aaccaggctg ggtgatggtg gcagatgcct tatgtcccag cacttgggaa gcagaggcag
     3601 gcggctcacg gagcctgttc tacagaacta gttccaggac agccaggact acacacaaag
     3661 aaatcctgtc ttaagaagaa aaaaaaaaca aagcaaaaca aaacaaaaca aaagaaaaaa
     3721 gccagtgctt actgtggtta ggcaactttt tcccaagtta cttgctggat ttgttcctga
     3781 atcataaagc cagtctcttc agatgtcaag atttaatatc agtcagtacc cgttgtcctg
     3841 ctgatccatg gtgtctgtta caggtgagcc ttgttaaagg aggtgccagt gctgcagctg
     3901 gtagactcca gagagagtga cataatcatt caagctgccc ctgagggtgt gggtgctgta
     3961 gtacagagaa cctgtgggcc gtgagcatcc tactttggct ttcagtgcac cttttattga
     4021 ggaacagttg tgaacagtgt aaaccgtgac tgatcttatt ctttttccag tattttgagc
     4081 tgtgaaccca tgtgtcccag cactggcttg ttccttttta gtttgattga attatcctcc
     4141 tatggaagtg gcaaaatcta tgtctttact gtccttacaa gcacagtgtg tgttaccaca
     4201 tactgtgagt gtgggttgtg gtgtgtgtca gtgtgtgtac atatgtgtat atgtatatat
     4261 cacacagcag gcctgtcatg cctctgtttg gtggcaaagc aacaagtaca ataaaagtca
     4321 gctcc
//
